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Koichi Hagiya
The procedure used for the genetic evaluation of dairy cattle in Japan has developed from a lactation sire-MGS model to a multiple-lactation random regression test-day animal model. Genetic evaluation of Holstein bulls in Japan began in 1989 with the use of field-style progeny testing; dairy herd improvement program data from all over Japan were used, along with a sire and maternal grandsire model. In 1993, an animal model was introduced to estimate breeding values for yield and type traits. A random regression test-day model was first applied in 2010...
February 14, 2019: Animal Science Journal, Nihon Chikusan Gakkaihō
Stephen J Carter, Gary R Hunter, J Walker Blackston, Nianjun Liu, Elliot J Lefkowitz, William J Van Der Pol, Casey D Morrow, Jesseca A Paulsen, Laura Q Rogers
NEW FINDINGS: What is the central question of this study? Does the link between cardiorespiratory fitness and gut microbiota diversity persist after adjusting for the potential effects of %body fat and activity-related energy expenditure (AEE)? What is the main finding and its importance? This is the first study to examine the link between cardiorespiratory fitness and gut microbiota diversity while accounting for the underlying effects of %body fat and free-living AEE. Results from the present work suggest cardiorespiratory fitness, not physical activity, is a superior correlate of gut microbiota diversity among post-primary treatment, non-metastatic breast cancer survivors...
February 14, 2019: Experimental Physiology
Russell E Banks, Delfina C Domínguez
Concussion is a transitory brain injury resulting from a blow to the head. Concussion is considered a mild traumatic brain injury (mTBI), which is self-limited. Repetitive mTBI has been associated with chronic, progressive neurological damage. Extreme biochemical changes occur in neuron cells as a result of mTBI. These metabolic disturbances may reflect the symptoms observed in patients who had suffered concussions. However, it has been difficult to correlate clinical signs and symptoms. Currently, there are no laboratory tests to diagnose concussion, though several biomarkers are being investigated...
February 14, 2019: Seminars in Speech and Language
Ulrich J Sachs
Although the detection of a characteristic autoantibody can prove immune thrombocytopenia (ITP), this diagnosis is often based on the exclusion of other causes of thrombocytopenia. Direct glycoprotein (GP)-specific tests have the property required to demonstrate such a characteristic autoantibody. In contrast, platelet-associated immunoglobulin G or antibody detection in plasma or serum is an insufficient diagnostic test. Moreover, data for commercial capture assays are sparse and their use is currently not recommended...
February 14, 2019: Hämostaseologie
Florian Zweipfenning, Sandra P Toelle, Christina Gerth-Kahlert
BACKGROUND: Evaluation and comparison of the ocular phenotype in patients diagnosed with tuberous sclerosis complex (TSC). Analysis of ocular complications during follow-up. PATIENTS AND METHODS: A retrospective chart review was performed of patients with TSC who had received an ocular examination at the eye clinic of the University Hospital Zurich. Data were analysed on visual acuity (VA) assessment, refraction, anterior and posterior eye examination including the distinction of different types of hamartomas and, when available, visual fields...
February 14, 2019: Klinische Monatsblätter Für Augenheilkunde
Christof Hänsli, Fabio Meier, Daniel Barthelmes, Christian Böni
PURPOSE: Cytomegalovirus (CMV) can cause recurrent or chronic hypertensive anterior uveitis in immunocompetent patients. Antiviral treatment options include topical ganciclovir or systemic valganciclovir. However, recurrences are common after stopping treatment. We evaluated the efficacy of long-term topical ganciclovir therapy as prophylaxis for recurrent activity. METHODS AND PATIENTS: Retrospective analysis of all CMV uveitis patients seen between 2011 and 2018 at Zurich University Hospital...
February 14, 2019: Klinische Monatsblätter Für Augenheilkunde
Elise R Facer-Childs, Brunno M Campos, Benita Middleton, Debra J Skene, Andrew P Bagshaw
INTRODUCTION: Functional connectivity (FC) of the human brain's intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC. STUDY OBJECTIVES: The aim of this study was to investigate resting state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day...
February 15, 2019: Sleep
Gang Seok Jeon, Jae Ryong Han
PURPOSE: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD). METHODS: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation...
February 14, 2019: Ophthalmologica. Journal International D'ophtalmologie
Enio Campos Amico, Izadora K de Souza, Juliana R Grigório Trigueiro, Fernanda Cunha Miranda, Rogério Lacerda Sousa, Adriano de Araújo Lima Liguori
BACKGROUND: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. AIM: To evaluate the results of conservative treatment in a series of patients with presumed FNH. METHODS: The study included patients diagnosed with FNH from May 2007 to July 2017 based on conventional imaging or magnetic resonance imaging with liver-specific contrast (MRI-LSC) or lesion biopsy (histology/immunohistochemical analysis)...
February 14, 2019: Digestive Diseases
Benedikt Scharf, Dinh Van Tuan, Igor Zutic, Hanan Dery
Monolayer transition-metal dichalcogenides (ML-TMDs) offer exciting opportunities to test the manifestations of many-body interactions through changes in the charge density. Tuning the charge density by a gate voltage leads to profound changes in the optical spectra of excitons in ML-TMDs. We review the band-gap renormalization and dynamical screening as a function of charge density, and then incorporate these effects through various approximations that model long-wavelength charge excitations in the Bethe-Salpeter Equation (BSE)...
February 14, 2019: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Qimeng Li, Xiaoyun Lu, Chendong Shuang, Chengdou Qi, Guoxiang Wang, Aimin Li, Haiou Song
In this paper, a series of mono-functional and bifunctional anion exchange resins with different kinds of trialkylammonium groups were synthesized and used for adsorption of nitrate from aqueous solution. The obtained resins were systematically characterized by scanning electron microscopy, Fourier transform infrared spectrometry and pore size distribution. Adsorptive behaviors and mechanisms were investigated by batch experiments. The nitrate could be preferentially adsorbed in the presence of chloride, sulfate and humic acid by longer-chain trialkylamine modified resins...
February 4, 2019: Chemosphere
Chiara Zecca, Zbyšek Pavelek, Kateřina Přikrylová, Mascia Ghielmetti, Andreas Beeler, Claudio Gobbi
BACKGROUND: Interferon beta (IFNB) and Glatiramer acetate, long-term first line disease modifying treatments (DMTs) for multiple sclerosis (MS), have different injection frequencies crucial for injection site related side effects. We aimed at investigating whether switching to intramuscular IFNB-1a injected once/week with the Avonex®Pen™ device improves treatment tolerability and quality of life in stable MS patients. METHODS: Clinically stable MS patients, whom their treating neurologist switched from high frequency injectable DMTs to weekly intramuscular IFNB-1a because of bothersome injection site reactions, were included...
February 6, 2019: Multiple Sclerosis and related Disorders
Clara Rodriguez-Sabate, Ingrid Morales, Jesus N Lorenzo, Manuel Rodriguez
The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others...
February 3, 2019: NeuroImage: Clinical
Eva-Maria Buchner, Oliver Happel, Carsten K Schmidt, Marco Scheurer, Beat Schmutz, Meike Kramer, Martina Knauer, Stefan Gartiser, Henner Hollert
The monitoring and control of drinking water quality is generally important as it significantly contributes to the health of the population. In this context, particular attention has to be paid to the use of treatment techniques during drinking water treatment. It is known that the formation of reaction products (transformation products) has to be taken into account when oxidizing agents such as ozone are used. Different transformation products are classified as critical to health and require analytical examination...
January 28, 2019: Water Research
Ting Su, Lipeng Wu, Xihao Pan, Cheng Zhang, Mingyang Shi, Ruru Gao, Xiaoliang Qi, Wei Dong
Polysaccharide is a renewable, biocompatible and biodegradable material that has received considerable attention. In this work, a series of polysaccharide gels were synthesized from the chemical cross-linking of pullulan with diglycerols. The effects of the diglycerol chain length on the performance of the gels were evaluated by XRD, TGA, SEM, rheological testings and swelling measurements. Overall, increasing the chain length resulted in a smaller pore size and stronger mechanical strength. Tetramethylene glycol diglycidyl ether (longest chain length)-derived Gel-T, which had the best performance (acceptable porous structure, good swelling ability and strong rigidity), was used to produce a nanocomposite hydrogel with montmorillonite (MMT)...
February 7, 2019: Journal of Colloid and Interface Science
Junji Hou, Guoqun Zhao, Lei Zhang, Guilong Wang, Bo Li
The preparation of high-expansion open-cell foam for oil spill clean-ups is important, but still challenging with linear isotactic polypropylene (PP). Therefore, a cooling batch foaming method was designed to fabricate the high-expansion PP foams using supercritical CO2 as a blowing agent. To investigate the relation between the crystallization and foaming of PP, an in-situ visualization system was employed. It is found that the CO2 dissolved in polymer melt depresses the crystallization temperature and nucleation of PP...
February 7, 2019: Journal of Colloid and Interface Science
Iris Leister, Stefan Tino Kulnik, Harald Kindermann, Reinhold Ortmaier, Jürgen Barthofer, Imre Vasvary, Klaus Katzensteiner, Georg Mattiassich
OBJECTIVES: Objective return to sport (RTS) criteria after anterior cruciate ligament (ACL) injury are lacking. Study purposes were (1) to report Limb Symmetry Index (LSI) values achieved in a test battery, (2) to detect how many subjects meet RTS criteria 12-18 months post-operative and (3) to identify whether patient-administered scores predict RTS criteria. DESIGN: Observer-blinded, cross-sectional observational study. SETTING: Traumacenter Linz, Austria...
February 7, 2019: Physical Therapy in Sport
Noor Atatreh, Amal M Youssef, Mohammad A Ghattas, Mohammad Al Sorkhy, Sara Alrawashdeh, Khaled B Al-Harbi, Ibrahim M El-Ashmawy, Tariq I Almundarij, Amani A Abdelghani, Alaa S Abd-El-Aziz
In this study, the acid chlorides of pyrazolo[3,4-d]pyrimidine compounds were prepared and reacted with a number of nucleophiles. The novel compounds were experimentally tested via enzyme assay and they showed cyclooxygenase-2 inhibition activity in the middle micro molar range (4b had a COX-1 IC50 of 26 µM and a COX-2 IC50 of 34 µM, 3b had a COX-1 IC50 of 19 µM and a COX-2 IC50 of 31 µM, 3a had a COX-2 IC50 of 42 µM). These compounds were analyzed via docking and were predicted to interact with some of the COX-2 key residues...
February 5, 2019: Bioorganic Chemistry
Pavitra S Thacker, Mallika Alvala, Mohammed Arifuddin, Andrea Angeli, Claudiu T Supuran
A series of novel 7-hydroxycoumarin-3-carboxamides was synthesized by the reaction of 7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid with various substituted aromatic amines. The newly synthesized compounds were evaluated for their inhibitory activity against the four physiologically relevant human carbonic anhydrase (hCA, EC isoforms CA I, CA II, CA IX and CA XII. The CA inhibition results show that the newly synthesized 7-hydroxycoumarin-3-carboxamides (4a-n) exhibited selective inhibition of the tumor associated isoforms, CA IX and CA XII over CA I and II isoforms...
February 5, 2019: Bioorganic Chemistry
Negin Ashoori, Marc Teixido, Stephanie Spahr, Gregory H LeFevre, David L Sedlak, Richard G Luthy
Stormwater is increasingly being valued as a freshwater resource in arid regions and can provide opportunities for beneficial reuse via aquifer recharge if adequate pollutant removal can be achieved. We envision a multi-unit operation approach to capture, treat, and recharge (CTR) stormwater using low energy, cost-effective technologies appropriate for larger magnitude, less frequent events. Herein, we tested nutrient, metal, and trace organic contaminant removal of a pilot-scale CTR system in the laboratory using biochar-amended woodchip bioreactors following eight months of aging under field conditions with exposure to real stormwater...
February 2, 2019: Water Research
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