keyword
https://read.qxmd.com/read/38173900/ab-initio-crystal-structure-prediction-of-the-energetic-materials-llm-105-rdx-and-hmx
#1
JOURNAL ARTICLE
Dana O'Connor, Imanuel Bier, Rithwik Tom, Anna M Hiszpanski, Brad A Steele, Noa Marom
Crystal structure prediction (CSP) is performed for the energetic materials (EMs) LLM-105 and α-RDX, as well as the α and β conformational polymorphs of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX), using the genetic algorithm (GA) code, GAtor, and its associated random structure generator, Genarris. Genarris and GAtor successfully generate the experimental structures of all targets. GAtor's symmetric crossover scheme, where the space group symmetries of parent structures are treated as genes inherited by offspring, is found to be particularly effective...
September 6, 2023: Crystal Growth & Design
https://read.qxmd.com/read/38097176/survey-of-georgia-community-pharmacists-needs-to-engage-in-advanced-community-pharmacy-services
#2
JOURNAL ARTICLE
Kyler Gator Hazelett, Chelsea Keedy, Amber D Fraley, Kelly Bazel, Joseph Crosby, Blake R Johnson
BACKGROUND: Community pharmacists improve health, reduce fragmentation in care, lower health costs, and improve health outcomes. In Georgia, pharmacists are able to enter collaborative drug therapy management protocols, such as hypertension management, with a collaborating physician, which may allow pharmacists to provide advanced community pharmacy services, however few Georgia pharmacists have this licensure. No program(s) exist that empower pharmacists to successfully engage in advanced community pharmacy services across the state of Georgia nor trains pharmacists to successfully engage in collaborative practice...
December 12, 2023: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/37662460/watch-out-for-gators-fasting-seizures-and-nutrient-sensing
#3
COMMENT
Cameron S Metcalf
No abstract text is available yet for this article.
2023: Epilepsy Currents
https://read.qxmd.com/read/37491868/refining-the-electroclinical-spectrum-of-nprl3-related-epilepsy-a-novel-multiplex-family-and-literature-review
#4
REVIEW
Alice Dainelli, Michele Iacomino, Sara Rossato, Samuela Bugin, Monica Traverso, Mariasavina Severino, Stefano Gustincich, Valeria Capra, Marco Di Duca, Federico Zara, Marcello Scala, Pasquale Striano
OBJECTIVE: NPRL3-related epilepsy (NRE) is an emerging condition set within the wide GATOR-1 spectrum with a particularly heterogeneous and elusive phenotypic expression. Here, we delineated the genotype-phenotype spectrum of NRE, reporting an illustrative familial case and reviewing pertinent literature. METHODS: Through exome sequencing (ES), we investigated a 12-year-old girl with recurrent focal motor seizures during sleep, suggestive of sleep-related hypermotor epilepsy (SHE), and a family history of epilepsy in siblings...
December 2023: Epilepsia Open
https://read.qxmd.com/read/37311539/functional-differentiation-of-sec13-paralogues-in-the-euglenozoan-protists
#5
JOURNAL ARTICLE
Drahomíra Faktorová, Kristína Záhonová, Corinna Benz, Joel B Dacks, Mark C Field, Julius Lukeš
The β-propeller protein Sec13 plays roles in at least three distinct processes by virtue of being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore complex (NPC) and the Seh1-associated (SEA)/GATOR nutrient-sensing complex. This suggests that regulatory mechanisms coordinating these cellular activities may operate via Sec13. The NPC, COPII and SEA/GATOR are all ancient features of eukaryotic cells, and in the vast majority of eukaryotes, a single Sec13 gene is present...
June 2023: Open Biology
https://read.qxmd.com/read/37037994/genome-wide-crispr-screens-identify-ilf3-as-a-mediator-of-mtorc1-dependent-amino-acid-sensing
#6
JOURNAL ARTICLE
Guokai Yan, Jinxin Yang, Wen Li, Ao Guo, Jialiang Guan, Ying Liu
The mechanistic target of rapamycin complex 1 (mTORC1) is an essential hub that integrates nutrient signals and coordinates metabolism to control cell growth. Amino acid signals are detected by sensor proteins and relayed to the GATOR2 and GATOR1 complexes to control mTORC1 activity. Here we perform genome-wide CRISPR/Cas9 screens, coupled with an assay for mTORC1 activity based on fluorescence-activated cell sorting analysis of pS6, to identify potential regulators of mTORC1-dependent amino acid sensing. We then focus on interleukin enhancer binding factor 3 (ILF3), one of the candidate genes from the screen...
May 2023: Nature Cell Biology
https://read.qxmd.com/read/37003255/clinical-course-may-be-independent-from-neuroimaging-in-depdc-5-related-epilepsy
#7
JOURNAL ARTICLE
Emanuele Bartolini, Stefania Della Vecchia, Tommaso Biagioni, Domenico Montanaro, Anna Rita Ferrari
DEPDC5 is an upstream repressor of the mechanistic target of rapamycin pathway via the GATOR-1 complex. Pathogenic variants causing loss of function typically result in familial focal epilepsy with variable foci. Neuroimaging may either be normal or show brain malformations. Lesional and nonlesional cases may be present within the same family. Here, we describe a parent-child dyad affected by a truncating DEPDC5 pathogenic variant (c.727C > T; p.Arg243*), analyze the epilepsy clinical course, and describe neuroimaging characteristics from a 3T brain magnetic resonance imaging...
October 2023: Neuropediatrics
https://read.qxmd.com/read/36899305/gene-expression-during-the-formation-of-resting-spores-induced-by-nitrogen-starvation-in-the-marine-diatom-chaetoceros-socialis
#8
JOURNAL ARTICLE
Angela Pelusi, Luca Ambrosino, Marco Miralto, Maria Luisa Chiusano, Alessandra Rogato, Maria Immacolata Ferrante, Marina Montresor
BACKGROUND: Dormancy is widespread in both multicellular and unicellular organisms. Among diatoms, unicellular microalgae at the base of all aquatic food webs, several species produce dormant cells (spores or resting cells) that can withstand long periods of adverse environmental conditions. RESULTS: We present the first gene expression study during the process of spore formation induced by nitrogen depletion in the marine planktonic diatom Chaetoceros socialis...
March 10, 2023: BMC Genomics
https://read.qxmd.com/read/36842889/a-case-report-of-hemimegalencephaly-with-super-refractory-status-epilepticus-and-brain-atrophy-associated-with-nprl3-gene-mutation
#9
JOURNAL ARTICLE
Alejandra Vasquez, Kai J Miller, Paul E Youssef, Duygu Selcen, Marc C Patterson, Keith Starnes
No abstract text is available yet for this article.
February 11, 2023: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/36818747/sestrin2-signaling-pathway-regulates-podocyte-biology-and-protects-against-diabetic-nephropathy
#10
REVIEW
Moein Ala
Sestrin2 regulates cell homeostasis and is an upstream signaling molecule for several signaling pathways. Sestrin2 leads to AMP-activated protein kinase- (AMPK-) and GTPase-activating protein activity toward Rags (GATOR) 1-mediated inhibition of mammalian target of rapamycin complex 1 (mTORC1), thereby enhancing autophagy. Sestrin2 also improves mitochondrial biogenesis via AMPK/Sirt1/peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 α ) signaling pathway. Blockade of ribosomal protein synthesis and augmentation of autophagy by Sestrin2 can prevent misfolded protein accumulation and attenuate endoplasmic reticulum (ER) stress...
2023: Journal of Diabetes Research
https://read.qxmd.com/read/36732623/ampk-knocks-at-the-gate-of-gator
#11
JOURNAL ARTICLE
Nerea Deleyto-Seldas, Alejo Efeyan
No abstract text is available yet for this article.
February 2, 2023: Nature metabolism
https://read.qxmd.com/read/36577058/wdr59-promotes-or-inhibits-torc1-activity-depending-on-cellular-context
#12
JOURNAL ARTICLE
Yingbiao Zhang, Chun-Yuan Ting, Shu Yang, John Reich, Karenne Fru, Mary A Lilly
Target of Rapamycin Complex I (TORC1) is a central regulator of metabolism in eukaryotes that responds to a wide array of negative and positive inputs. The GTPase-activating protein toward Rags (GATOR) signaling pathway acts upstream of TORC1 and is comprised of two subcomplexes. The trimeric GATOR1 complex inhibits TORC1 activity in response to amino acid limitation by serving as a GTPase-activating protein (GAP) for the TORC1 activator RagA/B, a component of the lysosomally located Rag GTPase. The multi-protein GATOR2 complex inhibits the activity of GATOR1 and thus promotes TORC1 activation...
January 3, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/36410445/dysregulated-amino-acid-sensing-drives-colorectal-cancer-growth-and-metabolic-reprogramming-leading-to-chemoresistance
#13
JOURNAL ARTICLE
Sumeet Solanki, Katherine Sanchez, Varun Ponnusamy, Vasudha Kota, Hannah N Bell, Chun-Seok Cho, Allison H Kowalsky, Michael Green, Jun Hee Lee, Yatrik M Shah
BACKGROUND & AIMS: Colorectal cancer (CRC) is a devastating disease that is highly modulated by dietary nutrients. Mechanistic target of rapamycin complex 1 (mTORC1) contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTORC1 activity after therapies that target oncogenic growth factor signaling. Amino acids potently activate mTORC1 via amino acid-sensing GTPase activity towards Rags (GATOR)...
March 2023: Gastroenterology
https://read.qxmd.com/read/36342087/identification-of-genetic-characteristics-in-pediatric-epilepsy-with-focal-cortical-dysplasia-type-2-using-deep-whole-exome-sequencing
#14
JOURNAL ARTICLE
Yan Xu, Rui Zhao, Min Wang, Xin-Hua Wang, Yi Wang, Hao Li, Yang-Yang Ma, Bing-Bing Wu, Yuan-Feng Zhou
BACKGROUND: Focal cortical dysplasia type 2 (FCD2) is a malformation of cortical development that constitutes a common cause of pediatric focal epilepsy. Germline or somatic variants in the mammalian target of rapamycin (mTOR) signaling pathway genes are the pathogenesis of FCD2. OBJECTIVE: In this study, whole-exome deep sequencing was performed on dysplastic cortex from focal epilepsy in children to explore genetic characteristics in FCD2. METHODS: Resected core lesions of FCD2 were confirmed by pathology, and peripheral blood was collected from 11 patients...
December 2022: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/36289347/cryo-em-structure-of-the-sea-complex
#15
JOURNAL ARTICLE
Lucas Tafur, Kerstin Hinterndorfer, Caroline Gabus, Chiara Lamanna, Ariane Bergmann, Yashar Sadian, Farzad Hamdi, Fotis L Kyrilis, Panagiotis L Kastritis, Robbie Loewith
The SEA complex (SEAC) is a growth regulator that acts as a GTPase-activating protein (GAP) towards Gtr1, a Rag GTPase that relays nutrient status to the Target of Rapamycin Complex 1 (TORC1) in yeast1 . Functionally, the SEAC has been divided into two subcomplexes: SEACIT, which has GAP activity and inhibits TORC1, and SEACAT, which regulates SEACIT2 . This system is conserved in mammals: the GATOR complex, consisting of GATOR1 (SEACIT) and GATOR2 (SEACAT), transmits amino acid3 and glucose4 signals to mTORC1...
October 26, 2022: Nature
https://read.qxmd.com/read/36047762/ait1-regulates-torc1-signaling-and-localization-in-budding-yeast
#16
JOURNAL ARTICLE
Ryan L Wallace, Eric Lu, Xiangxia Luo, Andrew P Capaldi
The target of rapamycin complex I (TORC1) regulates cell growth and metabolism in eukaryotes. Previous studies have shown that nitrogen and amino acid signals activate TORC1 via the highly conserved small GTPases, Gtr1/2 (RagA/C in humans), and the GTPase activating complex SEAC/GATOR. However, it remains unclear if, and how, other proteins/pathways regulate TORC1 in simple eukaryotes like yeast. Here we report that the previously unstudied GPCR-like protein, Ait1, binds to TORC1-Gtr1/2 in Saccharomyces cerevisiae and holds TORC1 around the vacuole during log-phase growth...
September 1, 2022: ELife
https://read.qxmd.com/read/35706463/letter-frequency-analysis-of-proprietary-prescription-drug-names-in-the-united-states-minding-the-zs-and-qs
#17
JOURNAL ARTICLE
Ron Carico, Keaton Kaplan, Kyler Gator Hazelett, Megan Dillon, Kelly Melvin
Background: Proprietary or brand names of prescription drugs are generally with letters that are unusual in common English. There is little academic research exploring if this perception is true, despite the fact that manufacturers pay millions of dollars to research and develop drug names that conform to regulatory standards while remaining marketable. Objectives: To assess the extent to which letters used in prescription drug names may deviate from common English and to test if prescription drug names show measurable trends in letter frequency over time...
June 2022: Explor Res Clin Soc Pharm
https://read.qxmd.com/read/35327579/amino-acid-signaling-for-tor-in-eukaryotes-sensors-transducers-and-a-sustainable-agricultural-futore
#18
REVIEW
Nanticha Lutt, Jacob O Brunkard
Eukaryotic cells monitor and regulate metabolism through the atypical protein kinase target of rapamycin (TOR) regulatory hub. TOR is activated by amino acids in animals and fungi through molecular signaling pathways that have been extensively defined in the past ten years. Very recently, several studies revealed that TOR is also acutely responsive to amino acid metabolism in plants, but the mechanisms of amino acid sensing are not yet established. In this review, we summarize these discoveries, emphasizing the diversity of amino acid sensors in human cells and highlighting pathways that are indirectly sensitive to amino acids, i...
March 2, 2022: Biomolecules
https://read.qxmd.com/read/34685669/sea-and-gator-10-years-later
#19
REVIEW
Yahir A Loissell-Baltazar, Svetlana Dokudovskaya
The SEA complex was described for the first time in yeast Saccharomyces cerevisiae ten years ago, and its human homologue GATOR complex two years later. During the past decade, many advances on the SEA/GATOR biology in different organisms have been made that allowed its role as an essential upstream regulator of the mTORC1 pathway to be defined. In this review, we describe these advances in relation to the identification of multiple functions of the SEA/GATOR complex in nutrient response and beyond and highlight the consequence of GATOR mutations in cancer and neurodegenerative diseases...
October 8, 2021: Cells
https://read.qxmd.com/read/34577450/the-data-sensor-hub-dash-a-physical-computing-system-to-support-middle-school-inquiry-science-instruction
#20
JOURNAL ARTICLE
Alexandra Gendreau Chakarov, Quentin Biddy, Colin Hennessy Elliott, Mimi Recker
This article describes a sensor-based physical computing system, called the Data Sensor Hub ( DaSH ), which enables students to process, analyze, and display data streams collected using a variety of sensors. The system is built around the portable and affordable BBC micro:bit microcontroller (expanded with the gator:bit), which students program using a visual, cloud-based programming environment intended for novices. Students connect a variety of sensors (measuring temperature, humidity, carbon dioxide, sound, acceleration, magnetism, etc...
September 17, 2021: Sensors
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