Constantin-Cristian Topriceanu, Mashael Alfarih, Alun D Hughes, Hunain Shiwani, Fiona Chan, Saidi A Mohiddin, William Moody, Richard P Steeds, Benjamin O'Brien, Jakob Vowinckel, Petros Syrris, Caroline Coats, Stephen Pettit, Eloisa Arbustini, James C Moon, Gabriella Captur
Lamins A/C (encoded by LMNA gene) can lead to dilated cardiomyopathy (DCM). This pilot study sought to explore the postgenomic phenotype of end-stage lamin heart disease. Consecutive patients with end-stage lamin heart disease (LMNA-group, n = 7) and ischaemic DCM (ICM-group, n = 7) undergoing heart transplantation were prospectively enrolled. Samples were obtained from left atrium (LA), left ventricle (LV), right atrium (RA), right ventricle (RV) and interventricular septum (IVS), avoiding the infarcted myocardial segments in the ICM-group...
2023: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology