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antimicrobial sutures

Sandeep Dhall, Turhan Coksaygan, Tyler Hoffman, Matthew Moorman, Anne Lerch, Jin-Qiang Kuang, Malathi Sathyamoorthy, Alla Danilkovitch
Post-operative adhesions, a common complication of surgery, cause pain, impair organ functionality, and often require additional surgical interventions. Control of inflammation, protection of injured tissue, and rapid tissue repair are critical for adhesion prevention. Adhesion barriers are biomaterials used to prevent adhesions by physical separation of opposing injured tissues. Current adhesion barriers have poor anti-inflammatory and tissue regenerative properties. Umbilical cord tissue (UT), a part of the placenta, is inherently soft, conforming, biocompatible, and biodegradable, with antimicrobial, anti-inflammatory, and antifibrotic properties, making it an attractive alternative to currently available adhesion barriers...
March 2019: Bioactive Materials
Tuba Baygar, Nurdan Sarac, Aysel Ugur, Inci Rana Karaca
Surgical sutures play important role during the wound healing of the surgical sites which are known to be sensitive to microbial infections. Silver nanoparticles (AgNPs) have been recently used as promising agents against multiple-drug resistant microorganisms. This study was designed to coat the sutures with silver nanoparticles obtained via a green synthesis approach. Microbial-mediated biological synthesis of AgNPs were carried out ecofriendly using Streptomyces sp. AU2 cell-free extract and deposited on silk sutures through an in situ process...
December 27, 2018: Bioorganic Chemistry
David M Krpata
BACKGROUND: The management of incisions and decisions on closure techniques for surgical wounds are driven by expected incisional morbidity and the severity of the potential morbidity for the patient. METHODS: This article reviews current literature on the potential strategies to be considered in closing the skin and fascia of incisions. RESULTS: The review of the literature indicates that low-risk wounds for infection should be closed primarily with subcuticular suture, and adjunctive local measures should be avoided...
December 11, 2018: Surgical Infections
Leonello Tacconi, Roberto Spinelli, Francesco Signorelli
BACKGROUND: Traditional wound closure techniques include skin sutures and metal clips. Cyanoacrylate has good neovascularization, epithelialization, and antimicrobial activity properties and a fast application procedure. This study presents our long-term experience. METHODS: We retrospectively selected 362 patients who underwent brain surgery from January 2007 to March 2017. Exclusion criteria were applied for repeat surgeries, emergency/posttraumatic procedures, wound infections, wounds longer than 16 cm, skull base cases, and postoperative patients who stayed in the intensive care unit more than 1 day...
October 15, 2018: World Neurosurgery
M G Onesti, S Carella, N Scuderi
OBJECTIVE: Surgical site infections (SSIs) are the third most common hospital-acquired infections and account for 14% to 16% of all such infections, and suture material may play a role in SSI rate. Given this risk of infection, sutures with antimicrobial activity have been developed. Both in vitro and in vivo experiments have shown that triclosan-coated sutures (TCS) are effective in the prevention of SSIs. Our aim is to analyze currently available RCTs, comparing the effect of antimicrobial-coated suture (ACS) with uncoated suture on the occurrence of SSIs following surgical procedures, we highlighted major contributions of most significant studies and evaluate the current "state of the art" on antimicrobial-coated sutures...
September 2018: European Review for Medical and Pharmacological Sciences
Utku Kürşat Ercan, Fatma İbiş, Caner Dikyol, Nesrin Horzum, Ozan Karaman, Çağla Yıldırım, Elif Çukur, Emine Afra Demirci
Surgical site infections have a remarkable impact on morbidity, extended hospitalization and mortality. Sutures strongly contribute to development of surgical site infections as they are considered foreign material in the human body. Sutures serve as excellent surfaces for microbial adherence and subsequent colonization, biofilm formation and infection on the site of a surgery. Various antimicrobial sutures have been developed to prevent suture-mediated surgical site infection. However, depending on the site of surgery, antimicrobial sutures may remain ineffective, and antimicrobial agents on them might have drawbacks...
2018: PloS One
Eldad Adler, Darlene Miller, Oded Rock, Oriel Spierer, Richard Forster
AIM: To investigate the relationships between corneal suture bacteriology, biofilm and the clinical setting using culture studies and scanning electron microscopy (SEM). METHODS: This is a prospective, observational study of patients with a history of penetrating keratoplasty presenting to a tertiary cornea clinic for routine or symptoms-related corneal suture removal. We documented for each patient the suture clinical setting (quiescent, exposed and keratitis-related), retention time, antimicrobial therapy, bacterial growth on culture studies, and bacterial presence and biofilm coverage on SEM...
November 2018: British Journal of Ophthalmology
Anna Lucia Gallo, Mauro Pollini, Federica Paladini
Chronic wounds and related infections cause physical and psychological distress in patients, increased mortality, disability and high health care costs. The healing process can be delayed by several factors and in particular by the risk of infections, which can be further complicated by the increasing number of antibiotic-resistant microorganisms. New approaches in wounds management have been encouraged, aiming at preventing infections and improving wound healing. In this scenario, silver has emerged as an ideal antimicrobial agent due to its recognized efficacy against bacteria, viruses and fungi...
August 9, 2018: Journal of Materials Science. Materials in Medicine
R L Nelson, A Kravets, R Khateeb, M Raza, M Siddiqui, I Taha, A Tummala, R Epple, S Huang, M Wen
BACKGROUND: Among the techniques investigated to reduce the risk of surgical wound infection or surgical space infection (SSI) in patients having colorectal surgery are topical application of antimicrobials (antibiotics and antiseptics) to the open wound or immediately after closure. The aim of the present study was to perform a systematic review of the literature on those treatments, with the exception of antibiotic ointments applied to closed skin, which are adequately assessed elsewhere, and a meta-analysis...
August 2018: Techniques in Coloproctology
Motoi Uchino, Toru Mizuguchi, Hiroki Ohge, Seiji Haji, Junzo Shimizu, Yasuhiko Mohri, Chizuru Yamashita, Yuichi Kitagawa, Katsunori Suzuki, Motomu Kobayashi, Masahiro Kobayashi, Fumie Sakamoto, Masahiro Yoshida, Toshihiko Mayumi, Koichi Hirata
BACKGROUND: Antimicrobial-coated sutures have recently become well known for preventing surgical site infections (SSIs). However, the evidence and recommendations from some organizations remain controversial. Therefore, we conducted a systematic review and meta-analysis to analyze the efficacy of antimicrobial-coated sutures for preventing SSIs in digestive surgery. METHODS: We performed a systematic review of literature published from 2000 to 2017 (registered on PROSPERO, No...
June 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
X Wu, N Z Kubilay, J Ren, B Allegranzi, P Bischoff, B Zayed, D Pittet, J Li
In the original version of this article, reference citations found in Tables 2, 3, and 4 contain errors in linking. The correct tables are reproduced below.
May 24, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Bruno Frota Amora-Silva, S C Ribeiro, C L Vieira, F R Mendes, A E Vieira-Neto, A P V Abdon, F N Costa, A R Campos
OBJECTIVES: The present study aimed to evaluate the efficacy of α-bisabolol (BISA)-based mouthwashes in the oral hygiene of patients submitted to oral and maxillofacial surgery. MATERIALS AND METHODS: A randomized, controlled, triple-blind clinical trial was conducted with 30 patients, undergoing oral and maxillofacial surgery. Three types of mouthwashes were developed, based at 0.12% chlorhexidine, 0.5% BISA, and 0.12% chlorhexidine + 0.5% BISA. The patients were evaluated in the preoperative and postoperative period, divided into three groups according to the mouthwash to be used...
May 3, 2018: Clinical Oral Investigations
Josep M Badia, Anna L Casey, Inés Rubio-Pérez, Cynthia Crosby, Nares Arroyo-García, José M Balibrea
BACKGROUND: The knowledge of the grade of implementation of preventative measures for surgical site infection (SSI) is crucial prior to planning dissemination strategies. METHODS: Online survey among the members of the Spanish Association of Surgeons (AEC) to know the actual application of measures, and to compare them with new recommendations issued by international organizations. RESULTS: Most of the 835 responding surgeons work in National Health Service Hospitals (91...
June 2018: International Journal of Surgery
Shih-Jie Lin, Fu-Chun Chang, Tsan-Wen Huang, Kuo-Ti Peng, Hsin Nung Shih, Mel S Lee
The risk of surgical site infections (SSIs) after total knee arthroplasty (TKA) can never be eliminated. Antimicrobial sutures containing triclosan have been used to decrease SSIs, but whether triclosan-coated sutures are effective with TKA is unclear. Between 2011 and 2012, 102 patients randomly assigned to a triclosan or a control group were prospectively assessed. The incidence of SSI within 3 months of surgery, length of hospital stay, pain scale, functional scores, wound condition, and serum inflammatory markers during hospitalization and within 3 months postoperatively were compared...
2018: BioMed Research International
Andreas Obermeier, Jochen Schneider, Norbert Harrasser, Jutta Tübel, Heinrich Mühlhofer, Dominik Pförringer, Constantin von Deimling, Peter Foehr, Barbara Kiefel, Christina Krämer, Axel Stemberger, Matthias Schieker, Rainer Burgkart, Rüdiger von Eisenhart-Rothe
[This corrects the article DOI: 10.1371/journal.pone.0190912.].
2018: PloS One
Andreas Obermeier, Jochen Schneider, Norbert Harrasser, Jutta Tübel, Heinrich Mühlhofer, Dominik Pförringer, Constantin von Deimling, Peter Foehr, Barbara Kiefel, Christina Krämer, Axel Stemberger, Matthias Schieker, Rainer Burgkart, Rüdiger von Eisenhart-Rothe
BACKGROUND: Surgical sutures can promote migration of bacteria and thus start infections. Antiseptic coating of sutures may inhibit proliferation of adhered bacteria and avoid such complications. OBJECTIVES: This study investigated the inhibition of viable adhering bacteria on novel antimicrobially coated surgical sutures using chlorhexidine or octenidine, a critical factor for proliferation at the onset of local infections. The medical need, a rapid eradication of bacteria in wounds, can be fulfilled by a high antimicrobial efficacy during the first days after wound closure...
2018: PloS One
O Dubovyk, М Mishyna, S Malanchuk, A Kuzmenko, O Kozlov
The purpose of the study - assessment of purulent-inflammatory processes etiologic factors and determination of microbial agents' in forms of plankton and biofilms sensitivity to antibiotics. Clinical microbial strains isolated from patients with purulent-inflammatory processes were the subject of the study. The study material comprised of wound tissue, pus, bandage and suture, catheters and drainage devices. Sensitivity of isolates to antimicrobial preparations with various mechanism of activity on the microbial cells was studied with the help of micro-test system...
October 2017: Georgian Medical News
Shixuan Chen, Liangpeng Ge, Adrian F Gombart, Franklin D Shuler, Mark A Carlson, Debra A Reilly, Jingwei Xie
AIM: The aim of this study was to develop nanofiber-based sutures capable of inducing endogenous antimicrobial peptide production. METHODS: We used co-axial electrospinning deposition and rolling to fabricate sutures containing pam3CSK4 peptide and 25-hydroxyvitamin D3 (25D3 ). RESULTS: The diameters and mechanical properties of the sutures were adjustable to meet the criteria of United States Pharmacopeia designation. 25D3 exhibited a sustained release from nanofiber sutures over 4 weeks...
November 2017: Nanomedicine
Michael V DeFazio, James M Economides, Ersilia L Anghel, Ryan K Mathis, John R Barbour, Christopher E Attinger
BACKGROUND/OBJECTIVE: Loss of domain often complicates attempts at delayed wound closure in regions of high tension. Wound temporization with traction-assisted internal negative pressure wound therapy (NPWT), using bridging retention sutures, can minimize the effects of edema and elastic recoil that contribute to progressive tissue retraction over time. The investigators evaluated the safety and efficacy of this technique for complex wound closure. MATERIALS AND METHODS: Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures...
October 2017: Wounds: a Compendium of Clinical Research and Practice
Maryanne Z A Mariyaselvam, Ken R Catchpole, David K Menon, Arun K Gupta, Peter J Young
BACKGROUND: Retained central venous catheter guidewires are never events. Currently, preventative techniques rely on clinicians remembering to remove the guidewire. However, solutions solely relying upon humans to prevent error inevitably fail. A novel locked procedure pack was designed to contain the equipment required for completing the procedure after the guidewire should have been removed: suture, suture holder, and antimicrobial dressings. The guidewire is used as a key to unlock the pack and to access the contents; thereby, the clinician must remove the guidewire from the patient to complete the procedure...
October 2017: Anesthesiology
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