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Benjamin Pirotte, Kenji Inaba, Morgan Schellenberg, Gustavo Recinos, Lydia Lam, Elizabeth Benjamin, Kazuhide Matsushima, Demetrios Demetriades
Intraoperative consultations are an important component of acute care surgery (ACS). The nature of these consultations is incompletely characterized by the existing literature. The study objective was to define the characteristics of intraoperative consults managed by a mature ACS program at a Level I trauma center. All intraoperative consultations requested from the ACS service at LAC+USC Medical Center (January 2011-July 2016) were identified. Demographics, date/time of consultation, referring service, procedure data, and outcomes were abstracted...
January 1, 2019: American Surgeon
Joel Pekow, Kyle Hernandez, Katherine Meckel, Zifeng Deng, Haider I Haider, Abdurahman Khalil, Chunling Zhang, Nitya Talisila, Shivi Siva, Farzana Jasmine, Yan Chun Li, David T Rubin, Neil Hyman, Marc Bissonnette, Christopher Weber, Muhammad G Kibriya
Background and Aims: As ulcerative colitis (UC)-associated colorectal cancer (CRC) and sporadic CRC differ in presentation and molecular features, we sought to evaluate differences in the impact of DNA methylation on gene expression. Methods : NA methylation was assessed in 11 UC-CRCs and adjacent tissue and 11 sporadic CRCs and adjacent tissue using Illumina arrays. RNA sequencing was performed on 10 UC-CRCs and adjacent tissue and 8 sporadic CRCs and adjacent tissues...
February 11, 2019: Journal of Crohn's & Colitis
Sigal Ben-Zaken, Yoav Meckel, Dan Nemet, Eias Kassem, Alon Eliakim
Ben-Zaken, S, Meckel, Y, Nemet, D, Kassem, E, and Eliakim, A. Genetic basis for the dominance of Israeli long-distance runners of Ethiopian origin. J Strength Cond Res XX(X): 000-000, 2018-Israeli long-distance runners of Ethiopian origin have a major influence on the track and field long-distance record table. The aim of this study was to determine whether genetic characteristics contribute to this long-distance dominance. We assessed polymorphisms in genes related to endurance (PPARD T/C), endurance trainability (ACSL A/G), speed (ACTN3 R/X), strength (AGT T/C), and the recovery from training (MTC1 A/T and IL6 G/C) among top Israeli long-distance runners of Ethiopian origin (n = 37), Israeli non-Ethiopian origin runners of Caucasian origin (n = 76), and Israeli nonathletic controls (n = 55)...
February 6, 2019: Journal of Strength and Conditioning Research
Hirotaka Sato, Satoru Hiroshima, Ryogo Anei, Kyousuke Kamada
We report a case of a primary malignant lymphoma of the trigeminal nerve that was associated with facial pain. A 65-year-old man was examined at another hospital for unilateral facial pain. Carbamazepine was prescribed, but his symptoms did not improve. Magnetic resonance imaging (MRI) revealed swelling of the trigeminal nerve and a mass lesion in Meckel's cave. The patient was referred to our hospital at this point. Gadolinium-enhanced MRI and F18-Fluorodeoxyglucose-position emission tomography suggested a likely malignant tumour and a biopsy was performed...
February 11, 2019: British Journal of Neurosurgery
Haley Prough, Sarah Jaffe, Brian Jones
Cases of small bowel diverticulitis, excluding Meckel's diverticulitis, are rare. Small bowel diverticular disease has been reported in approximately 0.3-1.3% cases of post mortem studies (Fisher JK, Fortin D. Partial small bowel obstruction secondary to ileal diverticulitis. Radiology 1977;122:321-322.) and in only 0.5-1.9% of contrast media study cases (Cattell RB, Mudge TJ. The surgical significance of duodenal diverticula. N Engl J Med 1952;246:317-324). Diverticula located within the small bowel may have presentations and complications similar to that of colonic diverticular disease...
January 2019: Journal of Surgical Case Reports
Matthew C Perez, James Sun, Clara Farley, Dale Han, Alexander H Sun, Deepak Narayan, Michael Lowe, Keith A Delman, Jane L Messina, Ricardo J Gonzalez, Vernon K Sondak, Nikhil I Khushalani, Jonathan S Zager
BACKGROUND: Increased cross-sectional imaging for surveillance of metastatic melanoma has led to more diagnoses of asymptomatic intussusception. METHODS: We performed a multi-institutional retrospective review of patient records with a history of metastatic melanoma and a diagnosis of intussusception. Patients were divided into three groups: 1) asymptomatic patients without current evidence of melanoma (no evidence of disease [NED]); 2) asymptomatic intussusception and known active metastatic melanoma; 3) symptomatic intussusception and known active metastatic melanoma; the number of patients requiring surgery and intraoperative findings were recorded...
February 7, 2019: Journal of Surgical Oncology
Andrea M Herrmann, Stephan Meckel, Matthew J Gounis, Leona Kringe, Edith Motschall, Christoph Mülling, Johannes Boltze
Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far...
February 7, 2019: Journal of Cerebral Blood Flow and Metabolism
Philipp Karschnia, Soma Sengupta, Jorg Dietrich
No abstract text is available yet for this article.
February 2, 2019: Acta Neurologica Belgica
Bardia Bidarmaghz, Hugh McGregor, Kasra Raufian, Chin Li Tee
BACKGROUND: Meckel's diverticulum (MD) is the most common congenital abnormality of the gastrointestinal (GI) tract. Most of the people remain asymptomatic during their lifetime, but some can develop complications such as inflammation, haemorrhage or obstruction. Perforation of Meckel's diverticulum is very rare, and we present a case of perforation by a chicken bone. CASE PRESENTATION: A 19-year-old man presented to the emergency department with abdominal pain, and based on examination and laboratory findings, he was diagnosed with appendicitis initially...
February 1, 2019: Surgical Case Reports
Epameinondas Dogeas, Maximiliano Magallanes, Matthew R Porembka, Sam C Wang, Adam C Yopp, Patricio M Polanco, John C Mansour, Michael A Choti, Herbert J Zeh, Mathew M Augustine
BACKGROUND: Meckel's diverticulum (MD) is an anomaly of the small intestine from which malignancy may arise. Among MD neoplasms, neuroendocrine tumors (NETs) are considered the most common. However, their metastatic potential and optimal surgical therapy remain ill-defined. METHODS: In a retrospective analysis of the National Cancer Database (2004-2015), patients with a diagnosis of MD malignancy were identified. Clinicopathologic factors were extracted and tumors arising in MD were compared...
January 31, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Joon W Shim, Paul R Territo, Stefanie Simpson, John C Watson, Lei Jiang, Amanda A Riley, Brian McCarthy, Scott Persohn, Daniel Fulkerson, Bonnie L Blazer-Yost
Transmembrane protein 67 (TMEM67) is mutated in Meckel Gruber Syndrome type 3 (MKS3) resulting in a pleiotropic phenotype with hydrocephalus and renal cystic disease in both humans and rodent models. The precise pathogenic mechanisms remain undetermined. Herein it is reported for the first time that a point mutation of TMEM67 leads to a gene dose-dependent hydrocephalic phenotype in the Wistar polycystic kidney (Wpk) rat. Animals with TMEM67 heterozygous mutations manifest slowly progressing hydrocephalus, observed during the postnatal period and continuing into adulthood...
January 31, 2019: Scientific Reports
Bruno Santos, André Pinto, Berta Barbosa, Vítor C Simões, Donzília S Silva, José Davide
Meckel's diverticulum is the commonest congenital abnormality of the gastrointestinal tract. Most cases are asymptomatic and only incidentally found. Its perforation by a foreign body is an extremely rare event. A 53-year-old female presented to Emergency Department with abdominal pain on the right iliac fossa and vomiting. CT scan was performed and showed an intestinal perforation by a foreign body. Diagnostic laparoscopy identified a perforation of a Meckel's diverticulum by a fish bone and a laparoscopic stapled diverticulectomy was performed...
January 2019: Journal of Surgical Case Reports
Syed Waleed Ahmad Bukhari, Benjamin Cribb, Matthew Clark
No abstract text is available yet for this article.
January 28, 2019: ANZ Journal of Surgery
Suleyman Celebi, Seyithan Ozaydin, Esra Polat, Cemile Basdas, Elmas Reyhan Alim, Serdar Sander
OBJECTIVE: The aim of this study was to review the management of pediatric cases of vitelline duct pathology (VDP) detected surgically or incidentally during the neonatal period and the outcomes. METHODS: The data of newborns who were symptomatic and underwent VDP resection or who were incidentally diagnosed with VDP at a single institution between 1985 and 2015 were retrospectively analyzed in terms of age, sex, clinical features, treatment, perioperative findings, ectopic tissue pathology, and postoperative follow-up information...
September 2018: Northern Clinics of Istanbul
Zhe Wen, Lorianne Salerno, Hongming Zhuang
Positive gastric mucosa Meckel diverticulum generally shows nonmoving activity in the right abdomen, which appears early in the study at about the same time of the appearance of the stomach. However, a stoma from ileostomy can result in similar findings on dynamic images. The difference between a true Meckel diverticulum and stoma can be exposed by lateral views.
January 25, 2019: Clinical Nuclear Medicine
Alfredo Vivas Lopez, Daniel Pastor Altaba, Oana-Anisa Nutu, Alberto Marcacuzco Quinto
No abstract text is available yet for this article.
January 21, 2019: Cirugía Española
Hyun Sik Kang, Jeong Sub Lee, Chang Rim Hyun, In-Ho Jung, Ki Soo Kang
We report a rare case of Meckel's diverticulum in a boy who initially presented with chronic iron deficiency anemia (IDA) without any history of gastrointestinal (GI) bleeding at 8 years-old. Isolated small bowel Crohn's disease was suspected based on findings of small bowel ulcers on capsule endoscopy. At four years from initial presentation, he developed massive GI bleeding. Abdominal computed tomographic angiography and small bowel series revealed findings suggestive of Meckel's diverticulum. Meckel's diverticulum should be suspected in children with unexplained chronic IDA even in the absence of prominent GI bleeding and negative findings on repetitive Meckel's scans...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
L Wauters, K Peeters, A Van Hootegem, P Goetstouwers, P Delvaux, J Callens
Meckel's diverticulum is the most common congenital gastrointestinal malformation and may present with bleeding, obstruction and diverticulitis. Symptomatic Meckel's diverticulum is associated with age <50 years, male gender, diverticular length > 2 cm and ectopic mucosa. Formation of enteroliths is a rare complication of Meckel's diverticulum and the majority of stones will remain in the diverticulum. Factors promoting enterolith formation through precipitation of calcium in the small intestinal alkaline environment include stasis as well as diverticular anatomy and histology...
October 2018: Acta Gastro-enterologica Belgica
Lin Lin, Kuiliang Liu, Hong Liu, Jing Wu, Yaopeng Zhang
OBJECTIVE: We described a case series of patients diagnosed with Meckel's diverticulum using capsule endoscopy (CE), reviewed the literature, and aimed to reveal the common CE characteristics of Meckel's diverticulum. MATERIALS AND METHODS: We reviewed a case series of Meckel's diverticulum in the Department of Gastroenterology, Beijing Shijitan Hospital Affliated to the Capital Medical University. In each case, primary upper endoscopy and colonoscopy failed to reveal a reason to explain the complaints (hematochezia in three cases and abdominal pain in one)...
January 13, 2019: Scandinavian Journal of Gastroenterology
Wisam Selbi, Hugh Sims-Williams, Paul Ince, Thomas A Carroll
Leiomyomas, benign neoplasms of mesenchymal origin, are common in gastrointestinal and genitourinary tracts. They are comprised of well-differentiated smooth muscle cells with few mitotic figures. Leiomyomas should not exhibit metastatic potential, though metastasis has been reported. Primary intracranial lesions remain rare. Only 4 cases have been reported in immunocompetent patients. Here we report an intracranial leiomyoma in an immunocompetent patient. A 60 year-old woman with unremarkable past medical history presented with a right sixth nerve palsy...
January 12, 2019: British Journal of Neurosurgery
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