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coronary artery disease, arrhythmias

Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis
Subclinical thyroid dysfunction (STD), presenting as subclinical hypothyroidism (SHypo) or subclinical hyperthyroidism (SHyper), defined as abnormal serum thyrotropin (TSH) and normal free thyroid hormones, is associated with increased cardiovascular (CV) risk and mortality. Depending on the degree of such dysfunction, atherosclerosis, coronary artery disease, heart failure and cardiac arrhythmias, predominantly atrial fibrillation, characterize both disorders and increase CV and total mortality compared to euthyroid persons...
March 5, 2019: Trends in Cardiovascular Medicine
Leopold Rupprecht, Christof Schmid, Kurt Debl, Dirk Lunz, Bernhard Flörchinger, Andreas Keyser
BACKGROUND: The incidence of perioperative myocardial infarction is reported to 2-8%. The aim of the study (retrospectively registered) was to evaluate whether control coronary angiography after surgery is useful in case of suspected postoperative myocardial ischemia. METHODS: All patients who demonstrated signs of myocardial ischemia post CABG and underwent coronary angiography from 6/2008 to 06/2015 were retrospectively analyzed. Myocardial ischemia post CABG was defined as an increase of CK/CK-MB, occasionally associated with arrhythmias or low output syndrome...
March 12, 2019: Journal of Cardiothoracic Surgery
Z Wang, L M Xia, K Song, X Y Li, Q Z Lyu, J Q Shen
Objective: To investigate the influence of different discontinuation time of aspirin and clopidogrel before off-pump coronary artery bypass grafting (OPCABG) on postoperative bleeding and blood products transfusion requirement. Methods: Three hundred and fifty-three coronary artery disease patients who underwent OPCABG from January 2017 to January 2018 at Department of Cardiac Surgery, Zhongshan Hospital, Fudan University were retrospectively analysed. There were 268 males and 85 females, aged (66.0±9.1)years...
March 1, 2019: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Raleigh Ems, Anisha Garg, Thomas A Ostergard, Jonathan P Miller
Hypertension is the single greatest contributor to human disease and mortality affecting over 75 million people in the United States alone. Hypertension is defined according to the American College of Cardiology as systolic blood pressure (SBP) greater than 120 mm Hg and diastolic blood pressure (DBP) above 80 mm Hg measured on two separate occasions. While there are multiple medication classes available for blood pressure control, fewer than 50% of hypertensive patients maintain appropriate control. In fact, 0...
2019: Frontiers in Neuroscience
Tatiana S Rodríguez-Reyna, Sandra G Rosales-Uvera, E Kimura-Hayama, Pablo Hernández-Reyes, Pamela Mercado-Velázquez, Sergio A Benavides-Suárez, Alexia Esquinca-González, Carlos A Núñez-Álvarez
INTRODUCTION: In previous studies we showed that prevalence of myocardial fibrosis as assessed by late enhancement on cardiac MRI in SSc patients is 45% and is associated to diffuse disease (dcSSc) and lower left ventricle ejection fraction; microvascular damage defined as decreased perfusion on cardiac MRI after adenosine infusion, was also very frequent (79%). Our aim was to identify baseline characteristics associated to the development of cardiovascular outcomes (heart failure, coronary artery disease, arrhythmias, vasculopathy, elevated systolic pulmonary artery pressure and death) in SSc patients with previously documented myocardial fibrosis and microvascular damage...
February 11, 2019: Seminars in Arthritis and Rheumatism
Samarth S Patel, Fei-Pi Lin, Viviana A Rodriguez, Chandra Bhati, Binu V John, Taylor Pence, Mohammad B Siddiqui, Adam P Sima, Antonio Abbate, Trevor Reichman, Mohammad S Siddiqui
Cardiovascular complications are major contributors to mortality at liver transplantation(LT). However, the impact of coronary artery disease(CAD) on these complications is not well-understood as the literature is limited by non-invasive assessment of CAD, which is suboptimal in patients with cirrhosis. Thus, the current study evaluated cardiovascular events at LT stratified according to presence and severity of CAD quantified on coronary angiography. METHODS: All patients who had LT from January 2010 to January 2017 were evaluated(N=348) but analysis was restricted to patients who had coronary angiography prior to LT(N=283)...
March 8, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
Guoquan Cao, Weijian Chen, Kehua Pan, Houchang Sun, Zhen Wang
OBJECTIVE: The aim of this study was to compare the feasibility of 640-slice with 64-slice computed tomography (CT) coronary angiography for diagnosing coronary lesions in patients with pacemakers. METHODS: Forty-five and 50 patients with pacemakers and with suspected or known coronary artery disease underwent 64-slice (64 group) and 640-slice (640 group) CT scans, respectively. All segments of the vessels were evaluated according to the 15-segment model recommended by the American Heart Association...
February 27, 2019: Journal of International Medical Research
Marie-A Chaix, May Chergui, Charles Leduc, Paul Khairy
BACKGROUND: Sudden death is the leading cause of mortality in patients with transposition of the great arteries (TGA) and atrial switch surgery. Understanding underlying mechanisms could contribute to identifying high-risk patients and preventing such catastrophic deaths. METHODS: A total of 144 adults (≥18 years) with TGA and atrial switch surgery were followed at our adult congenital center since 1989. Four patients were excluded: two with double-outlet right ventricles and two with subsequent arterial switch surgery in childhood...
February 14, 2019: International Journal of Cardiology
Gerrit Frommeyer, Johannes Brachmann, Hüseyin Ince, Stefan G Spitzer, Dierk Thomas, Stephan Willems, Burghard Schumacher, Petra Schirdewahn, Thorsten Lewalter, Matthias Hochadel, Jochen Senges, Lars Eckardt
BACKGROUND: Digitalis glycosides are employed for rate control of atrial fibrillation. Recent studies suggested potential harmful effects of digitalis monotherapy and combination with antiarrhythmic drugs. The aim of the present study was to assess the prevalence and potential impact of digitalis therapy on outcome in patients undergoing catheter ablation of supraventricular arrhythmias. METHODS AND RESULTS: The German Ablation Registry is a nationwide, prospective registry with a 1-year follow-up investigating 12,566 patients receiving catheter ablations of supraventricular arrhythmias in 52 German centres...
February 23, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Gjin Ndrepepa
Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in neutrophil antimicrobial activity and human defense against various pathogens primarily by participating in phagocytosis. Elevated MPO levels in circulation are associated with inflammation and increased oxidative stress. Multiple lines of evidence suggest an association between MPO and cardiovascular disease (CVD) including coronary artery disease, congestive heart failure, arterial hypertension, pulmonary arterial hypertension, peripheral arterial disease, myocardial ischemia/reperfusion-related injury, stroke, cardiac arrhythmia and venous thrombosis...
February 21, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Amer Harky, Mohamad Bashir, Ciaran Grafton-Clarke, Martin Lees, Sarah Fendius, Neil Roberts
Intraventricular conduction abnormalities following cardiac surgery have been thoroughly described, especially after valvular surgery. It is also widely known that several anesthetic factors can cause autonomic disturbances resulting in the unmasking of sinus node dysfunction, significant bradycardia, and cardiovascular collapse during the intraoperative period. However, little is known about asymptomatic episodes, especially those occurring prior to coronary artery bypass grafting (CABG). We report a rare occurrence of an intraventricular conduction defect that presented in an asymptomatic patient following non-ST-elevation myocardial infarction prior to urgent CABG...
July 2018: Journal of Tehran Heart Center
Chun Shing Kwok, Purvi J Parwani, David L Fischman, Ritu Thamman, Jassim Al Suwaidi, Mohamed Mohamed, Josip A Borovac, Yoon K Loke, Evangelos Kontopantelis, David L Brown, Mamas A Mamas
Chest pain is a common reason for admission to hospital and little is known regarding 30-day unplanned readmissions after an admission with a primary discharge diagnosis of nonspecific chest pain. We analyzed patients with a primary diagnosis of nonspecific chest pain in the Nationwide Readmission Database who were admitted in 2010 to 2014. Rates, causes, and predictors of 30-day unplanned readmissions were determined. A total of 1,842,270 patients had a diagnosis of nonspecific chest pain. The 30-day unplanned readmission rate was 8...
January 25, 2019: American Journal of Cardiology
Tienush Rassaf, Matthias Totzeck
Cardio-oncology has emerged as best option for many patients with cardiovascular complications related to cancer and cancer therapy. Classical chemotherapy, targeted and immune therapies as wells as radiotherapy challenge the cardiovascular system at multiple levels, including increased rates of e.g., hypertension, coronary artery disease, cardiomyopathy, arrhythmia, and thrombosis. The cardiologist working within the cardio-oncology team is confronted with a broad spectrum of therapies and combination protocols...
December 2018: Journal of Thoracic Disease
Lars Michel, Tienush Rassaf, Matthias Totzeck
Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Many novel treatment options have been implemented with yet incompletely characterized cardiovascular side effects including heart failure, coronary artery disease, arrhythmias, valvular disease, venous thromboembolism and myocarditis. Diagnosis of potential cardiotoxic side effects is essential for an optimal treatment but remains challenging. Cardiac biomarkers troponin and brain natriuretic peptide/N-terminal proBNP (BNP/NT-proBNP) have been extensively studied in heart failure and acute coronary syndromes...
December 2018: Journal of Thoracic Disease
Sung Tae Kim, Taehwan Park
Cardiac complications resulting from cocaine use have been extensively studied because of the complicated pathophysiological mechanisms. This study aims to review the underlying cellular and molecular mechanisms of acute and chronic effects of cocaine on the cardiovascular system with a specific focus on human studies. Studies have consistently reported the acute effects of cocaine on the heart (e.g., electrocardiographic abnormalities, acute hypertension, arrhythmia, and acute myocardial infarction) through multifactorial mechanisms...
January 29, 2019: International Journal of Molecular Sciences
M Piels, T Faes, J Vainer
BACKGROUND: Obstructive coronary artery disease is found in approximately 97% of patients presenting with ST-elevation myocardial infarction and 92% of patients with non ST-elevation myocardial infarction (Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al. Int J Cardiol 264: 12-17, 2018). Recent studies showed that myocardial infarction without obstructive coronary atherosclerosis (MINOCA) is also associated with a long-term risk of adverse events (Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al...
January 29, 2019: BMC Cardiovascular Disorders
Sami Viskin, Ehud Chorin, Dana Viskin, Aviram Hochstadt, Amir Halkin, Oholi Tovia-Brodie, John K Lee, Elad Asher, Avishag Laish-Farkash, Guy Amit, Ofer Havakuk, Bernard Belhassen, Raphael Rosso
BACKGROUND: Polymorphic ventricular tachycardia (VT) without QT prolongation is well described in patients without structural heart disease [mainly idiopathic ventricular fibrillation (VF) and Brugada syndrome] and in patients with acute ST-elevation myocardial infarction. METHODS: Retrospective study of patients with polymorphic VT related to coronary artery disease but without evidence of acute myocardial ischemia. RESULTS: We identified 43 patients who developed polymorphic VT within days of an otherwise uncomplicated myocardial infarction or coronary revascularization procedure...
January 30, 2019: Circulation
Paroma Sarkar, Sutapa Mukherjee, Ching Li Chai-Coetzer, R Doug McEvoy
Obstructive sleep apnoea, the most common form of sleep-disordered breathing, is highly prevalent in patients with cardiovascular disease. The last 30 years has seen a plethora of large scale epidemiological studies investigating the relationship between sleep apnoea and cardiovascular outcomes. This review highlights the key epidemiological studies addressing the links between sleep apnoea and hypertension, cardiac arrhythmias, cerebrovascular disease, coronary artery disease, heart failure and pulmonary hypertension, with a particular focus on some of the most recent reports...
December 2018: Journal of Thoracic Disease
Hai Deng, Alena Shantsila, Pi Guo, Tatjana S Potpara, Xianzhang Zhan, Xianhong Fang, Hongtao Liao, Yang Liu, Wei Wei, Lu Fu, Yumei Xue, Shulin Wu, Gregory Y H Lip
BACKGROUND: Female sex has been linked with worse prognosis in patients with atrial fibrillation (AF). Clinical risk stratification of women with AF may help decision-making before catheter ablation (CA). AIM: To evaluate arrhythmia outcomes and the predictive value of clinical scores for arrhythmia recurrence in a large cohort of Chinese patients with AF undergoing CA. METHODS: A total 1410 of patients (68.1% men) who underwent AF ablation with scheduled follow-up were analysed retrospectively...
January 22, 2019: Archives of Cardiovascular Diseases
Sophie I Mavrogeni, Konstantinos Tsarouhas, Demetrios A Spandidos, Christina Kanaka-Gantenbein, Flora Bacopoulou
Athletic pre-participation screening is essential for minimizing the risk for sudden cardiac death (SCD) in athletes participating in either competitive or leisure sporting activities. The primary causes of SCD in young athletes (<35 years of age) include hypertrophic cardiomyopathy, congenital anomalies of the coronary artery and arrhythmogenic right ventricular cardiomyopathy. Other abnormalities, such as malignant arrhythmia due to blunt trauma to the chest (commotio cordis), myocarditis, valvular disease, aortic rupture (in Marfan syndrome) and ion channelopathies (catecholaminergic polymorphic ventricular tachycardia, Brugada syndrome, long or short QT syndrome), also contribute to a lesser degree to SCD...
February 2019: Experimental and Therapeutic Medicine
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