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Metastatic spinal tumor

Vaner Köksal, Hüseyin Eren, Hasan Güçer
The most common cause of spinal tumors is metastases, but the cervical vertebra is the least common region of spinal metastasis, and relatively, little is published about surgery in metastasis to the cervical vertebra. While spinal metastasis is most often caused by neoplasms originating from the lung, breast, and prostate, renal cell carcinoma (RCC) metastasis is very rare. A 47-year-old patient introduced here presented with severe pain spontaneously on his neck and in his arm. In the radiology of the patient without neurological deficit, a pathologic vertebral collapse was detected in the C6 vertebral corpus...
October 2018: Journal of Craniovertebral Junction and Spine
Yun Liang, Peng Liu, Li-Bo Jiang, Hou-Lei Wang, An-Nan Hu, Xiao-Gang Zhou, Xi-Lei Li, Hong Lin, Dong Wu, Jian Dong
OBJECTIVE: A retrospective study was designed to evaluate the effectiveness of CT-guided core needle biopsy in diagnosing spinal lesions through comparison with C-arm guidance. METHODS: From April 2013 to July 2017, a total of 188 patients, who suffered from spinal lesions or had malignant tumor history with a new spinal fracture, were included in this study. There were 96 men and 92 women, with an average of 57.1 years. A total of 238 core needle biopsies were performed...
February 14, 2019: Orthopaedic Surgery
Amandine Crombé, Nicolas Alberti, Nicolas Villard, Frank Pilleul, Xavier Buy, François Le Loarer, Michèle Kind
OBJECTIVES: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS. METHODS: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. The locations, sizes, heterogeneity, margin definitions, and local extensions of the tumors were reported together with their impact on surrounding organs and regional and distant metastases...
February 14, 2019: European Radiology
Michael Zhang, Geoff Appelboom, John K Ratliff, Scott G Soltys, John R Adler, Jon Park, Steven D Chang
Purpose Pseudarthrosis within the spine tumor population is increased from perioperative radiation and complex stabilization for invasive and recurrent pathology. We report the radiographic and clinical rates of pseudarthrosis following multiple courses of instrumented fusion and perioperative stereotactic radiosurgery (SRS). Methods We performed a single institution review of 418 patients treated with non-isocentric SRS for spine between October 2002 and January 2013, identifying those with spinal instrumentation and greater than six months of follow-up...
November 25, 2018: Curēus
Stephanie A Harmon, Esther Mena, Joanna H Shih, Stephen Adler, Yolanda McKinney, Ethan Bergvall, Sherif Mehralivand, Adam G Sowalsky, Anna Couvillon, Ravi A Madan, James L Gulley, Janet Eary, Ronnie C Mease, Martin G Pomper, William L Dahut, Baris Turkbey, Liza Lindenberg, Peter L Choyke
Purpose: Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of 18 F-NaF PET/CT and 18 F-PSMA-targeted PET/CT within prostate cancer bone metastases. Methods: Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT (18 F-DCFBC or 18 F-DCFPyL) and 18 F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization...
December 28, 2018: Oncotarget
Daniel J Indelicato, Ronny L Rotondo, Haruka Uezono, Eric S Sandler, Philipp R Aldana, Nathan J Ranalli, Alexandra D Beier, Christopher G Morris, Julie A Bradley
BACKGROUND/OBJECTIVES: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the 4th most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited. DESIGN/METHODS: We reviewed the medical records of 174 children (≤21 years old) with non-metastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017 to assess clinical outcomes and toxicity, and analyze patient, tumor, and treatment-related variables...
January 23, 2019: International Journal of Radiation Oncology, Biology, Physics
Celine Chiu, Stefanie Loth, Michaela Kuhlen, Sebastian Ginzel, Jörg Schaper, Thorsten Rosenbaum, Torsten Pietsch, Arndt Borkhardt, Jessica I Hoell
Medulloblastoma is the most frequent malignant brain tumor in childhood. This highly malignant neoplasm occurs usually before 10 years of age and more frequently in boys. The 5-year event-free survival rate for high-risk medulloblastoma is low at 62% despite a multimodal therapy including surgical resection, radiation therapy and chemotherapy. We report the case of a boy, who was born to consanguineous parents. Prominently, he had multiple café-au-lait spots. At the age of 3 years he was diagnosed with a high-risk metastatic medulloblastoma...
January 24, 2019: Familial Cancer
Peter L Zhan, Babak S Jahromi, Tim J Kruser, Matthew B Potts
Spinal arteriovenous malformations (AVMs) comprise a group of complex vascular lesions whose treatment with microsurgery or transarterial embolization can be challenging. Stereotactic radiosurgery is a well-established treatment for intracranial AVMs, and spinal radiosurgery and fractionated radiotherapy are common treatments for spinal tumors of both primary and metastatic origin. The use of radiosurgery and fractionated radiotherapy for the treatment of spinal arteriovenous malformations, however, has been infrequently reported...
January 21, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Mingxing Lei, Jun Yu, Shiju Yan, Xiao An, Yaosheng Liu
Purpose: The aim of this study was to investigate the clinical results of surgery for cervical spine metastasis and identify clinical risk factors affecting postoperative survival and neurological outcome. Patients and methods: A retrospective analysis of medical records was performed on 19 patients who had undergone decompressive surgery and spine stabilization due to metastatic spinal cord compression in the cervical spine. All patients had severe pain before surgery...
2019: Therapeutics and Clinical Risk Management
Omer Slook, Sigal Levy, Ilana Slutzky-Shraga, Gloria Tsvetov, Eyal Robenshtok, Ilan Shimon, Carlos Benbassat, Dania Hirsch
OBJECTIVE: This institutional study sought to retrospectively evaluate disease progression and survival of patients with differentiated thyroid cancer (DTC) and bone metastases (BM) and to investigate variables predictive of better long-term outcomes. METHODS: The Rabin Medical Center Thyroid Cancer Registry was searched for patients with bone-metastatic DTC. Variables including patients' gender and age, pathology of the thyroid tumor and characteristics of BM were retrieved and analyzed in association with disease progression and mortality...
January 18, 2019: Endocrine Practice
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A Li, Radhika Rastogi, Yipeng Wang, Yong Liu
RATIONALE: Metastatic thymic carcinoma in the spine is a rare disease with no standard curative managements yet. The objective of this study is to report a very rare case of spinal metastases of thymic carcinoma successfully operated by combination of instrumentation and cement augmentation together with adjuvant treatment. The management of these unique cases has yet to be well-documented. PATIENT CONCERNS: A 57-year-old man presented with a 6-month history of continuous and progressive back pain...
January 2019: Medicine (Baltimore)
Sung-Lim Yoo, Young-Hoon Kim, Hyung-Youl Park, Sang-Il Kim, Kee-Yong Ha, Hyung-Ki Min, Jun-Yeong Seo, In-Soo Oh, Dong-Gune Chang, Joo-Hyun Ahn, Yong-Woo Kim
OBJECTIVE: The efficacy of preoperative embolization for hypervascular metastatic spine disease (MSD) such as renal cell and thyroid cancers has been reported. However, the debate on the efficacy of preoperative embolization for non-hypervascular MSD still remains unsettled. The purpose of this study is to determine whether preoperative embolization for non-hypervascular MSD decreases perioperative blood loss. METHODS: A total of 79 patients (36 cases of preoperative embolization and 43 cases of non-embolization) who underwent surgery for metastatic spine lesions were included...
January 2019: Journal of Korean Neurosurgical Society
Chih-Wei Sung, Kevin Li-Chun Hsieh, Yi-Jie Kuo
CONTEXT: Approximately 25% of all primary spinal cord tumors are meningiomas, and 80% of these tumors occur in the thoracic region. Few meningiomas of the lumbar spine have been presented. Extracranial metastasis of meningioma occurs extremely rare, only in about 0.1% of meningiomas. Even metastasis, the sites are seldom seen in deep soft tissue. We reported a woman original meningioma in the lumbar spine with distal deep neck metastasis. FINDINGS: A 59-year-old patient suffered from severe right drop foot, numbness, and radicular pain for the previous 6 months...
January 9, 2019: Journal of Spinal Cord Medicine
Dirk Rades, Antonio J Conde-Moreno, Jon Cacicedo, Theo Veninga, Barbara Segedin, Karmen Stanic, Steven E Schild
BACKGROUND: Local progression-free survival (LPFS = stable or improved motor function/resolution of paraplegia during RT without in-field recurrence following RT) is important when treating metastatic spinal cord compression (MSCC). An instrument to estimate LPFS was created to identify patients appropriately treated with short-course RT instead of longer-course RT plus/minus decompressive surgery. METHODS: In 686 patients treated with 20 Gy in 5 fractions alone, ten characteristics were retrospectively analyzed for LPFS including age, interval between tumor diagnosis and RT of MSCC, visceral metastases, other bone metastases, primary tumor type, gender, time developing motor deficits, pre-RT gait function, number of vertebrae affected by MSCC, and performance score...
December 29, 2018: Radiation Oncology
Jian Lu, Wei Huang, Zhongmin Wang, Ju Gong, Xiaoyi Ding, Zhijin Chen, Ning Xia, Nannan Yang, Zhiyuan Wu, Chen Wang, Jun Chen
Objective: The objective of this study is to investigate the safety and efficacy of 125 I seed interstitial implantation brachytherapy for metastatic epidural spinal cord compression (MESCC) as well as the life quality of patients. Materials and Methods: From April 2009 to May 2015, 28 patients who met the eligibility criteria were retrospectively reviewed. The number of implanted 125 I seeds ranged from 7 to 62, with appropriate activity of 0.5-0.8 mCi. The postplan showed that the matched peripheral dose (MPD) of tumors was 80-140 Gy...
2018: Journal of Cancer Research and Therapeutics
Sylvie Berthier, Louis Larrouquère, Pierre Champelovier, Edwige Col, Christine Lefebvre, Cécile Cottet-Rouselle, Josiane Arnaud, Catherine Garrel, François Laporte, Jean Boutonnat, Patrice Faure, Florence Hazane-Puch
Glioblastoma multiform (GBM) tumors are very heterogeneous, organized in a hierarchical pattern, including cancer stem cells (CSC), and are responsible for development, maintenance, and cancer relapse. Therefore, it is relevant to establish new GBM cell lines with CSC characteristics to develop new treatments. A new human GBM cell line, named R2J, was established from the cerebro-spinal fluid (CSF) of a patient affected by GBM with leptomeningeal metastasis. R2J cells exhibits an abnormal karyotype and form self-renewable spheres in a serum-free medium...
December 21, 2018: Cancers
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A Li, Radhika Rastogi, Yipeng Wang, Yong Liu
RATIONALE: Malignant thymoma in the spine is a rare disease without standard curative managements so far. The objective of this article is to report a very rare case of recurrent malignant thymoma with sacrum metastases causing severe lumbosacral pain, which was presented with acute radiculopathy and treated with 2 operations combined with stabilization and cement augmentation. The management of these unique cases is not well-documented. PATIENT CONCERNS: A 75-year-old man presented with lumbosacral pain, radiating pain and numbness of the left extremity...
December 2018: Medicine (Baltimore)
Bolong Zheng, Dingjun Hao, Hua Guo, Baorong He
PURPOSE: To explore whether the expression levels of matrix metalloproteinase-9 (MMP-9) are related to spinal metastasis of gastric carcinoma. METHODS: Fifty tissue specimens were collected from gastric carcinoma with spinal metastasis and set as test group A; 30 tissue specimens of primary gastric carcinoma were collected and set as control group B; 30 healthy paracancerous gastric tissue specimens were collected and set as control group C. The expression levels of MMP-9 and vascular endothelial growth factor (VEGF) in the specimens were analyzed by immunohistochemistry...
September 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Theresa Williamson, Brice Painter, Elizabeth P Howell, C Rory Goodwin
Nearly 20% of cancer patients develop symptomatic spine metastases. Metastatic spine tumors are most commonly extradural tumors that grow quickly and often cause persistent pain, weakness, paresthesias, urinary/bowel dysfunction, and/or paralysis. Surgical intervention aims to achieve more effective pain management, preserve/restore neurological function, provide local tumor control, and stabilize the spinal column. The desired result of treatment is ultimately to improve a patient's quality of life. Neurosurgeons employ multiple decision frameworks and grading scales to assess the need and effectiveness of a variety of surgical interventions ranging from minimally to maximally invasive...
January 2019: Journal of Palliative Medicine
Oluwaseun O Akinduro, Eric W Nottmeier
We describe the operative approach and management for thoracic metastatic disease in a 78-yr-old man with worsening mechanical lower back and left-sided thoracic radicular pain. Imaging of the thoracic spine revealed an osteolytic T11 mass with destruction of the left T11 pedicle and transverse process. Biopsy confirmed spinal metastasis from the liver. Preoperative angiogram was completed for localization of the artery of Adamkewicz and microparticle embolization of the left T11 intercostal artery. Surgical resection was supplemented with electrophysiological monitoring and neuronavigation...
December 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
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