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"micro RNA", "traumatic brain injury"

Biswadev Mitra, Thomas F Rau, Nanda Surendran, James H Brennan, Prasanthan Thaveenthiran, Edmond Sorich, Mark C Fitzgerald, Jeffrey V Rosenfeld, Sarjubhai A Patel
Prediction of post-concussive syndrome after apparent mild traumatic brain injury (TBI) and subsequent cognitive recovery remains challenging, with substantial limitations of current methods of cognitive testing. This pilot study aimed to determine if levels of micro ribonucleic acids (RNAs) circulating in plasma are altered following TBI, and if changes to levels of such biomarkers over time could assist in determination of prognosis after TBI. Patients were enrolled after TBI on presentation to the Emergency Department and allocated to three groups: A - TBI (physical trauma to the head), witnessed loss of consciousness, amnesia, GCS=15, a normal CT Brain and a recorded first pass after post-traumatic amnesia (PTA) scale; B TBI, witnessed LOC, amnesia, GCS=15, a normal CT brain and a PTA scale test fail and: C - TBI and initial GCS <13 on arrival to the ED...
April 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Irina Staib-Lasarzik, Oliver Kriege, Ralph Timaru-Kast, Dana Pieter, Christian Werner, Kristin Engelhard, Serge C Thal
Tissue sampling for gene expression analysis is usually performed under general anesthesia. Anesthetics are known to modulate hemodynamics, receptor-mediated signaling cascades, and outcome parameters. The present study determined the influence of anesthetic paradigms typically used for euthanization and tissue sampling on cerebral mRNA expression in mice. Naïve mice and animals with acute traumatic brain injury induced by controlled cortical impact (CCI) were randomized to the following euthanasia protocols (n=10-11/group): no anesthesia (NA), 1 min of 4 vol% isoflurane in room air (ISO), 3 min of a combination of 5 mg/kg midazolam, 0...
October 1, 2014: Journal of Neurotrauma
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