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https://read.qxmd.com/read/30772328/predictive-criteria-of-response-to-endoscopic-treatment-for-severe-strictures-in-primary-sclerosing-cholangitis
#1
Nora Cazzagon, Olivier Chazouillères, Christophe Corpechot, Sanaâ El Mouhadi, Edouard Chambenois, Benoit Desaint, Ulriikka Chaput, Sara Lemoinne, Lionel Arrivé
BACKGROUND: The aim of this study was to identify predictive criteria of improvement after endoscopic treatment (ET) for severe strictures of extrahepatic bile ducts in patients with primary sclerosing cholangitis (PSC). METHODS: PSC patients who had at least one ET for severe stricture were included. Features of magnetic resonance cholangiography (MRC), performed before ET, were evaluated according to a standard model of interpretation, and a radiologic qualitative score of probability of improvement after ET was built...
February 13, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30771050/traumatic-hyperextension-distraction-injuries-of-the-thoracolumbar-spine-a-technical-note-on-surgical-positioning
#2
Andrew S Moon, Carly A Cignetti, Jonathan A Isbell, Chong Weng, Sakthivel Rajan Rajaram Manoharan
PURPOSE: Hyperextension-distraction type injury of the thoracolumbar spine is an unstable fracture pattern that generally necessitates surgical stabilization by posterior instrumentation. Care must be taken when positioning these patients from supine to prone due to the unstable nature of their injury. The study objectives were (1) to describe a novel modification of the Jackson table turn technique, which may be safer and more effective than the conventional log-roll method and traditional Jackson table technique for positioning patients with hyperextension-distraction injuries of the thoracolumbar spine from supine to prone in the operating room and (2) to present two cases in which this technique was successfully performed...
February 15, 2019: European Spine Journal
https://read.qxmd.com/read/30753679/cognitive-outcomes-in-meningioma-patients-undergoing-surgery-individual-changes-over-time-and-predictors-of-late-cognitive-functioning
#3
Sophie J M Rijnen, Ikram Meskal, Marjan Bakker, Wouter De Baene, Geert-Jan M Rutten, Karin Gehring, Margriet M Sitskoorn
Background: Meningioma patients are known to face cognitive deficits before and after surgery. We examined individual changes in cognitive performance over time and identified preoperative predictors of cognitive functioning 12 months after surgery in a large sample of meningioma patients. Methods: Patients underwent neuropsychological assessment (NPA) using CNS Vital Signs 1 day before (T0), and 3 (T3) and 12 (T12) months after surgery. Patients' sociodemographically-corrected scores on 7 cognitive domains were compared to performance of a normative sample using one-sample z tests and Chi-square tests of independence...
February 7, 2019: Neuro-oncology
https://read.qxmd.com/read/30747259/design-and-preliminary-biomechanical-analysis-of-a-novel-motion-preservation-device-for-lumbar-spinal-disease-after-vertebral-corpectomy
#4
Jiantao Liu, Xijing He, Zhengchao Gao, Binbin Niu, Dongbo Lv, Yanzheng Gao
OBJECTIVE: To design a novel prosthesis, a movable artificial lumbar complex (MALC), for non-fusion reconstruction after lumbar subtotal corpectomy and to evaluate the stability, range of motion and load-bearing strength in the human cadaveric lumbar spine. METHODS: Biomechanical tests were performed on lumbar spine specimens from 15 healthy cadavers which were divided in three groups: non-fusion, fusion and intact group. The range of motion (ROM), stability and load-bearing strength were measured...
February 12, 2019: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/30746786/the-nociceptive-withdrawal-reflex-of-the-trunk-is-organized-with-unique-muscle-receptive-fields-and-motor-strategies
#5
Hugo Massé-Alarie, Sauro E Salomoni, Paul W Hodges
Noxious stimuli induce a nociceptive withdrawal reflex (NWR) to protect the tissue from injury. Although the NWR was once considered as a stereotyped response, previous studies report distinct responses depending on the stimulation site and context for limbs. We aimed to determine whether noxious stimuli over the trunk produced adaptable complex NWR. We hypothesized that organization of the NWR of the trunk muscle would vary with the site of noxious input and would differ between body and spine postures, which modify the potential for specific muscles to remove threat...
February 11, 2019: European Journal of Neuroscience
https://read.qxmd.com/read/30744347/effects-of-dietary-levels-of-tapioca-residue-on-growth-performance-and-carcass-characteristics-in-hanwoo-steers
#6
Byung Ki Park, Dong Kyo Lee, Jun Sang Ahn, Joong Kook Park, Min Ji Kim, Gi Hwal Son, Jong Suh Shin
Objective: This study was conducted to investigate the effects of dietary levels of tapioca residue on growth performance, carcass characteristics, and meat composition in Hanwoo steers. Methods: Twenty-eight steers were randomly assigned to one of four dietary groups; T0 (0% tapioca residue), T6.7 (6.7% tapioca residue), T9 (9% tapioca residue), and T12 (12% tapioca residue). Results: Supplementation with tapioca residue had no effect on overall growth performance...
January 4, 2019: Asian-Australasian Journal of Animal Sciences
https://read.qxmd.com/read/30741469/masticatory-ability-improves-after-maxillary-implant-overdenture-treatment-a-randomized-controlled-trial-with-1-year-follow-up
#7
Geessien C Boven, Caroline M Speksnijder, Henny J A Meijer, Arjan Vissink, Gerry M Raghoebar
BACKGROUND: The effect of maxillary implant overdentures on masticatory ability in edentulous patients with complaints regarding their conventional maxillary dentures is unknown. PURPOSE: To assess the change in objective masticatory ability (mixing ability index, MAI), patient reported masticatory ability (questionnaire), and patient satisfaction (GSS) after maxillary implant overdenture treatment with either solitary attachments or bars. MATERIALS AND METHODS: Two groups randomly received four-implant maxillary overdentures on either solitary attachments (group I, n = 25) or bars (group II, n = 25)...
February 11, 2019: Clinical Implant Dentistry and related Research
https://read.qxmd.com/read/30740380/parvimonas-micra-spondylodiscitis-a-case-report-and-systematic-review-of-the-literature
#8
D C van Duijvenbode, J W P Kuiper, R M Holewijn, A Stadhouder
Introduction: Treatment and risk factors for Parvimonas micra spinal infections are scarcely researched. This study reports a case and presents a systematic review of the literature to provide evidence-based ground for diagnosis and treatment of P. micra spinal infections. Case Report: This is a case of a 78-year-old male with severe back and leg pain. Advanced imaging demonstrated the destruction of L2-L3 with an extensive fluid collection in the remaining intervertebral space, paravertebral myositis, and multiple abscesses...
September 2018: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/30735210/tba-loop-mapping-with-3-inverted-deoxythymidine-for-fine-tuning-of-the-binding-affinity-for-%C3%AE-thrombin
#9
Zhilong Chai, Lei Guo, Hongwei Jin, Yang Li, Shanshan Du, Yucong Shi, Chuhan Wang, Weiguo Shi, Junlin He
TBA is a 15-mer DNA aptamer for human α-thrombin, and its three T-rich loops are involved in the binding interactions with thrombin differently. In order to clarify their specific spatial locations in the binding interactions and search for more favourable positions, here a systematic investigation of all the loop residues was conducted with 3'-inverted thymidine (iT), by which both unnatural 3'-3'- and 5'-5'-linkages for each incorporation were introduced in the tertiary structure. The changes in Tm values and CD spectra revealed that motifs T3T12 and T4T13 are structurally distinct...
February 8, 2019: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/30719932/esthetic-improvements-of-postorthodontic-white-spot-lesions-treated-with-resin-infiltration-and-microabrasion-a-split-mouth-randomized-clinical-trial
#10
Xi Gu, Lin Yang, Deqin Yang, Yuan Gao, Xiaolei Duan, Xin Zhu, He Yuan, Jiyao Li
OBJECTIVE: To compare the esthetic improvement between postorthodontic white-spot lesions (WSLs) treated by resin infiltration and microabrasion for 12 months. MATERIALS AND METHODS: A total of 20 patients with 128 teeth with postorthodontic WSLs were recruited. A simple randomized, split-mouth, positive controlled design was used to allocate patients to resin infiltration or microabrasion groups. The lesion area ratio (R value) was calculated between the area of a WSL and the labial surface of the corresponding tooth based on standardized clinical photographs...
February 5, 2019: Angle Orthodontist
https://read.qxmd.com/read/30716487/magnetically-controlled-growing-rod-for-early-onset-scoliosis-a-systematic-review-and-meta-analysis
#11
Ning Tang, Hong Zhao, Jian-Xiong Shen, Jian-Guo Zhang, Shu-Gang Li
BACKGROUND: The goal of the current systematic review and meta-analysis was to explore the utilization of magnetically controlled growing rod (MCGR) for the treatment of early onset scoliosis based on eligible studies demonstrating efficacy. METHODS: Online electronic databases were searched to identify the eligible studies updated to April 2018 according to the index words. Several literatures that were relevant to the present analysis were also included. Mean difference (MD) or relative risk (RR) along with 95% confidence interval (95% CI) was used to analyze the main outcomes...
February 1, 2019: World Neurosurgery
https://read.qxmd.com/read/30716122/the-stability-of-long-segment-and-short-segment-fixation-for-treating-severe-burst-fractures-at-the-thoracolumbar-junction-in-osteoporotic-bone-a-finite-element-analysis
#12
Yueh Wu, Chia-Hsien Chen, Fon-Yih Tsuang, Yi-Cheng Lin, Chang-Jung Chiang, Yi-Jie Kuo
The majority of compressive vertebral fractures in osteoporotic bone occur at the level of the thoracolumbar junction. Immediate decompression is often required in order to reduce the extent of neurological damage. This study evaluated four fixation methods for decompression in patients with thoracolumbar burst fractures, and presented the most suitable method for osteoporotic patients. A finite element model of a T7-L5 spinal segment was created and subjected to an L1 corpectomy to simulate a serious burst fracture...
2019: PloS One
https://read.qxmd.com/read/30711853/clinical-efficacy-of-trauma-focused-psychotherapies-in-treatment-resistant-depression-trd-in-patients-a-randomized-controlled-pilot-study
#13
Alessandra Minelli, Elisa Zampieri, Chiara Sacco, Roberta Bazzanella, Nicoletta Mezzetti, Elisabetta Tessari, Stefano Barlati, Marco Bortolomasi
In major depressive disorder (MDD) patients, life stress events represent a risk factor for a severe, early-onset, treatment-resistant and chronic endophenotype. Treatment-resistant depression (TRD) patients who have experienced traumatic events could benefit from evidence-based trauma-focused psychotherapies. Because this topic has never been investigated, the aim of this pilot trial was to evaluate whether trauma-focused cognitive-behavioural therapy (TF-CBT) and/or eye movement desensitization and reprocessing (EMDR) can help achieve depressive symptom remission in TRD patients...
January 24, 2019: Psychiatry Research
https://read.qxmd.com/read/30708391/microsurgical-experience-with-pedicle-sparing-transfacet-approach-for-thoracic-disk-herniation
#14
Suat Erol Çelik, Yavuz Samancı, Ferdi Özkaya, Olgün Peker
PURPOSE: Thoracic disk herniation (TDH) is relatively uncommon. The surgical approach differs from lumbar or cervical disk herniations because serious complications are associated with the posterior approach in TDH. Various different approaches have been tried for the surgical removal of TDH, but most of them are cumbersome surgeries such as thoracotomy or thoracoscopic or anterior approaches with or without instrumentation. The requirement for a simplified, familiar, and less morbid surgery has motivated some new approaches...
February 1, 2019: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://read.qxmd.com/read/30702572/challenges-in-diagnosis-of-spinal-epidural-abscess-a-case-report
#15
Xiaowei Yang, Runsheng Guo, Xin Lv, Qi Lai, Banglin Xie, Xiaozhen Jiang, Min Dai, Bin Zhang
RATIONALE: Spinal epidural abscess (SEA) is a rare condition that shows a high prevalence in immunocompromised patients. The clinical presentation of SEA includes the "classic triad" of pain, fever, and neurological dysfunction. However, these nonspecific features can lead to a high rate of misdiagnosis. SEA may lead to paralysis or even death; thus, prognosis of these patients remains unfavorable. PATIENT CONCERNS: We report a case of a multilevel (T6-T12) SEA in a 22-year-old woman...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30700854/respiratory-muscle-training-in-individuals-with-spinal-cord-injury-effect-of-training-intensity-and-volume-on-improvements-in-respiratory-muscle-strength
#16
Anja M Raab, Jörg Krebs, Mirjam Pfister, Claudio Perret, Maria Hopman, Gabi Mueller
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To investigate the effect of training intensity and -volume on improvements in respiratory muscle strength in individuals with spinal cord injury (SCI). SETTING: SCI rehabilitation center in Switzerland. METHODS: Inpatients with SCI, lesion level C4-T12, who had at least 10 individualized inspiratory muscle training sessions with respiratory function measurements before and after the training period...
January 30, 2019: Spinal Cord
https://read.qxmd.com/read/30695640/functional-characterization-of-the-prejunctional-receptors-mediating-the-inhibition-by-ergotamine-of-the-rat-perivascular-sensory-peptidergic-drive
#17
Abimael Gonzalez-Hernandez, Bruno A Marichal-Cancino, Jair Lozano-Cuenca, Antoinette MaassenVanDenBrink, Carlos M Villalon
Calcitonin gene-related peptide (α-CGRP) released from perivascular sensory nerves induces decreases in diastolic blood pressure (DBP). Experimentally, this can be shown by spinal thoracic (T9-T12) electrical stimulation of these afferent fibers. Since ergotamine inhibits these neurogenic vascular responses and displays affinity for monoaminergic receptors that inhibit neurotransmitter release, the present study investigated whether this ergotamine-induced inhibition results from activation of serotonin 5-HT1B/1D, dopamine D2-like and α2-adrenergic receptors...
January 29, 2019: ACS Chemical Neuroscience
https://read.qxmd.com/read/30694368/quantification-of-fat-and-skeletal-muscle-tissue-at-abdominal-computed-tomography-associations-between-single-slice-measurements-and-total-compartment-volumes
#18
Anton Faron, Julian A Luetkens, Frederic C Schmeel, Daniel L R Kuetting, Daniel Thomas, Alois M Sprinkart
PURPOSE: Body composition is of great prognostic value in several severe diseases, including different types of cancer as well as cardiometabolic disorders. We aimed to investigate the correlations of skeletal muscle mass and abdominal adipose tissue compartments between volumetric and single-slice measurements to study the usefulness of several anatomical landmarks for estimation of total compartment volumes using abdominal CT-scans. METHODS: In this retrospective study volumetric quantifications of paraspinal skeletal muscles (SM) and adipose tissue compartments (visceral adipose tissue, VAT; subcutaneous adipose tissue, SAT) were performed in 50 consecutive patients (26 male; mean age, 63 ± 15 years) who underwent abdominal multislice-CT for diagnostic purposes using an in-house software...
January 29, 2019: Abdominal Radiology
https://read.qxmd.com/read/30690782/thoracic-kyphosis-on-chest-ct-scans-is-associated-with-incident-vertebral-fractures-in-smokers
#19
Mayke J van Dort, Johanna H M Driessen, Elisabeth Romme, Piet Geusens, Paul C Willems, Frank W J M Smeenk, Emiel F M Wouters, Joop P W van den Bergh
Greater kyphosis angles lead to increased loading on vertebral bodies in computational models. However, results about the relationship between severity of kyphosis and incident vertebral fracture (VF) risk have been conflicting. Therefore, the aim of this study was to evaluate associations between a) prevalent VFs and severity of kyphosis, and b) severity of kyphosis and incident VF risk, in smokers with or without COPD. Former and current smokers with or without COPD were included. CT scans were made at baseline, one-year and three-year follow-up...
January 28, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30686484/evaluation-of-collateral-network-near-infrared-spectroscopy-during-and-after-segmental-artery-occlusion-in-a-chronic-large-animal-model
#20
Konstantin von Aspern, Josephina Haunschild, Martin Ziemann, Martin Misfeld, Friedrich W Mohr, Michael A Borger, Christian D Etz
OBJECTIVE: Ischemic spinal cord injury remains the most devastating complication after open and endovascular aortic repair. Collateral network near-infrared spectroscopy has been introduced to noninvasively monitor real-time spinal cord oxygenation. In view of recent advancements in endovascular treatment and minimally invasive staged preconditioning before aortic repair, this study sought to evaluate collateral network near-infrared spectroscopy during and after segmental artery occlusion in a chronic porcine model...
December 11, 2018: Journal of Thoracic and Cardiovascular Surgery
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