Philip A Efron, Scott C Brakenridge, Alicia M Mohr, Evan L Barrios, Valerie E Polcz, Stephen Anton, Tezcan Ozrazgat-Baslanti, Azra Bihorac, Faheem Guirgis, Tyler J Loftus, Martin Rosenthal, Christian Leeuwenburgh, Robert Mankowski, Lyle L Moldawer, Frederick A Moore
With the implementation of new intensive care unit (ICU) therapies in the 1970s, multiple organ failure (MOF) emerged as a fulminant inflammatory phenotype leading to early ICU death. Over the ensuing decades, with fundamental advances in care, this syndrome has evolved into a lingering phenotype of chronic critical illness (CCI) leading to indolent late post-hospital discharge death. In 2012, the University of Florida (UF) Sepsis Critical Illness Research Center (SCIRC) coined the term Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) to provide a mechanistic framework to study CCI in surgical patients...
August 8, 2023: Journal of Trauma and Acute Care Surgery