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https://read.qxmd.com/read/30899874/interleukin-6-contributes-to-the-development-of-anemia-in-juvenile-ckd
#1
Oleh Akchurin, Edwin Patino, Vidhi Dalal, Kelly Meza, Divya Bhatia, Simon Brovender, Yuan-Shan Zhu, Susanna Cunningham-Rundles, Eduardo Perelstein, Juhi Kumar, Stefano Rivella, Mary E Choi
Introduction: Anemia is a common complication of chronic kidney disease (CKD) in children; however, the role of inflammation in its pathogenesis remains incompletely understood. Methods: To elucidate the role of interleukin (IL)-6 in renal anemia, we induced CKD by adenine diet in juvenile wild-type (WT) and IL-6 deficient ( Il6 KO) mice, and examined serum IL-6 and relevant parameters in children with CKD. Results: WT-CKD mice developed anemia despite increases in serum erythropoietin and displayed low serum iron and elevated serum IL-6...
March 2019: KI Reports
https://read.qxmd.com/read/30898041/need-for-whole-large-bowel-investigation-in-sole-change-in-bowel-habit-an-analysis-of-719-patients
#2
Krashna Patel, Thomas Athisayaraj, Amitabh Mishra
Purpose/Aim of the study: Patients referred for suspected colorectal cancer typically undergo whole large bowel investigation (WLBI) as per national guidelines. Sole change in bowel habit (CIBH) with no anemia/abdominal mass at time of referral has low oncological yield following diagnostic investigations, particularly for tumors proximal to the splenic flexure. Study aims were to evaluate cancer yield of patients referred for suspected colorectal cancer presenting with sole-symptom CIBH and to assess clinical and financial feasibility of a straight-to-test flexible sigmoidoscopy (FS)...
March 21, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30896276/red-blood-cell-transfusion-in-palliative-care-a-survey-of-palliative-care-physicians
#3
Nicolas Chin-Yee, Joshua Taylor, James Downar, Peter Tanuseputro, Elianna Saidenberg
BACKGROUND: Red blood cell transfusion is one therapeutic option for the treatment of anemia. Current transfusion practices and factors influencing the decision to prescribe this therapy are not well understood. OBJECTIVE: To explore current transfusion practices, attitudes, and factors that influence the decision to transfuse among palliative care physicians. DESIGN: Self-administered questionnaire addressing clinical experiences and decision making pertaining to blood transfusion...
March 21, 2019: Journal of Palliative Medicine
https://read.qxmd.com/read/30894885/renal-anemia-and-hydration-status-in-non-dialysis-chronic-kidney-disease-is-there-a-link
#4
Simona Hildegard Stancu, Ana Stanciu, Mariana Lipan, Cristina Capusa
Rationale: Anemia, a common feature in chronic kidney disease (CKD), has multiple contributors to its pathogenesis. Besides the well recognized erythropoietin and iron deficiencies, hydration status might be involved. Objective: To assess the prevalence and correlations of anemia, iron deficiency and overhydration in patients with stage 2 to 5 CKD. Methods and Results: This cross-sectional study enrolled 125 erythropoietin and iron therapy naïve non-dialysis CKD patients, without a identifiable cause of anemia...
October 2018: Journal of Medicine and Life
https://read.qxmd.com/read/30893113/impact-of-sickle-cell-anemia-on-inpatient-morbidity-after-spinal-fusion
#5
Young Lu, Charles C Lin, Alex Doermann, Nilay Patel, Nitin N Bhatia, Phillip Douglas Kiester, Charles D Rosen, Yu-Po Lee
STUDY DESIGN: A retrospective study. OBJECTIVE: To determine the impact of sickle cell anemia on perioperative outcomes and resource utilization in elective spinal fusion surgery. SUMMARY OF BACKGROUND DATA: Sickle cell anemia has been identified as an important surgical risk factor in otolaryngology, cardiothoracic surgery, general surgery, and total joint arthroplasty. However, the impact of sickle cell anemia on elective spine surgery is unknown...
March 19, 2019: Clinical Spine Surgery
https://read.qxmd.com/read/30892987/binimetinib-encorafenib-and-cetuximab-triplet-therapy-for-patients-with-braf-v600e-mutant-metastatic-colorectal-cancer-safety-lead-in-results-from-the-phase-iii-beacon-colorectal-cancer-study
#6
Eric Van Cutsem, Sanne Huijberts, Axel Grothey, Rona Yaeger, Pieter-Jan Cuyle, Elena Elez, Marwan Fakih, Clara Montagut, Marc Peeters, Takayuki Yoshino, Harpreet Wasan, Jayesh Desai, Fortunato Ciardiello, Ashwin Gollerkeri, Janna Christy-Bittel, Kati Maharry, Victor Sandor, Jan H M Schellens, Scott Kopetz, Josep Tabernero
PURPOSE: To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, phase III BEACON Colorectal Cancer trial ( ClinicalTrials.gov identifier: NCT02928224; European Union Clinical Trials Register identifier: EudraCT2015-005805-35). PATIENTS AND METHODS: Before initiation of the randomized portion of the BEACON Colorectal Cancer trial, 30 patients with BRAF V600E-mutant mCRC who had experienced treatment failure with one or two prior regimens were to be recruited to a safety lead-in of encorafenib 300 mg daily, binimetinib 45 mg twice daily, plus standard weekly cetuximab...
March 20, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://read.qxmd.com/read/30892432/a-pancreatic-hemorrhagic-pseudocyst-with-pseudoaneurysm-and-the-role-of-doppler-ultrasonography-a-case-report
#7
Kyunghwa Ryu, Seong Sook Hong, Hwajin Cha, Jiyoung Hwang, EunJi Lee, Young Deok Cho, Yun-Woo Chang, Yong Jae Kim
Hemorrhagic pseudocysts with pseudoaneurysms are a rare and fatal complication of chronic pancreatitis due to the erosion of pancreatic to peripancreatic arteries. The timing of the rupture cannot be accurately predicted, but prompt diagnosis and management are essential to prevent further bleeding. We describe the case of a 68-year-old man who presented acute epigastric pain and anemia and had a history of chronic pancreatitis with a pseudocyst. A biliary and pancreas MRI showed an enlarged size of a known pancreatic pseudocyst with internal high signal intensity material...
February 2019: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/30885704/identifying-important-outcomes-for-young-people-with-ckd-and-their-caregivers-a-nominal-group-technique-study
#8
Camilla S Hanson, Talia Gutman, Jonathan C Craig, Sarah Bernays, Gayathri Raman, Yifan Zhang, Laura J James, Angelique F Ralph, Angela Ju, Karine E Manera, Armando Teixeira-Pinto, Andrea K Viecelli, Stephen I Alexander, Tom D Blydt-Hansen, Janis Dionne, Steven McTaggart, Mini Michael, Amanda Walker, Simon Carter, Scott E Wenderfer, Wolfgang C Winkelmayer, Detlef Bockenhauer, Allison Dart, Allison A Eddy, Susan L Furth, Debbie S Gipson, Stuart L Goldstein, Jaap Groothoff, Susan Samuel, Aditi Sinha, Nicholas J A Webb, Hui-Kim Yap, Michael Zappitelli, Helen Currier, Allison Tong
RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) has wide-ranging and long-term consequences for young people and their families. The omission of outcomes that are important to young people with CKD and their caregivers limits knowledge to guide shared decision making. We aimed to identify the outcomes that are important to young people with CKD and their caregivers. STUDY DESIGN: We used the nominal group technique whereby participants identified and ranked outcomes and explained their priorities...
March 15, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/30885152/multiplex-cytokine-analysis-in-mycobacterium-avium-complex-lung-disease-relationship-between-cxcl10-and-poor-prognostic-factors
#9
Yuuki Bamba, Hiroshi Moro, Nobumasa Aoki, Takeshi Koizumi, Yasuyoshi Ohshima, Satoshi Watanabe, Takuro Sakagami, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi
BACKGROUND: Mycobacterium avium complex lung disease (MAC-LD) can deteriorate rapidly to become fatal. Reported poor prognostic factors include radiographic findings, undernutrition, anemia and high inflammation test values. However, the association of these prognostic factors with the pathophysiology of the disease remains unknown. We aimed to clarify the pathophysiology of MAC-LD and develop a new biomarker that reflects the immune response to the disease. METHODS: We performed the cytokine panel analyses of serum from patients with MAC-LD and compared each cytokine level with clinically negative prognostic factors (radiographic disease type, body mass index, albumin, C-reactive protein and hemoglobin) and high-resolution CT scores...
March 18, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30879168/improving-anemia-in-inflammatory-bowel-disease-impact-of-the-anemia-care-pathway
#10
Talha Qureshi, T Peter Nguyen, Ruifei Wang, Diana Willis, Rajesh Shah, Jason K Hou
BACKGROUND: Anemia is a common complication of inflammatory bowel disease (IBD). Despite existing guidelines for anemia in IBD, it is frequently under-treated and the prevalence of anemia has remained high. To address this gap, the Crohn's and Colitis Foundation developed the Anemia Care Pathway (ACP). AIMS: To implement the ACP in a managed care setting and identify where it improves practice habits and where barriers remain. METHODS: The ACP was implemented from July 2016 through June 2017 and retrospectively studied...
March 16, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30877075/outcomes-and-treatment-strategies-for-autoimmunity-and-hyperinflammation-in-patients-with-rag-deficiency
#11
Jocelyn R Farmer, Zsofia Foldvari, Boglarka Ujhazi, Suk See De Ravin, Karin Chen, Jack J H Bleesing, Catharina Schuetz, Waleed Al-Herz, Roshini Sarah Abraham, Avni Y Joshi, Beatriz T Costa-Carvalho, David Buchbinder, Claire Booth, Andreas Reiff, Polly J Ferguson, Asghar Aghamohammadi, Hassan Abolhassani, Jennifer M Puck, Mehdi Adeli, Caterina Cancrini, Paolo Palma, Alice Bertaina, Franco Locatelli, Gigliola Di Matteo, Raif S Geha, Maria G Kanariou, Evangelia Lycopoulou, Marianna Tzanoudaki, John W Sleasman, Suhag Parikh, Gloria Pinero, Bernard M Fischer, Ghassan Dbaibo, Ekrem Unal, Turkan Patiroglu, Musa Karakukcu, Khulood Khalifa Al-Saad, Meredith A Dilley, Sung-Yun Pai, Cullen M Dutmer, Erwin W Gelfand, Christoph B Geier, Martha M Eibl, Hermann M Wolf, Lauren A Henderson, Melissa M Hazen, Carmem Bonfim, Beata Wolska-Kuśnierz, Manish J Butte, Joseph D Hernandez, Sarah K Nicholas, Polina Stepensky, Shanmuganathan Chandrakasan, Maurizio Miano, Emma Westermann-Clark, Vera Goda, Gergely Kriván, Steven M Holland, Olajumoke Fadugba, Sarah E Henrickson, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Ayca Kiykim, Robbert Bredius, Birgit Hoeger, Kaan Boztug, Olga Pashchenko, Benedicte Neven, Despina Moshous, Jean-Pierre de Villartay, Ahmed Aziz Bousfiha, Harry R Hill, Luigi D Notarangelo, Jolan E Walter
BACKGROUND: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series. OBJECTIVE: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency. METHODS: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology...
March 12, 2019: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/30875637/deoxyuracil-in-dna-and-disease-genomic-signal-or-managed-situation
#12
REVIEW
James Chon, Martha S Field, Patrick J Stover
Genomic instability is implicated in the etiology of several deleterious health outcomes including megaloblastic anemia, neural tube defects, and neurodegeneration. Uracil misincorporation and its repair are known to cause genomic instability by inducing DNA strand breaks leading to apoptosis, but there is emerging evidence that uracil incorporation may also result in broader modifications of gene expression, including: changes in transcriptional stalling, strand break-mediated transcriptional upregulation, and direct promoter inhibition...
February 27, 2019: DNA Repair
https://read.qxmd.com/read/30871608/transfusion-requirements-after-head-trauma-a-randomized-feasibility-controlled-trial
#13
André L N Gobatto, Milena A Link, Davi J Solla, Estevão Bassi, Paulo F Tierno, Wellingson Paiva, Fabio S Taccone, Luiz M Malbouisson
BACKGROUND: Anemia is frequent among patients with traumatic brain injury (TBI) and is associated with an increased risk of poor outcome. The optimal hemoglobin concentration to trigger red blood cell (RBC) transfusion in patients with TBI is not clearly defined. METHODS: All eligible consecutive adult patients admitted to the intensive care unit (ICU) with moderate or severe TBI were randomized to a "restrictive" (hemoglobin transfusion threshold of 7 g/dL), or a "liberal" (threshold 9 g/dL) transfusion strategy...
March 12, 2019: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/30871486/the-conundrum-of-postpartum-thrombotic-microangiopathy-case-report-and-considerations-for-management
#14
Katharina Artinger, Gerald Hackl, Gernot Schilcher, Florian Eisner, Marion J Pollheimer, Christoph Mache, Eva-Christine Weiss, Kathrin Eller, Philipp Eller
BACKGROUND: Microangiopathic hemolytic anemias and thrombocytopenias in pregnant or postpartum women constitute an interdisciplinary diagnostic and therapeutic challenge in the evaluation of thrombotic microangiopathies (TMA), where urgent care must be considered. CASE PRESENTATION: We here report the case of a 21-year-old Somali woman, who was delivered by emergency caesarean section at 35 weeks of gestational age with acute dyspnea, placental abruption and gross edema due to severe preeclampsia/HELLP syndrome...
March 14, 2019: BMC Nephrology
https://read.qxmd.com/read/30869426/-immuno-hematological-follow-up-of-pregnant-women
#15
Laurine Laget, Anne Cortey
Immuno-hematological follow up of pregnant women. The goal of immuno-hematological follow-up during pregnancy is to organize maternal transfusion safety and optimal management of fetal and neonatal hemolytic disease, that may result from maternal immunization. This follow-up relies on scheduled antibodies detection following regulation. Since May 2017 the refund by social security of the fetal RHD genotyping analysis on maternal plasma, it is possible to limit prophylaxis of allo-immunization to RhD-negative women with a RhD positive fetus...
May 2018: La Revue du Praticien
https://read.qxmd.com/read/30869342/-management-of-microcytic-anemia
#16
Charbel Aoun, Richard Delarue
No abstract text is available yet for this article.
September 2018: La Revue du Praticien
https://read.qxmd.com/read/30868957/pica-a-common-condition-that-is-commonly-missed-an-update-review
#17
Alexander K C Leung, Kam Lun Hon
BACKGROUND: Pica is a common condition in childhood that is commonly missed. OBJECTIVE: To familiarize physicians with the clinical evaluation and management of children with pica. METHODS: A PubMed search was completed in Clinical Queries using the key term "pica" OR "dirt-eating". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. Only papers published in the English literature were included in this review...
March 13, 2019: Current Pediatric Reviews
https://read.qxmd.com/read/30866023/-blood-transfusion-a-guide-to-clinical-decision-making
#18
Linda Tanner, Markus M Müller
Nowadays, management of hemotherapy is regulated in Germany by the transfusion act and several guidelines while the transfusing physician is responsible for correct implementation at the bedside. Indications for blood products have to be carefully adapted to the patient's current clinical situation and pre-existing diseases have to be considered as well. Today, for most perioperative elective surgeries, evidence-based transfusion thresholds for packed red blood cell concentrates (RBC) have been defined and should be considered...
March 2019: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://read.qxmd.com/read/30866022/-patient-blood-management-preoperative-anemia-and-case-reports-from-the-anemia-walk-in-clinic
#19
Sabine Westphal, Sabine Isik, Suma Choorapoikayil, Christoph Füllenbach, Kai Zacharowski, Patrick Meybohm
Preoperative anemia is independently associated with increased morbidity and mortality and represents the strongest predictor for transfusion of red blood cells. Iron deficiency anemia is the most frequent form of anemia and could easily be treated by supplementation with iron. Patient Blood Management (PBM) focusses on prevention and management of anemia to optimize the patient and reduce unnecessary allogeneic blood products.
March 2019: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://read.qxmd.com/read/30865367/clinical-features-of-heart-failure-with-mid-range-and-preserved-ejection-fraction-in-octogenarians-results-of-a-multicenter-observational-study
#20
Bülent Özlek, Eda Özlek, Mehmet Tekinalp, Serkan Kahraman, Hicaz Zencirkıran Ağuş, Oğuzhan Çelik, Cem Çil, Bedri Caner Kaya, İbrahim Rencüzoğulları, Kadir Uğur Mert, Mustafa Ozan Çakır, Altuğ Ösken, Lütfü Bekar, Yunus Çelik, Özcan Başaran, Volkan Doğan, Gurbet Özge Mert, Kadriye Memiç Sancar, Samet Sevinç, Murat Biteker
OBJECTIVES: To compare real-world characteristics and management of individuals aged 80 and older with heart failure (HF) and mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF) derived from a large cohort of survey and to compare them with those younger than 80 from the same survey. METHODS: This is an observational, multicenter and cross-sectional study conducted in Turkey (NCT03026114). Consecutive 1,065 (mean age of 67...
March 13, 2019: International Journal of Clinical Practice
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