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AKIN criteria

Samuel J Daniels, Diana J Leeming, Sönke Detlefsen, Maria F Bruun, Sara T Hjuler, Kim Henriksen, Peter Hein, Morten A Karsdal, Sarah Brockbank, Simon Cruwys
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is a prevalent disease that is highly associated with the metabolic syndrome and type II diabetes. The development of in vivo models that reflect all nuances of the human NASH pathology is essential for drug discovery and development. We aimed to further characterise a dietary induced model of NASH both biochemically and histologically. In addition, we also investigated whether pioglitazone and liraglutide, drugs that have both been investigated as potential NASH treatments, could modulate the pathological changes induced by the NASH diet...
March 2019: Biomedicine & Pharmacotherapy
Munna L Patel, D Himanshu, S C Chaudhary, Virendra Atam, Rekha Sachan, Ravi Misra, Shivabrata D Mohapatra
Dengue is a growing public health problem in India, and acute kidney injury (AKI) is one of the least studied complications of dengue virus infection (DVI). This study was conducted to investigate the incidence, clinical characteristics, and risk factors for AKI in DVI. This was a retrospective study of patients with confirmed DVI presenting as dengue fever (DF) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) at our center over a period of 2 years. A total of 620 subjects fulfilling inclusion criteria were studied...
January 2019: Indian Journal of Nephrology
Shahram Amini, Mona Najaf Najafi, Seyedeh Parissa Karrari, Mohammadghasem Etemadi Mashhadi, Sahereh Mirzaei, Mohammad Abbasi Tashnizi, Ali Asghar Moeinipour, Hamid Hoseinikhah, Mathias Hossain Aazami, Mahdieh Jafari
BACKGROUND: Acute kidney injury (AKI) is a frequent event after cardiac surgery with increased mortality and morbidity. We explored frequency, risk factors, and associated morbidity and mortality of AKI after isolated coronary artery bypass grafting (CABG) surgery at a single institution. METHODS: All consecutive adults undergoing CABG surgery from March 2013 to October 2016 were assessed for development and severity of AKI based on Acute Kidney Injury Network (AKIN) criteria...
January 2019: Brazilian Journal of Cardiovascular Surgery
Iris C Steenstraten, Kerem Sebib Korkmaz, Palak J Trivedi, Akin Inderson, Bart van Hoek, Mar D M Rodriguez Girondo, P W Jeroen Maljaars
BACKGROUND: After liver transplantation primary sclerosing cholangitis (PSC), the condition returns in the transplanted liver in a subset of patients (recurrent primary sclerosing cholangitis, rPSC). AIM: To define risk factors for rPSC. METHODS: We searched Pubmed, Embase, Web of Science, and Cochrane library for articles published until March 2018. Studies addressing risk factors for developing rPSC were eligible for inclusion. A random effects meta-analysis was conducted using hazard ratios (HR) as effect measure...
February 10, 2019: Alimentary Pharmacology & Therapeutics
Peter Valent, Cem Akin, Patrizia Bonadonna, Karin Hartmann, Knut Brockow, Marek Niedoszytko, Boguslaw Nedoszytko, Frank Siebenhaar, Wolfgang R Sperr, Joanna N G Oude Elberink, Joseph H Butterfield, Ivan Alvarez-Twose, Karl Sotlar, Andreas Reiter, Hanneke C Kluin-Nelemans, Olivier Hermine, Jason Gotlib, Sigurd Broesby-Olsen, Alberto Orfao, Hans-Peter Horny, Massimo Triggiani, Michel Arock, Lawrence B Schwartz, Dean D Metcalfe
Mast cell activation (MCA) accompanies diverse physiologic and pathologic processes and is one of the more frequently encountered conditions in medicine. MCA-related symptoms are usually mild and often transient. In such cases, histamine receptor blockers and other mediator-targeting drugs can usually control MCA. In severe cases, an MCA syndrome (MCAS) may be diagnosed. However, overt MCAS is an unusual condition, and many patients referred because of suspected MCAS are diagnosed with other diseases (autoimmune, neoplastic, or infectious) unrelated to MCA or suffer from MCA-related (eg, allergic) disorders and/or comorbidities without fulfilling criteria of an overt MCAS...
February 5, 2019: Journal of Allergy and Clinical Immunology in Practice
Signe Søvik, Marie Susanna Isachsen, Kine Marie Nordhuus, Christine Kooy Tveiten, Torsten Eken, Kjetil Sunde, Kjetil Gundro Brurberg, Sigrid Beitland
PURPOSE: To perform a systematic review and meta-analysis of acute kidney injury (AKI) in trauma patients admitted to the intensive care unit (ICU). METHODS: We conducted a systematic literature search of studies on AKI according to RIFLE, AKIN, or KDIGO criteria in trauma patients admitted to the ICU (PROSPERO CRD42017060420). We searched PubMed, Cochrane Database of Systematic Reviews, UpToDate, and NICE through 3 December 2018. Data were collected on incidence of AKI, risk factors, renal replacement therapy (RRT), renal recovery, length of stay (LOS), and mortality...
February 6, 2019: Intensive Care Medicine
Elhanan Nahum, Gili Kadmon, Eytan Kaplan, Avichai Weissbach, Hanan Hijazi, Orly Haskin, Yael Mozer-Glassberg
PURPOSE: To compare the application of three standardized definitions of acute kidney injury (AKI), using corrected serum creatinine values, in children immediately after liver transplantation. METHODS: Retrospective search of a tertiary pediatric hospital database yielded 77 patients (age < 18 years) who underwent liver transplantation in 2007-2017. Serum creatinine levels during the 24 h before and after surgery were corrected to daily fluid balance, and the prevalence of AKI was calculated using the Pediatric RIFLE (pRIFLE), AKI Network (AKIN), and Kidney Disease Improving Global Outcomes (KDIGO) criteria...
April 2019: Journal of Critical Care
Rozina Abbasi Larki, Bahareh Jamali, Mohsen Meidani, Sarah Mousavi
Objective: Recent studies have shown that serum cystatin C (Cys C) is a better marker for measuring the glomerular filtration rate and may rise more quickly with acute kidney injury (AKI). The purpose of this study was to evaluate the clinical application of serum Cys C to predict colistin-induced nephrotoxicity in comparison with serum creatinine (SCr). Methods: Thirty-two adult patients with no history of acute or chronic kidney injury having been planned to receive intravenous colistin for an anticipated duration of at least 1 week for any indication were recruited...
October 2018: Journal of Research in Pharmacy Practice
Davide Di Vece, Rodolfo Citro, Victoria L Cammann, Ken Kato, Sebastiano Gili, Konrad A Szawan, Jozef Micek, Stjepan Jurisic, Katharina J Ding, Beatrice Bacchi, Moritz Schwyzer, Alessandro Candreva, Eduardo Bossone, Fabrizio D'Ascenzo, Annahita Sarcon, Jennifer Franke, L Christian Napp, Milosz Jaguszewski, Michel Noutsias, Thomas Münzel, Maike Knorr, Susanne Wagner, Hugo A Katus, Christof Burgdorf, Heribert Schunkert, Holger Thiele, Johann Bauersachs, Carsten Tschöpe, Burkert Pieske, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Gerd Hasenfuβ, Mahir Karakas, Wolfgang Koenig, Wolfgang Rottbauer, Samir M Said, Ruediger C Braun-Dullaeus, Adrian Banning, Florim Cuculi, Richard Kobza, Thomas A Fischer, Tuija Vasankari, K E Juhani Airaksinen, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Klaus Empen, Stephan B Felix, Clément Delmas, Olivier Lairez, Ibrahim El-Battrawy, Ibrahim Akin, Martin Borggrefe, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, John Horowitz, Martin Kozel, Petr Tousek, Petr Widimsky, David E Winchester, Christian Ukena, Carlo Di Mario, Abhiram Prasad, Michael Böhm, Jeroen J Bax, Thomas Lüscher, Frank Ruschitzka, Jelena R Ghadri, Christian Templin
The clinical course of takotsubo syndrome (TTS) can be complicated by several life-threatening conditions.1 In particular, cardiogenic shock (CS) represents one of the leading causes of mortality in the acute phase and occurs in a considerable number of patients with TTS, with an incidence of ≈10%.2,3 At present, no established guidelines are available to support specific treatment recommendations,and the conventional therapy for CS leads to uncertain results in TTS cases.4 The International Takotsubo Registry (www...
November 10, 2018: Circulation
Domingo Palacios-Ceña, Pilar Famoso-Pérez, Jaime Salom-Moreno, Pilar Carrasco-Garrido, Jorge Pérez-Corrales, Paula Paras-Bravo, Javier Güeita-Rodriguez
Background : Rett syndrome has considerable effects on the quality of life of affected children, impairing everyday activities and potentially impacting the life of both the caregivers and the family. Our aim was to explore the experiences of a group of caregivers of children with Rett syndrome with regards to living and caring for their children. Methods : We conducted a qualitative case study to examine how 31 caregivers of children with Rett syndrome perceived living with their children. Data were collected through in-depth interviews, focus groups, researchers' field notes and caregivers' personal documents...
December 25, 2018: International Journal of Environmental Research and Public Health
Marzieh Ansaritoroghi, Shankar Prasad Nagaraju, Rajesh Parameshwaran Nair, Vinod Kumar, Lakshman I Kongwad, Ravindra Prabhu Attur, Girish Menon Ramachandran, Ajay Hegde
INTRODUCTION: Acute kidney injury (AKI) is an independent risk factor for adverse clinical outcomes in patients with haemorrhagic stroke.There is limited data regarding the occurrence and impact of AKI in the setting of spontaneous intracerebral hemorrhage (SICH). Herewith, we sought to determine the incidence and risk factors for AKI in patients with SICH and to determine the role of AKI on SICH mortality in our population. MATERIALS AND METHODS: A retrospective analysis of the data recorded in the stroke registry maintained by the department of neurosurgery, Kasturba hospital, Kasturba Medical College, MAHE after ethical committee clearance...
December 19, 2018: World Neurosurgery
Sameeha A Alshelleh, Ashraf O Oweis, Karem H Alzoubi
Background: Improvements in health care systems worldwide have had notable effects on the life expectancy of older individuals. As a result, nonagenarians are emerging as a separate age group with distinct health care needs. The aim of this study was to evaluate the incidence of acute kidney injury (AKI), the mortality rates, and length of in-hospital stay among nonagenarians. Methods: This is a retrospective case-control chart review of patients of age 90 years and above who were admitted to hospital...
2018: International Journal of Nephrology and Renovascular Disease
Jill Vanmassenhove, Wim Van Biesen, Raymond Vanholder, Norbert Lameire
There has been considerable progress over the last decade in the standardization of the acute kidney injury (AKI) definition with the publication of the RIFLE, AKIN, KDIGO and ERBP classification criteria. However, these classification criteria still rely on imperfect parameters such as serum creatinine and urinary output. The use of timed urine collections, kinetic eGFR (estimated glomerular filtration rate), real time measurement of GFR and direct measures of tubular damage can theoretically aid in a more timely diagnosis of AKI and improve patients' outcome...
December 6, 2018: Journal of Nephrology
Khosro Barkhordari, Ali Mohammad Fakhre Yasseri, Fardin Yousefshahi, Akbar Shafiee
Background: Acute kidney injury (AKI) after coronary artery bypass graft surgery (CABG) is a common complication. The present study sought to determine AKI risk factors based on the Acute Kidney Injury Network (AKIN) classification. Methods: In a cross-sectional study, performed from March 2010 to April 2012 at Tehran Heart Center, affiliated with Tehran University of Medical Sciences, 29 independent risk factors for AKI based on the AKIN criteria were examined in isolated post-CABG patients. The patients' demographic data and risk factors were extracted from the Electronic Database of Tehran Heart Center...
April 2018: Journal of Tehran Heart Center
Fufeng Qu, Jie Cai, Xiaojun Liang, Jun Lu, Qiu Zeng, Weina Ji
Objective: To evaluate the short-term effectiveness of Scarf osteotomy and Akin osteotomy combined with soft tissue procedures for hallux valgus associated with mild to moderate metatarsus adductus. Methods: The clinical data of 30 patients (48 feet) who were diagnosised hallux valgus associated with mild to moderate metatarsus adductus and treated by Scarf osteotomy and Akin osteotomy combined with soft tissue procedures between February 2013 and May 2015 were analyzed retrospectively...
November 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Ryan W Haines, Alex J Fowler, Christopher J Kirwan, John R Prowle
BACKGROUND: As more patients are surviving the initial effects of traumatic injury clinicians are faced with managing the systemic complications of severe tissue injury. Of these, acute kidney injury (AKI) may be a sentinel complication contributing to adverse outcomes. OBJECTIVE: To establish the incidence of AKI in patients admitted to critical care after major trauma, to explore any risk factors and to evaluate the association of AKI with outcomes. DATA SOURCES: Systematic search of MEDLINE, Excerpta Medica database and Cochrane library from January 2004 to April 2018...
January 2019: Journal of Trauma and Acute Care Surgery
Cigdem Benlice, Akin Onder, Rovnat Babazade, Jennifer Hrabe, Luca Stocchi, Scott Steele, Emre Gorgun
PURPOSE: We aimed to evaluate the association between preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR) and 30-day postoperative complications after colorectal surgery. METHODS: Patients undergoing elective colorectal surgery between January, 2010 and December, 2014 were identified. Patients who had preoperative and postoperative days 1 and 2 (Postoperative day [POD]-1, POD-2) NLR were included in the study. Primary study outcomes were optimal NLR cutoff values at preop, POD-1, and POD-2...
October 23, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Sreja Gangadharan, K R Sundaram, Senthilvelan Vasudevan, B Ananthakrishnan, Rakhi Balachandran, Abraham Cherian, Praveen Kerala Varma, Luis Bakero Gracia, K Murukan, Ashish Madaiker, Rajesh Jose, Rakesh Seetharaman, Kirun Gopal, Sujatha Menon, M Thushara, Reshmi Liza Jose, G Deepak, Sudheer Babu Vanga, Aveek Jayant
Background: Acute kidney injury (AKI) after cardiac surgery (CS) is not uncommon and has serious effects on mortality and morbidity. A majority of patients suffer mild forms of AKI. There is a paucity of Indian data regarding this important complication after CS. Aims and Objectives: The primary objective was to study the incidence of AKI associated with CS in an Indian study population. Secondary objectives were to describe the risk factors associated with AKI-CS in our population and to generate outcome data in patients who suffer this complication...
October 2018: Annals of Cardiac Anaesthesia
K Bhaskaran, Ganapathy Arumugam, P V Vinay Kumar
Context and Aims: Off-pump coronary artery bypass graft (OPCABG) is a form of CABG surgery. It is performed without the use of cardiopulmonary bypass machine as a surgical treatment for coronary heart disease. Acute kidney injury (AKI) is one of the common postoperative complications of OPCABG. Previous studies suggest important differences related to intravenous fluid (IVF) chloride content and renal function. We hypothesize that perioperative use of chloride restricted IVFs may decrease incidence and severity of postoperative AKI in patients undergoing OPCABG...
October 2018: Annals of Cardiac Anaesthesia
J G Gwon, M-G Kim, K T Park, S-Y Ko, C W Jung
INTRODUCTION: Kidneys from acute kidney injury (AKI) donors are used for kidney transplantation. However, different Acute Kidney Injury Network (AKIN) criteria may show varying results after transplantation. We investigated the clinical outcomes in kidney transplantation from deceased donors with AKI as defined by the AKIN criteria at a single center. METHODS: We retrospectively reviewed the medical records of 101 consecutive deceased donors and kidney transplantation recipients from March 2009 to June 2015 in a single center...
October 2018: Transplantation Proceedings
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