keyword
https://read.qxmd.com/read/34230093/reducing-unnecessary-imaging-in-children-with-multicystic-dysplastic-kidney-or-solitary-kidney
#21
JOURNAL ARTICLE
Natasha A Jawa, Norman D Rosenblum, Seetha Radhakrishnan, Rachel J Pearl, Leo Levin, Mina Matsuda-Abedini
BACKGROUND AND OBJECTIVES: Children with isolated unilateral multicystic dysplastic kidney (MCDK) or congenital solitary kidney (CSK) undergo serial renal ultrasonography with variable frequency until they are transitioned to adult care. A growing body of literature suggests the value of frequent ultrasonography in this population is limited, providing no benefit to overall outcomes. Despite emerging evidence, ultrasound remains overused, resulting in avoidable health care expenditures and unnecessary use of resources...
August 2021: Pediatrics
https://read.qxmd.com/read/33964640/postnatal-outcome-of-prenatally-detected-simple-renal-cysts-are-they-really-simple
#22
JOURNAL ARTICLE
Jessica Ng, Stavros Loukogeorgakis, Elisabetta Sanna, Iris Derwig, Christina Yu, Gowri Paramasivam, Christoph Lees, Marie-Klaire Farrugia
BACKGROUND: The majority of simple renal cysts diagnosed postnatally are asymptomatic and rarely require treatment unless they become symptomatic or complex. We hypothesised that prenatally-detected simple renal cysts would have a similar harmless outcome. AIMS: To establish the natural history and postnatal outcome of prenatally-diagnosed simple renal cysts. STUDY DESIGN: Single-centre retrospective case-series review (12-year period). SUBJECTS: All patients with prenatally-diagnosed simple renal cysts (defined as a solitary, non-septated, non-communicating cyst in an otherwise normal kidney)...
May 4, 2021: Early Human Development
https://read.qxmd.com/read/33954810/outcomes-of-solitary-functioning-kidneys-renal-agenesis-is-different-than-multicystic-dysplastic-kidney-disease
#23
JOURNAL ARTICLE
Douglas G Matsell, Carol Bao, Teagan Po White, Ella Chan, Eli Matsell, Dan Cojocaru, Marisa Catapang
BACKGROUND: Multicystic dysplastic kidney (MCDK) disease and unilateral renal agenesis (URA) are well-known causes of a solitary functioning kidney (SFK) and are associated with long-term kidney injury. The aims of this study were to characterize the natural history of SFK at our center, define the risk factors associated with chronic kidney injury, and identify distinguishing features between URA and MCDK that predict outcome. METHODS: This was a retrospective cohort study of 230 SFK patients...
November 2021: Pediatric Nephrology
https://read.qxmd.com/read/33800671/expression-pattern-of-%C3%AE-tubulin-inversin-and-its-target-dishevelled-1-and-morphology-of-primary-cilia-in-normal-human-kidney-development-and-diseases
#24
JOURNAL ARTICLE
Ivana Solic, Anita Racetin, Natalija Filipovic, Snjezana Mardesic, Ivana Bocina, Danica Galesic-Ljubanovic, Meri Glavina Durdov, Mirna Saraga-Babić, Katarina Vukojevic
The spatiotemporal expression of α-tubulin, inversin and dishevelled-1 (DVL-1) proteins associated with the Wnt-signaling pathway, and primary cilia morphology were analyzed in developing kidneys (14th-38th developmental weeks), healthy postnatal (1.5- and 7-years old) and pathologically changed human kidneys, including multicystic dysplastic kidneys (MCDK), focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome of the Finnish type (CNF). The analysis was performed by double immunofluorescence, electron microscopy, semiquantitative and statistical methods...
March 28, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33790410/cytogenomic-aberrations-in-isolated-multicystic-dysplastic-kidney-in-children
#25
JOURNAL ARTICLE
Tian-Jian Chen, Renfang Song, Adam Janssen, Ihor V Yosypiv
BACKGROUND: Multicystic dysplastic kidney (MCDK) is a common form of congenital kidney anomaly. The cause of MCDK is unknown. We investigated whether MCDK in children is linked to cytogenomic aberrations. METHODS: We conducted array comparative genomic hybridization (aCGH) in ten unrelated children with MCDK. The pattern of inheritance was determined by real-time PCR in patients and their biological parents. RESULTS: Pathogenic aberrations were detected in three patients: a deletion at 7p14...
February 2022: Pediatric Research
https://read.qxmd.com/read/33752977/renal-function-in-children-with-a-congenital-solitary-functioning-kidney-a-systematic-review
#26
REVIEW
Kelly Ann Hutchinson, Lyra Halili, Andre Guerra, Pavel Geier, Melise Keays, Luis Guerra
INTRODUCTION: Abnormal renal development that results in lack of function or development of one of two kidneys is known as congenital solitary functioning kidney (CSFK). Two well characterized sub-categories of CFSK are unilateral renal agenesis (URA) and multicystic dysplastic kidney (MCDK). This systematic review sought to evaluate the change in renal function in children ≤18 years old with a CSFK as a result of URA or MCDK. METHODS: A literature search in MEDLINE and Embase was conducted (1946 to July 13, 2020)...
March 5, 2021: Journal of Pediatric Urology
https://read.qxmd.com/read/33723159/overexpression-of-beclin1-gene-leads-to-reduction-of-telomerase-activity-in-mdck-cells-and-enhances-apoptosis
#27
JOURNAL ARTICLE
Fatemeh Taji, Asghar Abdoli, Kazem Baesi, Farzaneh Sheikholeslami, Homa Mohseni Kouchesfahani
Background: Telomeres through maintaining chromosomal integrity have key roles in the cell life span. The autophagy is typically a pro-survival process and important for maintaining cellular homeostasis. Conversely, in some conditions, autophagy acts as caspase-independent cell death program. Beclin1 gene plays a principal role in the initiation of autophagy. Objective: The aim of this study was to evaluate the effect of autophagy induction via recombinant Beclin1 on telomerase activity and programmed cell death (apoptosis) in MCDK cells...
January 2021: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/33546619/pathophysiological-clinical-features-of-an-infant-with-hypertension-secondary-to-multicystic-dysplastic-kidney-a-case-report
#28
JOURNAL ARTICLE
Keisuke Sugimoto, Takuji Enya, Kensuke Joh, Kohei Miyazaki, Tomoki Miyazawa, Rina Ohshima, Satoshi Marutani, Takemura Tsukasa, Mitsuru Okada
BACKGROUND: The association of hypertension with congenital renal hypoplasia has been established. We report a case of an infant who underwent nephrectomy for hypertension. CASE PRESENTATION: Magnetic resonance imaging for the mother revealed fetal renal masses, and fetal multicystic dysplastic kidney was suspected. Following birth, the baby developed hypertension. Numerous investigations revealed that the left kidney was non-functional, and she was initiated on benazepril hydrochloride...
February 5, 2021: BMC Nephrology
https://read.qxmd.com/read/33512816/retrospective-evaluation-of-the-pediatric-multicystic-dysplastic-kidney-patients-experience-of-two-centers-from-southeastern-turkey
#29
JOURNAL ARTICLE
Mehtap Akbalık Kara, Aysel Taktak, Caner Alparslan
BACKGROUND/AIM: The objective of this study is to determine the clinical features of unilateral multicystic dysplastic kidney (MCDK) patients. MATERIALS AND METHODS: The demographic, clinical, laboratory, and radiologic features of MCDK patients at Diyarbakır Children’s Hospital and Diyarbakır Gazi Yaşargil Training and Research Hospital between January 2008-June 2019 were retrospectively evaluated. RESULTS: A total of 111 [59 (53...
June 28, 2021: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/33459097/prenatal-diagnosis-and-outcome-of-unilateral-multicystic-kidney
#30
JOURNAL ARTICLE
Gurcan Turkyilmaz, Bilal Cetin, Emircan Erturk, Tugba Sivrikoz, Ibrahim Kalelioglu, Recep Has, Atıl Yuksel, Tayfun Oktar, Orhan Ziylan
We reviewed the records of 144 patients. The mean gestational age at first US diagnosis was 27.5 ± 4.3 weeks. An anomaly of the contralateral kidney was detected in 25% of cases. An extrarenal anomaly was detected in 13.8%. Karyotype analysis was performed in 16.6% of cases and revealed trisomy 18 in 2 cases with extrarenal defects. Karyotype analysis was normal in all the patients who had isolated multicystic dysplastic kidney (MCDK). The diagnostic accuracy of prenatal ultrasound was 92.2%. Contralateral kidney anomaly was detected 33...
January 16, 2021: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/33418012/diagnosis-and-management-of-renal-cystic-disease-of-the-newborn-core-curriculum-2021
#31
REVIEW
Rupesh Raina, Ronith Chakraborty, Sidharth K Sethi, Deepak Kumar, Kelly Gibson, Carsten Bergmann
Renal cystic disease encompasses a large variety of illnesses with various phenotypic expressions that can manifest in utero, in infancy, and in childhood. These diseases may be unilateral or bilateral and present with single or multiple cysts. Various cystic diseases may also progress to chronic kidney disease (CKD), including kidney failure, and hepatic disease, thus potentially being life threatening. The prevalence and serious complications of CKD in the pediatric population make it vital that health care providers detect these conditions early and provide effective management...
July 2021: American Journal of Kidney Diseases
https://read.qxmd.com/read/33351224/multicystic-dysplastic-kidney-prenatal-compensatory-renal-growth-pattern
#32
JOURNAL ARTICLE
Noa Gilad, Alina Weissmann-Brenner, Yinon Gilboa, Benjamin Dekel, Reuven Achiron, Sharon Perlman
OBJECTIVES: To assess the prenatal growth pattern of the normal kidney contralateral to a multicystic dysplastic kidney (MCDK). METHODS: A retrospective study was conducted in a single referral center over 4 years. Cases diagnosed prenatally as MCDK and confirmed postnatally constituted the study group. For creation of nomograms, only isolated cases of MCDK were included. RESULTS: Sixty-one fetuses had a diagnosis of an MCDK during the study period...
October 2021: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/33309706/multicystic-dysplastic-kidney-with-mass-effect-in-a-neonate-treated-with-nephrectomy-case-report
#33
JOURNAL ARTICLE
Samuel M Pettit, William J Devan, David J Chalmers, Allison Zanno
Multicystic Dysplastic Kidney is a developmental disease that results in a lobulated kidney of noncommunicating cysts and abnormal parenchymal tissue. Dysplastic kidneys are usually benign and often involute over time with conservative management. The second most common cause of palpable abdominal mass in a neonate, Multicystic Dysplastic Kidney can cause respiratory distress secondary to extrinsic compression. However, such cases are sparse. Here we present the case of an otherwise healthy term newborn with an exceptionally large MCDK requiring CPAP support and intubation...
December 10, 2020: Urology
https://read.qxmd.com/read/33252759/imaging-of-fetal-cystic-kidney-disease-multicystic-dysplastic-kidney-versus-renal-cystic-dysplasia
#34
REVIEW
Mariana L Meyers, Amy L Treece, Brandon P Brown, Vijaya M Vemulakonda
With the advent of routine prenatal imaging, the number of renal anomalies identified prenatally has significantly increased; however, the underlying etiologies of these anomalies and the clinical significance of these findings remains unclear. This confusion is especially true for the prenatal diagnosis of cystic renal changes. The terms "cystic kidney disease" and "renal cystic dysplasia" encompass myriad renal diseases. Although renal cystic dysplasia in infants shares many similarities with multicystic dysplastic kidney (MCDK), it is important to distinguish MCDK from other etiologies that would lead to renal cysts, to ensure proper patient diagnosis and appropriate counseling regarding risks and to guide clinical management...
December 2020: Pediatric Radiology
https://read.qxmd.com/read/33249815/renal-growth-slope-in-children-with-congenital-and-acquired-solitary-functioning-kidneys
#35
JOURNAL ARTICLE
Seung Myeon Choi, Hyun Joo Shin, Haesung Yoon, Myeongjee Lee, Yong Seung Lee, Sang Won Han, Mi-Jung Lee
PURPOSE: This study aimed to analyze the renal growth slope in children with congenital and acquired solitary functioning kidneys. METHODS: This retrospective study included all renal ultrasonography examinations performed in children in the agenesis, multicystic dysplastic kidney (MCDK), or nephrectomy group between September 2002 and February 2019. We reviewed the images and recorded the contralateral kidney size only when there was no focal lesion. Linear mixed model or piecewise linear mixed model analyses with a time point of 24 months of age were performed...
September 12, 2020: Ultrasonography
https://read.qxmd.com/read/33173183/sequence-variants-in-the-renin-angiotensin-system-genes-are-associated-with-isolated-multicystic-dysplastic-kidney-in-children
#36
JOURNAL ARTICLE
Renfang Song, Ihor V Yosypiv
BACKGROUND: Multicystic dysplastic kidney (MCDK) is a common form of congenital cystic kidney disease in children. The etiology of MCDK remains unclear. Given an important role of the renin-angiotensin system in normal kidney development, we explored whether MCDK in children is associated with variants in the genes encoding renin-angiotensin system components by Sanger sequencing. METHODS: The coding regions of renin (REN), angiotensinogen (AGT), ACE, and angiotensin 1 receptor (AGTR1) genes were amplified by PCR...
November 10, 2020: Pediatric Research
https://read.qxmd.com/read/33108076/clinical-characteristics-of-children-with-congenital-anomalies-of-the-kidney-and-urinary-tract-and-predictive-factors-of-chronic-kidney-disease
#37
JOURNAL ARTICLE
Pınar Gür Çetinkaya, Bora Gülhan, Ali Düzova, Nesrin Beşbaş, Mutlu Hayran, Rezan Topaloğlu, Fatih Özaltın
BACKGROUND: Congenital anomalies of kidney and urinary tract (CAKUT) are the leading causes of chronic kidney disease (CKD) in childhood. Determining the clinical course, outcome, and prognostic factors of this heterogeneous disease group is important to provide appropriate management and follow-up. Therefore, we aimed to identify the risk factors of CKD in CAKUT and the differences in clinical courses between disease subgroups. METHODS: Three hundred patients (M/F: 203/97) divided into 16 CAKUT categories were enrolled in the study...
2020: Turkish Journal of Pediatrics
https://read.qxmd.com/read/32927453/high-activation-of-the-akt-pathway-in-human-multicystic-renal-dysplasia
#38
JOURNAL ARTICLE
Alexia Apostolou, Brice Poreau, Loris Delrieu, Julien Thévenon, Pierre-Simon Jouk, Guillaume Lallemand, Anouk Emadali, Herve Sartelet
Multicystic renal dysplasia is a congenital cystic anomaly of the kidney caused by abnormal metanephric differentiation with immature tubules. It is surrounded by mesenchymal collars and islands of immature mesenchyma present between the cysts. The PI3K-AKT-mTOR signaling pathway is a key regulator involved in cell growth, proliferation, motility, survival, and apoptosis. Activation of the PI3K-AKT-mTOR pathway results in the survival and proliferation of tumor cells in many cancers. The aim of this study is to analyze the topographic expression of phospho-AKT, phospho-mTOR, and phospho-70S6K in renal development and in the multicystic dysplastic kidney (MCDK)...
September 14, 2020: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://read.qxmd.com/read/32850538/-watch-and-wait-strategy-for-multicystic-dysplastic-kidney-mcdk-status-survey-of-perceptions-attitudes-and-treatment-selection-in-chinese-pediatric-urologists-and-pediatric-surgeons
#39
JOURNAL ARTICLE
Qi Wang, Zhengzhou Shi, Dapeng Jiang
To investigate the perceptions, attitudes, and treatment selection of Chinese pediatric urologists and pediatric surgeons regarding a "watch and wait" strategy for multicystic dysplastic kidney (MCDK). We used a cross-sectional survey in this study. We sent the questionnaire to pediatric urologists and pediatric surgeons to capture their views via the "Questionnaire Star" online survey platform between November and December 2019. The questionnaire contained the basic information and surgical experiences of the respondent, respondents' awareness regarding the counseling of prenatally-diagnosed MCDK and the treatment of MCDK, and respondents' knowledge regarding the imaging modalities, frequency, and duration of follow-up...
2020: Frontiers in Pediatrics
https://read.qxmd.com/read/32818222/urine-hepcidin-netrin-1-neutrophil-gelatinase-associated-lipocalin-and-c-c-motif-chemokine-ligand-2-levels-in-multicystic-dysplastic-kidney
#40
JOURNAL ARTICLE
Nuran Cetin, Zeynep Kusku Kiraz, Nadide Melike Sav
INTRODUCTION: Glomerular hyperfiltration may lead to proteinuria and chronic kidney disease in unilateral multicystic dysplastic kidney (MCDK). We aimed to investigate the urine neutrophil-gelatinase-associated lipocalin (NGAL), netrin-1, hepcidin, and C-C motif chemokine ligand-2 (MCP-1/CCL-2) levels in patients with MCDK. METHODS: Thirty-two patients and 25 controls were included. The urine hepcidin, netrin-1, NGAL, and MCP-1/CCL-2 levels were determined by ELISA...
August 19, 2020: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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