Cynthia M Cascabulho, Marcelo Meuser-Batista, Kelly Cristina G de Moura, Maria do Carmo Pinto, Thabata Lopes Alberto Duque, Kelly C Demarque, Ana Carolina Ramos Guimarães, Pedro Paulo de Abreu Manso, Marcelo Pelajo-Machado, Gabriel M Oliveira, Solange L De Castro, Rubem Fs Menna-Barreto
BACKGROUND: Chagas disease, which is caused by the protozoan Trypanosoma cruzi, is endemic to Latin America and mainly affects low-income populations. Chemotherapy is based on two nitrocompounds, but their reduced efficacy encourages the continuous search for alternative drugs. Our group has characterised the trypanocidal effect of naphthoquinones and their derivatives, with naphthoimidazoles derived from β-lapachone (N1, N2 and N3) being the most active in vitro. OBJECTIVES: In the present work, the effects of N1, N2 and N3 on acutely infected mice were investigated...
2020: Memórias do Instituto Oswaldo Cruz