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Michaël Grynberg, Claire Murphy, Carole Doré, Laurence Fresneau, Ségolène Paillet, Nicoleta Petrica, Maurel Frédérique, Harinala Ravonimbola
OBJECTIVE: To assess the cost-effectiveness (CE) of the originator follitropin-α (Gonal-F) in patients undergoing a medically assisted reproduction (MAR) program in comparison to its biosimilars Bemfola and Ovaleap in a French context. METHODS: A CE model was developed for France with a National Health Service (NHS) perspective. Clinical, safety, and dosage data were derived from pivotal clinical trials that compared Gonal-F to Ovaleap and Bemfola. Costs pertaining to drugs, hospitalizations, specialist visits, and examinations were retrieved from the French Programme de Médicalisation des Systèmes d'Information (PMSI) hospital database, literature review, and French clinical experts using 2017 Euro tariffs...
November 21, 2018: Journal of Medical Economics
Afsoon Zarei, Saeed Alborzi, Elham Askary, Mahshid Alborzi, Fatemeh Shahbazi
The objective of the study is to determine the effects of clomiphene citrate (CC) on preventing premature luteinizing hormone (LH) surge in infertile patients with polycystic ovary syndrome (PCOS) undergoing intrauterine insemination (IUI). This was a randomized clinical trial being performed at Shiraz Mother and Child Hospital. We included 162 women with PCOS selected for IUI cycles. Patients were randomly allocated to receive 150 mg/day CC from the 8th of the cycle though the day of human chorionic gonadotropin (hCG) injection ( n = 81) or nothing in the same period ( n = 81)...
July 2018: Journal of Advanced Pharmaceutical Technology & Research
Steven T Frey, Hillary A Ramirez, Manpreet Kaur, Jerry P Jasinski
Structural analysis of (acetato-κ2 O , O ')(methanol-κ O )[tris-(pyridin-2-ylmeth-yl)amine-κ4 N , N ', N '', N ''']manganese(II) tetraphenyl-borate, [Mn(C2 H3 O2 )(C18 H18 N4 )(CH3 OH)](C24 H20 B) or [Mn(TMPA)(Ac)(CH3 OH)]BPh4 [TMPA = tris-(pyridin-2-ylmeth-yl)amine, Ac = acetate, BPh4 = tetra-phenyl-borate] by single-crystal X-ray diffraction reveals a complex cation with tetra-dentate coordination of the tripodal TMPA ligand, bidentate coordination of the Ac ligand and monodentate coordination of the methanol ligand to a single MnII center, balanced in charge by the presence of a tetra-phenyl-borate anion...
August 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Salvatore Gizzo, Marcos Ferrando, Monica Lispi, Claudio Ripellino, Nazarena Cataldo, Klaus Bühler
BACKGROUND/OBJECTIVE: Although biosimilar drugs may be cheaper to purchase than reference biological products, they may not be the most cost-effective treatment to achieve a desired outcome. The analysis reported here compared the overall costs to achieve live birth using the reference follitropin alfa (GONAL-f) or a biosimilar (Ovaleap) in Spain, Italy and Germany. METHODS: Patient and treatment data was obtained from published sources; assisted-reproductive technology, gonadotropin, follow-up and adverse-event-related costs were calculated from tariffs and reimbursement frameworks for each country...
August 31, 2018: Journal of Medical Economics
Nicola Colacurci, Vincenzo De Leo, Giovanni Ruvolo, Paola Piomboni, Francesca Caprio, Rosario Pivonello, Enrico Papaleo, Eugenio La Verde, Raffaella Depalo, Monica Lispi, Salvatore Longobardi, Donatella Paoli, Francesco Pallotti, Francesco Lombardo
Background and objectives: Male infertility is a global health dilemma and Follicle-Stimulating Hormone (FSH) administration has shown promising results. Several studies showed that infertile men with normal semen parameters have low levels of DNA damage while infertile men with abnormal semen parameters have more damage at the DNA level. Sperm DNA damage may affect the reproductive outcome and has been associated with failure in the achievement of competent embryos and pregnancy fulfillment. The aim of this study was to evaluate whether the administration of recombinant FSH (Gonal-f® PEN 900 IU) could improve sperm DNA fragmentation in men with infertility...
2018: Frontiers in Endocrinology
Emil Stoyanov, Kurt Leinenweber, Thomas L Groy, Abds-Sami Malik
Single crystals of a GeO2 -TiO2 solid solution with the corresponding composition Ge0.57 Ti0.43 O2 (germanium titanium tetra-oxide) were obtained by devitrification of germania-titania glass at high pressure and temperature. The new compound crystallizes in the rutile structure type (space group P 42 / mnm ), where Ge and Ti share the same position M (site symmetry ), with occupancy values of 0.57 (3) and 0.43 (3), respectively, and one O-atom position ( m .2 m ). The M site is in a sixfold O-atom coordination and, as in the original TiO2 rutile structure, an elongation of the O- M -O bonds along the c -axis direction of the coordination polyhedron and deviation of the angles from 90° lead to a decrease in the coordination symmetry from octa-hedral to tetra-gonal...
July 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Tuncer Hökelek, Safiye Özkaya, Hacali Necefoğlu
The asymmetric unit of the title complex, [Cd(C10 H11 O2 )2 (C6 H6 N2 O)2 (H2 O)], contains one half of the complex mol-ecule, with the CdII cation and the coordinated water O atom residing on a twofold rotation axis. The CdII cation is coordinated in a bidentate manner to the carboxyl-ate O atoms of the two symmetry-related 2,4,6-tri-methyl-benzoate (TMB) anions and to the water O atom at distances of 2.297 (2), 2.527 (2) and 2.306 (3) Å to form a distorted penta-gonal arrangement, while the distorted penta-gonal-bipyramidal coordin-ation sphere is completed by the two pyridine N atoms of the two symmetry-related monodentate nicotinamide (NA) ligands at distances of 2...
February 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Mamour Sarr, Mayoro Diop, Elhadj Ibrahima Thiam, Aliou Hamady Barry, Mohamed Gaye, Pascal Retailleau
The search for novel manganese(II) compounds having inter-esting magnetic properties, using 1-(pyridin-2-yl)-2-(pyridin-2-yl-methyl-idene)hydrazine (H L ) as a tridendate ligand, led to the preparation of the title mononuclear material, [MnCl(NO3 )(C11 H10 N4 )(H2 O)], and the determination of its structure by XRD. The asymmetric unit comprises a discrete mol-ecule in which the cation MnII is hepta-coordinated. The environment around the cation is an almost perfect penta-gonal bipyramid. The base is defined by the two N atoms of the pyridine rings, the N atom of the imino function of the ligand and the two O atoms of the chelating bidentate nitrate ligand...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Ercan Aydemir, Sevgi Kansiz, Mustafa Kemal Gumus, Nikolay Yu Gorobets, Necmi Dege
The title compound, C19 H19 N5 O2 , was prepared by the reaction of 3-amino-5-(pyridin-3-yl)-1,2,4-triazole with acetone and 2-hy-droxy-3-eth-oxy-benzaldehyde. It crystallizes from ethanol in a tetra-gonal space group, with one mol-ecule in the asymmetric unit. The 1,2,4-triazole five-membered ring is planar (maximum deviation = 0.0028 Å). The pyridine and phenyl rings are also planar with maximum deviations of 0.0091 and 0.0094 Å, respectively. In the crystal, N-H⋯N hydrogen bonds link the mol-ecules into supra-molecular chains propagating along the c- axis direction...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Bin Wang, Na Kong, Jing-Yu Liu, Ning-Yuan Zhang, Ying-Chun Zhu, Jian-Jun Zhou
Objective: To analyze the clinical outcomes of repeated superovulation induction in patients with adenomyosis or moderate to severe pelvic endometriosis after failure in previous IVF-ET cycles with the ultra-long protocol. METHODS: We retrospectively analyzed the clinical data about 37 patients with adenomyosis or moderate to severe pelvic endometriosis in our center from 2009 to 2013, who underwent repeated IVF-ET after failure in the previous cycles with the ultra-long protocol, namely by injection of 2-6 ampoules of 3...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
Ramaraju G A, Ravikrishna Cheemakurthi, Kavitha Prathigudupu, Kavitha Lakshmi Balabomma, Madan Kalagara, Sivanarayana Thota, Muralikrishna Kota
STUDY OBJECTIVES: To investigate the effect of N312S polymorphism in the LHCGR gene as a predictive pharmacogenetic marker on clinical and embryological parameters and determining the need of r-hLH supplementation combine with r-hFSH in patients undergoing ART treatment. STUDY DESIGN: In a cross-sectional study, a retrospective analysis of women (n = 553), who underwent controlled ovarian stimulation treatment protocol was conducted during the years 2012-2014...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Marzieh Aghahosseini, Ashraf Aleyasin, Venus Chegini, Victoria Chegini
Background: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication, which can cause high morbidity and mortality. Use of gonadotropin releasing hormone (GnRH) agonist instead of human chorionic gonadotropin (hCG) in GnRH antagonist cycles causes luteinizing hormone surge by GnRH stimulation which reduces the risk of OHSS by reducing the total amount of gonadotropin; however, there is no possibility of transferring fresh embryos. Objective: The current study aimed to evaluate the effect of hCG along with GnRH agonist administration in the occurrence of OHSS and pregnancy rate in females undergoing in vitro fertilization...
November 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
Wayland E Noland, Jessica E Shudy, Janel L Rieger, Zoe H Tu, Kenneth J Tritch
In the title crystals, C8 H5 Br2 N, which are isomorphous, the steric bulk of the methyl group causes neighboring mol-ecules to become mutually inclined. This prevents the formation of planar or nearly planar sheets, which were observed in the tri-chloro and tri-bromo analogs. Instead of CN/NC⋯Br contacts, tetra-meric Br⋯Br contacts are observed. These contacts form tetra-gonally puckered sheets parallel to (001). The CN/NC and methyl groups are grouped at the peaks and troughs. Both mol-ecules lie across crystallographic mirror planes; thus, the methyl H atoms are disordered over two sets of sites with equal occupancy...
December 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Stephan W Prömper, Walter Frank
Dissolving lithium chloride and aluminium chloride in boiling para - or meta -xylene and keeping the colourless solution at room temperature led to crystal growth of a new modification of lithium tetra-chlorido-aluminate, LiAlCl4 , which represents a second modification ( oP 12, Pmn 21 ) of the ternary salt besides the long known monoclinic form [LiAlCl4 ( mP 24, P 21 / c ); Mairesse et al. (1977 ▸). Cryst. Struct. Commun. 6 , 15-18]. The crystal structures of both modifications can be described as slightly distorted hexa-gonal closest packings of chloride anions...
October 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Mary Mahony, Andrea Dwyer, Raschelle Barkume, Allison Strochlic, Fabien Jeannerot, Thomas Stüdeli
OBJECTIVES: The multi-dose, pre-filled GONAL-f® RFF Redi-ject® (follitropin alfa injection) pen injector was updated following feedback on user experience and pen functionality, as part of a continuous assessment program. Human-factors engineering (HFE) evaluations were conducted to confirm that the updated pen injector could be used by intended users to safely and effectively perform critical tasks identified by the risk-management plan. METHODS: Five rounds of formative evaluation and a simulated-use summative evaluation of the pen injector, instructions for use (IFU), and training video were conducted by HFE specialists or the intended users of the pen injector...
January 2018: Expert Opinion on Drug Delivery
Suk-Hee Moon, Youngjin Kang, Ki-Min Park
The asymmetric unit of the title compound, [Co(NO3 )2 L ] n , L = N -(pyridine-2-ylmeth-yl)pyridine-3-amine (C11 H11 N3 ), contains one CoII centre, two nitrate anions and one L ligand in which the Cpy -C-N-Cpy moiety adopts a trans conformation with a torsion angle of -173.1 (3) Å. The coordination geometry of the CoII atom is a distorted penta-gonal bipyramid. One amine N atom from the L ligand and four O atoms from two η2 -nitrato ligands form the basal plane and two pyridyl N atoms from two symmetry-related L ligands occupy the apical positions [N-Co-N = 171...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
John L Yovich, Kevin N Keane, Gayatri Borude, Satvinder S Dhaliwal, Peter M Hinchliffe
PIVET recombinant FSH (rFSH) dosing algorithms have been designed for rFSH injection pens, providing optimal pregnancy and live birth productivity rates whilst minimizing risk and occurrence of ovarian hyperstimulation syndrome (OHSS). Recently, long-acting recombinant gonadotrophin corifollitropin (Elonva) was approved for use in assisted reproduction, and welcomed by patients as the single injection allowed ovarian stimulation over 7 days without need for multiple injections. Consequently, another rFSH dosing algorithm was devised to incorporate Elonva, and these cycles were compared to standard rFSH agents, Gonal-f and Puregon...
January 2018: Reproductive Biomedicine Online
L C Mendes, P A Ferreira, N Miotto, L Zanaga, E S L Gonçales, M N Pedro, M S Lazarini, F L G Júnior, R S B Stucchi, A G Vigani
Vibration-controlled transient elastography (VCTE) is widely used for noninvasive fibrosis staging in chronic hepatitis C. However, internal validation is based solely on variability and success rate and lacks reproducible quality indicators. We analysed the graphic representation of shear wave propagation in comparison with morphometric results of liver biopsy, eliminating observer variability bias. Individual elastograms were classified according to two morphologic criteria: extension of wave propagation (length of the graphic representation) and shear wave dispersal (level of parallelism displayed in the elastogram)...
April 2018: Journal of Viral Hepatitis
Suellen Laís Vicentino-Vieira, Marcelo Biondaro Góis, Aline Rosa Trevizan, Lainy Leiny de Lima, Elen Paula Leatte, Gessilda de Alcântara Nogueira de Melo, João Luiz Garcia, Eduardo José de Almeida Araújo, Débora de Mello Gonçales Sant'Ana
AIM: To evaluate the mucosal tunic and submucosal plexus of the jejunum of rats infected with different inoculum doses of Toxoplasma gondii. MAIN METHODS: Rats were infected with different inoculum doses (50, 500, 1000 and 5000 oocysts) of the T. gondii for 30days, while a control group (CG) received saline solution. Blood and feces were collected before euthanasia for analysis of blood and fecal leukocytes (LEs). Histological analysis of the mucosa, submucosa, villi, crypts and enterocytes were performed...
December 15, 2017: Life Sciences
R Ricci-Azevedo, R A Gonçales, M C Roque-Barreira, D Girard
OBJECTIVE AND DESIGN: Paracoccin (PCN), a lectin expressed by Paracoccidioides brasiliensis (Pb), is known to exert activities on the fungal biology, as well as different immune cells of myeloid origin. The aim of this study was to investigate the direct interaction of the recombinant form of the lectin (rPCN) with neutrophils, a neglected area. MATERIALS OR SUBJECTS: Freshly isolated human neutrophils from healthy donors were used. TREATMENT: Neutrophils were incubated with rPCN in vitro...
January 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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