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Cenker Eken, Mustafa Serinken, Hayri Elicabuk, Emrah Uyanik, Muhammed Erdal
STUDY OBJECTIVE: The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED). METHODS: This randomised double-blind study compared the efficacy of intravenous 1 gm paracetamol, 50 mg dexketoprofen and 0.1 mg/kg morphine in patients with acute mechanical LBP. Visual analogue scale (VAS) was used for pain measurement at baseline, after 15 and after 30 min...
March 2014: Emergency Medicine Journal: EMJ
S Pacreu, J Fernández Candil, L Moltó, J Carazo, S Fernández Galinski
BACKGROUND: A synergy between ketamine and methadone (ME) to produce antinociception has been demonstrated in experimental neuropathy. We wanted to compare post-operative opioid requirements in patients undergoing multilevel lumbar arthrodesis after the administration combined ME-ketamine (MK) or ME alone. METHODS: This was a randomised double-blind study. During sevoflurane-remifentanil anaesthesia, 11 patients in each group received the following: ketamine bolus (0...
November 2012: Acta Anaesthesiologica Scandinavica
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