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https://read.qxmd.com/read/30773899/comparison-of-the-short-term-and-long-term-efficacies-of-the-mycoplasma-gallisepticum-vaccines-ts-11-and-6-85
#1
Amir H Noormohammadi, Kevin G Whithear
In order to compare the short-term efficacies of the live attenuated Mycoplasma gallisepticum (MG) vaccine strains ts-11 and 6/85, four groups of SPF chickens were vaccinated with each of the vaccines using eye drop and aerosol inoculations, and were subsequently challenged with a wild-type MG strain. When administered by the recommended routes (eye drop for ts-11 and fine aerosol for 6/85), both vaccines induced substantial and comparable levels of protection against airsacculitis and tracheitis caused by wild-type MG...
February 18, 2019: Avian Pathology: Journal of the W.V.P.A
https://read.qxmd.com/read/30771577/aquaporin-4-antibody-positive-short-transverse-myelitis-associated-with-breast-cancer
#2
Weijing Liao, Cheng Li, Yulan Tang, Fan Huang, Huimin Kuang, Shuolin Liang, Yi Yang
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS). A typical finding on spinal magnetic resonance imaging (MRI) of NMOSD is longitudinally extensive transverse myelitis (LETM). However, patients with NMOSD presenting with short-segment transverse myelitis (STM) during myelitis attacks associated with breast cancer are uncommon. We report a case of a 35-year-old woman with STM and left eye optic neuritis. The patient was positive for serum aquaporin-4 antibodies (AQP4-IgG), and a biopsy of the left breast showed invasive ductal carcinoma...
February 8, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30765901/dry-eye-serum-eye-drops
#3
COMMENT
Phillip Mondy
No abstract text is available yet for this article.
February 2019: Australian Prescriber
https://read.qxmd.com/read/30758529/a-hierarchical-cobalt-carbon-nanotube-hybrid-nanocomplex-based-ratiometric-fluorescent-nanosensor-for-ultrasensitive-detection-of-hydrogen-peroxide-and-glucose-in-human-serum
#4
Pengcheng Qian, Yingnan Qin, Yanlong Lyu, Yunfei Li, Lei Wang, Shuo Wang, Yaqing Liu
Highly sensitive detection of H2 O2 and glucose is critical for fundamental research and disease diagnosis. A ratiometric sensor can simultaneously afford two readout signals that provide an internally normalized response to change, thereby reducing false results and improving detection accuracy. A novel ratiometric fluorescent nanosensor for ultrasensitive detection of hydrogen peroxide and glucose was constructed on the basis of the peroxidase-like properties of a hierarchical cobalt/carbon nanotube hybrid nanocomplex (Co-CNT)...
February 13, 2019: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/30745300/a-phase-i-multicenter-dose-escalation-study-of-the-oral-selective-fgfr-inhibitor-debio-1347-in-patients-with-advanced-solid-tumors-harboring-fgfr-gene-alterations
#5
Martin H Voss, Cinta Hierro, Rebecca S Heist, James M Cleary, Funda Meric-Bernstam, Josep Tabernero, Filip Janku, Leena Gandhi, A John Iafrate, Darrell R Borger, Nobuya Ishii, Youyou Hu, Yulia Kirpicheva, Valerie Nicolas-Metral, Anna Pokorska-Bocci, Anne Vaslin Chessex, Claudio Zanna, Keith T Flaherty, José Baselga
PURPOSE: To investigate tolerability, efficacy, and pharmacokinetics/-dynamics (PK/PD) of Debio 1347, a selective fibroblast growth factor receptor (FGFR) Inhibitor. EXPERIMENTAL DESIGN: This was a first-in-human, multicenter, open-label study in patients with advanced solid tumors harboring FGFR1-3 gene alterations. Eligible patients received oral Debio 1347 at escalating doses once daily until disease progression or intolerable toxicity. Dose limiting toxicities (DLTs) were evaluated during the first 4 weeks on treatment, PK/PD post-first dose and after 4 weeks...
February 11, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://read.qxmd.com/read/30741377/sleep-disturbances-are-common-in-patients-with-autoimmune-encephalitis
#6
Margaret S Blattner, Gabriela S de Bruin, Robert C Bucelli, Gregory S Day
OBJECTIVES: Autoimmune encephalitis (AE) is increasingly recognized as an important cause of subacute cognitive decline, seizures, and encephalopathy, with an ever-broadening clinical phenotype. Sleep disturbances are reported in AE patients, including rapid eye movement sleep behavior disorder, hypersomnia, fragmented sleep, and sleep-disordered breathing; however, the prevalence of sleep disturbances and contributions to outcomes in AE patients remain unknown. There is a need to determine the prevalence of sleep disturbances in AE patients, and to clarify the relationship between specific autoantibodies and disruptions in sleep...
February 11, 2019: Journal of Neurology
https://read.qxmd.com/read/30741024/therapeutic-effects-of-three-human-derived-materials-in-a-mouse-corneal-alkali-burn-model
#7
Kyung Eun Han, Mi Hye Park, Kyoung Hye Kong, Euno Choi, Kyu-Ryong Choi, Roo Min Jun
PURPOSE: To compare the therapeutic effects of human derivatives in a mouse alkali burn model. METHODS: The right eyes of mice were injured using NaOH. After alkali injury, one of the following agents was topically administered for 7 days: human amniotic membrane (hAM) suspension, human umbilical cord serum (hUCS), and human peripheral blood serum (hPBS), or saline. The epithelial defect areas on days 1, 2, and 3, degrees of opacity on days 2, 3, and 7, and corneal neovascularization (NV) areas on day 7 were evaluated...
February 10, 2019: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/30737591/distinction-between-mpo-anca-and-pr3-anca-associated-glomerulonephritis-in-chinese-patients-a-retrospective-single-center-study
#8
Yan Hong, Pengxian Shi, Xia Liu, Liu Yang, Kang Li, Feng Xu, Shaoshan Liang, Zhengzhao Liu, Haitao Zhang, Yinghua Chen, Weixin Hu
OBJECTIVES: To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes. METHOD: A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. RESULTS: In this study, 429 (91.9%) patients tested positive for MPO-ANCA, and 38 (8...
February 8, 2019: Clinical Rheumatology
https://read.qxmd.com/read/30735698/toxicology-study-of-long-term-administration-of-rhkgf-2-eye-drops-on-rabbit-corneas
#9
JianQiu Cai, Wenqing Li, Jinghang Li, Qingde Zhou, Yadong Huang, Xiaokun Li, Qi Hui, Xiaojie Wang
Keratinocyte growth factor -2 promotes corneal repair. Its mechanism of action involves regulating regeneration and migration of corneal cells, as well as activating corneal limbal stem cells. However, KGF-2 being a carcinogenic growth factor and its potential adverse effect in over dosage long-term treatment had not yet been reported. In this study, we used New Zealand white rabbits to study possible toxic effects of ocular administration of recombinant human keratinocyte growth factor-2 eye drops. Animals in the medium- and high-dose groups had some ocular irritant reactions during the course of drug administration; however this reaction was harmless to the cornea and it ended up when administration was stopped...
February 5, 2019: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/30723690/acute-glufosinate-based-herbicide-treatment-in-rats-leads-to-increased-ocular-interleukin-1%C3%AE-and-c-fos-protein-levels-as-well-as-intraocular-pressure
#10
Selim Çomaklı, Çiğdem Sevim, George Kontadakis, Elif Doğan, Ali Taghizadehghalehjoughi, Mustafa Özkaraca, Michael Aschner, Taxiarchis Konstantinos Nikolouzakis, Aristides Tsatsakis
Glufosinate is a common herbicide with neurotoxic effects, leading to seizures, convulsions and memory loss. Glufosinate indirectly induces glutamate toxicity by inhibiting glutamine synthesis in astrocytes. Here, we studied the acute toxic effects of a glufosinate-based herbicide in rat optic nerve at three doses (40, 80 or 120 μM, equal to 714 or 21 mg/kg bw/day). Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, glucose, calcium, as well as creatinine concentrations were analyzed after 24, 48 and 72 h treatment...
2019: Toxicology Reports
https://read.qxmd.com/read/30719254/sleep-architecture-and-hypothalamic-pituitary-adrenal-activity-in-paradoxical-and-psychophysiological-insomnia
#11
Hiwa Mohammadi, Mohammad Rezaei, Seyed Mojtaba Amiri, Zohreh Rahimi, Kamran Mansouri, Habibolah Khazaie
Introduction: There are controversial reports about association between sleep and Hypothalamic-Pituitary-Adrenal (HPA) activity. Studies have reported the influence of insomnia on HPA hormones. However, they usually ignored the heterogeneity of insomnia symptoms, so subtypes of the disorder have not been considered in the reports. The present study aimed to investigate the final and intermediate products of HPA system among a group of psychophysiological and paradoxical insomniac patients in comparison to a group of normal sleepers...
November 2018: Basic and Clinical Neuroscience
https://read.qxmd.com/read/30716185/serum-vascular-endothelial-growth-factor-changes-and-safety-after-topical-anti-human-vegf-antibody-bevacizumab-in-healthy-dogs
#12
Lisa-Marie Muellerleile, Alexander Tichy, Barbara Nell
OBJECTIVE: To evaluate ocular and general safety of topical anti-human VEGF bevacizumab and the effect on serum vascular endothelial growth factor (VEGF) values in healthy dogs. PROCEDURES: Nine university-owned beagles received 0.05 mL of 0.25% bevacizumab eyedrops (Avastin® , Roche) in one eye and 0.05 mL of 0.9% saline solution in the other eye as a control, administered at 12 hours intervals over a period of 28 days. Continuous monitoring for vital parameters and ocular examinations were conducted...
February 4, 2019: Veterinary Ophthalmology
https://read.qxmd.com/read/30715678/current-status-of-the-acquired-immune-system-of-iranian-patients-with-long-term-complications-of-sulfur-mustard-poisoning
#13
Mahdi Balali-Mood, Bamdad Riahi-Zanjani, Mahmoud Mahmoudi, Mahmood Sadeghi
BACKGROUND: Sulfur mustard (SM) is a powerful blistering chemical warfare agent that has genotoxic effects. Cells with excessive proliferation such as lymphocytes may inherit this cellular toxicity which can lead to their malfunctions in the long-term. This study was designed to evaluate the status of acquired immunity among SM poisoned veterans around three decades after exposure. METHODS: Thirty five male Iranian veterans having at least 25% disability due to SM poisoning with long-term complications in the respiratory system, skin or eyes were investigated...
February 4, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://read.qxmd.com/read/30712133/association-between-serum-lipid-profile-and-obstructive-respiratory-events-during-rem-and-non-rem-sleep
#14
Andras Bikov, Zsofia Lazar, Peter Horvath, David Laszlo Tarnoki, Adam Domonkos Tarnoki, Luca Fesus, Marton Horvath, Martina Meszaros, Gyorgy Losonczy, Laszlo Kunos
PURPOSE: Obstructive sleep apnoea (OSA) represents a risk for dyslipidaemia. Obstructive respiratory events during rapid eye movement (REM) sleep are more strongly related to the development of hypertension and diabetes than in non-REM. However, the relationship between sleep phases and serum lipid profile is unclear. We aimed to analyse the relationship between obstructive respiratory events in REM and non-REM sleep as well as serum lipid profile. METHODS: Polysomnography was performed in 94 adult subjects who did not take any lipid-modifying medications...
February 2, 2019: Lung
https://read.qxmd.com/read/30701899/relationship-between-serologic-profile-anca-type-and-clinical-features-of-renal-involvement-in-anca-associated-vasculitides
#15
N M Bulanov, E A Makarov, E M Shchegoleva, A S Zykova, E S Vinogradova, P I Novikov, L V Lysenko Kozlovskaya, S V Moiseev
AIM: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). MATERIALS AND METHODS: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. AAV was diagnosed according to ACR criteria and Chapel Hill consensus conference definition (2012)...
June 20, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30700349/efficacy-of-femtosecond-laser-assisted-phacoemulsification-for-cataract-patients-and-its-influence-on-serum-levels-of-inflammatory-factors
#16
Jianming Chen, Dengting Wang, Jiqi Zheng, Chen Gao
OBJECTIVE: To investigate effect of femtosecond laser-assisted phacoemulsification in treating cataract patients, and to analyse its influence on serum inflammatory factors IL-6, IL-1β, TNF-α . STUDY DESIGN: An analytical, descriptive study. PLACE AND DURATION OF STUDY: The Ophthalmologic Center, Rehabilitation Center Hospital of Gansu, China, from January 2016 to September 2017. METHODOLOGY: A total of 94 eyes were randomly divided into control group (47 cases) and observation group (47 cases)...
February 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/30681547/a-case-of-cat-scratch-disease-diagnosed-by-indirect-fluorescent-antibody-assay-of-igm-specific-for-a-japanese-strain-of-bartonella-henselae
#17
Sho-Hei Uchi, Ryoji Yanai, Hidehiro Tsuneoka, Ken-Ichiro Otsuyama, Koh-Hei Sonoda, Kazuhiro Kimura
PURPOSE: To report a case of cat scratch disease-associated retinitis diagnosed with an indirect fluorescent antibody (IFA) assay for immunoglobulin M (IgM) specific for a strain (YH-01) of Bartonella henselae recently identified in Japan. METHODS: Case report of a 24-year-old pregnant woman presented with general fever, fatigue, as well as blurred vision, and a central visual field deficiency in her right eye and was suspected as cat scratch disease because she had started to feed a feral dog a month ago...
January 23, 2019: Retinal Cases & Brief Reports
https://read.qxmd.com/read/30677879/increased-prevalence-of-sjogren-s-syndrome-in-where-soils-contain-high-levels-of-chromium
#18
Chien-Pang Lee, Peng-Yang Hsu, Che-Chun Su
Previously, we showed that farm soil levels of chromium were strongly correlated with people's serum chromium levels and an increase (3.6 fold) in both the incidence and prevalence of sicca syndrome in areas where farm soil chromium was high. Because Sjogren's syndrome (SS) is the major disease causing a dry mouth and dry eyes, we aimed in the study to investigate whether these areas with high soil chromium have a high SS prevalence. We used a database from the authority in charge of catastrophic illness certificates...
March 20, 2019: Science of the Total Environment
https://read.qxmd.com/read/30677505/translocation-of-dead-or-alive-bacteria-from-mucosa-to-joints-and-epiphyseal-bone-marrow-facts-and-hypotheses
#19
Jean-Marie Berthelot, Daniel Wendling
The recent demonstration that DNA from several mucosal bacteria, including Prevotella spp, could be found in numerous tissues (mesenteric lymph nodes, spleen, serum, liver, lung, eye and ankle joints), either in HLA-B27 rats with or without arthritis, or control rats without HLA-B27, could be a revolution in our understanding of spondyloarthritis and close disorders, including rheumatoid arthritis. Indeed, similar translocations of dead or alive bacteria or fungi from mucosa to joints, could contribute to the onset and flares of inflammatory rheumatisms...
January 21, 2019: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/30671181/a-novel-non-invasive-technique-of-measuring-bilirubin-levels-using-bilicapture
#20
Moattar Raza Rizvi, Farah Mansoor Alaskar, Raid Saleem Albaradie, Noor Fatima Rizvi, Khaled Al-Abdulwahab
Objectives: In preterm infants, hyperbilirubinemia is common and can impair the central nervous system. The tests available for measuring bilirubin is to collect blood from heel pricking and occasionally taking blood samples from inserted cannulas, which is painful. Therefore, there is a need to develop a non-invasive device to detect bilirubin levels in newborns and interpret the severity of jaundice. Methods: We conducted a cross-sectional study of 100 neonates...
January 2019: Oman Medical Journal
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