Rita Rocha, João M P Jorge, Celso M Teixeira-Duarte, Inês R Figueiredo-Costa, Tatiana B Cereija, Paula F Ferreira-Teixeira, Christina Herzberg, Jörg Stülke, João H Morais-Cabral
In bacteria, intracellular K+ is involved in the regulation of membrane potential, cytosolic pH, and cell turgor as well as in spore germination, environmental adaptation, cell-to-cell communication in biofilms, antibiotic sensitivity, and infectivity. The second messenger cyclic-di-AMP (c-di-AMP) has a central role in modulating the intracellular K+ concentration in many bacterial species, controlling transcription and function of K+ channels and transporters. However, our understanding of how this regulatory network responds to c-di-AMP remains poor...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America