keyword
https://read.qxmd.com/read/37040878/diffusion-tensor-imaging-to-predict-neurodevelopmental-impairment-in-infants-after-hypoxic-ischemic-injury
#1
JOURNAL ARTICLE
Christa Tabacaru, Adebayo Braimah, Beth Kline-Fath, Nehal Parikh, Stephanie Merhar
OBJECTIVE:  Magnetic resonance imaging (MRI) is the standard of care for evaluation of brain injury after hypoxic-ischemic encephalopathy (HIE) in term newborns. This study utilizes diffusion tensor imaging (DTI) to (1) identify infants at highest risk of development of cerebral palsy (CP) following HIE and to (2) identify regions of the brain critical to normal fidgety general movements (GMs) at 3 to 4 months of postterm. Absence of these normal, physiological movements is highly predictive of CP...
May 11, 2023: American Journal of Perinatology
https://read.qxmd.com/read/35983227/development-of-a-composite-diffusion-tensor-imaging-score-correlating-with-short-term-neurological-status-in-neonatal-hypoxic-ischemic-encephalopathy
#2
JOURNAL ARTICLE
Kengo Onda, Eva Catenaccio, Jill Chotiyanonta, Raul Chavez-Valdez, Avner Meoded, Bruno P Soares, Aylin Tekes, Harisa Spahic, Sarah C Miller, Sarah-Jane Parker, Charlamaine Parkinson, Dhananjay M Vaidya, Ernest M Graham, Carl E Stafstrom, Allen D Everett, Frances J Northington, Kenichi Oishi
Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal acquired brain injury. Although conventional MRI may predict neurodevelopmental outcomes, accurate prognostication remains difficult. As diffusion tensor imaging (DTI) may provide an additional diagnostic and prognostic value over conventional MRI, we aimed to develop a composite DTI (cDTI) score to relate to short-term neurological function. Sixty prospective neonates treated with therapeutic hypothermia (TH) for HIE were evaluated with DTI, with a voxel size of 1 × 1 × 2 mm...
2022: Frontiers in Neuroscience
https://read.qxmd.com/read/34601311/hyperglycemia-associated-with-acute-brain-injury-in-neonatal-encephalopathy
#3
JOURNAL ARTICLE
Emily W Y Tam, Daphne Kamino, Anwar S Shatil, Vann Chau, Aideen M Moore, Rollin Brant, Elysa Widjaja
OBJECTIVE: To identify how alterations in glucose levels are associated with regional brain injury in neonatal encephalopathy. METHODS: This was a prospective cohort study of 102 newborns with neonatal encephalopathy, with continuous glucose monitoring for 72 h. 97 (95%) completed 72 h of therapeutic hypothermia. Brain imaging around day 5 of life included diffusion tensor imaging and MR spectroscopy. Regions of interest were placed for both DTI and MR spectroscopy, and tractography of the optic radiation and corticospinal tract were evaluated...
2021: NeuroImage: Clinical
https://read.qxmd.com/read/33658541/mammillary-body-atrophy-and-other-mri-correlates-of-school-age-outcome-following-neonatal-hypoxic-ischemic-encephalopathy
#4
JOURNAL ARTICLE
Kim V Annink, Linda S de Vries, Floris Groenendaal, Rian M J C Eijsermans, Manouk Mocking, Monique M J van Schooneveld, Jeroen Dudink, Henrica L M van Straaten, Manon J N L Benders, Maarten Lequin, Niek E van der Aa
The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children with HIE were included, who were treated with therapeutic hypothermia (n = 22) or would have qualified but were born before this became standard of care (n = 28)...
March 3, 2021: Scientific Reports
https://read.qxmd.com/read/33203279/dti-parameters-in-neonates-with-hypoxic-ischemic-encephalopathy-after-total-body-hypothermia
#5
JOURNAL ARTICLE
D Longo, F Bottino, G Lucignani, L Scarciolla, L Pasquini, M C Rossi Espagnet, C Polito, L Figà-Talamanca, G Calbi, I Savarese, P Giliberti, A Napolitano
BACKGROUND AND PURPOSE: MR imaging provides means for discriminating different patterns of Hypoxic-ischemic encephalopathy (HIE) and may distinguish most severe cases from less severe but is unable to predict long-term outcome. Diffusion tensor imaging (DTI) offers information for a more complete characterization of HIE. The purpose of this study is to compare the modifications of DTI parameters in newborns one week and six months following total-body cooling to healthy controls. METHODS: Forty-seven cooled newborns were studied with MRI, 20 underwent follow-up at 6 months...
November 2022: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/31206969/ultrasound-predicts-white-matter-integrity-after-hypothermia-therapy-in-neonatal-hypoxic-ischemic-injury
#6
JOURNAL ARTICLE
Jacqueline Salas, Nihaal Reddy, Kathryn A Carson, Frances J Northington, Thierry A G M Huisman
BACKGROUND: Hypoxic-ischemic injury (HII) is a major cause of neonatal death and neurodevelopmental disability. Head ultrasounds (HUS) in neonates with HII often show enhanced gray/white matter differentiation. We assessed the significance of this finding in predicting white matter structural integrity measured by diffusion tensor imaging (DTI) in neonates with HII. METHODS: We performed a quantitative region of interest-based analysis of white and gray matter echogenicity within the cingulate gyrus on pre- and posthypothermia HUS...
June 17, 2019: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://read.qxmd.com/read/29622488/cerebral-autoregulation-and-conventional-and-diffusion-tensor-imaging-magnetic-resonance-imaging-in-neonatal-hypoxic-ischemic-encephalopathy
#7
JOURNAL ARTICLE
Melisa Carrasco, Jamie Perin, Jacky M Jennings, Charlamaine Parkinson, Maureen M Gilmore, Raul Chavez-Valdez, An N Massaro, Raymond C Koehler, Frances J Northington, Aylin Tekes, Jennifer K Lee
BACKGROUND: Deviation of mean arterial blood pressure (MAP) from the range that optimizes cerebral autoregulatory vasoreactivity (optimal MAP) could increase neurological injury from hypoxic-ischemic encephalopathy (HIE). We tested whether a global magnetic resonance imaging (MRI) brain injury score and regional diffusion tensor imaging (DTI) are associated with optimal MAP in neonates with HIE. METHODS: Twenty-five neonates cooled for HIE were monitored with the hemoglobin volume index...
May 2018: Pediatric Neurology
https://read.qxmd.com/read/29247238/trpv1-mediated-pharmacological-hypothermia-promotes-improved-functional-recovery-following-ischemic-stroke
#8
JOURNAL ARTICLE
Zhijuan Cao, Adithya Balasubramanian, Steen E Pedersen, Jonathan Romero, Robia G Pautler, Sean P Marrelli
Hypothermia shows promise for stroke neuroprotection, but current cooling strategies cause undesirable side effects that limit their clinical applications. Increasing efforts have focused on pharmacological hypothermia as a treatment option for stroke. Previously, we showed that activation of a thermoregulatory ion channel, transient receptor potential vanilloid 1 (TRPV1), by dihydrocapsaicin (DHC) produces reliable hypothermia. In this study, we investigate the effects of TRPV1-mediated hypothermia by DHC on long-term ischemic stroke injury and functional outcome...
December 15, 2017: Scientific Reports
https://read.qxmd.com/read/28095379/diffusion-tensor-imaging-detects-occult-cerebellar-injury-in-severe-neonatal-hypoxic-ischemic-encephalopathy
#9
JOURNAL ARTICLE
Monica E Lemmon, Matthias W Wagner, Thangamadhan Bosemani, Kathryn A Carson, Frances J Northington, Thierry A G M Huisman, Andrea Poretti
BACKGROUND: Despite the benefits of whole-body hypothermia therapy, many infants with hypoxic-ischemic encephalopathy (HIE) die or have significant long-term neurodevelopmental impairment. Prospectively identifying neonates at risk of poor outcome is essential but not straightforward. The cerebellum is not classically considered to be a brain region vulnerable to hypoxic-ischemic insults; recent literature suggests, however, that the cerebellum may be involved in neonatal HIE. In this study, we aimed to assess the microstructural integrity of cerebellar and linked supratentorial structures in neonates with HIE compared to neurologically healthy neonatal controls...
2017: Developmental Neuroscience
https://read.qxmd.com/read/26246138/neonatal-neurobehavior-after-therapeutic-hypothermia-for-hypoxic-ischemic-encephalopathy
#10
JOURNAL ARTICLE
An N Massaro, Iordanis Evangelou, Judy Brown, Ali Fatemi, Gilbert Vezina, Robert McCarter, Penny Glass, Catherine Limperopoulos
BACKGROUND: Perinatal hypoxic ischemic encephalopathy (HIE) is a major cause of neurodevelopmental impairment including cerebral palsy and intellectual disability. Brain magnetic resonance imaging is the gold standard for acute assessment of cerebral injury in HIE. Limited data are available regarding the significance of clinically manifested neurobehavioral impairments in the neonatal period. AIM: To evaluate brain structure-function relationships in newborns with HIE using diffusion tensor imaging (DTI) and the NICU Network Neurobehavioral Scale (NNNS)...
October 2015: Early Human Development
https://read.qxmd.com/read/26229690/evolution-of-apparent-diffusion-coefficient-and-fractional-anisotropy-in-the-cerebrum-of-asphyxiated-newborns-treated-with-hypothermia-over-the-first-month-of-life
#11
JOURNAL ARTICLE
Saskia Kwan, Elodie Boudes, Anouk Benseler, Guillaume Gilbert, Christine Saint-Martin, Michael Shevell, Pia Wintermark
The objective of this study was to assess the evolution of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) over the first month of life in asphyxiated newborns treated with hypothermia and to compare it with that of healthy newborns. Asphyxiated newborns treated with hypothermia were enrolled prospectively; and the presence and extent of brain injury were scored on each MRI. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured in the basal ganglia, in the white matter and in the cortical grey matter...
2015: Neural Plasticity
https://read.qxmd.com/read/25492527/white-matter-tract-integrity-and-developmental-outcome-in-newborn-infants-with-hypoxic-ischemic-encephalopathy-treated-with-hypothermia
#12
JOURNAL ARTICLE
An N Massaro, Iordanis Evangelou, Ali Fatemi, Gilbert Vezina, Robert Mccarter, Penny Glass, Catherine Limperopoulos
AIM: To determine whether corpus callosum (CC) and corticospinal tract (CST) diffusion tensor imaging (DTI) measures relate to developmental outcome in encephalopathic newborn infants after therapeutic hypothermia. METHOD: Encephalopathic newborn infants enrolled in a longitudinal study underwent DTI after hypothermia. Parametric maps were generated for fractional anisotropy, mean, radial, and axial diffusivity. CC and CST were segmented by DTI-based tractography...
May 2015: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/25169927/apparent-diffusion-coefficient-scalars-correlate-with-near-infrared-spectroscopy-markers-of-cerebrovascular-autoregulation-in-neonates-cooled-for-perinatal-hypoxic-ischemic-injury
#13
JOURNAL ARTICLE
A Tekes, A Poretti, M M Scheurkogel, T A G M Huisman, J A Howlett, E Alqahtani, J-H Lee, C Parkinson, K Shapiro, S-E Chung, J M Jennings, M M Gilmore, C W Hogue, L J Martin, R C Koehler, F J Northington, J K Lee
BACKGROUND AND PURPOSE: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function. MATERIALS AND METHODS: Thirty-one neonates with hypoxic-ischemic injury were enrolled...
January 2015: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/24192275/concurrent-erythropoietin-and-hypothermia-treatment-improve-outcomes-in-a-term-nonhuman-primate-model-of-perinatal-asphyxia
#14
JOURNAL ARTICLE
Christopher M Traudt, Ronald J McPherson, Larry A Bauer, Todd L Richards, Thomas M Burbacher, Ryan M McAdams, Sandra E Juul
BACKGROUND: Up to 65% of untreated infants suffering from moderate to severe hypoxic-ischemic encephalopathy (HIE) are at risk of death or major disability. Therapeutic hypothermia (HT) reduces this risk to approximately 50% (number needed to treat: 7-9). Erythropoietin (Epo) is a neuroprotective treatment that is promising as an adjunctive therapy to decrease HIE-induced injury because Epo decreases apoptosis, inflammation, and oxidative injury and promotes glial cell survival and angiogenesis...
2013: Developmental Neuroscience
https://read.qxmd.com/read/23618911/evolution-of-pattern-of-injury-and-quantitative-mri-on-days-1-and-3-in-term-newborns-with-hypoxic-ischemic-encephalopathy
#15
JOURNAL ARTICLE
Dawn Gano, Vann Chau, Kenneth J Poskitt, Alan Hill, Elke Roland, Rollin Brant, Mark Chalmers, Steven P Miller
BACKGROUND: Brain injury in term neonatal hypoxic-ischemic encephalopathy (HIE) emerges on magnetic resonance imaging (MRI) by day 3. This study aimed to address the relationship of MRI, diffusion tensor imaging (DTI), and MR spectroscopic imaging (MRSI) findings on days 1 and 3 in a prospective cohort of term newborns with HIE. METHODS: A total of 24 term newborns with HIE were prospectively studied with MRI on days 1 and 3; 19 were imaged with DTI and MRSI on days 1 and 3...
July 2013: Pediatric Research
https://read.qxmd.com/read/23269413/white-matter-integrity-on-fractional-anisotropy-maps-in-encephalopathic-neonates-post-hypothermia-therapy-with-normal-appearing-mr-imaging
#16
JOURNAL ARTICLE
Earn Chun Christabel Lee, Neha S Kwatra, Gilbert Vezina, Zarir P Khademian
BACKGROUND: Neonatal encephalopathy (NE) is a clinically defined neurological syndrome commonly caused by ischemia. OBJECTIVE: We investigated white matter integrity in children with NE using diffusion tensor imaging (DTI) and examined the hypothesis that white matter insults not visible on conventional MRI may have abnormal fractional anisotropy (FA) on DTI. MATERIALS AND METHODS: DTI was performed on 36 term encephalopathic neonates who had hypothermia therapy...
June 2013: Pediatric Radiology
https://read.qxmd.com/read/22595900/therapeutic-hypothermia-for-neonatal-encephalopathy-results-in-improved-microstructure-and-metabolism-in-the-deep-gray-nuclei
#17
RANDOMIZED CONTROLLED TRIAL
S L Bonifacio, A Saporta, H C Glass, P Lee, D V Glidden, D M Ferriero, A J Barkovich, D Xu
BACKGROUND AND PURPOSE: Therapeutic hypothermia has reduced morbidity and mortality and is associated with a lower burden of lesions on conventional imaging in NE. However, its effects on brain microstructure and metabolism have not been fully characterized. We hypothesized that therapeutic hypothermia improves measures of brain microstructure and metabolism. MATERIALS AND METHODS: Forty-one neonates with moderate/severe NE (29 treated with hypothermia, 12 nontreated) and 12 healthy neonates underwent MR imaging, DTI, and (1)H-MR spectroscopy...
December 2012: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/22447318/prediction-of-neurodevelopmental-outcome-after-hypoxic-ischemic-encephalopathy-treated-with-hypothermia-by-diffusion-tensor-imaging-analyzed-using-tract-based-spatial-statistics
#18
JOURNAL ARTICLE
Nora Tusor, Courtney Wusthoff, Natalie Smee, Nazakat Merchant, Tomoki Arichi, Joanna M Allsop, Frances M Cowan, Denis Azzopardi, A David Edwards, Serena J Counsell
INTRODUCTION: Objective biomarkers are needed to assess neuroprotective therapies after perinatal hypoxic-ischemic encephalopathy (HIE). We tested the hypothesis that, in infants who underwent therapeutic hypothermia after perinatal HIE, neurodevelopmental performance was predicted by fractional anisotropy (FA) values in the white matter (WM) on early diffusion tensor imaging (DTI) as assessed by means of tract-based spatial statistics (TBSS). METHODS: We studied 43 term infants with HIE...
July 2012: Pediatric Research
https://read.qxmd.com/read/22013426/use-of-high-resolution-3d-diffusion-tensor-imaging-to-study-brain-white-matter-development-in-live-neonatal-rats
#19
JOURNAL ARTICLE
Yu Cai, Matthew S McMurray, Ipek Oguz, Hong Yuan, Martin A Styner, Weili Lin, Josephine M Johns, Hongyu An
High resolution diffusion tensor imaging (DTI) can provide important information on brain development, yet it is challenging in live neonatal rats due to the small size of neonatal brain and motion-sensitive nature of DTI. Imaging in live neonatal rats has clear advantages over fixed brain scans, as longitudinal and functional studies would be feasible to understand neuro-developmental abnormalities. In this study, we developed imaging strategies that can be used to obtain high resolution 3D DTI images in live neonatal rats at postnatal day 5 (PND5) and PND14, using only 3 h of imaging acquisition time...
2011: Frontiers in Psychiatry
https://read.qxmd.com/read/20520585/tract-based-spatial-statistics-of-magnetic-resonance-images-to-assess-disease-and-treatment-effects-in-perinatal-asphyxial-encephalopathy
#20
JOURNAL ARTICLE
Emma J Porter, Serena J Counsell, A David Edwards, Joanna Allsop, Denis Azzopardi
Biomarkers are required for efficient trials of neuroprotective interventions after perinatal asphyxia. This study aimed to determine whether diffusion tensor imaging (DTI) analyzed by tract-based spatial statistics (TBSS) may be a suitable biomarker of disease and treatment effects after perinatal asphyxia in small groups of patients. We performed TBSS from DTI obtained at 3 T from eight healthy control infants, 10 untreated and 10 hypothermia-treated infants with neonatal encephalopathy. Median (range) postnatal age at scan was 1 d (1-21) in the healthy infants, 6 d (4-20) in the cooled, and 7 d (4-18) in noncooled infants...
September 2010: Pediatric Research
keyword
keyword
164776
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.