C Alicia Traughber, Kara Timinski, Ashutosh Prince, Nilam Bhandari, Kalash Neupane, Mariam R Khan, Esther Opoku, Emmanuel Opoku, Gregory Brubaker, Junchul Shin, Junyoung Hong, Babunageswararao Kanuri, Elif G Ertugral, Prabhakara R Nagareddy, Chandrasekhar R Kothapalli, Olga Cherepanova, Jonathan D Smith, Kailash Gulshan
BACKGROUND: Pyroptosis executor GsdmD (gasdermin D) promotes atherosclerosis in mice and humans. Disulfiram was recently shown to potently inhibit GsdmD, but the in vivo efficacy and mechanism of disulfiram's antiatherosclerotic activity is yet to be explored. METHODS AND RESULTS: We used human/mouse macrophages, endothelial cells, and smooth muscle cells and a hyperlipidemic mouse model of atherosclerosis to determine disulfiram antiatherosclerotic efficacy and mechanism...
April 2, 2024: Journal of the American Heart Association