keyword
https://read.qxmd.com/read/38429639/the-non-linear-relationship-between-serum-albumin-and-diabetic-retinopathy-in-type-2-diabetes-mellitus-a-secondary-analysis-based-on-a-cross-sectional-study
#21
JOURNAL ARTICLE
Guo-Qiang Zeng, Yu-Feng Yao, Jian-Bo Zhong, Yi Zhang, Bai-Kang Ye, Xiao-Yan Dou, Li Cai
BACKGROUND: Most studies had shown a linear relationship between serum albumin (sALB) and the prevalence of diabetic retinopathy (DR). Thus, the purpose of this study is to investigate whether their relationship is non-linear. METHODS: We included 426 patients with type 2 diabetes who were hospitalized in Guangdong Provincial People's Hospital from December 2017 to November 2018. The outcome was the prevalence of DR. A two-piecewise logistics regression model was performed to identify the non-linear relationship between sALB and the prevalence of DR...
March 1, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38420570/early-iron-supplementation-in-exclusively-breastfed-gambian-infants-a-randomized-controlled-trial
#22
RANDOMIZED CONTROLLED TRIAL
Mamadou Bah, Isabella Stelle, Hans Verhoef, Alasana Saidykhan, Sophie E Moore, Bubacarr Susso, Andrew M Prentice, Carla Cerami
OBJECTIVE: To investigate the effect of daily iron supplementation for 14 weeks on the serum iron concentration and other markers of iron status in exclusively breastfed infants in Gambia. METHODS: A placebo-controlled, randomized, double-blind trial was performed in rural Gambia between 3 August 2021 and 9 March 2022. Overall, 101 healthy, exclusively breastfed infants aged 6 to 10 weeks were recruited at vaccination clinics and through community health workers...
March 1, 2024: Bulletin of the World Health Organization
https://read.qxmd.com/read/38419219/retrospective-analysis-of-the-clinical-significance-of-ro52-trim21-antibody-and-specific-antinuclear-antibody-patterns-by-indirect-immunofluorescence
#23
JOURNAL ARTICLE
Kaifang Liu, Yunfeng Liao, Pu Li, Jing Shi
OBJECTIVES: To determine the clinical significance of Ro52 protein/tripartite motif-containing 21 antibody and specific antinuclear antibody patterns using indirect immunofluorescence technique. METHODS: The retrospective study was conducted at the clinical laboratory of the First Affiliated Hospital of Chongqing Medical University, China, and comprised data from January 2017 to December 2021 of patients who underwent antinuclear antibody and anti-extractable nuclear antigen antibody detection...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38413424/high-serum-levels-of-leucine-rich-%C3%AE-2-glycoprotein-1-lrg-1-are-associated-with-poor-survival-in-patients-with-early-breast-cancer
#24
JOURNAL ARTICLE
Andy Göbel, Tilman D Rachner, Oliver Hoffmann, Daniel Martin Klotz, Sabine Kasimir-Bauer, Rainer Kimmig, Lorenz C Hofbauer, Ann-Kathrin Bittner
BACKGROUND: Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (BC), high intratumoral LRG-1 protein expression levels are associated with reduced survival. In this study, we assessed serum levels of LRG-1 in patients with early BC and investigated its correlation with the presence of disseminated tumor cells (DTCs) in the bone marrow and survival outcomes...
February 28, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38410521/quality-of%C3%A2-chronic-disease-diabetes-hypertension-care-in-health-care-facilities-in-high-disease-burden-areas-in-sidama-region-cross-sectional-study
#25
JOURNAL ARTICLE
Bedilu Deribe Derese, Fikru Tadesse, Gezahegn Bekele Dadi, Mohammed Ayalew, Yacob Abraham Borie, Tinbete Samuel Alemayehu, Amdehiwot Aynalem, Ephrem Geja Gechere, Martha Girma Gebrekidan, Alemu Tamiso Debiso, Akalewold Alemayehu, Meskerem Jisso Ebido, Kindalem Worku Mihrete, Rekiku Fikre, Amanuel Ejeso, Wondwossen Abera
BACKGROUND: Diabetes and hypertension are major synergistic risk factors for microvasculopathy, microangiopathy, and neuropathy problems among patients with chronic disorder. Control of hypertension and diabetes have significant value in delaying these complications. The key for delaying complications in diabetes and hypertension is the quality of care. OBJECTIVE: This study explored the quality of diabetes-hypertension care in health care facilities with high disease burden in Sidama region...
2024: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38408375/functional-group-assisted-fluorescence-sensing-platform-for-nanomolar-level-detection-of-an-antineoplastic-drug-and-a-neurotransmitter-from-environmental-water-and-human-biofluids
#26
JOURNAL ARTICLE
Abhijeet Rana, Gyanesh Mishra, Shyam Biswas
A fast, sensitive, selective, and biocompatible dual sensor of an antineoplastic medication (methotrexate) and a neurotransmitter (adrenaline) is still being searched by present-day scientists. To overcome this issue, we have designed a functionalized, robust, bio-friendly luminescent MOF for the sensitive, selective, and rapid monitoring of methotrexate and adrenaline. This probe is the first ever reported MOF-based fluorescence sensor of methotrexate and second only for adrenaline. This fluorescence probe has a very low limit of detection (LOD) of 0...
February 26, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38392846/development-of-a-gold-nanoparticle-based-elisa-for-detection-of-pcv2
#27
JOURNAL ARTICLE
Caroline Rodrigues Basso, Taís Fukuta Cruz, Larissa Baldo Vieira, Valber de Albuquerque Pedrosa, Fábio Sossai Possebon, João Pessoa Araujo Junior
In this new methodology, plasmonic ELISA (pELISA) was used to detect Circovirus porcine2 (PCV2) in serum samples without the need for plate reading equipment. This process occurs by adapting the conventional ELISA test with gold nanoparticles (AuNPs) to promote a color change on the plate and quickly identify this difference with the naked eye, generating a dark purple-gray hue when the samples are positive and red when the samples are negative. The technique demonstrated high efficiency in detecting samples with a viral load ≥ 5 log10 copies/mL...
January 26, 2024: Pathogens
https://read.qxmd.com/read/38385308/tubulointerstitial-nephritis-and-uveitis-syndrome-during-the-covid-19-pandemic-a-case-series
#28
JOURNAL ARTICLE
Kübra Özdemir Yalçınsoy, Anıl Güngör, Deniz Karakaya, Levent Özdal, Meltem Kılıç, Yasemin Özdamar Erol, Pınar Çakar Özdal
OBJECTIVES: To report the ocular findings, laboratory results, and management of patients with tubulointerstitial nephritis and uveitis syndrome (TINU), whose numbers increased during the 2019 coronavirus disease (COVID-19) pandemic. MATERIALS AND METHODS: Demographic characteristics, ophthalmic examination findings, laboratory results including polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), serum SARS-CoV-2 immunoglobulin G (IgG) antibody, and treatment of patients diagnosed with TINU between March 2020 and March 2022 were evaluated retrospectively...
February 22, 2024: Turkish Journal of Ophthalmology
https://read.qxmd.com/read/38384125/neurotrophic-keratopathy-in-marfan-syndrome-patient-after-micropulse-transscleral-cyclophotocoagulation-a-call-for-risk-stratification
#29
JOURNAL ARTICLE
Nouf Alzendi, Furat Alrajhi, Deema Jomar, Ohoud Owaidhah
BACKGROUND Micropulse transscleral cyclophotocoagulation is a non-invasive, widely employed procedure that uses diode laser to target the ciliary body to lower the intraocular pressure. Despite its acknowledged efficacy, certain complications are recognized, with neurotrophic keratopathy being a rare yet serious consequence. This report seeks to shed light on a potential high-risk subgroup susceptible to neurotrophic keratopathy, exemplified by our patient with Marfan syndrome, a condition characterized by thin sclera...
February 22, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38381740/intralesional-interferon-alpha-2b-as-a-novel-treatment-for-periocular-squamous-cell-carcinoma-in-horses
#30
JOURNAL ARTICLE
Brittany B Martabano, Steven Dow, Lyndah Chow, Margaret M V Williams, Maura K Mack, Rebecca Bellone, Kathryn L Wotman
OBJECTIVE: To determine the safety and efficacy of perilesional human recombinant interferon alpha-2b (IFNα2b) for treatment of periocular squamous cell carcinoma (PSCC) in horses. ANIMALS STUDIED: Eleven horses (12 eyes) with PSCC were enrolled in this prospective clinical study with owner consent. PROCEDURES: Systemically healthy horses were included in the study following confirmation of PSCC via biopsy. Every two weeks for a maximum of six treatments, horses were sedated and perilesional injection of IFNα2b (10 million IU) was performed...
2024: PloS One
https://read.qxmd.com/read/38375271/intraocular-pressure-and-its-determinants-in-a-very-old-population-the-ural-very-old-study
#31
JOURNAL ARTICLE
Mukharram M Bikbov, Gyulli M Kazakbaeva, Ellina M Rakhimova, Songhomitra Panda-Jonas, Azaliia M Tuliakova, Albina A Fakhretdinova, Iulia A Rusakova, Jost B Jonas
PURPOSE: To explore intraocular pressure (IOP) and its associated parameters in an aged population. METHODS: The epidemiologic Ural Very Old Study (UVOS) conducted in Bashkortostan/Russia included 1526 participants with an age of ≥85 years. Besides a whole series of ocular and systemic examinations, IOP was determined applying non-contact tonometry. Body mass index, diastolic blood pressure and age were the factors used to estimate the cerebrospinal fluid pressure (CSFP)...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38374579/selenium-supplementation-in-inactive-moderate-to-severe-graves-orbitopathy-patients-a-randomized-controlled-trial
#32
JOURNAL ARTICLE
Panida Potita, Vannakorn Pruksakorn, Panudda Srichomkwun, Kanaungnit Kingpetch, Preamjit Saonanon
PURPOSE: This study was designed to evaluate the effect of selenium supplementation in inactive moderate-severe Graves' orbitopathy (GO) patients. METHODS: This study was a single-center, placebo-controlled, double-masked, randomized trial. Inactive moderate-severe GO participants were randomized to receive six months of 200 micrograms/day of selenium supplementation or placebo. Thorough eye exams, clinical activity score (CAS), Graves' Ophthalmopathy quality of life questionnaire (GO-QOL), and serum selenium level were evaluated at baseline and 6 months after the interventions...
February 19, 2024: Orbit
https://read.qxmd.com/read/38371793/simple-and-cost-effective-quantum-dot-chemodosimeter-for-visual-detection-of-biothiols-in-human-blood-serum
#33
JOURNAL ARTICLE
Vinayakan Ramachandran Nair, Kulangara Sandeep, Madhavan Shanthil, Santhakumar Dhanya, Aravind Archana, Muthunayagam Vibin, Hareendran Divyalakshmi
An emission "turn-off" chemodosimeter for the naked-eye detection of biothiols using silica-overcoated cadmium selenide quantum dots is developed. Hole scavenging by the thiol group of cysteine, homocysteine, or glutathione on interaction with quantum dots resulted in an instant and permanent emission quenching under physiologically relevant conditions. Also, the emission suppression is so specific that thiols and substituted thiols (methionine and cystine) can easily be distinguished. A pilot experiment for the visual detection of serum thiols in human blood was also conducted...
February 13, 2024: ACS Omega
https://read.qxmd.com/read/38371263/intravitreal-injection-of-conbercept-for-diabetic-macular-edema-complicated-with-diabetic-nephropathy
#34
JOURNAL ARTICLE
Yuan-Zhang Zhu, Zhi-Zhi Dou, Wen-Ying Wang, Qing-Yue Ma, Wen-Dan Yi, Ning-Ning Yao, Yi-Chong Liu, Xiao-Di Gao, Qian Zhang, Wen-Juan Luo
AIM: To observe the therapeutic effect of conbercept on diabetic macular edema (DME) complicated with diabetic nephropathy (DN). METHODS: In this retrospective study, 54 patients (54 eyes) that diagnosed as DME from January 2017 to October 2021 were collected. The patients were divided into two groups: DME patients with DN (25 eyes), and DME patients without DN (29 eyes). General conditions were collected before treatment, laboratory tests include fasting blood glucose, HbA1c, microalbumin/creatinine, serum creatinine...
2024: International Journal of Ophthalmology
https://read.qxmd.com/read/38370463/inflammation-and-neurodegeneration-in-glaucoma-isolated-eye-disease-or-a-part-of-a-systemic-disorder-serum-proteomic-analysis
#35
JOURNAL ARTICLE
Michał Andrzej Okruszko, Maciej Szabłowski, Mateusz Zarzecki, Magdalena Michnowska-Kobylińska, Łukasz Lisowski, Magda Łapińska, Zofia Stachurska, Anna Szpakowicz, Karol Adam Kamiński, Joanna Konopińska
INTRODUCTION: Glaucoma is the most common optic neuropathy and the leading cause of irreversible blindness worldwide, which affects 3.54% of the population aged 40-80 years. Despite numerous published studies, some aspects of glaucoma pathogenesis, serum biomarkers, and their potential link with other diseases remain unclear. Recent articles have proposed that autoimmune, oxidative stress and inflammation may be involved in the pathogenesis of glaucoma. METHODS: We investigated the serum expression of 92 inflammatory and neurotrophic factors in glaucoma patients...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38365378/neurological-psychiatric-and-sleep-investigations-after-treatment-of-anti-leucine-rich-glioma-inactivated-protein-1-lgi1-encephalitis-in-spain-a-prospective-cohort-study
#36
JOURNAL ARTICLE
Amaia Muñoz-Lopetegi, Mar Guasp, Laia Prades, Eugenia Martínez-Hernández, Mireia Rosa-Justícia, Víctor Patricio, Thaís Armangué, Lorena Rami, Roger Borràs, Josefina Castro-Fornieles, Albert Compte, Carles Gaig, Joan Santamaria, Josep Dalmau
BACKGROUND: Anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis is an autoimmune disorder that can be treated with immunotherapy, but the symptoms that remain after treatment have not been well described. We aimed to characterise the clinical features of patients with anti-LGI1 encephalitis for 1 year starting within the first year after initial immunotherapy. METHODS: For this prospective cohort study, we recruited patients with anti-LGI1 encephalitis as soon as possible after they had received conventional immunotherapy for initial symptoms; patients were recruited from 21 hospitals in Spain...
March 2024: Lancet Neurology
https://read.qxmd.com/read/38363513/autoimmune-retinopathy-in-a-patient-with-smoldering-multiple-myeloma-a-case-report
#37
JOURNAL ARTICLE
Zachary Bergman, Taariq Mohammed, Lisa Schocket, Rachid Aouchiche, Mary A Johnson
PURPOSE: Multiple myeloma (MM) is a plasma cell dyscrasia leading to proliferation of monoclonal plasma cells. Ocular involvement in multiple myeloma is uncommon but can occur. The ocular manifestations of MM may include the cornea, uvea, and retinal vasculature. We present a rare case of autoimmune retinopathy associated with smoldering MM. CASE: A 76-year-old female with no significant past medical or ocular history presented with four months of worsening vision, difficulty with night driving, and loss of peripheral vision...
February 16, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38363462/lutein-and-zeaxanthin-supplementation-improves-dynamic-visual-and-cognitive-performance-in-children-a-randomized-double-blind-parallel-placebo-controlled-study
#38
JOURNAL ARTICLE
Rajesh Parekh, Billy R Hammond, Divya Chandradhara
INTRODUCTION: Supplementation with dietary neuro-pigments lutein (L) and zeaxanthin (Z) has been shown to improve many aspects of visual and cognitive function in adults. In this study, we tested whether a similar intervention could improve such outcomes in preadolescent children. METHODS: Sixty children (age range 5-12 years) were randomized in a 2:1 ratio in this double-blind, placebo-controlled clinical trial. Subjects were supplemented with gummies containing either a combination of 10 mg lutein and 2 mg zeaxanthin (LZ) or placebo for 180 days...
February 16, 2024: Advances in Therapy
https://read.qxmd.com/read/38361150/prostaglandin-e2-may-clinically-alleviate-dry-eye-disease-by-inducing-th17-cell-differentiation
#39
JOURNAL ARTICLE
Jingyao Chen, Yu Gong, Xiaoyu Sun, Nuo Chen, Zijun Zhao, Weijia Zhang, Yixin Zheng
Dry eye (DE) is a multifactorial ocular surface disease characterised by an imbalance in tear homeostasis. The pathogenesis of DE is complex and related to environmental, immunological (e.g., T helper 17 cells) and other factors. However, the DE disease pathogenesis remains unclear, thereby affecting its clinical treatment. This study aimed to explore the mechanism through which prostaglandin E2 (PGE2) affects DE inflammation by regulating Th17. The DE mouse model was established through subcutaneous injection of scopolamine hydrobromide...
February 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38359614/extracellular-vesicles-contain-filamentous-alpha-synuclein-and-facilitate-the-propagation-of-parkinson-s-pathology
#40
JOURNAL ARTICLE
Yuta Ishiguro, Taiji Tsunnemi, Tomoyo Shimada, Asako Yoroisaka, Shin-Ichi Ueno, Haruka Takeshige-Amano, Taku Hatano, Yuichi Inoue, Shinji Saiki, Nobutaka Hattori
Parkinson's disease (PD) is characterized by the pathological deposition of a-synuclein (a-syn) inclusions, known as Lewy bodies/neurites. Emerging evidence suggests that extracellular vesicles (EVs) play a role in facilitating the spreading of Lewy pathology between the peripheral nervous system and the central nervous system. We analyzed serum EVs obtained from patients with PD (n = 142), multiple system atrophy (MSA) (n = 18), progressive supranuclear palsy (PSP) (n = 28), rapid eye movement sleep behavior disorder (n = 31), and controls (n = 105)...
February 2, 2024: Biochemical and Biophysical Research Communications
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