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Kao-Hsian Hsieh, Ya-Ling Chou, Wen-Jue Soong, Yu-Sheng Lee, Pei-Chen Tsao
BACKGROUND: Tracheobronchial (TB) lumen narrowing may require prolonged positive-pressure ventilation, endotracheal tube intubation or even surgical interventions. Therapeutic flexible bronchoscopy (TFB) of balloon-expandable metallic stent (BEMS) placement and subsequent forceps, laser and balloon dilatation management might be less invasive and helpful. This study aimed to analyse the placement, follow-up management with TFB and long-term outcomes in small infants with BEMS. METHODS: This retrospective study reviewed the medical records and associated TFB videos of infants with a maximum BW of 5...
March 11, 2019: Journal of the Chinese Medical Association: JCMA
Po-Cheng Hsu, Po-Yin Chen, Yi-Shun Chung, Tai-Chi Lin, De-Kuang Hwang, Shih-Jen Chen, Chung-Lan Kao
The implantation of the Argus II retinal prosthesis system in a 54-year-old woman with retinitis pigmentosa who presented with an eye of long axial length at 26.82 mm was successful. Post-operative examination revealed a gap of 700 um between the electrode array and the retina, which caused decreased visual perception. A modified strategy with quad and quinary electrode stimulation was introduced to generate higher perceptual thresholds. The patient experienced visual function changes during the first half of the year after surgery, although no remarkable difference was observed in terms of implant-retina distance...
March 11, 2019: Journal of the Chinese Medical Association: JCMA
Arlen C Moller, Andrew J Jager, Geoffrey C Williams, Audiey C Kao
BACKGROUND: Poor occupational health among physicians poses a serious risk both to physicians themselves and the patients under their care. Prior research has found that occupational health among nonphysicians is associated with both degree and type of work motivation. OBJECTIVE: The main purpose of this article was to assess the association between physician work motivation and their occupational health. RESEARCH DESIGN: This study was a national survey of practicing physicians...
March 19, 2019: Medical Care
Alice T Shaw, Benjamin J Solomon, Benjamin Besse, Todd M Bauer, Chia-Chi Lin, Ross A Soo, Gregory J Riely, Sai-Hong Ignatius Ou, Jill S Clancy, Sherry Li, Antonello Abbattista, Holger Thurm, Miyako Satouchi, D Ross Camidge, Steven Kao, Rita Chiari, Shirish M Gadgeel, Enriqueta Felip, Jean-François Martini
PURPOSE: Lorlatinib is a potent, brain-penetrant, third-generation anaplastic lymphoma kinase (ALK)/ROS1 tyrosine kinase inhibitor (TKI) with robust clinical activity in advanced ALK-positive non-small-cell lung cancer, including in patients who have failed prior ALK TKIs. Molecular determinants of response to lorlatinib have not been established, but preclinical data suggest that ALK resistance mutations may represent a biomarker of response in previously treated patients. PATIENTS AND METHODS: Baseline plasma and tumor tissue samples were collected from 198 patients with ALK-positive non-small-cell lung cancer from the registrational phase II study of lorlatinib...
March 20, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Jiantong Dong, Ryan Yue Zhang, Na Sun, Matthew Dennis Smalley, Zipeng Wu, Anqi Zhou, ShihJie Chou, Yu Jen Alex Jan, Peng Yang, Lirong Bao, Dongping Qi, Xinghong Tang, Patrick Tseng, Yue Hua, Dianwen Xu, RueiHung Kao, Meng Meng, Xirun Zheng, Ying Liu, Tatyana Vagner, Xiaoshu Chai, Dongjing Zhou, Mengyuan Li, Shih-Hwa Chiou, Guangjuan Zheng, Dolores Di Vizio, Vatche Agopian, Edwin Posadas, Steven J Jonas, Shin-Pon Ju, Paul S Weiss, Meiping Zhao, Hsian-Rong Tseng, Yazhen Zhu
Tumor-derived extracellular vesicles (EVs) present in bodily fluids are emerging liquid biopsy markers for non-invasive cancer diagnosis and treatment monitoring. Since the majority of EVs in circulation are not of tumor origin, it is critical to develop new platforms capable of enriching tumor-derived EVs from the blood. Herein, we introduce a biostructure-inspired NanoVilli Chip, capable of highly efficient and reproducible immunoaffinity capture of tumor-derived EVs from blood plasma samples. Anti-EpCAM-grafted silicon nanowire arrays were engineered to mimic the distinctive structures of intestinal microvilli, dramatically increasing surface area and enhancing tumor-derived EV capture...
March 20, 2019: ACS Applied Materials & Interfaces
Fang-Chuan Kuo, Kuo-Liang Chiang, Yu-San Kao
BACKGROUND: Ankylosing spondylitis causes structural damage and motion restriction in spine. The study was designed to assess structural damage and incoordination pattern between the spine and hip during trunk lateral bending in ankylosing spondylitis. METHODS: Twenty-three healthy adults and 39 adults with ankylosing spondylitis were recruited from a tertiary care medical centre. Patients with ankylosing spondylitis were divided into two subgroups: sacroiliitis or lumbar-level syndesmophytes (n = 27) and thoracic or cervical-level syndesmophytes (n = 12)...
February 23, 2019: Clinical Biomechanics
Chun-Yi Lin, Ming-Tsung Lee, Cheng-Li Lin, Chia-Hung Kao
PURPOSE: PET/CT using prostate-specific membrane antigen (PSMA) and choline radiotracers is widely used for diagnosis of prostate cancer. However, the roles of and differences in diagnostic performance between these 2 radiotracers for prostate cancer are unclear. The aim of this study was to compare the staging and restaging performance of Ga-labeled PSMA and F-choline PET/CT imaging in prostate cancer. METHODS: A comprehensive search was performed in PubMed for studies reporting the staging performance of Ga-PSMA and F-choline PET/CT in prostate cancer from the inception of the database to October 1, 2018, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement...
March 15, 2019: Clinical Nuclear Medicine
Tamkin Ahmadzada, Kenneth Lee, Candice Clarke, Wendy A Cooper, Anthony Linton, Brian McCaughan, Rebecca Asher, Stephen Clarke, Glen Reid, Steven Kao
OBJECTIVES: A number of key immune regulators show prognostic value in malignant pleural mesothelioma (MPM), but the association between Bridging integrator 1 (BIN1), indoleamine 2,3 dioxygenase 1 (IDO1) and patient outcome has not been investigated. We aimed to determine the expression of BIN1 and IDO1, their association with other markers and impact on overall survival (OS) in MPM. MATERIALS AND METHODS: The expression of BIN1, IDO1, CD3, CD20 and CD68 were evaluated by immunohistochemistry in 67 patients who underwent pleurectomy/decortication...
April 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Shih-Han Kao, Wei-Chung Cheng, Yi-Ting Wang, Han-Tsang Wu, Han-Yu Yeh, Yu-Ju Chen, Ming-Hsui Tsai, Kou-Juey Wu
Markers of cancer stemness predispose patients to tumor aggressiveness, drug and immunotherapy resistance, relapse, and metastasis. DDX17 is a co-factor of the Drosha-DGCR8 complex in miRNA biogenesis and transcriptional coactivator and has been associated with cancer stem-like properties. However, the precise mechanism by which DDX17 controls cancer stem-like features remains elusive. Here we show that the E3 ligase HectH9 mediated K63-polyubiquitination of DDX17 under hypoxia to control stem-like properties and tumor-initiating capabilities...
March 15, 2019: Cancer Research
Po-Chun Chen, Wei-Yu Kao, Yuan-Lung Cheng, Yuan-Jen Wang, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su
BACKGROUND/PURPOSE: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. METHODS: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS)...
March 12, 2019: Journal of the Formosan Medical Association
Asima K Ahmad, Molly Quinn, Chia-Ning Kao, Eleni Greenwood, Marcelle I Cedars, Heather G Huddleston
OBJECTIVE: To determine optimal criteria for polycystic ovary morphology. DESIGN: Cross-sectional study. SETTING: Multidisciplinary polycystic ovary syndrome (PCOS) clinic at a tertiary academic center. PATIENT(S): Subjects with PCOS were seen between 2006 and 2015 and met PCOS 1992 National Institutes of Health criteria. Controls were from the Ovarian Aging (OVA) study (2006-2011), a longitudinal study including healthy women with regular menstrual cycles...
March 11, 2019: Fertility and Sterility
Dong-Yu Yang, Mei Hung Chi, Ching-Lin Chu, Chun-Yu Lin, Shuo-En Hsu, Kao Chin Chen, I Hui Lee, Po See Chen, Yen Kuang Yang
OBJECTIVE: The present study aimed to detect differences in the reward response between adults with attention deficit hyperactivity disorder (ADHD) and healthy controls (HCs) using functional magnetic resonance imaging (fMRI). METHODS: The Iowa gambling task (IGT) was designed to explore participants' reward-related decision-making in relation to selections during risky behaviors. Twenty adults with ADHD and 20 HCs were enrolled. fMRI with a modified IGT was performed...
February 19, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Phillip Parente, Bryan A Chan, Brett G M Hughes, Kevin Jasas, Rohit Joshi, Steven Kao, Fiona Hegi-Johnson, Rina Hui, Sara McLaughlin-Barrett, Ina Nordman, Emily Stone
Stage III non-small cell lung cancer (NSCLC) makes up a third of all NSCLC cases and is potentially curable. Despite this 5-year survival rates remain between 15% and 20% with chemoradiation treatment alone given with curative intent. With the recent exciting breakthroughs in immunotherapy use (durvalumab) for stage III NSCLC, further improvements in patient survival can be expected. Most patients with stage III NSCLC present initially to their general practitioner (GP). The recommended time from GP referral to first specialist appointment is less than 14 days with treatment initiated within 42 days...
March 14, 2019: Asia-Pacific Journal of Clinical Oncology
Yu-Cheng Kao, Hao-Ming Chou, Shun-Chieh Hsu, Albert Lin, Chien-Chung Lin, Zun-Hao Shih, Chun-Ling Chang, Hwen-Fen Hong, Ray-Hua Horng
The integration of III-V and Si multi-junction solar cells as photovoltaic devices has been studied in order to achieve high photovoltaic conversion efficiency. However, large differences in the coefficients of thermal expansion and the lattice parameters of GaAs, Si, and InGaAs have made it difficult to obtain high-efficiency solar cells grown as epilayers on Si and InP substrates. In this paper, two types of devices, including GaInP/GaAs stacked on Si (GaInP/GaAs//Si) and GaInP/GaAs stacked on InGaAs (GaInP/GaAs//InGaAs), are fabricated via mechanical stacking and wire bonding technologies...
March 13, 2019: Scientific Reports
Heekuk Park, Michael R Laffin, Juan Jovel, Braden Millan, Jae E Hyun, Naomi Hotte, Dina Kao, Karen L Madsen
BACKGROUND: Fecal microbial transplantation (FMT) is used in the treatment of relapsing Clostridium difficile infection (rCDI). Failure rate for FMT is as high as 10% but the mechanisms contributing to a failed FMT are not understood. We utilized metagenomic data to identify the role of bacteria and bacteriophages on FMT success. RESULTS: Subjects with rCDI (n = 19) received FMT from volunteer donors (n = 7) via colonoscopy. Twelve patients fully recovered after a single FMT, while seven patients required a subsequent FMT...
March 13, 2019: Gut Microbes
Vedran Pavlovic, Lei Yang, Henry Lik-Yuen Chan, Jinlin Hou, Harry L Janssen, Jia-Horng Kao, Pietro Lampertico, Cheng-Yuan Peng, Teerha Piratvisuth, Alexander J Thompson, Heiner Wedemeyer, Lai Wei, Cynthia Wat
BACKGROUND: Peginterferon alfa-2a (PEG-IFN) treatment stopping rules in chronic hepatitis B (CHB) are clinically desirable. Previous studies exploring this topic contained important limitations resulting in inconsistent recommendations within the current treatment guidelines. We undertook a systematic review and individual patient data meta-analysis to identify the most appropriate PEG-IFN treatment stopping rules. METHODS: Roche's internal database, PubMed, and conference abstracts were searched for studies that enrolled >50 treatment-naïve patients with CHB who received PEG-IFN treatment for 48 weeks...
March 13, 2019: Antiviral Therapy
Pedram Argani, Yu-Chien Kao, Lei Zhang, Yun-Shao Sung, Rita Alaggio, David Swanson, Andres Matoso, Brendan C Dickson, Cristina R Antonescu
BCOR immunoreactivity is a sensitive and highly specific marker for clear cell sarcoma of the kidney (CCSK). However, a subset of adult renal sarcomas which overexpress BCOR are negative for BCOR genetic alterations, including BCOR gene fusions or BCOR-internal tandem duplication, and thus remain unclassified. We report 5 such undifferentiated renal/perirenal sarcomas which raised the differential diagnosis of CCSK due to their morphologic appearance and strong BCOR immunoreactivity, but which on RNA sequencing proved to be malignant solitary fibrous tumors (SFTs)...
March 8, 2019: American Journal of Surgical Pathology
Dina Skroza, Jelena Macan
Prema podacima iz Registra profesionalnih bolesti Hrvatskoga zavoda za zaštitu zdravlja i sigurnost na radu, u posljednjih deset godina (2008. ‒ 2017.) prijavljeno je samo 20 slučajeva profesionalne astme od ukupno 2234 prijavljene profesionalne bolesti. To upućuje na značajne nedostatke u prepoznavanju toga poremećaja u našoj radnoj populaciji. Cilj ovoga rada bio je opisati standardnu metodu praćenja vršnog ekspiratornog protoka zraka (eng. peak expiratory flow, PEF) i predložiti praktičnu smjernicu za korištenje te dijagnostičke metode u ambulantama medicine rada i sporta...
December 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
Po-Sen Peng, Tung-Wei Kao, Pi-Kai Chang, Wei-Liang Chen, Po-Jui Peng, Li-Wei Wu
Previous literatures revealed that homeostasis model assessment-estimated insulin resistance (HOMA-IR) was one of the cardio-metabolic risk factors. This study was conducted to access the association between HOMA-IR and frailty in the United States of America (U.S.) middle-aged and elderly high-risk insulin-resistant population. In the National Health and Nutrition Examination Survey (NHANES III) from 1988 to 1994, the study included 3,893 participants. In order to exam the association between HOMA-IR and frailty in the middle-aged and elderly population through the regression model adjusted for multiple covariates, we divided the participants into middle aged group (Age <65 years) and elderly group (Age > = 65 years) in this study...
March 12, 2019: Scientific Reports
Victoria Cotero, Ying Fan, Tea Tsaava, Adam M Kressel, Ileana Hancu, Paul Fitzgerald, Kirk Wallace, Sireesha Kaanumalle, John Graf, Wayne Rigby, Tzu-Jen Kao, Jeanette Roberts, Chitresh Bhushan, Suresh Joel, Thomas R Coleman, Stavros Zanos, Kevin J Tracey, Jeffrey Ashe, Sangeeta S Chavan, Christopher Puleo
Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). Next, hepatic U/S stimulation is shown to modulate pathways that regulate blood glucose and is as effective as VNS in suppressing the hyperglycemic effect of endotoxin exposure...
March 12, 2019: Nature Communications
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