Felipe A Escalona-Rodriguez, Yoelys Cruz Leal, Javier La O-Bonet, Julio A PerezErviti, Mario Ernesto Valdés Tresanco, Ada L Rivero-Hernández, Maricary Sifontes-Niebla, Alexis MansoVargas, Belinda Sánchez, Carlos Alvarez, Leandro R S Barbosa, Rosangela Itri, María E Lanio
Non-viral gene delivery systems offer significant potential for gene therapy due to their versatility, safety, and cost advantages over viral vectors. However, their effectiveness can be hindered by the challenge of efficiently releasing the genetic cargo from endosomes to prevent degradation in lysosomes. To overcome this obstacle, functional components can be incorporated into these systems. Sticholysin II (StII) is one of the pore-forming proteins derived from the sea anemone Stichodactyla helianthus, known for its high ability to permeabilize cellular and model membranes...
December 21, 2023: Toxicon: Official Journal of the International Society on Toxinology