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Patricia Brasil

Carina Pacheco Cantelli, Marcelle Figueira Marques da Silva, Tulio Machado Fumian, Denise Cotrim da Cunha, Juliana da Silva Ribeiro de Andrade, Fábio Correia Malta, Sérgio da Silva E Mouta Junior, Alexandre Madi Fialho, Marcia Terezinha Baroni de Moraes, Patricia Brasil, Marize Pereira Miagostovich, José Paulo Gagliardi Leite
We report on the occurrence and diversity of noroviruses in children (younger than 5 years old of age) from a low-income urban area in Rio de Janeiro, Brazil. Sixty-one stool specimens collected from children between 1 and 4 years old with acute diarrhoeic episodes (ADE) and non-ADE were investigated. RT-qPCR and sequencing of PCR products after conventional RT-PCR analysis were performed. Noroviruses were detected in 29 (47.5%) samples: 21 (46.7%) from cases with ADE and 8 (50%) from non-ADE cases. Molecular characterization showed 10 different genotypes circulating in this community between November 2014 and April 2018...
March 11, 2019: Archives of Virology
Dusan Kostic, Glenda Priscila Neves Dos Santos Beozzo, Saulo Brasil do Couto, André Henrique Teruaki Kato, Laila Lima, Patricia Palmeira, Vera Lúcia Jornada Krebs, Victor Bunduki, Rossana Pulcineli Vieira Francisco, Marcelo Zugaib, Werther Brunow de Carvalho, Vera Hermina Kalika Koch
BACKGROUND: Diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. Use of renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and prevention or minimization of definitive renal damage. METHODS: This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-β1), retinol-binding protein (RBP), cystatin C (uCyC), and microalbuminuria (μALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight...
January 29, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Fátima C P A Di Maio Ferreira, Anamaria S V da Silva, Ana M Bispo de Filippis, Patrícia Brasil
We report here a probable case of vertical transmission of chikungunya infection with confirmed maternal viremia close to labor that led to severe infection in the newborn. The newborn progressed with cutaneous lesions and irritability 2 months after vertical transmission, when chikungunya virus was detected in the infant's CSF by a molecular diagnostic test (real-time polymerase chain reaction).
January 18, 2019: Journal of the Pediatric Infectious Diseases Society
Christa Einspieler, Fabiana Utsch, Patricia Brasil, Carolina Y Panvequio Aizawa, Colleen Peyton, Renata Hydee Hasue, Fernanda Françoso Genovesi, Luana Damasceno, Maria Elisabeth Moreira, Kristina Adachi, Peter B Marschik, Karin Nielsen-Saines
Importance: There is an urgent need to assess neurodevelopment in Zika virus (ZIKV)-exposed infants. Objectives: To perform general movement assessment (GMA) at 9 to 20 weeks' postterm age and to evaluate whether the findings are associated with neurodevelopmental outcomes at age 12 months in infants prenatally exposed to acute maternal illness with rash in Brazil during the ZIKV outbreak and in age-matched controls. Design, Setting, and Participants: In this cohort study, infants prenatally exposed to acute maternal illness with rash were recruited at medical institutions in Rio de Janeiro and Belo Horizonte, Brazil, from February 1, 2016, to April 30, 2017, while infants without any exposure to maternal illness originated from the Graz University Audiovisual Research Database for the Interdisciplinary Analysis of Neurodevelopment...
January 4, 2019: JAMA Network Open
Jose Paulo Pereira, Karin Nielsen-Saines, Jeffrey Sperling, Melanie M Maykin, Luana Damasceno, Renan Fonseca Cardozo, Helena Abreu Valle, Beatriz Ribeiro Torres Dutra, Helder Dotta Gama, Kristina Adachi, Andrea A Zin, Irena Tsui, Zilton Vasconcelos, Patricia Brasil, Maria E Moreira, Stephanie L Gaw
Importance: Congenital Zika virus infection causes a spectrum of adverse birth outcomes, including severe birth defects of the central nervous system. The association of prenatal ultrasonographic findings with adverse neonatal outcomes, beyond structural anomalies such as microcephaly, has not been described to date. Objective: To determine whether prenatal ultrasonographic examination results are associated with abnormal neonatal outcomes in Zika virus-affected pregnancies...
December 7, 2018: JAMA Network Open
Jose Paulo Pereira, Melanie M Maykin, Zilton Vasconcelos, Elyzabeth Avvad-Portari, Andrea A Zin, Irena Tsui, Patricia Brasil, Karin Nielsen-Saines, Maria E Moreira, Stephanie L Gaw
There is limited data on amniocentesis as a diagnostic tool for congenital Zika syndrome. Here we report on a prospective cohort of 16 women with suspected Zika virus infection in a highly endemic area, and discusss the role of amniocentesis in the prenatal diagnosis of fetal Zika infection.
January 8, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
M Elisabeth Lopes Moreira, Karin Nielsen-Saines, Patricia Brasil, Tara Kerin, Luana Damasceno, Marcos Pone, Liege M A Carvalho, Sheila M Pone, Zilton Vasconcelos, Ieda P Ribeiro, Andrea A Zin, Irena Tsui, Kristina Adachi, Stephanie L Gaw, Umme-Aiman Halai, Tania S Salles, Denise C da Cunha, Myrna C Bonaldo, Claudia Raja Gabaglia, Leticia Guida, Jociele Malacarne, Roozemerie P Costa, S Clair Gomes, A Beatriz Reis, Fernanda V M Soares, Renata H Hasue, Carolina Y P Aizawa, Fernanda F Genovesi, Mitsue Aibe, Christa Einspieler, Peter B Marschik, J Paulo Pereira, Elyzabeth A Portari, Carla Janzen, James D Cherry
New England Journal of Medicine, Volume 379, Issue 24, Page 2377-2379, December 2018.
December 13, 2018: New England Journal of Medicine
Suan-Sin Foo, Weiqiang Chen, Yen Chan, Wai-Suet Lee, Shin-Ae Lee, Genhong Cheng, Karin Nielsen-Saines, Patrícia Brasil, Jae U Jung
BACKGROUND: An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations. METHODS: To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV+ pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles...
November 2, 2018: JCI Insight
Andrea A Zin, Irena Tsui, Julia D Rossetto, Stephanie L Gaw, Luiza M Neves, Olivia A Zin, Lorena Haefeli, Joel Carlos Barros Silveira Filho, Kristina Adachi, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Natalia Molleri, Jose Paulo Pereira, Rubens Belfort, Vaithilingaraja Arumugaswami, Zilton Vasconcelos, Patricia Brasil, Karin Nielsen-Saines, Maria Elisabeth Lopes Moreira
PURPOSE: To report the findings of a cross-sectional study of visual function in infants with confirmed or suspected antenatal Zika virus (ZIKV) infection seen at a single referral center in Rio de Janeiro. METHODS: Infants were examined following the ZIKV outbreak period at Instituto Fernandes Figueira/FIOCRUZ. Visual function was considered abnormal if an infant could not fix and follow a standardized high-contrast target (10 cm) by 3-6 months of age. Visual function and associations with structural eye abnormalities, central nervous system (CNS) abnormalities, microcephaly, and nystagmus were assessed...
December 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Kathleen M O'Reilly, Rachel Lowe, W John Edmunds, Philippe Mayaud, Adam Kucharski, Rosalind M Eggo, Sebastian Funk, Deepit Bhatia, Kamran Khan, Moritz U G Kraemer, Annelies Wilder-Smith, Laura C Rodrigues, Patricia Brasil, Eduardo Massad, Thomas Jaenisch, Simon Cauchemez, Oliver J Brady, Laith Yakob
BACKGROUND: Zika virus (ZIKV) emerged in Latin America and the Caribbean (LAC) region in 2013, with serious implications for population health in the region. In 2016, the World Health Organization declared the ZIKV outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. In 2017, Zika cases declined, but future incidence in LAC remains uncertain due to gaps in our understanding, considerable variation in surveillance and the lack of a comprehensive collation of data from affected countries...
October 3, 2018: BMC Medicine
Filipe Vieira Santos de Abreu, Larissa Rodrigues Gomes, Aline Rosa Lavigne Mello, Cesare Bianco-Júnior, Anielle de Pina-Costa, Edmilson Dos Santos, Danilo Simonini Teixeira, Patrícia Brasil, Cláudio Tadeu Daniel-Ribeiro, Ricardo Lourenço-de-Oliveira, Maria de Fátima Ferreira-da-Cruz
BACKGROUND: Zoonotic infections with epidemic potential, as non-human primate malaria and yellow fever (YF), can overlap geographically. Optimizing a small blood sample for diagnosis and surveillance is of great importance. Blood are routinely collected for YF diagnosis and blood clots usually discarded after serum obtention. Aiming to take sample advantage, the sensitivity of a PCR using extracted DNA from long-term frozen clots from human and non-human primates for detection of Plasmodium spp...
September 24, 2018: Malaria Journal
Irena Tsui, Maria Elisabeth Lopes Moreira, Julia D Rossetto, Zilton Vasconcelos, Stephanie L Gaw, Luiza M Neves, Olivia A Zin, Lorena Haefeli, Joel Carlos Barros Silveira Filho, Saint Clair Gomes, Kristina Adachi, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Jose Paulo Pereira, Rubens Belfort, Vaithilingaraja Arumugaswami, Patricia Brasil, Karin Nielsen-Saines, Andrea A Zin
: media-1vid110.1542/5804915134001PEDS-VA_2018-1104 Video Abstract OBJECTIVES: To characterize ophthalmic manifestations of confirmed or suspected antenatal Zika virus (ZIKV) exposure. METHODS: Infants with antenatal ZIKV exposure were referred for evaluation during the 2015-2016 Rio de Janeiro outbreak. Mothers with symptomatic ZIKV infection during pregnancy and/or infants with microcephaly or other findings that were suggestive of suspected antenatal exposure were tested with reverse transcriptase polymerase chain reaction (RT-PCR)...
October 2018: Pediatrics
Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, Michel Mansur Machado
Hypertension, a chronic non-transmissible multifactorial condition, it is highly frequent in Brazil, affecting about 32.5% of the population over 25 years of age. It is characterized by the sustained increase in systolic and diastolic blood pressure levels above 140 mmHg and 90 mmHg, respectively. It is the major aggravating factor in cardiovascular complications and the appearance of other comorbidities. Aiming to promote greater adherence to treatment and improve the population's access to basic medicament, in 2004 the Federal Government created the Programa Farmácia Popular do Brasil (PFPB); partnership with private institutions that provides the population with medicament to control hypertension, free of charge or subsidized at up to 90% of the value...
October 2018: Environmental Toxicology and Pharmacology
Larissa Rodrigues Gomes, Aline Lavigne, Cassio Leonel Peterka, Patrícia Brasil, Didier Ménard, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz
Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch ( PfK13 ) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre ( n = 14), Amapá ( n = 15), Amazonas ( n = 30), and Pará ( n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas...
October 2018: Antimicrobial Agents and Chemotherapy
Amanda Q Lemos, Cristina A Brasil, Cecília M Alvares, Jaqueline C G Passos, Patrícia Lordêlo, Katia N Sá
AIMS: To Compare the angular parameters of the pelvis of continents and incontinent women and to correlate them with the electrical activity and the function of the pelvic floor muscles. METHODS: Cross-sectional study. Incontinent and continent women, aged between 18 and 59 years. The anatomical points were marked following the SAPO protocols, the photographic records were made and analyzed through the SAPO Software. The evaluation of the function of the MPF was performed by bidigital vaginal palpation, using the PERFECT scheme...
November 2018: Neurourology and Urodynamics
Guilherme Amaral Calvet, Patricia Brasil, Andre Machado Siqueira, Heruza Einsfeld Zogbi, Bianca de Santis Gonçalves, Aline da Silva Santos, Otilia Lupi, Rogerio Valls de Souza, Cintia Damasceno Dos Santos Rodrigues, Clarisse da Silveira Bressan, Mayumi Duarte Wakimoto, Eliane Saraiva de Araújo, Ingrid Cardoso Dos Santos, Ingebourg Georg, Rita Maria Ribeiro Nogueira, Valdilea Gonçalves Veloso, Ana Maria Bispo de Filippis
BACKGROUND: Zika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. OBJECTIVES: We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients. METHODS: HIV-infected patients aged 18 years and older with clinical suspected arboviral disease from an ongoing cohort were followed from February 2015 through December 2015...
October 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
J Moreira, C S Bressan, P Brasil, A M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America are diverse and their complexity increases as the proportion of fever due to malaria decreases, as malaria control measures and new pathogens emerge in the region. In this context, it is important to shed light on the gaps in the epidemiological characteristics and the geographic range for many AFI aetiologies. OBJECTIVES: To review studies on community-acquired fever aetiology other than malaria in Latin America, and to highlight knowledge gaps and challenges needing further investigation...
August 2018: Clinical Microbiology and Infection
Edson Delatorre, Milene Miranda, Diogo A Tschoeke, Patrícia Carvalho de Sequeira, Simone Alves Sampaio, Giselle Barbosa-Lima, Yasmine Rangel Vieira, Luciana Leomil, Fernando A Bozza, José Cerbino-Neto, Patricia T Bozza, Rita Maria Ribeiro Nogueira, Patrícia Brasil, Fabiano L Thompson, Ana M B de Filippis, Thiago Moreno L Souza
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine)...
May 17, 2018: Journal of General Virology
Tania Ayllón, Daniel Cardoso Portela Câmara, Fernanda Cristina Morone, Larissa da Silva Gonçalves, Fábio Saito Monteiro de Barros, Patrícia Brasil, Marilia Sá Carvalho, Nildimar Alves Honório
Aedes albopictus, originally considered as a secondary vector for arbovirus transmission, especially in areas where this species co-exist with Aedes aegypti, has been described in most regions of the world. Dispersion and domiciliation of Ae. albopictus in a complex of densely urbanized slums in Rio de Janeiro, Southeastern Brazil, was evidenced. In this study, we tested the hypotheses that 1) Ae. albopictus distribution in urban slums is negatively related to distance from vegetation, and 2) these vectors have taken on a domestic life style with a portion of the population feeding, ovipositing, and resting indoors...
2018: PloS One
Patricia de Oliveira da Silva, Joanna Miguez Nery Guimarães, Rosane Härter Griep, Enirtes Caetano Prates Melo, Sheila Maria Alvim Matos, Maria Del Carmem Molina, Sandhi Maria Barreto, Maria de Jesus Mendes da Fonseca
This study investigated whether the association between body image dissatisfaction and poor self-rated health is mediated by insufficient physical activity and unhealthy eating habits. The participants were 6727 men and 8037 women from the baseline (2008–2010) of the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto, ELSA-Brasil). Structural equation modelling was used. Associations were found between body image dissatisfaction and poor self-rated health in both sexes...
April 18, 2018: International Journal of Environmental Research and Public Health
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