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JOURNAL ARTICLE
Marlena Rohm, Gabriele Russo, Xavier Helluy, Martijn Froeling, Vincent Umathum, Nicolina Südkamp, Denise Manahan-Vaughan, Robert Rehmann, Johannes Forsting, Frank Jacobsen, Andreas Roos, Yoon Shin, Anne Schänzer, Matthias Vorgerd, Lara Schlaffke
Quantitative muscle MRI is increasingly important in the non-invasive evaluation of neuromuscular disorders and their progression. Underlying histopathotological alterations, leading to changes in qMRI parameters are incompletely unraveled. Early microstructural differences of unknown origin reflected by Diffusion MRI in non-fat infiltrated muscles were detected in Pompe patients. This study employed a longitudinal approach with a Pompe disease mouse model to investigate the histopathological basis of these changes...
December 20, 2023: Scientific Reports
#22
JOURNAL ARTICLE
Jacob Y Shin, Michael Offin, Charles B Simone, Zhigang Zhang, Annemarie F Shepherd, Abraham J Wu, Narek Shaverdian, Daphna Y Gelblum, Daniel R Gomez, Jennifer L Sauter, Michelle S Ginsberg, Prasad S Adusumilli, Valerie W Rusch, Marjorie G Zauderer, Andreas Rimner
BACKGROUND: The objective of this study is to determine the outcomes and toxicities of patients with malignant pleural mesothelioma (MPM) treated with stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: Data were extracted from an institutional tumor registry for patients diagnosed with mesothelioma and treated with SBRT. Kaplan-Meier and Cox regression analyses were employed to determine local control (LC) and overall survival (OS). RESULTS: Forty-four patients with 59 total treated tumors from December 2006 to April 2022 were identified...
February 2024: Radiotherapy and Oncology
#23
EDITORIAL
Andrea Shin
No abstract text is available yet for this article.
January 2024: Alimentary Pharmacology & Therapeutics
#24
JOURNAL ARTICLE
Alexandra F DeJong Lempke, Andrea Stracciolini, Sarah B Willwerth, Kathryn E Ackerman, Pierre A d'Hemecourt, William P Meehan, Kristin E Whitney
PURPOSE: Over a 10-year time frame, this study aimed to evaluate diagnosis, treatment, and referral trends for adolescent runners seeking care for running-related injuries (RRIs) at a clinic that specializes in running medicine. METHODS: This study was a retrospective chart review of 392 adolescent runners (2,326 encounters) who sought care for RRIs between the years 2011 and 2021. Descriptive statistics were used to summarize clinical assessments, referrals, assistive devices, and medications prescribed or administered overall and by injury type...
November 18, 2023: Journal of Pediatric Rehabilitation Medicine
#25
JOURNAL ARTICLE
Andreas Dechant, Jérôme Garnier-Brun, Shin-Ichi Sasa
We derive a variational expression for the correlation time of physical observables in steady-state diffusive systems. As a consequence of this variational expression, we obtain lower bounds on the correlation time, which provide speed limits on the self-averaging of observables. In equilibrium, the bound takes the form of a trade-off relation between the long- and short-time fluctuations of an observable. Out of equilibrium, the trade-off can be violated, leading to an acceleration of self-averaging. We relate this violation to the steady-state entropy production rate, as well as the geometric structure of the irreversible currents, giving rise to two complementary speed limits...
October 20, 2023: Physical Review Letters
#26
REVIEW
Cosimo Durante, Laszlo Hegedüs, Dong Gyu Na, Enrico Papini, Jennifer A Sipos, Jung Hwan Baek, Andrea Frasoldati, Giorgio Grani, Edward Grant, Eleonora Horvath, Jenny K Hoang, Susan J Mandel, William D Middleton, Rose Ngu, Lisa Ann Orloff, Jung Hee Shin, Pierpaolo Trimboli, Jung Hyun Yoon, Franklin N Tessler
Multiple US-based systems for risk stratification of thyroid nodules are in use worldwide. Unfortunately, the malignancy probability assigned to a nodule varies, and terms and definitions are not consistent, leading to confusion and making it challenging to compare study results and craft revisions. Consistent application of these systems is further hampered by interobserver variability in identifying the sonographic features on which they are founded. In 2018, an international multidisciplinary group of 19 physicians with expertise in thyroid sonography (termed the International Thyroid Nodule Ultrasound Working Group) was convened with the goal of developing an international system, tentatively called the International Thyroid Imaging Reporting and Data System, or I-TIRADS, in two phases: (phase I) creation of a lexicon and atlas of US descriptors of thyroid nodules and (phase II) development of a system that estimates the malignancy risk of a thyroid nodule...
October 2023: Radiology
#27
JOURNAL ARTICLE
Diego Izquierdo Veraza, Gerardo Calderon, Claire Jansson-Knodell, Rawan Aljaras, Erin D Foster, Huiping Xu, Annabel Biruete, Andrea Shin
BACKGROUND: Numerous individual and environmental factors including diet may play an important role in the pathophysiology of irritable bowel syndrome (IBS). It is unclear to what degree dietary intake is affected in individuals with IBS. We aimed to perform a systematic review and meta-analysis to summarize dietary intake of adults with IBS and to compare dietary intake between adults with IBS and non-IBS controls. METHODS: Ovid MEDLINE, Embase, Cochrane, CINAHL, and Scopus were searched through February 2023 for clinical trials and observational studies measuring usual diet in adults with IBS...
October 27, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#28
JOURNAL ARTICLE
Camille V Trinidad, Harsh B Pathak, Shibo Cheng, Shin-Cheng Tzeng, Rashna Madan, Mihaela E Sardiu, Leonidas E Bantis, Clayton Deighan, Andrea Jewell, Sagar Rayamajhi, Yong Zeng, Andrew K Godwin
High grade serous ovarian carcinoma (HGSOC) accounts for ~ 70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. Since most HGSOCs typically arise from the fallopian tubes (FT), our biomarker search focused on proteins found on the surface of extracellular vesicles (EVs) released by both FT and HGSOC tissue explants and representative cell lines. Using mass spectrometry, 985 EV proteins (exo-proteins) were identified that comprised the FT/HGSOC EV core proteome...
October 26, 2023: Scientific Reports
#29
JOURNAL ARTICLE
Christos Gatsios, Andreas Opitz, Dominique Lungwitz, Ahmed E Mansour, Thorsten Schultz, Dongguen Shin, Sebastian Hammer, Jens Pflaum, Yadong Zhang, Stephen Barlow, Seth R Marder, Norbert Koch
The surface molecular doping of organic semiconductors can play an important role in the development of organic electronic or optoelectronic devices. Single-crystal rubrene remains a leading molecular candidate for applications in electronics due to its high hole mobility. In parallel, intensive research into the fabrication of flexible organic electronics requires the careful design of functional interfaces to enable optimal device characteristics. To this end, the present work seeks to understand the effect of surface molecular doping on the electronic band structure of rubrene single crystals...
October 26, 2023: Physical Chemistry Chemical Physics: PCCP
#30
JOURNAL ARTICLE
Aditi Iyer, Aditya P Apte, Ethan Bendau, Maria Thor, Ishita Chen, Jacob Shin, Abraham Wu, Daniel Gomez, Andreas Rimner, Ellen Yorke, Joseph O Deasy, Andrew Jackson
BACKGROUND AND OBJECTIVES: Radiotherapy prescriptions currently derive from population-wide guidelines established through large clinical trials. We provide an open-source software tool for patient-specific prescription determination using personalized dose-response curves. METHODS: We developed ROE, a plugin to the Computational Environment for Radiotherapy Research to visualize predicted tumor control and normal tissue complication simultaneously, as a function of prescription dose...
October 14, 2023: Computer Methods and Programs in Biomedicine
#31
JOURNAL ARTICLE
Alexander L Ling, Isaac H Solomon, Ana Montalvo Landivar, Hiroshi Nakashima, Jared K Woods, Andres Santos, Nafisa Masud, Geoffrey Fell, Xiaokui Mo, Ayse S Yilmaz, James Grant, Abigail Zhang, Joshua D Bernstock, Erickson Torio, Hirotaka Ito, Junfeng Liu, Naoyuki Shono, Michal O Nowicki, Daniel Triggs, Patrick Halloran, Raziye Piranlioglu, Himanshu Soni, Brittany Stopa, Wenya Linda Bi, Pierpaolo Peruzzi, Ethan Chen, Seth W Malinowski, Michael C Prabhu, Yu Zeng, Anne Carlisle, Scott J Rodig, Patrick Y Wen, Eudocia Quant Lee, Lakshmi Nayak, Ugonma Chukwueke, L Nicolas Gonzalez Castro, Sydney D Dumont, Tracy Batchelor, Kara Kittelberger, Ekaterina Tikhonova, Natalia Miheecheva, Dmitry Tabakov, Nara Shin, Alisa Gorbacheva, Artemy Shumskiy, Felix Frenkel, Estuardo Aguilar-Cordova, Laura K Aguilar, David Krisky, James Wechuck, Andrea Manzanera, Chris Matheny, Paul P Tak, Francesca Barone, Daniel Kovarsky, Itay Tirosh, Mario L Suvà, Kai W Wucherpfennig, Keith Ligon, David A Reardon, E Antonio Chiocca
Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM)1,2 . Here we report the results of a first-in-human phase I trial in 41 patients with rGBM who were injected with CAN-3110-an oncolytic herpes virus (oHSV)3 . In contrast to other clinical oHSVs, CAN-3110 retains the viral neurovirulence ICP34.5 gene transcribed by a nestin promoter; nestin is overexpressed in GBM and other invasive tumours, but not in the adult brain or healthy differentiated tissue4 ...
October 18, 2023: Nature
#32
JOURNAL ARTICLE
Andrea C Wong, Ashwarya S Devason, Iboro C Umana, Timothy O Cox, Lenka Dohnalová, Lev Litichevskiy, Jonathan Perla, Patrick Lundgren, Zienab Etwebi, Luke T Izzo, Jihee Kim, Monika Tetlak, Hélène C Descamps, Simone L Park, Stephen Wisser, Aaron D McKnight, Ryan D Pardy, Junwon Kim, Niklas Blank, Shaan Patel, Katharina Thum, Sydney Mason, Jean-Christophe Beltra, Michaël F Michieletto, Shin Foong Ngiow, Brittany M Miller, Megan J Liou, Bhoomi Madhu, Oxana Dmitrieva-Posocco, Alex S Huber, Peter Hewins, Christopher Petucci, Candice P Chu, Gwen Baraniecki-Zwil, Leila B Giron, Amy E Baxter, Allison R Greenplate, Charlotte Kearns, Kathleen Montone, Leslie A Litzky, Michael Feldman, Jorge Henao-Mejia, Boris Striepen, Holly Ramage, Kellie A Jurado, Kathryn E Wellen, Una O'Doherty, Mohamed Abdel-Mohsen, Alan L Landay, Ali Keshavarzian, Timothy J Henrich, Steven G Deeks, Michael J Peluso, Nuala J Meyer, E John Wherry, Benjamin A Abramoff, Sara Cherry, Christoph A Thaiss, Maayan Levy
Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the etiology of PASC, including viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction. Here, we propose a mechanism that links all four hypotheses in a single pathway and provides actionable insights for therapeutic interventions. We find that PASC are associated with serotonin reduction...
October 9, 2023: Cell
#33
JOURNAL ARTICLE
Minxing Xu, Dongil Shin, Paolo M Sberna, Roald van der Kolk, Andrea Cupertino, Miguel A Bessa, Richard A Norte
For decades, mechanical resonators with high sensitivity have been realized using thin-film materials under high tensile loads. Although there have been remarkable strides in achieving low-dissipation mechanical sensors by utilizing high tensile stress, the performance of even the best strategy is limited by the tensile fracture strength of the resonator materials. In this study, a wafer-scale amorphous thin film is uncovered, which has the highest ultimate tensile strength ever measured for a nanostructured amorphous material...
October 12, 2023: Advanced Materials
#34
JOURNAL ARTICLE
Minta Thomas, Yu-Ru Su, Elisabeth A Rosenthal, Lori C Sakoda, Stephanie L Schmit, Maria N Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J B van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T Chan, Ann G Zauber, Anna H Wu, Annika Lindblom, Caroline Y Um, Catherine M Tangen, Chris Gignoux, Christina Newton, Christopher A Haiman, Conghui Qu, D Timothy Bishop, Daniel D Buchanan, David R Crosslin, David V Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R Schumacher, Gad Rennert, Graham G Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K Lee, Jennifer L Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L Hopper, Julie R Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J Gunter, Marco Matejcic, Mark A Jenkins, Martha L Slattery, Mauro D'Amato, Meilin Wang, Michael Hoffmeister, Michael O Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T Campbell, Polly A Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K Pai, Robert E Schoen, Robert S Steinfelder, Robert W Haile, Rosita Vandenputtelaar, Ross L Prentice, Sébastien Küry, Sergi Castellví-Bel, Shoichiro Tsugane, Sonja I Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J Weinstein, Stephen J Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A Harrison, Taiki Yamaji, Temitope O Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K Stadler, Bethany Van Guelpen, Cornelia M Ulrich, Elizabeth A Platz, John D Potter, Christopher I Li, Reinier Meester, Victor Moreno, Jane C Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G Dunlop, Stephen B Gruber, Richard B Hayes, Paul D P Pharoah, Richard S Houlston, Gail P Jarvik, Ian P Tomlinson, Wei Zheng, Douglas A Corley, Ulrike Peters, Li Hsu
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls)...
October 2, 2023: Nature Communications
#35
JOURNAL ARTICLE
Marina Eskandar, Laura Tochen, Mi Ran Shin, Bennett Lavenstein, Meira Meltzer, Andrea Gropman, Kuntal Sen
In the past couple of decades, literature in pediatric neurology and clinical genetics has identified hundreds of monogenic disorders that can masquerade as infantile cerebral palsy (CP). Accurate and prompt diagnosis in such cases may be challenging due to several reasons. There are commercial multigene CP panels, but their diagnostic yield is often limited compared with exome sequencing because of diverse etiologies that may mimic CP. We report one such case where a patient with spastic hemiplegia underwent a long diagnostic journey before genetic diagnosis was established with exome sequencing and appropriate management was started...
December 2023: Pediatric Neurology
#36
JOURNAL ARTICLE
Gianluca Pontone, Alexia Rossi, Andrea Baggiano, Daniele Andreini, Edoardo Conte, Laura Fusini, Chaterine Gebhard, Mark G Rabbat, Andrea Guaricci, Marco Guglielmo, Giuseppe Muscogiuri, Saima Mushtaq, Mouaz H Al-Mallah, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Eun Ju Chun, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Yong Jin Kim, Byoung Kwon Lee, Sang-Eun Lee, Erica Maffei, Hugo Marques, Habib Samady, Sanghoon Shin, Ji Min Sung, Alexander van Rosendael, Renu Virmani, Jeroen J Bax, Jonathon A Leipsic, Fay Y Lin, James K Min, Jagat Narula, Leslee J Shaw, Hyuk-Jae Chang
OBJECTIVES: No clear recommendations are endorsed by the different scientific societies on the clinical use of repeat coronary computed tomography angiography (CCTA) in patients with non-obstructive coronary artery disease (CAD). This study aimed to develop and validate a practical CCTA risk score to predict medium-term disease progression in patients at a low-to-intermediate probability of CAD. METHODS: Patients were part of the Progression of AtheRosclerotic PlAque Determined by Computed Tomographic Angiography Imaging (PARADIGM) registry...
September 26, 2023: European Radiology
#37
Lorenzo M Donini, Juan Ramón Barrada, Friederike Barthels, Thomas M Dunn, Camille Babeau, Anna Brytek-Matera, Hellas Cena, Silvia Cerolini, Hye-Hyun Cho, Maria Coimbra, Massimo Cuzzolaro, Claudia Ferreira, Valeria Galfano, Maria G Grammatikopoulou, Souheil Hallit, Linn Håman, Phillipa Hay, Masahito Jimbo, Clotilde Lasson, Eva-Carin Lindgren, Renee McGregor, Marianna Minnetti, Edoardo Mocini, Sahar Obeid, Crystal D Oberle, Maria-Dolores Onieva-Zafra, Marie-Christine Opitz, María-Laura Parra-Fernández, Reinhard Pietrowsky, Natalija Plasonja, Eleonora Poggiogalle, Adrien Rigó, Rachel F Rodgers, Maria Roncero, Carmina Saldaña, Cristina Segura-Garcia, Jessica Setnick, Ji-Yeon Shin, Grazia Spitoni, Jana Strahler, Nanette Stroebele-Benschop, Patrizia Todisco, Mariacarolina Vacca, Martina Valente, Màrta Varga, Andrea Zagaria, Hana Flynn Zickgraf, Rebecca C Reynolds, Caterina Lombardo
No abstract text is available yet for this article.
September 16, 2023: Eating and Weight Disorders: EWD
#38
EDITORIAL
Maura Corsetti, Andrea Shin, Christopher Black, Daniel Keszthelyi, Fedias L Christofi, Frank Zerbib, Kirsteen Browning, Michael Jones
No abstract text is available yet for this article.
September 13, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#39
JOURNAL ARTICLE
Nadine J Ortner, Anupam Sah, Enrica Paradiso, Josef Shin, Strahinja Stojanovic, Niklas Hammer, Maria Haritonova, Nadja T Hofer, Andrea Marcantoni, Laura Guarina, Petronel Tuluc, Tamara Theiner, Florian Pitterl, Karl Ebner, Herbert Oberacher, Emilio Carbone, Nadia Stefanova, Francesco Ferraguti, Nicolas Singewald, Jochen Roeper, Joerg Striessnig
Germline de novo missense variants of the CACNA1D gene, encoding the pore-forming α1-subunit of Cav1.3 L-type Ca2+ channels (LTCCs), have been found in patients with neurodevelopmental and endocrine dysfunction, but their disease-causing potential is unproven. These variants alter channel gating enabling enhanced Cav1.3 activity, suggesting Cav1.3 inhibition as a potential therapeutic option. Here we provide direct proof of the disease-causing nature of such gating-modifying CACNA1D variants using mice (Cav1...
September 12, 2023: JCI Insight
#40
EDITORIAL
Michael P Jones, Kirsteen Browning, Maura Corsetti, Daniel Keszthelyi, Andrea Shin, Rajan Singh, Pierfrancesco Visaggi, Frank Zerbib
No abstract text is available yet for this article.
November 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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