keyword
https://read.qxmd.com/read/38530583/long-non-coding-rna-h19-mediates-the-mir-29b-transforming-growth-factor-%C3%AE-1-drosophila-mothers-against-decapentaplegic-3-signalling-pathway-to-promote-bladder-fibrosis-in-diabetic-rats
#1
JOURNAL ARTICLE
Ji Sun, Qiang Du, Liwei Zhao, Jiaguo Huang, Hui Yu, Hongxiang Ding, Dikai Mao, Shengcheng Tai
PURPOSE: Diabetic bladder fibrosis is a common comorbidity. Altered expression of some long non-coding RNAs (LncRNAs) has been associated with bladder fibrosis. LncRNA H19 has been reported to regulate bladder cancer through miR-29b. However, the action mechanism of LncRNA H19 in bladder fibrosis is unclear. METHODS: In vitro, human bladder smooth muscle cells (HBSMCs) were cultured with transforming growth factor-β1 (TGF-β1) for 48 h to construct cell model of bladder fibrosis...
March 26, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38511065/plasma-mirnas-as-potential-biomarkers-for-schizophrenia-in-a-jordanian-cohort
#2
JOURNAL ARTICLE
Mohammad Shboul, Amal Bani Domi, Abdulmalek Abu Zahra, Aws G Khasawneh, Reem Darweesh
BACKGROUND: Schizophrenia (SZ), a complex and chronic neuropsychiatric disorder affecting approximately 1 % of the general population, presents diagnostic challenges due to the absence of reliable biomarkers, and relying mainly on clinical observations. MicroRNAs (miRNAs) signatures in a wide range of diseases, including psychiatric disorders, hold immense potential for serving as biomarkers. This study aimed to analyze the expression levels of specific microRNAs (miRNAs) namely miR-29b-3p, miR-106b-5p, and miR-199a-3p and explore their diagnostic potential for SZ in Jordanian patients...
June 2024: Non-Coding RNA Research
https://read.qxmd.com/read/38511059/systematic-review-and-meta-analysis-of-dysregulated-micrornas-derived-from-liquid-biopsies-as-biomarkers-for-amyotrophic-lateral-sclerosis
#3
JOURNAL ARTICLE
Hemerson Casado Gama, Mariana A Amorós, Mykaella Andrade de Araújo, Congzhou M Sha, Mirella P S Vieira, Rayssa G D Torres, Gabriela F Souza, Janaína A Junkes, Nikolay V Dokholyan, Daniel Leite Góes Gitaí, Marcelo Duzzioni
The discovery of disease-specific biomarkers, such as microRNAs (miRNAs), holds the potential to transform the landscape of Amyotrophic Lateral Sclerosis (ALS) by facilitating timely diagnosis, monitoring treatment response, and accelerating drug discovery. Such advancement could ultimately improve the quality of life and survival rates for ALS patients. Despite more than a decade of research, no miRNA biomarker candidate has been translated into clinical practice. We conducted a systematic review and meta-analysis to quantitatively synthesize data from original studies that analyzed miRNA expression from liquid biopsies via PCR and compared them to healthy controls...
June 2024: Non-Coding RNA Research
https://read.qxmd.com/read/38492245/peptide-om-lv20-promotes-arteriogenesis-induced-by-femoral-artery-ligature-via-the-mir-29b-3p-vegfa-axis
#4
JOURNAL ARTICLE
Yingxuan Zhang, Zijian Kang, Jianjun Wang, Sahua Liu, Xin Liu, Zhiruo Li, Yilin Li, Yinglei Wang, Zhe Fu, Jiayi Li, Yubing Huang, Zeqiong Ru, Ying Peng, Zhiyu Yang, Ying Wang, Xinwang Yang, Mingying Luo
BACKGROUND AND AIMS: Therapeutic arteriogenesis is a promising direction for the treatment of ischemic disease caused by atherosclerosis. However, pharmacological or biological approaches to stimulate functional collateral vessels are not yet available. Identifying new drug targets to promote and explore the underlying mechanisms for therapeutic arteriogenesis is necessary. METHODS: Peptide OM-LV20 (20 ng/kg) was administered for 7 consecutive days on rat hindlimb ischemia model, collateral vessel growth was assessed by H&E staining, liquid latex perfusion, and specific immunofluorescence...
February 28, 2024: Atherosclerosis
https://read.qxmd.com/read/38438251/smyd4-monomethylates-prmt5-and-forms-a-positive-feedback-loop-to-promote-hepatocellular-carcinoma-progression
#5
JOURNAL ARTICLE
Zhenyu Zhou, Zheng Chen, Qianlei Zhou, Shiyu Meng, Juanyi Shi, Sintim Mui, Hai Jiang, Jianhong Lin, Gui He, Wenbin Li, Jianlong Zhang, Jie Wang, Chuanchao He, Yongcong Yan, Zhiyu Xiao
Both lysine and arginine methyltransferases are thought to be promising therapeutic targets for malignant tumors, yet how these methyltransferases function in malignant tumors, especially hepatocellular carcinoma (HCC), has not been fully elucidated. Here, we reported that SMYD4, a lysine methyltransferase, acts as an oncogene in HCC. SMYD4 was highly upregulated in HCC and promoted HCC cell proliferation and metastasis. Mechanistically, PRMT5, a well-known arginine methyltransferase, was identified as a SMYD4-binding protein...
March 4, 2024: Cancer Science
https://read.qxmd.com/read/38434562/m-3-subtype-of-muscarinic-acetylcholine-receptor-inhibits-cardiac-fibrosis-via-targeting-microrna-29b-beta-site-app-cleaving-enzyme-1-axis
#6
JOURNAL ARTICLE
Wen Li, Jie Yu, Yilian Yang, Jia Wang, Yunqi Liu, Jiapan Wang, Juan Hu, Ye Yuan, Zhimin Du
BACKGROUND: Previous studies have confirmed that choline exerts anti-fibrotic effect in the heart by activating the M3 subtype of muscarinic acetylcholine receptor (M3 receptor), but the mechanism remains to be clarified. MicroRNA-29b (miR-29b) plays an important role in the fibrotic process and can directly target collagen to resist myocardial fibrosis. This study investigated whether miR-29b is involved in the anti-fibrotic effect of activating M3 receptor. METHODS: Proliferation of cardiac fibroblasts was induced by transforming growth factor (TGF)-β1 in vitro ...
February 15, 2024: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/38414758/lncrna-hcp5-promotes-cell-invasion-and-migration-by-sponging-mir-29b-3p-in-human-bladder-cancer-retraction
#7
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S249770.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38414350/mir-29b-1-5p-exacerbates-myocardial-injury-induced-by-sepsis-in-a-mouse-model-by-targeting-terf2
#8
JOURNAL ARTICLE
Yaqing Jiang, Junmei Xu, Hua Zeng, Zhaojing Lin, Qiong Yi, Jiali Guo, Feng Xiao
Myocardial damage is a critical complication and a significant contributor to mortality in sepsis. MicroRNAs (miRNAs) have emerged as key players in sepsis pathogenesis. In this study, we explore the effect and mechanisms of miR-29b-1-5p on sepsis-induced myocardial damage. Sepsis-associated Gene Expression Omnibus (GEO) datasets (GSE72380 and GSE29914) are examined for differential miRNAs. The mouse sepsis-induced cardiac injury was established by Lipopolysaccharide (LPS) or cecal ligation and puncture (CLP)...
February 27, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38413218/microrna-29b-3p-degenerates-terminally-differentiated-dopaminergic-sh-sy5y-cells-by-perturbation-of-mitochondrial-functions
#9
JOURNAL ARTICLE
Sana Sarkar, Anuj Pandey, Sanjeev Kumar Yadav, Pragati Raghuwanshi, Mohammed Haris Siddiqui, Saripella Srikrishna, Aditya Bhushan Pant, Sanjay Yadav
Mitochondrial dysfunction is the main cause of gradual deterioration of structure and function of neuronal cells, eventually resulting in neurodegeneration. Studies have revealed a complex interrelationship between neurotoxicant exposure, mitochondrial dysfunction, and neurodegenerative diseases. Alteration in the expression of microRNAs (miRNAs) has also been linked with disruption in mitochondrial homeostasis and bioenergetics. In our recent research (Cellular and Molecular Neurobiology (2023) https://doi...
February 27, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38382189/whole-transcriptome-sequencing-reveals-a-melanin-related-cerna-regulatory-network-in-the-breast-muscle-of-xichuan-black-bone-chicken
#10
JOURNAL ARTICLE
Ruiting Li, DongHua Li, Shuohui Xu, Pengwei Zhang, Zhiyuan Zhang, Fumin He, Wenting Li, Guirong Sun, Ruirui Jiang, Zhuanjian Li, Yadong Tian, Xiaojun Liu, Xiangtao Kang
The economic losses incurred due to reduced muscle pigmentation highlight the crucial role of melanin-based coloration in the meat of black-bone chickens. Melanogenesis in the breast muscle of black-bone chickens is currently poorly understood in terms of molecular mechanisms. This study employed whole-transcriptome sequencing to analyze black and white breast muscle samples from black-bone chickens, leading to the identification of 367 differentially expressed (DE) mRNAs, 48 DElncRNAs, 104 DEcircRNAs, and 112 DEmiRNAs involved in melanin deposition...
February 8, 2024: Poultry Science
https://read.qxmd.com/read/38354830/mirna-signatures-related-to-invasiveness-and-recurrence-in-patients-with-non-functioning-pituitary-neuroendocrine-tumours-a-pilot-study-in-a-single-tertiary-center
#11
JOURNAL ARTICLE
Emiliya Nikolova, Anelia Boydeva Nankova, Silvia Kalenderova, Bilyana Georgieva, Asen Hadzhiyanev, Stoyan Bichev, Alexey Savov, Albena Todorova, Vanyo Mitev, Atanaska Elenkova
PURPOSE: The aim of this preliminary study was to analyze and identify differentially expressed miRNAs in Bulgarian patients with non-functioning pituitary neuroendocrine tumors (NFPitNET). The relationship between deregulated miRNAs and tumor invasiveness, recurrence, and size was determined. METHODS: Twenty patients with non-functioning pituitary neuroendocrine tumors were selected and fresh pituitary tumor tissues were collected. RNA containing miRNAs were isolated using miRNAeasy mini kit and analysed with LNA miRNA Cancer Focus PCR Panel (Qiagen) by quantitative real-time PCR...
February 14, 2024: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/38338785/exosomal-osteoclast-derived-mirna-in-rheumatoid-arthritis-from-their-pathogenesis-in-bone-erosion-to-new-therapeutic-approaches
#12
REVIEW
Sandra Pascual-García, Pascual Martínez-Peinado, Carolina Pujalte-Satorre, Alicia Navarro-Sempere, Jorge Esteve-Girbés, Ana B López-Jaén, Juan Javaloyes-Antón, Raúl Cobo-Velacoracho, Francisco J Navarro-Blasco, José M Sempere-Ortells
Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation, pain, and ultimately, bone erosion of the joints. The causes of this disease are multifactorial, including genetic factors, such as the presence of the human leukocyte antigen (HLA)-DRB1*04 variant, alterations in the microbiota, or immune factors including increased cytotoxic T lymphocytes (CTLs), neutrophils, or elevated M1 macrophages which, taken together, produce high levels of pro-inflammatory cytokines. In this review, we focused on the function exerted by osteoclasts on osteoblasts and other osteoclasts by means of the release of exosomal microRNAs (miRNAs)...
January 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38328848/expression-profile-of-mir-145-182-21-27a-29b-and-34a-in-breast-cancer-patients-of-young-age
#13
JOURNAL ARTICLE
V Chekhun, T Borikun, O Mushii, T Zadvornyi, О Martyniuk, E Kashuba, V Bazas, S Hrybach, M Krotevych, S Lyalkin, N Lukianova
BACKGROUND: Breast cancer (BC) in young women remains a significant public health concern. While progress has been made in understanding the etiology, diagnosis, and treatment of BC in this population, challenges persist. The identification and utilization of prognostic biomarkers offer valuable tools for tailoring treatment strategies and improving outcomes for BC patients. AIM: To evaluate the relationship between the expression of tumor-associated microRNAs and the clinical and pathological features of BC in young patients...
February 3, 2024: Experimental Oncology
https://read.qxmd.com/read/38318212/c-myc-h19-mir-29b-axis-downregulates-nerve-glial-ng-2-expression-in-glioblastoma-multiforme
#14
JOURNAL ARTICLE
Anne S Boewe, Selina Wrublewsky, Jessica Hoppstädter, Claudia Götz, Alexandra K Kiemer, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo
Nerve/glial antigen (NG)2 is highly expressed in glioblastoma multiforme (GBM). However, the underlying mechanisms of its upregulated expression are largely unknown. In silico analyses reveal that the tumor-suppressive miR-29b targets NG2. We used GBM-based data from The Cancer Genome Atals databases to analyze the expression pattern of miR-29b and different target genes, including NG2. Moreover, we investigated the regulatory function of miR-29b on NG2 expression and NG2-related signaling pathways. We further studied upstream mechanisms affecting miR-29b-dependent NG2 expression...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38313262/micrornas-associated-with-metformin-treatment-in-the-diabetes-prevention-program
#15
Kimberly A Lewis, Benjamin Stroebel, Li Zhang, Bradley Aouizerat, Aras Mattis, Elena Flowers
The Diabetes Prevention Program (DPP) randomized controlled trial demonstrated that metformin treatment reduced progression to type 2 diabetes (T2D) by 31% compared to placebo in adults with prediabetes. Circulating micro-ribonucleic acids (miRs) are promising biomarkers of T2D risk, but little is known about their associations with metformin regimens for T2D risk reduction. We compared the change in 24 circulating miRs from baseline to 2 years in a subset from DPP metformin intervention (n = 50) and placebo (n = 50) groups using Wilcoxon signed rank tests...
January 16, 2024: Research Square
https://read.qxmd.com/read/38303299/-intraperitoneal-transfer-of-mir-29b-containing-exosome-suppresses-the-development-of-peritoneal-metastases-from-gastric-cancer
#16
JOURNAL ARTICLE
Yuki Kimura, Hideyuki Ohzawa, Yuki Kaneko, Hideyo Miyato, Kentaro Kurashina, Shin Saito, Hironori Yamaguchi, Yoshinori Hosoya, Naohiro Sata, Joji Kitayama
Although miR-29b levels in peritoneal exosomes was markedly reduced in patients with peritoneal metastases(PM), their role has not been fully clarified. Bone marrow derived mesenchymal stem cells(BMSC)were transfected with miR-29b- integrating lentivirus and exosomes isolated from culture supernatants using ultracentrifugation. The effects of the exosomes on human peritoneal mesothelial cells(HPMC)were examined in vitro. The in vivo effect of murine BMSC-derived exosomes was examined with a syngeneic PM model...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38270119/revisiting-skeletal-muscle-dysfunction-and-exercise-in-chronic-obstructive-pulmonary-disease-emerging-significance-of-myokines
#17
REVIEW
Lihua Han, Peijun Li, Qinglan He, Chen Yang, Meiling Jiang, Yingqi Wang, Yuanyuan Cao, Xiaoyu Han, Xiaodan Liu, Weibing Wu
Skeletal muscle dysfunction (SMD) is the most significant extrapulmonary complication and an independent prognostic indicator in patients with chronic obstructive pulmonary disease (COPD). Myokines, such as interleukin (IL)-6, IL-15, myostatin, irisin, and insulin-like growth factor (IGF)-1, play important roles in skeletal muscle mitochondrial function, protein synthesis and breakdown balance, and regeneration of skeletal muscles in COPD. As the main component of pulmonary rehabilitation, exercise can improve muscle strength, muscle endurance, and exercise capacity in patients with COPD, as well as improve the prognosis of SMD and COPD by regulating the expression levels of myokines...
December 7, 2023: Aging and Disease
https://read.qxmd.com/read/38256206/modulation-of-mir-29a-and-mir-29b-expression-and-their-target-genes-related-to-inflammation-and-renal-fibrosis-by-an-oral-nutritional-supplement-with-probiotics-in-malnourished-hemodialysis-patients
#18
JOURNAL ARTICLE
Corina Verónica Sasso, Said Lhamyani, Francisco Hevilla, Marina Padial, María Blanca, Guillermina Barril, Tamara Jiménez-Salcedo, Enrique Sanz Martínez, Ángel Nogueira, Ana María Lago-Sampedro, Gabriel Olveira
Malnutrition is prevalent in patients with chronic kidney disease (CKD), especially those on hemodialysis. Recently, our group described that a new oral nutritional supplement (ONS), specifically designed for malnourished (or at risk) hemodialysis patients with a "similar to the Mediterranean diet" pattern, improved caloric-protein intake, nutritional status and biomarkers of inflammation and oxidation. Our aim in this study was to evaluate whether the new ONS, associated with probiotics or not, may produce changes in miRNA's expression and its target genes in malnourished hemodialysis patients, compared to individualized diet recommendations...
January 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38256177/the-role-of-micrornas-related-to-apoptosis-for-n-methyl-d-aspartic-acid-induced-neuronal-cell-death-in-the-murine-retina
#19
JOURNAL ARTICLE
Kohei Sone, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara
Glaucoma is one of the leading causes of acquired blindness and characterized by retinal ganglion cell (RGC) death. MicroRNAs are small noncoding RNAs that degrade their target mRNAs. Apoptosis is one of the common mechanisms leading to neuronal death in many neurodegenerative diseases, including glaucoma. In the present study, we identified microRNAs that modulate RGC death caused by the intravitreal injection of N -methyl-d-aspartic acid (NMDA). We found an upregulation of miR-29b and downregulation of miR-124 in the retina of the NMDA-injected eyes...
January 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38225865/in-silico-and-in-vitro-evidence-suggest-linc01405-as-a-sponge-for-mir-29b-and-mir-497-5p-and-a-potential-regulator-of-wnt-pi3k-and-tgfb-signaling-pathways-in-breast-carcinoma
#20
JOURNAL ARTICLE
Romina Norouzi, Zahra Mohamadzade, Rambod Norouzi, Radin Norouzi, Rezvan Esmaeili, Bahram M Soltani
BACKGROUND: Carcinoma of the breast, a prevailing factor in female mortality worldwide, involves dysregulation of lncRNAs and microRNAs. AIM: The main goal of this research was to predict and experimentally examine the LINC01405 expression status in breast cancer subtypes, along with investigation of its interaction with miR-29b and miR-497-5p that results in regulating PI3-Kinase, WNT, and TGF-beta signaling pathways. METHODS AND RESULTS: We performed a meta-analysis of five GEO datasets, encompassing microarray and RNA-seq data, to identify differentially expressed genes...
January 15, 2024: Cancer reports
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