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pediatric blood

Xiaoan Zhang, Yanzi Ding, Yurong Zhang, Jinfang Xing, Yanpeng Dai, Enwu Yuan
INTRODUCTION: Reference intervals for pediatric laboratory tests need to be interpreted in the context of age- and sex-dependent dynamics. However, few reference intervals for healthy ethnic Han Chinese children have previously attempted to establish using large sample sizes. As such, there are no national hematological standards in China for pediatric reference intervals. METHODS: We used a direct method to enroll a total of 2164 healthy 1- to 7-year-old children from Henan province...
February 20, 2019: International Journal of Laboratory Hematology
Geisa Cristina da Silva Alves, Farah Maria Drumond Chequer, Cristina Sanches
OBJECTIVE: Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment. METHODS: This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year period (2016 to 2017). Children of both sexes, aged 2 to 12 years, were included in the study; burn children, and children in renal replacement therapy were excluded. For the pharmacokinetic analysis, two samples of 2mL of whole blood were collected, respecting the 2-hour interval between each withdrawal...
February 14, 2019: Einstein
Ryun Ha, Byeoung Woo Lim, Dong Hyun Kim, Jung Woo Park, Chang Hyun Cho, Ju Hyoung Lee
BACKGROUND AND OBJECTIVES: No consensus has been reached regarding the optimum treatment or factors affecting prognosis in pediatric idiopathic sudden sensorineural hearing loss (ISSNHL) due to its rarity. In the present study, treatment outcomes and prognostic factors of ISSNHL were investigated in pediatric patients who underwent steroid therapy. SUBJECTS: and Methods: Forty-two patients diagnosed with ISSNHL were enrolled in this retrospective study and compared with 39 normal healthy controls with respect to demography and complete blood cell count test results...
February 11, 2019: International Journal of Pediatric Otorhinolaryngology
Yu-Tang Chang, Ming-Yii Huang, Hsiang-Hung Shih, Chun-Chieh Wu, Tzu-Ying Lu, Pei-Chin Lin
BACKGROUND: Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% of malignancies arising in the stomach, small intestine, or colon. The stomach is the most common extranodal site of lymphoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 40% of primary gastric lymphoma. Gastric MALT lymphoma reaches its peak incidence between 50 to 60 years of age, therefore, it is rarely encountered in pediatric population. The presenting symptoms of gastric MALT lymphoma are usually nonspecific and primary perforation of gastric MALT lymphoma is uncommon...
February 19, 2019: BMC Pediatrics
Alice Monzani, Roberta Ricotti, Marina Caputo, Arianna Solito, Francesca Archero, Simonetta Bellone, Flavia Prodam
The incidence of skipping breakfast in pediatric subjects is rising, and a relationship with overweight (OW) and obesity (OB) has been shown. Associations with cardiovascular outcomes and skipping breakfast in adults have been reported. The purpose of this systematic review was to summarize the association of skipping breakfast with body weight and metabolic outcomes in the pediatric population. We searched relevant databases (2008⁻2018) and identified 56 articles, of which 39 were suitable to be included, basing on inclusion criteria (observational; defined breakfast skipping; weight and/or metabolic outcomes)...
February 13, 2019: Nutrients
Karen Huen, Daneida Lizarraga, Katherine Kogut, Brenda Eskenazi, Nina Holland
Epigenetic mechanisms have emerged as an important pathway through which environmental exposures can affect health through the regulation of gene expression without changes in DNA sequence: microRNAs (miRNAs) are short non-coding RNAs that target protein-coding mRNAs, leading to post-transcriptional repression. They are involved in important physiologic processes, but little is known about how miRNA expression may change with age in children. We used an nCounter miRNA assay to assess the expression of 43 miRNAs in buffy coat samples collected from newborns ( n = 121) and 7-year-old ( n = 142) children...
February 13, 2019: International Journal of Environmental Research and Public Health
Hari K Somineni, Suresh Venkateswaran, Varun Kilaru, Urko M Marigorta, Angela Mo, David T Okou, Richard Kellermayer, Kajari Mondal, Dawayland Cobb, Thomas D Walters, Anne Griffiths, Joshua D Noe, Wallace V Crandall, Joel R Rosh, David R Mack, Melvin B Heyman, Susan S Baker, Michael C Stephens, Robert N Baldassano, James F Markowitz, Marla C Dubinsky, Judy Cho, Jeffrey S Hyams, Lee A Denson, Greg Gibson, David J Cutler, Karen N Conneely, Alicia K Smith, Subra Kugathasan
BACKGROUND & AIMS: Crohn's disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated disease, which includes stricturing (B2) within 5 years. We analyzed DNA methylation patterns in blood samples of pediatric patients with Crohn's disease at diagnosis and later time points to identify changes that associate with and might contribute to disease development and progression...
February 16, 2019: Gastroenterology
Babak Pourakbari, Mohamadreza Abdolsalehi, Shima Mahmoudi, Maryam Banar, Farbod Masoumpour, Setareh Mamishi
BACKGROUND: Brucellosis is endemic in Iran. Children constitute 20-25% of cases. We determined clinical, laboratory, and epidemiologic characteristics of pediatric brucellosis patients hospitalized at the Children's Medical Center from May 2011 to December 2016. METHODS: Medical records were reviewed retrospectively. For each patient, a questionnaire was provided containing demographic characteristics (sex, age, nationality, date of admission, city of residence, history of ingestion of unpasteurized dairy products, family history of brucellosis, history of contact with suspicious animals) and clinical information (signs and symptoms, laboratory findings, history of disease relapse, treatment)...
February 18, 2019: Wiener Medizinische Wochenschrift
Nicholas G Larkins, Armando Teixeira-Pinto, Siah Kim, David P Burgner, Jonathan C Craig
OBJECTIVE: Hypertension is increasingly recognized as a disease spanning the entire life course. Continued efforts to refine the diagnosis and management of hypertension in children are highlighted by the recent American Academy of Pediatrics (AAP) guidelines, which include lower threshold values than the previous reference standard (Fourth Report). We aimed to determine the population-based prevalence of children exceeding thresholds for hypertension using these two guidelines. We also sought to identify the correlates of blood pressure (BP) among Australian children...
February 18, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Ramya Uppuluri, Meena Sivasankaran, Shivani Patel, Venkateswaran Vellaichamy Swaminathan, Kesavan Melarcode Ramanan, Nikila Ravichandran, Balasubramaniam Ramakrishnan, Indira Jayakumar, Lakshman Vaidhyanathan, Revathi Raj
Haploidentical stem cell transplantation (haplo SCT) has emerged as an acceptable alternative to matched family donor transplantation for children diagnosed to have primary immune deficiency disorders (PIDs). We present data over 4 years on the challenges and efficacy of unmanipulated T cell replete haplo SCTs with post-transplant cyclophosphamide (PTCy) in children diagnosed to have PIDs. We performed a retrospective study in the pediatric blood and marrow transplantation unit where all children less than 18 years of age diagnosed to have PIDs and who underwent haplo SCT with PTCy from January 2014 to February 2018 were included in the study...
February 18, 2019: Journal of Clinical Immunology
Marios Koutsakos, Patricia T Illing, Thi H O Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, David C Jackson, Tom C Kotsimbos, Allen C Cheng, Michael Richards, Glen P Westall, Thomas Loudovaris, Stuart I Mannering, Michael Elliott, Stuart G Tangye, Linda M Wakim, Jamie Rossjohn, Dhanasekaran Vijaykrishna, Fabio Luciani, Paul G Thomas, Stephanie Gras, Anthony W Purcell, Katherine Kedzierska
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross-protection against IAV strains, however the responses of CD8+ T cells to IBV and ICV are understudied. We investigated the breadth of CD8+ T cell cross-recognition and provide evidence of CD8+ T cell cross-reactivity across IAV, IBV and ICV. We identified immunodominant CD8+ T cell epitopes from IBVs that were protective in mice and found memory CD8+ T cells directed against universal and influenza-virus-type-specific epitopes in the blood and lungs of healthy humans...
February 18, 2019: Nature Immunology
Farahnaz Sadegh Beigee, Fariba Ghorbani, Shagin Shahryari, Meysam Mojtabaee
OBJECTIVES: Donor characteristics can directly affect transplant outcomes. In this study, we examined donor patterns in an organ procurement unit, which covered one-third of the population in Tehran, Iran over the past 12 years (2005 to 2018). MATERIALS AND METHODS: Demographic data of donors, including sex, age, cause of death, blood group, outcome of donation, number of organs per donor, and comorbidities (including diabetes mellitus and hypertension), were assessed...
January 2019: Experimental and Clinical Transplantation
Ebru H Ayvazoğlu Soy, Humaira Alam, Lale Olcay, Zeren Barış, Sedat Yıldırım, Adnan Torgay, Mehmet Haberal
Hemophagocytic lymphohistiocytosis is a rare and life-threatening systemic disease that can cause hepatic infiltration and present as acute liver failure. Here, we report a case of a 3-year-old pediatric patient who presented with acute liver failure and hepatic encephalopathy secondary to hemophagocytic lymphohistiocytosis. She had left lateral segment liver transplant from her father. After 27 months, she had bone marrow transplant from her sister. At the time of reporting (36 months after liver transplant), she showed normal liver function and blood peripheral counts...
January 2019: Experimental and Clinical Transplantation
Nathan Kuppermann, Peter S Dayan, Deborah A Levine, Melissa Vitale, Leah Tzimenatos, Michael G Tunik, Mary Saunders, Richard M Ruddy, Genie Roosevelt, Alexander J Rogers, Elizabeth C Powell, Lise E Nigrovic, Jared Muenzer, James G Linakis, Kathleen Grisanti, David M Jaffe, John D Hoyle, Richard Greenberg, Rajender Gattu, Andrea T Cruz, Ellen F Crain, Daniel M Cohen, Anne Brayer, Dominic Borgialli, Bema Bonsu, Lorin Browne, Stephen Blumberg, Jonathan E Bennett, Shireen M Atabaki, Jennifer Anders, Elizabeth R Alpern, Benjamin Miller, T Charles Casper, J Michael Dean, Octavio Ramilo, Prashant Mahajan
Importance: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications. However, lumbar punctures and hospitalizations involve risks and costs. Clinical prediction rules using biomarkers beyond the white blood cell count (WBC) may accurately identify febrile infants at low risk for SBIs. Objective: To derive and validate a prediction rule to identify febrile infants 60 days and younger at low risk for SBIs...
February 18, 2019: JAMA Pediatrics
Heather Cleveland, Sheena Pimpalwar, Daniel Ashton, Alex Chau, Aaditya Nagaraj, J Alberto Hernandez
PURPOSE: To evaluate technical and clinical success and report long-term outcomes of portal vein (PV) recanalization in pediatric orthotopic liver transplant (OLT) patients with chronic PV occlusion. MATERIALS AND METHODS: This is a retrospective review of 15 OLT patients (5 males) with chronic PV occlusion who underwent PV recanalization (33 procedures) between October 2011 and February 2018. Median age was 4.5 years (range, 1-16 years); median weight was 16.6 kg (range, 11...
February 14, 2019: Journal of Vascular and Interventional Radiology: JVIR
Shirley Friedman, Lilach Zac, Anat Cattan, Dror Ovadia, David E Lebel, Idit Matot
BACKGROUND: Hyperchloremia is frequent in adult surgical patients and is associated with renal dysfunction. Studies in surgical pediatric patients are lacking. OBJECTIVES: To identify both the incidence of postoperative hyperchloremia in children undergoing surgery for idiopathic and non-idiopathic scoliosis, and the association of postoperative hyperchloremia with intraoperative fluid management and postoperative diuresis. METHODS: The records of 74 children and adolescents who underwent elective scoliosis surgery were retrospectively evaluated...
February 2019: Israel Medical Association Journal: IMAJ
Gang Li, Peng Jia, Jian Zhao, Xingdan Wu, Yan Duan, Dong Liu, Ting Wang, Bin Liu
INTRODUCTION: We aimed to assess the performance of red blood cell distribution width (RDW), C-reactive protein (CRP) or the combination of both to predict clinical outcomes in pediatric non-cardiovascular critical illness. MATERIALS AND METHODS: We analyzed 404 pediatric non-cardiovascular critically ill patients admitted to pediatric intensive care unit (PICU). Potential predictors were identified using multivariable logistic regression. We also calculated the power of RDW and CRP additive to pediatric critical illness score (PCIS) to predict mortality with calculation of C-index value, integrated discrimination improvement (IDI) and net reclassification improvement (NRI) indices...
January 23, 2019: American Journal of Emergency Medicine
Ann Dahlberg, Filippo Milano
No abstract text is available yet for this article.
February 13, 2019: Biology of Blood and Marrow Transplantation
Keiichi Hirose, Akio Ikai, Hisao Nagato, Masaya Murata, Kenta Imai, Kazuyoshi Kanno, Motonari Ishido, Keisuke Ota, Hideto Iwafuchi, Kisaburo Sakamoto
A 2-year-old boy underwent right ventricular outflow tract reconstruction (RVOTR) with a bovine jugular vein graft. He presented with high fever on postoperative day 6. Blood and drainage effusion cultures were all positive for S.lugdunensis and vancomycin was prescribed. Echocardiography showed vegetation at the BJV. Re-re-RVOTR was performed 51 days after re-RVOTR. In the operation, vegetation was adhered to the right-sided leaflet and three leaflets were degenerated. After complete BJV graft resection, an expanded polytetrafluoroethylene conduit with tri-leaflets was implanted...
February 13, 2019: Annals of Thoracic Surgery
Tony H Truong, Jason D Pole, Henrique Bittencourt, Tal Schechter, Geoff D E Cuvelier, Kristjan Paulson, Meera Rayar, David Mitchell, Kirk R Schultz, Debbie O'Shea, Randy Barber, Donna Wall, Lillian Sung
INTRODUCTION: Access to hematopoietic stem cell transplantation (HSCT) in pediatric acute lymphoblastic leukemia (ALL) is primarily dependent on disease-related factors but may be influenced by social and economic determinants. METHODS: We included all children < 15 years old with newly diagnosed ALL in Canada between 2001 and 2018 using the Cancer in Young People in Canada (CYP-C) national registry. We examined factors potentially associated with the likelihood of receiving HSCT using univariate and multivariable logistic regression models...
February 12, 2019: Biology of Blood and Marrow Transplantation
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