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https://read.qxmd.com/read/30764800/serum-indoxyl-sulfate-is-associated-with-mortality-in-hospital-acquired-acute-kidney-injury-a-prospective-cohort-study
#1
Wenji Wang, Guihua Hao, Yu Pan, Shuai Ma, Tianye Yang, Peng Shi, Qiuyu Zhu, Yingxin Xie, Shaojun Ma, Qi Zhang, Hong Ruan, Feng Ding
BACKGROUND: Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury. METHODS: Adults with hospital-acquired AKI (HA-AKI) were enrolled in this prospective cohort study between 2014 and 2015, according to the KDIGO creatinine criteria. The primary end point was all-cause death during follow-up...
February 14, 2019: BMC Nephrology
https://read.qxmd.com/read/30745571/urinary-acute-kidney-injury-biomarkers-in-very-low-birth-weight-infants-on-indomethacin-for-patent-ductus-arteriosus
#2
Sina Waldherr, Alexander Fichtner, Bernd Beedgen, Thomas Bruckner, Franz Schaefer, Burkhard Tönshoff, Johannes Pöschl, Timm H Westhoff, Jens H Westhoff
BACKGROUND: Serum creatinine (SCr)- or urine output-based definitions of acute kidney injury (AKI) have important limitations in neonates. This study evaluates the diagnostic value of urinary biomarkers in very low-birth-weight (VLBW) infants receiving indomethacin for closure of a patent ductus arteriosus (PDA). METHODS: Prospective cohort study in 14 indomethacin-treated VLBW infants and 18 VLBW infants without indomethacin as controls. Urinary biomarkers were measured before, during, and after indomethacin administration...
February 11, 2019: Pediatric Research
https://read.qxmd.com/read/30741743/the-impact-of-preinfarct-angina-on-the-incidence-of-acute-kidney-injury-in-patients-with-myocardial-infarction-interaction-with-pre-existent-chronic-kidney-disease
#3
Raquel B Santos, Inês Silveira, Maria Trêpa, Bruno Brochado, Rui Magalhães, Patrícia Rodrigues, Maria J Sousa, André Luz, João Silveira, Aníbal Albuquerque, Severo Torres, Adelino F Leite-Moreira, Henrique Carvalho
AIM: Remote ischemic conditioning may reduce acute kidney injury (AKI) in patients undergoing a coronary intervention. As preinfarct angina (PIA) might act as a preconditioning stimulus in patients with ST-elevation myocardial infarction (STEMI), we aimed to study whether PIA reduces AKI in accordance to pre-existing chronic kidney disease. PATIENTS AND METHODS: We conducted a retrospective study including 891 consecutive STEMI patients who underwent primary coronary intervention from January 2008 to March 2016...
February 7, 2019: Coronary Artery Disease
https://read.qxmd.com/read/30740579/perioperative-statin-use-and-acute-kidney-injury-in-patients-undergoing-partial-nephrectomy
#4
Shreyas S Joshi, Karen Ruth, Marc C Smaldone, David Y T Chen, Richard E Greenberg, Rosalia Viterbo, Alexander Kutikov, Robert G Uzzo
Background: Statin use is widespread among the general population. Data suggest a potentially beneficial effect of statin therapy on renal function following surgery. The impact of statins on post-partial nephrectomy (PN) renal function is unknown. We hypothesized that perioperative statin use may be associated with reduced rates of acute kidney injury (AKI) in patients undergoing PN. Objectives: To evaluate the effect of perioperative statin use on AKI rates in patients undergoing PN...
March 30, 2018: Kidney cancer
https://read.qxmd.com/read/30739741/perioperative-risk-factors-of-acute-kidney-injury-after-non-cardiac-surgery-a-multicenter-prospective-observational-study-in-patients-with-low-grade-american-society-of-anesthesiologists-physical-status
#5
Müzeyyen Iyigun, Güclü Aykut, Melis Tosun, Meltem Kilercik, Ugur Aksu, Tayfun Güler, Fevzi Toraman
BACKGROUND: The aim of this study was to determine the incidence and the perioperative risk factors of acute kidney injury (AKI) using "Kidney Disease: Improving Global Outcomes" (KDIGO) guidelines, in patients with low grade American Society of Anesthesiologists physical status (ASA-PS) undergoing non-cardiac surgery. METHODS: In this multicenter, prospective, observational study, 870 surgical patients older than 40 years with ASA-PS I-II who underwent noncardiac surgery, were included...
January 31, 2019: American Journal of Surgery
https://read.qxmd.com/read/30725141/acute-kidney-injury-in-trauma-patients-admitted-to-the-icu-a-systematic-review-and-meta-analysis
#6
REVIEW
Signe Søvik, Marie Susanna Isachsen, Kine Marie Nordhuus, Christine Kooy Tveiten, Torsten Eken, Kjetil Sunde, Kjetil Gundro Brurberg, Sigrid Beitland
PURPOSE: To perform a systematic review and meta-analysis of acute kidney injury (AKI) in trauma patients admitted to the intensive care unit (ICU). METHODS: We conducted a systematic literature search of studies on AKI according to RIFLE, AKIN, or KDIGO criteria in trauma patients admitted to the ICU (PROSPERO CRD42017060420). We searched PubMed, Cochrane Database of Systematic Reviews, UpToDate, and NICE through 3 December 2018. Data were collected on incidence of AKI, risk factors, renal replacement therapy (RRT), renal recovery, length of stay (LOS), and mortality...
February 6, 2019: Intensive Care Medicine
https://read.qxmd.com/read/30720690/intraoperative-hemodynamic-parameters-and-acute-kidney-injury-after-living-donor-liver-transplantation
#7
Won Ho Kim, Hye-Won Oh, Seong-Mi Yang, Je Hyuk Yu, Hyung-Chul Lee, Chul-Woo Jung, Kyung-Suk Suh, Kook Hyun Lee
BACKGROUND: Acute kidney injury (AKI) after living donor liver transplantation (LDLT) is associated with increased mortality. We sought to identify associations between intraoperative hemodynamic variables and postoperative AKI. METHODS: We retrospectively reviewed 734 cases of LDLT. Intraoperative hemodynamic variables of systemic and pulmonary arterial pressure, central venous pressure (CVP), and pulmonary artery catheter-derived parameters including mixed venous oxygen saturation (SvO2), right ventricular end-diastolic volume (RVEDV), stroke volume, systemic vascular resistance, right ventricular ejection fraction, and stroke work index were collected...
January 30, 2019: Transplantation
https://read.qxmd.com/read/30706125/patent-ductus-arteriosus-is-associated-with-acute-kidney-injury-in-the-preterm-infant
#8
Batoule Majed, David A Bateman, Natalie Uy, Fangming Lin
BACKGROUND: This study aimed to test the hypothesis that a patent ductus arteriosus (PDA) is independently associated with acute kidney injury (AKI) in neonates ≤ 28 weeks gestation. METHODS: Preterm infants with echocardiographic diagnosis of moderate-large PDA at age ≤ 30 days were studied retrospectively. AKI, the primary outcome, was defined and staged according to serum creatinine using Kidney Disease Improving Global Outcomes (KDIGO) neonatal criteria...
January 31, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30701902/cardiorenal-syndrome-in-the-early-stages-of-coronary-bypass-surgery
#9
L V Kremneva, O V Abaturova, A Y Efanov, S V Shalaev
AIM: Evaluate the frequency and risk factors of postoperative atrial fibrillation (pAF) in patients with chronic coronary artery disease (CHD) with acute kidney injury (AKI) developed in connection with coronary artery bypass grafting (CABG). MATERIALS AND METHODS: The study involved 90 patients (pts) undergoing CABG at age 58±7 years, duration of CHD - 6±6 years. 80% of pts had previous myocardial infarction. Chronic heart failure, functional class II was detected in 53...
June 20, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30701899/relationship-between-serologic-profile-anca-type-and-clinical-features-of-renal-involvement-in-anca-associated-vasculitides
#10
N M Bulanov, E A Makarov, E M Shchegoleva, A S Zykova, E S Vinogradova, P I Novikov, L V Lysenko Kozlovskaya, S V Moiseev
AIM: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). MATERIALS AND METHODS: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. AAV was diagnosed according to ACR criteria and Chapel Hill consensus conference definition (2012)...
June 20, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30701735/risk-factors-and-in-hospital-outcomes-of-acute-kidney-injury-that-developed-after-coronary-artery-bypass-grafting-in-patients-with-stable-angina
#11
L V Kremneva, S N Suplotov
AIM: The aim of the study is to assess frequency, risk factors and in-hospital outcomes of acute kidney injury after coronary artery bypass grafting in patients with stable angina. MATERIALS AND METHODS: The study included patients with stable angina pectoris and indications for coronary artery bypass grafting. We examined 93 patients aged 58±7.6 years, with duration of coronary heart disease 6±6.0 years. Previous myocardial infarction had 79.6% of patients. Arterial hypertension was present in 92...
September 20, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30682106/trauma-induced-acute-kidney-injury
#12
Zane B Perkins, Gabriella Captur, Ruth Bird, Liam Gleeson, Ben Singer, Benjamin O'Brien
BACKGROUND: Injured patients are at risk of developing acute kidney injury (AKI), which is associated with increased morbidity and mortality. The aim of this study is to describe the incidence, timing, and severity of AKI in a large trauma population, identify risk factors for AKI, and report mortality outcomes. METHODS: A prospective observational study of injured adults, who met local criteria for trauma team activation, and were admitted to a UK Major Trauma Centre...
2019: PloS One
https://read.qxmd.com/read/30665180/prevalence-of-acute-kidney-injury-after-liver-transplantation-in-children-comparison-of-the-prifle-akin-and-kdigo-criteria-using-corrected-serum-creatinine
#13
Elhanan Nahum, Gili Kadmon, Eytan Kaplan, Avichai Weissbach, Hanan Hijazi, Orly Haskin, Yael Mozer-Glassberg
PURPOSE: To compare the application of three standardized definitions of acute kidney injury (AKI), using corrected serum creatinine values, in children immediately after liver transplantation. METHODS: Retrospective search of a tertiary pediatric hospital database yielded 77 patients (age < 18 years) who underwent liver transplantation in 2007-2017. Serum creatinine levels during the 24 h before and after surgery were corrected to daily fluid balance, and the prevalence of AKI was calculated using the Pediatric RIFLE (pRIFLE), AKI Network (AKIN), and Kidney Disease Improving Global Outcomes (KDIGO) criteria...
April 2019: Journal of Critical Care
https://read.qxmd.com/read/30658667/vascular-endothelial-cadherin-shedding-is-more-severe-in-sepsis-patients-with-severe-acute-kidney-injury
#14
Wen-Kuang Yu, J Brennan McNeil, Nancy E Wickersham, Ciara M Shaver, Julie A Bastarache, Lorraine B Ware
BACKGROUND: Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial permeability, and angiogenesis. During inflammatory processes, VE-cadherin is shed into circulation (sVE-cadherin). Plasma sVE-cadherin is elevated in sepsis, malignancy, autoimmune diseases, and coronary atherosclerosis. However, the relationship between specific organ failures, especially severe acute kidney injury (AKI) defined by requirement for renal replacement therapy (AKI-RRT), and plasma sVE-cadherin levels in severe sepsis has not been well studied...
January 18, 2019: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/30647494/epidemiology-and-outcomes-of-acute-kidney-injury-in-critically-ill-experience-from-a-tertiary-care-center
#15
P S Priyamvada, R Jayasurya, Vijay Shankar, S Parameswaran
There is only limited information on the epidemiology and outcomes of acute kidney injury (AKI) in critically ill patients from low- and middle-income countries. This study aims to identify the etiology, short-term outcomes, and determinants of mortality in patients with AKI admitted to multiple medical and surgical Intensive Care Units (ICU's) in a tertiary care center. The study also aims to compare the clinical characteristics and outcomes of community-acquired AKI (CAAKI) and hospital-acquired AKI (HAAKI)...
November 2018: Indian Journal of Nephrology
https://read.qxmd.com/read/30615667/characteristics-and-associated-factors-of-acute-kidney-injury-among-adult-dengue-patients-a-retrospective-single-center-study
#16
Ajib Diptyanusa, Weerapong Phumratanaprapin, Benjaluck Phonrat, Kittiyod Poovorawan, Borimas Hanboonkunupakarn, Natthida Sriboonvorakul, Usa Thisyakorn
Severe dengue cases have been increasingly reported in Thailand, and the under-reporting of acute kidney injury (AKI) in cases of dengue viral infection has become an obstacle in obtaining an accurate description of the true nature and epidemiology of AKI. Because AKI may lead to patient morbidity and mortality, an early diagnosis is important in preventing its onset in dengue patients. This study aimed to determine the prevalence, clinical and laboratory characteristics, and associated factors of AKI among adult dengue patients...
2019: PloS One
https://read.qxmd.com/read/30579025/study-on-acute-kidney-injury-in-patients-with-spontaneous-intracranial-hemorrhage-an-overview-from-a-tertiary-care-hospital-in-south-india
#17
Marzieh Ansaritoroghi, Shankar Prasad Nagaraju, Rajesh Parameshwaran Nair, Vinod Kumar, Lakshman I Kongwad, Ravindra Prabhu Attur, Girish Menon Ramachandran, Ajay Hegde
INTRODUCTION: Acute kidney injury (AKI) is an independent risk factor for adverse clinical outcomes in patients with haemorrhagic stroke.There is limited data regarding the occurrence and impact of AKI in the setting of spontaneous intracerebral hemorrhage (SICH). Herewith, we sought to determine the incidence and risk factors for AKI in patients with SICH and to determine the role of AKI on SICH mortality in our population. MATERIALS AND METHODS: A retrospective analysis of the data recorded in the stroke registry maintained by the department of neurosurgery, Kasturba hospital, Kasturba Medical College, MAHE after ethical committee clearance...
December 19, 2018: World Neurosurgery
https://read.qxmd.com/read/30569444/transient-and-persistent-acute-kidney-injury-in-acute-liver-failure
#18
Silvia Coelho, José Nuno Fonseca, Joana Gameiro, Sofia Jorge, José Velosa, José António Lopes
BACKGROUND: Acute Kidney Injury (AKI) is a very frequent complication in the Acute Liver Failure (ALF) population associated with negative outcomes. We aim to evaluate the impact of AKI duration on the outcomes of an ALF population. METHODS: A 20-year retrospective analysis of ALF patients admitted to an Intensive Care Unit (ICU) was performed. Chronic liver failure, chronic kidney disease on renal replacement therapy, dialysis requirement within the week prior or an ICU stay of less than 48 h after AKI diagnosis, were exclusion criteria...
December 19, 2018: Journal of Nephrology
https://read.qxmd.com/read/30563520/diagnostic-performance-of-salivary-urea-nitrogen-dipstick-to-detect-and-monitor-acute-kidney-disease-in-patients-with-malaria
#19
Viviane Calice-Silva, Euclides Sacomboio, Jochen G Raimann, Rhys Evans, Cruz Dos Santos Sebastião, Adelino Tchilanda Tchivango, Peter Kotanko, Nathan Levin, Roberto Pecoits-Filho
BACKGROUND: Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, a lack of diagnostic tools and delayed treatment of malaria associated AKI lead to significant morbidity and mortality. The aim of this study was to assess the diagnostic performance of salivary urea nitrogen (SUN) dipstick to detect and monitor kidney disease [KD = AKI or acute kidney disease (AKD) without AKI] in malaria patients in Angola. METHODS: Patients 11-50 years old admitted with malaria at the Josina Machel (Maria-Pia) Hospital, Luanda, Angola, between 2nd March and 10th May 2016 were enrolled in this study...
December 18, 2018: Malaria Journal
https://read.qxmd.com/read/30546043/late-onset-neonatal-acute-kidney-injury-results-from-the-awaken-study
#20
Jennifer R Charlton, Louis Boohaker, David Askenazi, Patrick D Brophy, Mamta Fuloria, Jason Gien, Russell Griffin, Sangeeta Hingorani, Susan Ingraham, Ayesa Mian, Robin K Ohls, Shantanu Rastogi, Christopher J Rhee, Mary Revenis, Subrata Sarkar, Michelle Starr, Alison L Kent
BACKGROUND: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d). METHODS: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Late AKI was defined as occurring >7 days after birth according to the KDIGO criteria. Models were constructed to assess the association between late AKI and death or length of stay...
December 13, 2018: Pediatric Research
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