Florian Renosi, Anne Roggy, Ambre Giguelay, Lou Soret, Pierre-Julien Viailly, Meyling Cheok, Sabeha Biichle, Fanny Angelot-Delettre, Vahid Asnafi, Elizabeth Macintyre, Sandrine Geffroy, Mary Callanan, Tony Petrella, Eric Deconinck, Etienne Daguindau, Véronique Harrivel, Sabrina Bouyer, Véronique Salaun, Pascale Saussoy, Jean Feuillard, Pascal Fuseau, Philippe Saas, Olivier Adotévi, Fabrice Jardin, Christophe Ferrand, Claude Preudhomme, Jacques Colinge, Christophe Roumier, Francine Garnache-Ottou
Oncogenesis and ontogeny of blastic plasmacytoid dendritic cell neoplasm (BPDCN) remain uncertain, between canonical plasmacytoid dendritic cells (pDCs) and AXL+ SIGLEC6+ DCs (AS-DCs). We compared 12 BPDCN to 164 acute leukemia by Affymetrix HG-U133 Plus 2.0 arrays: BPDCN were closer to B-cell acute lymphoblastic leukemia (ALL), with enrichment in pDC, B-cell signatures, vesicular transport, deubiquitination pathways, and AS-DC signatures, but only in some cases. Importantly, 1 T-cell ALL clustered with BPDCN, with compatible morphology, immunophenotype (cCD3+ sCD3- CD123+ cTCL1+ CD304+), and genetics...
March 9, 2021: Blood Advances