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biomaterials in surgery

Jaroslav Pelisek, Renate Hegenloh, Sabine Bauer, Susanne Metschl, Jessica Pauli, Nadiya Glukha, Albert Busch, Benedikt Reutersberg, Michael Kallmayer, Matthias Trenner, Heiko Wendorff, Pavlos Tsantilas, Sofie Schmid, Christoph Knappich, Christoph Schaeffer, Thomas Stadlbauer, Gabor Biro, Uta Wertern, Franz Meisner, Kerstin Stoklasa, Anna-Leonie Menges, Oksana Radu, Sabine Dallmann-Sieber, Angelos Karlas, Eva Knipfer, Christian Reeps, Alexander Zimmermann, Lars Maegdefessel, Hans-Henning Eckstein
Collecting biological tissue samples in a biobank grants a unique opportunity to validate diagnostic and therapeutic strategies for translational and clinical research. In the present work, we provide our long-standing experience in establishing and maintaining a biobank of vascular tissue samples, including the evaluation of tissue quality, especially in formalin-fixed paraffin-embedded specimens (FFPE). Our Munich Vascular Biobank includes, thus far, vascular biomaterial from patients with high-grade carotid artery stenosis ( n = 1567), peripheral arterial disease ( n = 703), and abdominal aortic aneurysm ( n = 481) from our Department of Vascular and Endovascular Surgery (January 2004⁻December 2018)...
February 16, 2019: Journal of Clinical Medicine
Rajat Vashistha, Prasoon Kumar, Arun Kumar Dangi, Naveen Sharma, Deepak Chhabra, Pratyoosh Shukla
Digitalization of health care practices is substantially manifesting itself as an effective tool to diagnose and rectify complex cardiovascular abnormalities. For cardiovascular abnormalities, precise non-invasive imaging interventions are being used to develop patient specific diagnosis and surgical planning. Concurrently, pre surgical 3D simulation and computational modeling are aiding in the effective surgery and understanding of valve biomechanics, respectively. Consequently, 3D printing of patient specific valves that can mimic the original one will become an effective outbreak for valvular problems...
2019: Journal of Biological Engineering
Iman Manavitehrani, Pegah Ebrahimi, Irene Yang, Sean Daly, Aaron Schindeler, Akshat Saxena, David G Little, David F Fletcher, Fariba Dehghani, David S Winlaw
Despite advances in modern surgery, congenital heart disease remains a medical challenge and major cause of infant mortality. Valved conduits are routinely used to surgically correct blood flow in hearts with congenital malformations by connecting the right ventricle to the pulmonary artery (RV-PA). This review explores the current range of RV-PA conduits and describes their strengths and disadvantages. Homografts and xenografts are currently the primary treatment modalities, however both graft types have limited biocompatibility and durability, and present a disease transmission risk...
February 14, 2019: Cardiovascular Engineering and Technology
Massimiliano Merola, Saverio Affatato
Replacement surgery of hip joint consists of the substitution of the joint with an implant able to recreate the articulation functionality. This article aims to review the current state of the art of the biomaterials used for hip implants. Hip implants can be realized with different combination of materials, such as metals, ceramics and polymers. In this review, we analyze, from international literature, the specific characteristics required for biomaterials used in hip joint arthroplasty, i.e., being biocompatible, resisting heavy stress, opposing low frictional forces to sliding and having a low wear rate...
February 5, 2019: Materials
Patrick J Louis, Anthony B Morlandt
For the 75th anniversary of the Journal of Oral and Maxillofacial Surgery, the authors were asked to review the past and examine advancements in the management of facial trauma. Several important advances in the management of maxillofacial trauma have resulted in improved outcomes. These include the development of high-resolution computed tomography, improved classification schemes, rigid fixation techniques, improved biomaterials, soft tissue resuspension, and primary bone grafting. Further advances in outcomes have occurred with the use of microsurgical techniques, free tissue transfer techniques, virtual surgical planning, endoscopic techniques, and surgical navigation...
November 2018: Journal of Oral and Maxillofacial Surgery
Sandeep Dhall, Turhan Coksaygan, Tyler Hoffman, Matthew Moorman, Anne Lerch, Jin-Qiang Kuang, Malathi Sathyamoorthy, Alla Danilkovitch
Post-operative adhesions, a common complication of surgery, cause pain, impair organ functionality, and often require additional surgical interventions. Control of inflammation, protection of injured tissue, and rapid tissue repair are critical for adhesion prevention. Adhesion barriers are biomaterials used to prevent adhesions by physical separation of opposing injured tissues. Current adhesion barriers have poor anti-inflammatory and tissue regenerative properties. Umbilical cord tissue (UT), a part of the placenta, is inherently soft, conforming, biocompatible, and biodegradable, with antimicrobial, anti-inflammatory, and antifibrotic properties, making it an attractive alternative to currently available adhesion barriers...
March 2019: Bioactive Materials
Antian Xu, Chuan Zhou, Wenting Qi, Fuming He
PURPOSE: The aim of this study was to investigate the in vivo performance, including bone regeneration and biomaterial degradation, of three hydroxyapatite-based bone substitutes at surgically created defects in the cranium of rabbits. MATERIALS AND METHODS: A bovine-derived hydroxyapatite (BHA), a synthetic hydroxyapatite (SHA), and a nano-hydroxyapatite with collagen I (nHAC) composite were characterized and then placed in calvarial defects in rabbits. After surgery at 6 weeks and 12 weeks, the animals were sacrificed for further microcomputed tomography, histologic, and histomorphometric analyses...
January 31, 2019: International Journal of Oral & Maxillofacial Implants
A Sculean, A Stavropoulos, D D Bosshardt
OBJECTIVE: To provide an overview on the self-regenerative capacity of various types of intraoral bone defects. MATERIALS AND METHODS: This paper has narratively reviewed the most important aspects of bone biology and the healing outcomes related to the self-regenerative capacity (i.e. without the placement of any biomaterial) of bone defects that occur following tooth extraction, autogenous graft harvesting, periapical lesions, cystic lesions of the jaws, third molar extraction and experimentally created ridge defects...
January 30, 2019: Journal of Clinical Periodontology
Rebecca A Hortensius, Jill H Ebens, Marley J Dewey, Brendan A C Harley
Tendon injuries often require surgical intervention and even then result in poor outcomes due to scar formation and repeated failure. Biomaterial implants offer the potential to address multiple underlying concerns preventing improved tendon repair. Here, we describe modifications to the composition of an anisotropic collagen-glycosaminoglycan (CG) scaffold biomaterial, incorporating amniotic membrane (AM)-derived matrix to alter the inflammatory response and establish conditions for improved regenerative repair...
December 10, 2018: ACS Biomaterials Science & Engineering
Pedro Henrique Silva Gomes Ferreira, Danila De Oliveira, Ciro Borges Duailibe De Deus, Roberta Okamoto
The aim of this study was to use a literature review to evaluate and compare the different biomaterials used in surgeries for the closure of the palatal and alveolar clefts as alternatives to isolated autografting. For the search strategy, the PubMed and Medline databases were used with the indexing terms "'cleft palate' (Mesh), 'biocompatible materials' (Mesh), and 'dentistry' (Mesh)." There was no restriction on language or publication time. After the research, 26 articles were found, and then, only the filter for clinical trials was selected...
July 2018: Annals of Maxillofacial Surgery
Felix Heymann, Klaus-Thilo von Trotha, Christian Preisinger, Petra Lynen-Jansen, Anjali A Roeth, Melanie Geiger, Lukas Jonathan Geisler, Anna Katharina Frank, Joachim Conze, Tom Luedde, Christian Trautwein, Marcel Binnebösel, Ulf P Neumann, Frank Tacke
Polypropylene meshes that are commonly used for inguinal hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages expressing high levels of inflammatory activation markers. In mice, mesh implantation by the onlay technique induced rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloid cells segregated into distinct macrophage subsets with separate spatial distribution, activation profiles, and functional properties, showing a stable inflammatory phenotype in the tissue surrounding the biomaterial and a mixed, wound-healing phenotype in the surrounding stromal tissue...
January 24, 2019: JCI Insight
Agata Przekora
The aim of engineering of biomaterials is to fabricate implantable biocompatible scaffold that would accelerate regeneration of the tissue and ideally protect the wound against biodevice-related infections, which may cause prolonged inflammation and biomaterial failure. To obtain antimicrobial and highly biocompatible scaffolds promoting cell adhesion and growth, materials scientists are still searching for novel modifications of biomaterials. This review presents current trends in the field of engineering of biomaterials concerning application of various modifications and biophysical stimulation of scaffolds to obtain implants allowing for fast regeneration process of bone and cartilage as well as providing long-lasting antimicrobial protection at the site of injury...
January 20, 2019: International Journal of Molecular Sciences
Moriarty T Fintan, Harris G Llinos, Mooney A Robert, Wenke C Joseph, Riool Martijn, Zaat Aj Sebastian, Moter Annette, Schaer P Thomas, Khanna Nina, Kuehl Richard, Alt Volker, Montali Andrea, Liu Jianfeng, Zeiter Stephan, Busscher HenkJ, Grainger W David, Richards R Geoff
Orthopedic device-related infection (ODRI), including both fracture-related infection (FRI) and periprosthetic joint infection (PJI), remain amongst the most challenging complications in orthopedic and musculoskeletal trauma surgery. ODRI has been convincingly shown to delay healing, worsen functional outcome and incur significant socio-economic costs. To address this clinical problem, ever more sophisticated technologies targeting the prevention and/or treatment of ODRI are being developed and tested in vitro and in vivo...
January 22, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Xingwang Liu, Chen Chen, Hangzhou Zhang, Ang Tian, Junhua You, Lin Wu, Zeming Lei, Xi Li, Xizhuang Bai, Shiyi Chen
Background: Implant-related infection is a major problem postsurgery. As an alternative to a localized antibiotic release system, we used Ag to fabricate Ti-Ag alloys with nanotubular coatings (TiAg-NTs). Ag has excellent antibacterial properties, but its biological toxicity is a concern. Therefore, we performed biological experiments both in vitro and in vivo to evaluate the biocompatibility of TiAg-NTs with different concentrations of Ag (1%, 2%, and 4%). Methods: For in vitro experiments, cytocompatibility, including cell attachment, viability, and proliferation, was tested, and genes and proteins related to osteogenic differentiation were also evaluated...
2019: International Journal of Nanomedicine
Yuxiao Lai, Ye Li, Huijuan Cao, Jing Long, Xinluan Wang, Long Li, Cairong Li, Qingyun Jia, Bin Teng, Tingting Tang, Jiang Peng, David Eglin, Mauro Alini, Dirk W Grijpma, Geoff Richards, Ling Qin
Bone defect repair is a challenging clinical problem in musculoskeletal system, especially in orthopaedic disorders such as steroid associated osteonecrosis (SAON). Magnesium (Mg) as a biodegradable metal with properly mechanical properties has been investigating for a long history. In this study, Mg powder, poly (lactide-co-glycolide) (PLGA), β-tricalcium phosphate (β-TCP) were the elements to formulate a novel porous PLGA/TCP/Mg (PTM) scaffolds using low temperature rapid prototyping (LT-RP) technology...
January 7, 2019: Biomaterials
Sepideh Kamrani, Claudia Fleck
The study of innovative biodegradable implant materials is one of the most interesting research topics at the forefront in the area of biomaterials. Biodegradable implant materials in the human body can be gradually dissolved, absorbed, consumed or excreted, so there is no need for the secondary surgery to remove implants after the surgery regions have healed. However, most of the biodegradable materials, usually polymers, do not have good mechanical properties to be reliable for bearing the load of the body...
January 18, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Cristiana R Carvalho, Joana Silva-Correia, Joaquim M Oliveira, Rui L Reis
The recent progress in biomaterials science and development of tubular conduits (TCs) still fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in particular when disease-related and long-gap defects need to be addressed. Nanotechnology-based therapies that seemed unreachable in the past are now being considered for the repair and reconstruction of PNIs, having the power to deliver bioactive molecules in a controlled manner, to tune cellular behavior, and ultimately guide tissue regeneration in an effective manner...
January 10, 2019: Advanced Drug Delivery Reviews
Kewen Lei, Li Tang
Immunotherapy can harness the power of host's immune system to fight cancer. In the last few decades, tremendous progress has been made in this field, with remarkable clinical successes achieved consisting of a durable response in a fraction of patients. However, there are enormous challenges to extending this therapy to the majority of cancer patients while retaining minimal adverse effects. Local immunotherapy is a promising approach for concentrating immunomodulation in situ without systemic exposure, therefore minimizing systemic toxicities...
January 14, 2019: Biomaterials Science
Ming Lu, Song Xu, Zi-Xiong Lei, Dong Lu, Wei Cao, Marko Huttula, Chang-He Hou, Shao-Hua Du, Wei Chen, Shuang-Wu Dai, Hao-Miao Li, Da-Di Jin
BACKGROUND: Some porous materials have been developed to enhance biologic fusion of the implants to bone in spine fusion surgeries. However, there are several inherent limitations. In this study, a novel biomedical porous tantalum was applied to in vitro and in vivo experiments to test its biocompatibility and osteocompatibility. METHODS: Bone marrow-derived mesenchymal stem cells (BMSCs) were cultured on porous tantalum implant. Scanning electron microscope (SEM) and Cell Counting Kit-8 assay were used to evaluate the cell toxicity and biocompatibility...
January 5, 2019: Chinese Medical Journal
Andrzej Hudecki, Dorota Łyko-Morawska, Wirginia Likus, Magdalena Skonieczna, Jarosław Markowski, Renata Wilk, Aleksandra Kolano-Burian, Wojciech Maziarz, Jolanta Adamska, Marek J Łos
We have tested titanium (Ti) plates that are used for bone reconstruction in maxillofacial surgery, in combination with five types of novel long-resorbable biomaterials: (i) PCL₀-polycaprolactone without additives, (ii) PCLMWCNT -polycaprolactone with the addition of multiwall carbon nanotubes (MWCNT), (iii) PCLOH -polycaprolactone doped with multiwall carbon nanotubes (MWCNT) containing ⁻OH hydroxyl groups, (iv) PCLCOOH -polycaprolactone with the addition of multiwall carbon nanotubes (MWCNT) containing carboxyl groups, and (v) PCLTI -polycaprolactone with the addition of Ti nanoparticles...
January 4, 2019: Nanomaterials
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