keyword
https://read.qxmd.com/read/38532955/the-enterics-for-global-health-efgh-shigella-surveillance-study-in-malawi
#21
JOURNAL ARTICLE
Donnie Mategula, Maureen Ndalama, Clement Lefu, Jobiba Chinkhumba, Latif Ndeketa, Vitumbiko Munthali, Clifford Chitala, Thandizo Malemia, Gertrude Million, Ishmail Mbutuka, Ranken Mhone, Ethel Makwenda, Mussa James, Cornelius Bwanali, Gift Kazembe, Abell Manundo, Evance Chauluka, Salama Chitalo, Ethel Alumando, Dalitso Longwe, Maggie Matandika, Paul Jonasi, Agra Thindwa, Deborah Phiri, Richard Wachepa, Flywell Kawonga, Victor Maiden, Mary Charles, Ida Kapindula, Desiree Witte, Ann M Turner, Christina Bronowski, Kate Baker, Naor Bar-Zeev, Melita A Gordon, Queen Dube, Nigel A Cunliffe, Khuzwayo C Jere, Jennifer Cornick
BACKGROUND: Malawi is among 7 countries participating in the Enterics for Global Health (EFGH) Shigella surveillance study, which aims to determine the incidence of medically attended diarrhea attributed to Shigella , a leading bacterial cause of diarrhea in children in low-resource settings. METHODS: We describe the EFGH study site in the densely populated informal settlement of Ndirande Township, Blantyre, Malawi. We explore the site's geographical location, demographic characteristics, and the healthcare-seeking behavior of its population, particularly for childhood diarrhea...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532954/the-enterics-for-global-health-efgh-shigella-surveillance-study-in-mali
#22
JOURNAL ARTICLE
Adama Mamby Keita, Sanogo Doh, Jane Juma, Dilruba Nasrin, Awa Traoré, Uma Onwuchekwa, Rebecca Maguire, Fadima C Haidara, Samba O Sow, Karen L Kotloff, Milagritos D Tapia
BACKGROUND: In 2002, the Centre pour le Développement des Vaccins du Mali (CVD-Mali) was established as a partnership between the Mali Ministry of Health and the University of Maryland, Baltimore. Since its creation, CVD-Mali has been dedicated to describing the epidemiology of infectious diseases, supporting the development of vaccines, and training a team of local researchers. CVD-Mali participated in the Global Enteric Multicenter Study from 2007 to 2010 and the Vaccine Impact on Diarrhea in Africa study from 2015 to 2018, where the importance of Shigella as an enteric pathogen was established...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532953/the-enterics-for-global-health-efgh-shigella-surveillance-study-in-kenya
#23
JOURNAL ARTICLE
Richard Omore, Alex O Awuor, Billy Ogwel, Caleb Okonji, Catherine Sonye, Caren Oreso, Victor Akelo, Manase Amollo, Isaiah Ogudi, Raphael O Anyango, Marjorie Audi, Evans Apondi, Laura Riziki, Lilian Ambila, Nasrin Dilruba, Erick Muok, Stephen Munga, John B Ochieng, Karen L Kotloff
BACKGROUND: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella- targeted clinical trials are needed to improve Shigella -related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532952/data-management-in-multicountry-consortium-studies-the-enterics-for-global-health-efgh-shigella-surveillance-study-example
#24
JOURNAL ARTICLE
Erika Feutz, Prasanta K Biswas, Latif Ndeketa, Billy Ogwel, Uma Onwuchekwa, Golam Sarwar, Shazia Sultana, Pablo Peñataro Yori, Alyssa Acebedo, Naveed Ahmed, Imran Ahmed, Hannah E Atlas, Alex O Awuor, Md Amirul Islam Bhuiyan, Bakary Conteh, Oualy Diawara, Sarah Elwood, Moussa Fane, Md Ismail Hossen, Mahzabeen Ireen, Abdoulie F Jallow, Mehrab Karim, Margaret N Kosek, Karen L Kotloff, Clement Lefu, Jie Liu, Rebecca Maguire, Farah Naz Qamar, Maureen Ndalama, John Benjamin Ochieng, Caleb Okonji, Loyda Fiorella Zegarra Paredes, Patricia B Pavlinac, Karin Perez, Sonia Qureshi, Francesca Schiaffino, Moussa Traore, Kirkby D Tickell, Richard Wachepa, Desiree Witte, Jennifer Cornick, M Jahangir Hossain, Farhana Khanam, Maribel Paredes Olortegui, Richard Omore, Samba O Sow, Mohammad Tahir Yousafzai, Sean R Galagan
BACKGROUND: Rigorous data management systems and planning are essential to successful research projects, especially for large, multicountry consortium studies involving partnerships across multiple institutions. Here we describe the development and implementation of data management systems and procedures for the Enterics For Global Health (EFGH) Shigella surveillance study-a 7-country diarrhea surveillance study that will conduct facility-based surveillance concurrent with population-based enumeration and a health care utilization survey to estimate the incidence of Shigella- -associated diarrhea in children 6 to 35 months old...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532951/the-enterics-for-global-health-efgh-shigella-surveillance-study-in-peru
#25
JOURNAL ARTICLE
Katia Manzanares Villanueva, Tackeshy Pinedo Vasquez, Pablo Peñataro Yori, Lucero Romaina Cacique, Paul F Garcia Bardales, Wagner V Shapiama Lopez, Fiorella Zegarra Paredes, Karin F Perez, Silvia Rengifo Pinedo, Hermann Silva Delgado, Thomas Flynn, Francesca Schiaffino, Josh M Colston, Maribel Paredes Paredes Olortegui, Margaret N Kosek
BACKGROUND: The Enterics for Global Health (EFGH) Peru site will enroll subjects in a periurban area of the low Amazon rainforest. The political department of Loreto lags behind most of Peru in access to improved sources of water and sanitation, per capita income, children born <2.5 kg, and infant and child mortality. Chronic undernutrition as manifested by linear growth shortfalls is common, but wasting and acute malnutrition are not. METHODS: The recruitment of children seeking care for acute diarrheal disease takes place at a geographic cluster of government-based primary care centers in an area where most residents are beneficiaries of free primary healthcare...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532950/the-enterics-for-global-health-efgh-shigella-surveillance-study-in-pakistan
#26
JOURNAL ARTICLE
Naveed Ahmed, Mohammad Tahir Yousafzai, Farah Naz Qamar
BACKGROUND: The Enterics for Global Health (EFGH) Shigella surveillance study is a longitudinal multicountry study that aims to estimate incidence rates and document consequences of Shigella diarrhea within 7 countries in Africa, Asia, and Latin America. In addition to a high incidence of childhood diarrhea, Pakistan is facing a problem of antimicrobial resistance in urban and peri-urban areas of Karachi. METHODS: In Pakistan, EFGH will be conducted in Karachi, which is one of the metropolitan cities bordering the Arabian Sea and has a diverse population of 1...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532949/microbiological-methods-used-in-the-enterics-for-global-health-shigella-surveillance-study
#27
JOURNAL ARTICLE
Bri'Anna Horne, Henry Badji, Md Taufiqur Rahman Bhuiyan, Lucero Romaina Cachique, Jennifer Cornick, Aneeta Hotwani, Jane Juma, John Benjamin Ochieng, Mahamadou Abdou, Evans Apondi, Hannah E Atlas, Alex O Awuor, Kate S Baker, Bubacarr E Ceesay, Mary Charles, Nigel A Cunliffe, Erika Feutz, Sean R Galagan, Ibrehima Guindo, M Jahangir Hossain, Junaid Iqbal, Fatima Jallow, Noumou Yakhouba Keita, Farhana Khanam, Karen L Kotloff, Victor Maiden, Katia Manzanares Villanueva, Oscar Mito, Md Parvej Mosharraf, Joseph Nkeze, Usman N Ikumapayi, Maribel Paredes Olortegui, Patricia B Pavlinac, Tackeshy Pinedo Vasquez, Firdausi Qadri, Farah Naz Qamar, Sonia Qureshi, Nazia Rahman, Aminata Sangare, Sunil Sen, Pablo Peñataro Yori, Mohammad Tahir Yousafzai, Dilruba Ahmed, Khuzwayo C Jere, Margaret N Kosek, Richard Omore, Jasnehta Permala-Booth, Ousman Secka, Sharon M Tennant
BACKGROUND: Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting Shigella are in development, and phase 3 clinical trials are imminent to determine efficacy against shigellosis. METHODS: The Enterics for Global Health (EFGH) Shigella surveillance study is designed to determine the incidence of medically attended shigellosis in 6- to 35-month-old children in 7 resource-limited settings. Here, we describe the microbiological methods used to isolate and identify Shigella ...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532937/the-association-between-intradialytic-symptom-clusters-and-recovery-time-in-patients-undergoing-maintenance-hemodialysis-an-exploratory-analysis
#28
JOURNAL ARTICLE
Arrti A Bhasin, Jennifer M MacRae, Braden Manns, Kelvin C W Leung, Amber O Molnar, Jason W Busse, David Collister, K Scott Brimble, Christian G Rabbat, Jessica Tyrwhitt, Andrea Mazzetti, Michael Walsh
BACKGROUND: Individuals receiving hemodialysis often experience concurrent symptoms during treatment and frequently report feeling unwell after dialysis. The degree to which intradialytic symptoms are related, and which specific symptoms may impair health-related quality of life (HRQoL) is uncertain. OBJECTIVES: To explore intradialytic symptoms clusters, and the relationship between intradialytic symptom clusters with dialysis treatment recovery time and HRQoL...
2024: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/38532799/coexisting-primary-sclerosing-cholangitis-and-autoimmune-hepatitis-overlapping-challenges-in-diagnosis-and-treatment
#29
Hannah W Fiske, Firrah Saeed, Christopher Ward, Boris Sinayuk, Veronica Ulici, Michael Curry, Edward Feller, Samir A Shah
INTRODUCTION: Hepatobiliary overlap syndromes describe the coinciding presentation of more than one immune-mediated biliary and liver disease in a single patient and present complex challenges in diagnosis and treatment. We report a case of ulcerative colitis with primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome responsive to vancomycin. CASE PRESENTATION: The patient is a 30-year-old female with known ulcerative pancolitis and autoimmune hepatitis...
2024: Case Reports in Gastroenterology
https://read.qxmd.com/read/38532729/serplulimab-monotherapy-in-extensive-stage%C3%A2-small-cell-lung-cancer-with-brain-metastasis-a-case-report
#30
JOURNAL ARTICLE
Xudong Xiang, Heng Li, Bao Lei, Benchao Chen, Gaofeng Li
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with limited treatment options, especially for extensive-stage (ES) patients. We present a case of a 70-year-old male with ES-SCLC and asymptomatic brain metastasis who opted for immune monotherapy with serplulimab (an anti-PD-1 antibody). After four cycles, the patient achieved a confirmed partial response and a progression-free survival of over 1 year. Moreover, we observed a consistent decline in tumor biomarkers, and brain MRI indicated reduced metastatic activity...
March 27, 2024: Immunotherapy
https://read.qxmd.com/read/38532694/a-one-step-immunoassay-based-on-switching-peptides-for-diagnosis-of-porcine-epidemic-diarrhea-virus-pedv-using-screened-fv-antibodies
#31
JOURNAL ARTICLE
Tae-Hun Kim, Jae-Yeon Park, Jaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Hyun-Jin Shin, Min-Jung Kang, Joachim Jose, Jae-Chul Pyun
In this study, a one-step immunoassay for porcine epidemic diarrhea virus (PEDV) based on Fv-antibodies and switching peptides was developed, and the assay results of PEDV were obtained by just mixing samples without any further reaction or washing steps. The Fv-antibodies with binding affinity to the spike protein of PEDV were screened from the Fv-antibody library using the receptor-binding domain (RBD) of the spike protein as a screening probe. Screened Fv-antibodies with binding affinities to the RBD antigen were expressed, and the binding constants ( K D ) were calculated to be 83-142 nM...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38532145/the-alarming-rate-of-malnutrition-after-single-anastomosis-sleeve-ileal-bypass-a-single-centre-experience
#32
JOURNAL ARTICLE
Ala Wafa, Ahmad Bashir, Ricardo V Cohen, Ashraf Haddad
BACKGROUND: Single anastomosis sleeve ileal (SASI) bypass is a modification of sleeve gastrectomy with transit bipartition (SG + TB). This study aims to assess the safety and efficacy of SASI as a primary metabolic and bariatric surgery (MBS). METHODS: This is a retrospective case series of 30 patients who underwent SASI bypass from January to December 2021. All patients completed at least 12 months of follow-up. RESULTS: Among the 30 patients, 93...
March 27, 2024: Obesity Surgery
https://read.qxmd.com/read/38532057/mechanisms-of-medicinal-pharmaceutical-and-immunomodulatory-action-of-probiotics-bacteria-and-their-secondary-metabolites-against-disease-management-an-overview
#33
REVIEW
Sundas Nasreen, Shaukat Ali, Saiqa Andleeb, Muhammad Summer, Tauqeer Hussain, Kaleem Imdad, Chaman Ara, Hafiz Muhammad Tahir
Probiotics or bacteriotherapy is today's hot issue for public entities (Food and Agriculture Organization, and World Health Organization) as well as health and food industries since Metchnikoff and his colleagues hypothesized the correlation between probiotic consumption and human's health. They contribute to the newest and highly efficient arena of promising biotherapeutics. These are usually attractive in biomedical applications such as gut-related diseases like irritable bowel disease, diarrhea, gastrointestinal disorders, fungal infections, various allergies, parasitic and bacterial infections, viral diseases, and intestinal inflammation, and are also worth immunomodulation...
March 27, 2024: Folia Microbiologica
https://read.qxmd.com/read/38531428/molecular-characterization-of-cryptosporidium-spp-and-giardia-duodenalis-in-pet-cats-in-henan-province-central-china
#34
JOURNAL ARTICLE
Liangliang Li, Yuzhen Sui, Xinmiao Li, Pengtao Song, Guizhen Chen, Hu Liu, Shoujun Zuo, Jinjie Guo, Qiong Wang, Qiyuan Sun, Hongyu Dai, Junqiang Li, Tao Zhang, Fang Liu, Longxian Zhang, Haiju Dong
Cryptosporidium spp. and G. duodenalis often infect humans, cats, and other mammals, causing diarrhea and being responsible for numerous outbreaks of waterborne and foodborne infections worldwide. The rapid increase in the number of pet cats poses a substantial public health risk. However, there were few reports about the infection of Cryptosporidium spp. and G. duodenalis infections in pet cats in Henan Province, central China. Thus, to understand the prevalence and genetic distribution of Cryptosporidium spp...
March 24, 2024: Acta Tropica
https://read.qxmd.com/read/38531427/outbreak-of-persistently-infected-heifer-calves-with-bovine-viral-diarrhea-virus-subgenotypes-1b-and-1d-in-a-bvdv-vaccinated-open-dairy-herd
#35
JOURNAL ARTICLE
Juliana Torres Tomazi Fritzen, Natalia Zaparoli Zucoloto, Elis Lorenzetti, Alice Fernandes Alfieri, Amauri Alcindo Alfieri
Bovine viral diarrhea virus (BVDV) infection has a significant economic impact on beef and dairy industries worldwide. Fetal infection with a non-cytopathic strain may lead to the birth of persistently infected (PI) offspring, which is the main event in the epidemiological chain of BVDV infection. This report describes the birth of 99 BVDV-PI heifer calves within 52 days of birth in a regular BVDV-vaccinated Brazilian dairy cattle herd and the subgenotypes of the infecting field strains. This study was conducted in a high-yielding open dairy cattle herd that frequently acquired heifers from neighboring areas for replacement...
March 24, 2024: Acta Tropica
https://read.qxmd.com/read/38530746/a-review-on-the-traditional-applications-phytochemistry-and-pharmacology-of-the-genus-physochlaina-g-don
#36
JOURNAL ARTICLE
Younas Rasheed Tantray, Ishrat Jan, Irshad Mohiuddin, Preeti Gorla, Charul Anand, Jagdesh Chandra Arya, Shahnawaz Ahmad Bhat, Vijay Kumar, Shiddamallayya Nagayya, Rabinaryana Acharya
Physochlaina is a genus of flowering plants belonging to the family Solanaceae and consists of 10 species distributed in various Asian countries. The species of the genus have been traditionally used to cure a variety of illnesses due to their highly valuable medicinal properties, including cancer, asthma, cough, weakness, stomachache, diarrhea, swelling, spasms, toothache, boils, ulcers, rheumatic pain, chronic bronchitis, gastric problems, abdominal pain, palpitation, and insomnia. The species have gained significant attention due to their remarkable ethnopharmacological and ethnomedicinal significance...
March 26, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38530319/serum-fibroblast-growth-factor-19-level-correlates-inversely-with-clinical-and-endoscopic-activity-of-inflammatory-bowel-disease
#37
JOURNAL ARTICLE
Agata Łukawska, Agata Mulak
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition with relapsing-remitting course. Diarrhea and abdominal pain are the most common IBD symptoms. Fibroblast growth factor 19 (FGF19) is an endocrine factor that inhibits hepatic bile acid production and may be used as a diagnostic marker for bile acid malabsorption. OBJECTIVES: To assess serum FGF19 levels in active and inactive phases of IBD and find a potential correlation between FGF19 and disease activity...
March 26, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38530212/prevalence-of-intestinal-trichomonads-in-captive-non-human-primates-in-china
#38
JOURNAL ARTICLE
Ping-Ping Ma, Yang Zou, Wen-Jie Mu, Yue-Yue Zhang, Ya-Qi Li, Zhong-Li Liu, Long Zhang, Li-Xian Chen, Guo-Hua Liu, Shuai Wang
Trichomonads are protozoan symbionts with the capacity to infect vertebrates including humans and non-human primates (NHPs), sometimes with pathogenic effects. However, their diversity and prevalence in NHPs in China are poorly understood. A total of 533 fecal samples were collected from captive NHPs in Yunnan Province, China, of which 461 samples from Macaca fascicularis and 72 from Macaca mulatta. Trichomonadidae species were identified using PCR amplification of the ITS-1/5.8S/ITS-2 sequences. The overall prevalence of trichomonads in NHPs was determined to be 11...
2024: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/38530211/unraveling-the-pathogenic-potential-of-the-pentatrichomonas-hominis-phgd-strain-impact-on-ipec-j2-cell-growth-adhesion-and-gene-expression
#39
JOURNAL ARTICLE
Yibin Zhu, Haiming Cai, Siyun Fang, Hanqin Shen, Zhuanqiang Yan, Dingai Wang, Nanshan Qi, Juan Li, Minna Lv, Xuhui Lin, Junjing Hu, Yongle Song, Xiangjie Chen, Lijun Yin, Jianfei Zhang, Shenquan Liao, Mingfei Sun
Pentatrichomonas hominis, a flagellated parasitic protozoan, predominantly infects the mammalian digestive tract, often causing symptoms such as abdominal pain and diarrhea. However, studies investigating its pathogenicity are limited, and the mechanisms underlying P. hominis-induced diarrhea remain unclear. Establishing an in vitro cell model for P. hominis infection is imperative. This study investigated the interaction between P. hominis and IPEC-J2 cells and its impact on parasite growth, adhesion, morphology, and cell viability...
2024: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/38530162/the-effect-of-nurse-led-remote-telephone-triage-on-symptom-management-of-patients-with-cancer-a-systematic-review-and-meta-analysis
#40
REVIEW
Merve Gozde Sezgin, Hicran Bektas
BACKGROUND: Cancer patients experience many symptoms. Nurse-led remote telephone triage can improve their quality of life by contributing to the management of these symptoms. AIMS: This study aimed to investigate the effects of nurse-led remote telephone triage on symptom management of patients with cancer. METHODS: The searches were conducted in 10 databases and gray literature from May 2023 to July 2023 without any year limitations. A fixed-effects model was used in the meta-analysis...
March 26, 2024: Worldviews on Evidence-based Nursing
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