Kengo Onda, Eva Catenaccio, Jill Chotiyanonta, Raul Chavez-Valdez, Avner Meoded, Bruno P Soares, Aylin Tekes, Harisa Spahic, Sarah C Miller, Sarah-Jane Parker, Charlamaine Parkinson, Dhananjay M Vaidya, Ernest M Graham, Carl E Stafstrom, Allen D Everett, Frances J Northington, Kenichi Oishi
Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal acquired brain injury. Although conventional MRI may predict neurodevelopmental outcomes, accurate prognostication remains difficult. As diffusion tensor imaging (DTI) may provide an additional diagnostic and prognostic value over conventional MRI, we aimed to develop a composite DTI (cDTI) score to relate to short-term neurological function. Sixty prospective neonates treated with therapeutic hypothermia (TH) for HIE were evaluated with DTI, with a voxel size of 1 × 1 × 2 mm...
2022: Frontiers in Neuroscience