Alexia Apostolou, Brice Poreau, Loris Delrieu, Julien Thévenon, Pierre-Simon Jouk, Guillaume Lallemand, Anouk Emadali, Herve Sartelet
Multicystic renal dysplasia is a congenital cystic anomaly of the kidney caused by abnormal metanephric differentiation with immature tubules. It is surrounded by mesenchymal collars and islands of immature mesenchyma present between the cysts. The PI3K-AKT-mTOR signaling pathway is a key regulator involved in cell growth, proliferation, motility, survival, and apoptosis. Activation of the PI3K-AKT-mTOR pathway results in the survival and proliferation of tumor cells in many cancers. The aim of this study is to analyze the topographic expression of phospho-AKT, phospho-mTOR, and phospho-70S6K in renal development and in the multicystic dysplastic kidney (MCDK)...
September 14, 2020: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology