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Congenital heart disease pregnancy

Marie Vincenti, Sophie Guillaumont, Beatrice Clarivet, Valerie Macioce, Thibault Mura, Pierre Boulot, Gilles Cambonie, Pascal Amedro
BACKGROUND: Prenatal diagnosis of congenital heart disease (CHD) is controversial because of unclear benefits in terms of morbidity and mortality, and issues with healthcare costs and organization. AIM: To compare, in children with severe CHD, 1-year morbidity and mortality between prenatal and postnatal diagnosis groups. METHODS: All pregnancies and children aged<1 year with a diagnosis of severe CHD were collected over a 5-year period from our database...
February 2, 2019: Archives of Cardiovascular Diseases
Despoina Ntiloudi, George Giannakoulas
No abstract text is available yet for this article.
February 4, 2019: European Journal of Preventive Cardiology
Jenny Lord, Dominic J McMullan, Ruth Y Eberhardt, Gabriele Rinck, Susan J Hamilton, Elizabeth Quinlan-Jones, Elena Prigmore, Rebecca Keelagher, Sunayna K Best, Georgina K Carey, Rhiannon Mellis, Sarah Robart, Ian R Berry, Kate E Chandler, Deirdre Cilliers, Lara Cresswell, Sandra L Edwards, Carol Gardiner, Alex Henderson, Simon T Holden, Tessa Homfray, Tracy Lester, Rebecca A Lewis, Ruth Newbury-Ecob, Katrina Prescott, Oliver W Quarrell, Simon C Ramsden, Eileen Roberts, Dagmar Tapon, Madeleine J Tooley, Pradeep C Vasudevan, Astrid P Weber, Diana G Wellesley, Paul Westwood, Helen White, Michael Parker, Denise Williams, Lucy Jenkins, Richard H Scott, Mark D Kilby, Lyn S Chitty, Matthew E Hurles, Eamonn R Maher
BACKGROUND: Fetal structural anomalies, which are detected by ultrasonography, have a range of genetic causes, including chromosomal aneuploidy, copy number variations (CNVs; which are detectable by chromosomal microarrays), and pathogenic sequence variants in developmental genes. Testing for aneuploidy and CNVs is routine during the investigation of fetal structural anomalies, but there is little information on the clinical usefulness of genome-wide next-generation sequencing in the prenatal setting...
January 31, 2019: Lancet
Tanima Dwivedi, Manasi Gosavi
NeuLaxova syndrome (NLS) is a rare congenital abnormality involving multiple systems. Until date, only 60 cases of this syndrome have been reported in the literature. A stillborn fetus from a 23-year-old female with bad obstetrics history and consanguinity marriage, presented at 41 weeks gestation and not appreciating fetal movements for the past 3 days. Ultrasound examination revealed the absence of fetal cardiac activity and features of growth retardation. The fetus was sent for pathological examination. At autopsy, fetus had ichthyosis over the scalp and face, depressed nasal bridge, low set ears, microcephaly, slopping forehead, wide interdigital spaces, edema of hands and feet, hypoplastic penis, right leg showed congenital talipes equinovarus and left leg showed rocker bottom foot...
January 2019: Indian Journal of Pathology & Microbiology
Dan G Halpern, Catherine R Weinberg, Rebecca Pinnelas, Shilpi Mehta-Lee, Katherine E Economy, Anne Marie Valente
Cardiovascular disease complicating pregnancy is rising in prevalence secondary to advanced maternal age, cardiovascular risk factors, and the successful management of congenital heart disease conditions. The physiological changes of pregnancy may alter drug properties affecting both mother and fetus. Familiarity with both physiological and pharmacological attributes is key for the successful management of pregnant women with cardiac disease. This review summarizes the published data, available guidelines, and recommendations for use of cardiovascular medications during pregnancy...
February 5, 2019: Journal of the American College of Cardiology
R I Stryuk, C A Burns, M P Filippov, Ya V Brytkova, I V Borisov, E L Barkova, T A Gomova, E A Kozina, O A Nagirnyak
AIM: the Aim of the BEREG Registry was to analyze the prevalence and structure of cardiovascular diseases, associated comorbid conditions and assess their effects on pregnancy and perinatal outcomes in real clinical practice. MATERIALS AND METHODS: In Tula city regional perinatal center the observation study named &quot;Assessment of the clinical condition of the pregnant women with cardiovascular disease during gestation, at child delivery, at the early postpartum period and at twelve months after childbirth and assesment of perinatal outcomes, condition of the fetus and the newborn and the quality of treatment of these patients groups...
February 14, 2018: Terapevticheskiĭ Arkhiv
Yair Blumenfeld
Approximately 0.8% of all pregnancies are complicated by congenital heart disease (CDH) (Zhao QM et al. J Pediatr 2019 Jan;204:53-58). Prenatal diagnosis of CHD has been shown to reduce neonatal morbidity when compared with postnatal diagnosis, and significant efforts have been made by experts and leading professional societies to educate sonographers in optimal cardiac imaging techniques (Friedberg MK et al. J Pediatr 2009 Jul;155(1):26-31, ISUOG Practice Guideline, Ultrasound Obstet Gynecol 2013;41:348-359), Despite such efforts many CHD cases are still undetected during prenatal ultrasound exams...
January 29, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Ginnie Abarbanell, Naomi K Tepper, Sherry L Farr
OBJECTIVE: Women with congenital heart disease (CHD) are at increased risk of pregnancy complications and need information on safe, effective contraceptive methods to avoid unintended pregnancy. This systematic review examines evidence regarding safety of contraceptive use among women with CHD. METHODS: The PubMed database was searched for any peer-reviewed articles published through April 2018 that included safety outcomes associated with reversible contraceptive methods among women with CHD...
January 25, 2019: Congenital Heart Disease
Leqian Guo, Doudou Zhao, Ruo Zhang, Shanshan Li, Rong Liu, Hongli Wang, Shaonong Dang, Hong Yan
The purpose of this study was to explore the association between colds, depressive symptoms during pregnancy and offspring congenital heart disease (CHD). A 1:2 matching case-control study was conducted in Northwest China. Information was gathered by a structured questionnaire and was reviewed by investigators on the spot. Multivariate logistic regressions and nonlinear mixed effect model were performed. 614 cases and 1228 controls were available in this study. After adjusting for potential confounders, the colds during the entire pregnancy were associated with increased risk of offspring CHD (OR = 1...
January 24, 2019: Scientific Reports
Samantha C Do, Maurice L Druzin
PURPOSE OF REVIEW: The aim of this study was to describe risks of systemic lupus erythematosus (SLE) in pregnancy and the importance of preconception counselling, medication optimization and close surveillance. RECENT FINDINGS: Advances in care for pregnant patients with SLE have led to improved obstetric outcomes, but maternal and foetal risks continue to be elevated. Conception during periods of disease quiescence and continuation of most medications decrease adverse pregnancy outcomes...
January 22, 2019: Current Opinion in Obstetrics & Gynecology
Maria T Grønning Dale, Per Magnus, Elisabeth Leirgul, Henrik Holmstrøm, Håkon K Gjessing, Kristoffer Brodwall, Margaretha Haugen, Camilla Stoltenberg, Nina Øyen
Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened soft beverages during pregnancy and risk of CHD. Prospective cohort data with 88,514 pregnant women participating in the Norwegian Mother and Child Cohort Study was linked with information on infant CHD diagnoses from national health registers and the Cardiovascular Diseases in Norway Project...
January 19, 2019: European Journal of Epidemiology
Mechthild Westhoff-Bleck, Denise Hilfiker-Kleiner, Sabine Pankuweit, Bernhard Schieffer
Pregnancy-associated diseases of the cardiovascular system occur in up to 10% of all pregnancies and the incidence is increasing. Besides congenital heart disease or pre-existing cardiomyopathy in the mother, the clinical focus has moved especially to peripartum cardiomyopathy (PPCM) because of the condition's dramatic clinical course and the identification of the underlying mechanisms. This review article concentrates therefore on PPCM, which occurs either in the last month of pregnancy or in the first 6 months following delivery in women with previously healthy hearts...
December 2018: Geburtshilfe und Frauenheilkunde
Jan Pavlicek, Tomas Gruszka, Slavka Polanska, Erika Dolezalkova, David Matura, Richard Spacek, Ondrej Simetka, Dana Salounova, Marian Kacerovsky
OBJECTIVES: This study aimed to evaluate the prenatal rate of congenital heart defects (CHDs) and the frequency of termination of pregnancy (TOP) due to a CHD, depending on the severity of the defect and concomitant diseases of the fetus. METHODS: The data were assessed retrospectively between 2002 and 2017. Ultrasound examination was performed mostly in the second trimester. For analysis, the CHDs were divided into three groups of severity and three groups of fetus impairment...
January 15, 2019: Journal of Maternal-fetal & Neonatal Medicine
Jian Wang, Yujiao Ye, Tiantian Xin, Xi Zhang, Sun Chen, Yurong Wu, Kun Sun
AIM: Previous evidence on the relationship between single umbilical artery (SUA) and congenital heart disease (CHD) is controversial. We thus conducted a retrospective study to explore the potential risk factors associated with CHD in SUA fetuses, and verify if all these SUA fetuses should be referred for detail fetal echocardiography. METHODS: We reviewed medical records of SUA fetuses referred to Xinhua Hospital for fetal echocardiography between September 2009 and February 2014...
January 15, 2019: Journal of Obstetrics and Gynaecology Research
Wen Xu, C Tyler Smith, Anna Binstock, Grace Lim
Mirror syndrome is a rare pregnancy complication, life-threatening to mother and fetus. Increasing survival rates of congenital heart disease into reproductive age mean that complications like Mirror syndrome in this population may be more challenging to diagnose, given overlapping signs of edema in cases of heart failure exacerbation. We report a case of a pregnant woman with a history of unspecified congenital heart disease, presenting with swelling and distension, with diagnostic findings not consistent with preeclampsia...
January 10, 2019: A&A practice
S-E Sonesson, A Ambrosi, M Wahren-Herlenius
OBJECTIVE: Assuming that autoimmune congenital heart block (CHB) is a progressive disease amenable to therapeutic modulation, we introduced a surveillance program for at risk pregnancies with the dual aim of investigating if fetal atrioventricular block (AVB) could be detected and treated before becoming complete and irreversible and to establish the incidence of AVB I-III in a large prospective cohort. METHODS: From 2000 to 2015, 212 anti-Ro52 antibody-exposed pregnancies were followed weekly between 18 and 24 weeks' gestation at our tertiary fetal cardiology centre...
January 8, 2019: Ultrasound in Obstetrics & Gynecology
Camille Noël, Marie-Hélène Gagnon, Mikhail-Paul Cardinal, Olivier Guertin, Antoine Déry, Cassandre Têtu, Alain Vanasse, Marie-Ève Roy-Lacroix, Thomas G Poder, Ariane J Marelli, Tiscar Cavallé-Garrido, Laurence Vaujois, Jean-Luc Bigras, Frédéric Dallaire
OBJECTIVE: Prenatal detection of congenital heart diseases (CHD) decreases morbidity and cost. To improve detections rates, most physicians refer pregnant women with high-risk pregnancies to fetal cardiologists even when there is no suspicion of CHD at the second trimester screening. This paper presents the rationale and detailed method of the Fetal Cardiac Registry of Québec to Improve Resource Utilization in Fetal Cardiology (FREQUENCY) study. The overall objective is to assess the impact of second trimester ultrasound screening (U/S) and referral pattern in fetal cardiology on detection rates, health care costs, and resource utilization, as well as perinatal morbidity and mortality...
December 24, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Hirohiko Motoki, Satoshi Yasukochi, Kiyohiro Takigiku, Kohta Takei, Toru Okamura, Kazuhiro Kimura, Masatoshi Minamisawa, Ayako Okada, Tatsuya Saigusa, Soichiro Ebisawa, Tatsuichiro Seto, Morio Shoda, Kenji Okada, Koichiro Kuwahara
BACKGROUND: Despite the best efforts of pediatricians, healthcare for adult patients with congenital heart disease (ACHD) has proven challenging because of the increased numbers. This study presents the process of establishing an ACHD care system as a collaborative effort between Shinshu University Hospital and Nagano Children's Hospital.Methods and Results: Establishing an outpatient clinic for transition, a cooperation agreement for in-patient care between the 2 hospitals, and quality management of diagnostic imaging and educational meetings for adult cardiologists were the 3 major challenges...
December 20, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Amara Majeed, Alfred Abuhamad, Letty Romary, Elena Sinkovskaya
OBJECTIVES: To determine whether ultrasound (US) imaging of obese pregnant women in early gestation improves fetal cardiac visualization. METHODS: We report a prospective longitudinal trial comparing late first- and early second-trimester US to traditional second-trimester US for fetal cardiac screening in maternal obesity. All study participants received US for fetal cardiac screening at a gestational age of 13 weeks 15 weeks 6 days using a transvaginal or transabdominal approach (UST1)...
December 18, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Meiying Cai, Hailong Huang, Linjuan Su, Na Lin, Xiaoqing Wu, Xiaorui Xie, Gang An, Ying Li, Yuan Lin, Liangpu Xu
BACKGROUND: Congenital heart disease (CHD) is one of the most common birth defects; however, the mechanisms underlying its development are poorly understood. Recently, heritable genetic factors, including copy number variations (CNVs) and single nucleotide polymorphisms (SNPs), have been implicated in its etiology. The aim of this study was to investigate the utility of a SNP array for the prenatal diagnosis of CHD and the improvement of prenatal genetic counseling and to compare this approach to traditional chromosome analysis...
December 2018: Medicine (Baltimore)
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