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Atahualpa Cauê Paim Strapasson, Ápio Cláudio Martins Antunes, Paulo Petry Oppitz, Marcos Dalsin, Carlos Roberto de Mello Rieder
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for patients suffering from Parkinson's disease (PD). One of its adverse events is the development of postoperative confusion. OBJECTIVE: To report the incidence and associated factors of postoperative confusion after STN-DBS surgery Methods: retrospective cohort study by chart review of patients with PD, who underwent STN-DBS surgery in a Brazilian public academic hospital from January 2013 to October 2017...
February 11, 2019: World Neurosurgery
Xuan Gao, Jiang Ming, Shiwen Liu, Bin Lai, Fang Fang, Jing Cang
The neurotoxicity of anesthetics on developing brain has been a focused issue for years. However, controversy exists between human and animal studies and surgery may be a potential reason for this. The discovery of glymphatic system, a pathway eliminating soluble substance from central nervous system (CNS), together with recent evidence that surgery-induced Aβ increase contributes to cognition dysfunction made us rethink about the influence of anesthetics on cognitive function. The function of glymphatic system was proved to be enhanced by sleep and sedation, so we assumed that under clinical situation Aβ1-40 whose accumulation played important role in cognitive dysfunction was increased by surgery and eliminated from CNS by glymphatic system...
February 11, 2019: Life Sciences
Ya Zhang, Ao Li, Jie He, Minghui Wang
Glioblastoma Multiforme (GBM) is one of the most malignant brain tumors with very short prognosis expectation. To improve patients' clinical treatment and their life quality after surgery. Researches have developed tremendous in silico models and tools for predicting GBM prognosis based on molecular datasets and have earned great success. However, pathology still plays the most critical role in cancer diagnosis and prognosis in the clinic at present. Recent advancement of storing and processing histopathological images have drawn attention from researches...
February 11, 2019: IEEE Journal of Biomedical and Health Informatics
Calum D Moulton, Polychronis Pavlidis, Christine Norton, Sam Norton, Carmine Pariante, Bu Hayee, Nick Powell
Depressive symptoms are reported by more than 20% of people with inflammatory bowel disease (IBD), whilst sleep difficulties and fatigue are even more common. Comorbid depressive symptoms predict a poor IBD course, including increased risk of relapse and surgery, which is inconsistently improved by psychological treatments. Rather than being distinct systems, there is compelling evidence for bidirectional communication between gut and brain, driven by neural, metabolic, endocrine and inflammatory mediators...
February 14, 2019: Clinical and Experimental Immunology
Nicolas Louarn, Aurélie Dauta, Emmanuèle Lechapt-Zalcman, Paul Kauv, Emmanuel Itti
A 63-year-old woman was referred to our PET/MRI platform to evaluate the possible relapse of a meningeal metastasis, complicating an invasive ductal carcinoma of the left breast. This metastasis was diagnosed on a left hemiparesis and treated by surgery and radiation therapy. One year later, the same symptoms led to another brain MRI examination that found a contrast-enhanced lesion in the operating site. We decided to perform a F-DOPA PET/MRI to document this lesion, which confirmed the diagnosis of a probable relapse and revealed a focal uptake on the bone flap...
February 8, 2019: Clinical Nuclear Medicine
M Aiello, D Terenzi, G Furlanis, M Catalan, P Manganotti, R Eleopra, E Belgrado, R I Rumiati
Although deep brain stimulation of the subthalamic nucleus is an effective surgical treatment for Parkinson's disease, it may expose patients to non-motor side effects such as increased impulsivity and changes in decision-making behavior. Even if several studies have shown that stimulation of the subthalamic nucleus increases the incentive salience of food rewards in both humans and animals, temporal discounting for food rewards has never been investigated in patients who underwent STN-DBS. In this study, we measured inter-temporal choice after STN-DBS, using both primary and secondary rewards...
February 14, 2019: Journal of Neurology
Geoffrey C Owens, Alejandro J Garcia, Aaron Y Mochizuki, Julia W Chang, Samuel D Reyes, Noriko Salamon, Robert M Prins, Gary W Mathern, Aria Fallah
Brain-infiltrating lymphocytes (BILs) were isolated from resected brain tissue from 10 pediatric epilepsy patients who had undergone surgery for Hemimegalencephaly (HME) ( n = 1), Tuberous sclerosis complex (TSC) ( n = 2), Focal cortical dysplasia (FCD) ( n = 4), and Rasmussen encephalitis (RE) ( n = 3). Peripheral blood mononuclear cells (PBMCs) were also isolated from blood collected at the time of the surgery. Cells were immunostained with a panel of 20 antibody markers, and analyzed by mass cytometry. To identify and quantify the immune cell types in the samples, an unbiased clustering method was applied to the entire data set...
2019: Frontiers in Immunology
Jiri Bartek, Petter Förander, Erik Thurin, Theresa Wangerid, Roger Henriksson, Göran Hesselager, Asgeir Store Jakola
Background: Vestibular Schwannoma (VS) is a benign neoplasm arising from the 8th cranial nerve, with surgery one of the treatment modalities. In a nation-wide registry study, we describe the baseline, treatment characteristics, and short-term outcome in patients surgically treated for VS. Methods: We performed a nationwide study with data from the Swedish Brain Tumor Registry (SBTR) for all adults diagnosed with VS 2009-2015. Patient symptoms, tumor characteristics, and postoperative complications were analyzed...
2019: Frontiers in Neurology
Hao Liu, Nadya Povysheva, Marie E Rose, Zhiping Mi, Joseph S Banton, Wenjin Li, Fenghua Chen, Daniel P Reay, Germán Barrionuevo, Feng Zhang, Steven H Graham
Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme. Mutations in and aberrant function of UCHL1 have been linked to many neurological disorders. UCHL1 activity protects neurons from hypoxic injury, and binding of stroke-induced reactive lipid species to the cysteine 152 (C152) of UCHL1 unfolds the protein and disrupts its function. To investigate the role of UCHL1 and its adduction by reactive lipids in inhibiting repair and recovery of function following ischemic injury, a knock-in (KI) mouse expressing the UCHL1 C152A mutation was generated...
February 13, 2019: Proceedings of the National Academy of Sciences of the United States of America
Ida Christine Olesrud, Mette Katrine Schulz, Ljubo Marcovic, Bjarne Winther Kristensen, Christian Bonde Pedersen, Charlotte Kristiansen, Frantz Rom Poulsen
BACKGROUND: This study aimed to investigate the incidence of residual tumour after resection of brain metastases using early postoperative magnetic resonance imaging (MRI) and the influence of residual tumour on overall patient survival. METHODS: Data from 72 consecutive adult patients undergoing surgery for cerebral metastases over an 18-month study period were retrospectively collected. Early postoperative MRI was used to determine the presence of postoperative residual tumour...
February 13, 2019: Acta Neurochirurgica
Albert Snowball, Elodie Chabrol, Robert C Wykes, Tawfeeq Shekh-Ahmad, Jonathan H Cornford, Andreas Lieb, Michael P Hughes, Giulia Massaro, Ahad A Rahim, Kevan S Hashemi, Dimitri M Kullmann, Matthew C Walker, Stephanie Schorge
Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes to brain tissue, so vector design must be carefully optimized to guarantee safety without compromising efficacy. We set out to develop an epilepsy gene therapy vector optimized for clinical translation. The gene encoding the voltage-gated potassium channel Kv1.1, KCNA1 , was codon-optimized for human expression and mutated to accelerate the channels' recovery from inactivation...
February 12, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Elise F Nassif, Alexandre Arsène-Henry, Youlia M Kirova
Thirty per cent of cancer patients develop brain metastases, with multiple combination or sequential treatment modalities available, to treat systemic or central nervous system (CNS) disease. Most patients experience toxicities as a result of these treatments, of which cognitive impairment is one of the adverse events most commonly reported, causing major impairment of the patient's quality of life. Areas covered: This article reviews the role of cancer treatments in cognitive decline of patients with brain metastases: surgery, radiotherapy, chemotherapy, targeted therapies, immunotherapies and hormone therapy...
February 12, 2019: Expert Review of Anticancer Therapy
Piotr Duchnowski, Tomasz Hryniewiecki, Mariusz Kuśmierczyk, Piotr Szymanski
AIM: The usefulness of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) as a predictor of perioperative hemodynamic instability is not fully elucidated. METHODS: This prospective study was conducted on a group of 455 patients undergoing elective heart valve surgery. The primary end point at the 30-day follow-up was postoperative hemodynamic instability. The secondary end point was death from all causes in patients with postoperative hemodynamic instability...
February 13, 2019: Biomarkers in Medicine
Anders Christian Meidahl, Christian K E Moll, Bernadette van Wijk, Alessandro Gulberti, Gerd Tinkhauser, Manfred Westphal, Andreas K Engel, Wolfgang Hamel, Peter Brown, Andrew Sharott
Both phase-amplitude coupling (PAC) and beta-bursts in the subthalamic nucleus have been significantly linked to symptom severity in Parkinson's disease (PD) in humans and emerged independently as competing biomarkers for closed-loop deep brain stimulation (DBS). However, the underlying nature of subthalamic PAC is poorly understood and its relationship with transient beta burst-events has not been investigated. To address this, we studied macro- and micro electrode recordings of local field potentials (LFPs) and single unit activity from 15 hemispheres in 10 PD patients undergoing DBS surgery...
February 9, 2019: Neurobiology of Disease
Lisa S Kahalley, M Douglas Ris, Anita Mahajan, M Fatih Okcu, Murali Chintagumpala, Arnold C Paulino, William E Whitehead, Charles G Minard, Heather H Stancel, Jessica Orobio, Judy J Xue, Emily A Warren, David R Grosshans
Background: Proton radiotherapy (PRT) reduces the volume of normal tissue receiving radiation dose, which may lead to better neurocognitive outcomes. We examined change in neurocognitive scores over time in pediatric brain tumor patients treated with proton craniospinal irradiation (CSI), proton focal RT, or surgery only. Methods: Patients received annual neurocognitive evaluations for up to 6 years. We examined Full Scale IQ (FSIQ), Verbal Comprehension (VCI), Perceptual Reasoning (PRI), Working Memory (WMI), and Processing Speed Index (PSI) scores...
February 7, 2019: Neuro-oncology
Fabien Rech, Guillaume Herbet, Yann Gaudeau, Sophie Mézières, Jean-Marie Moureau, Sylvie Moritz-Gasser, Hugues Duffau
Negative motor responses (NMRs) are defined as movement arrests induced by direct electrical stimulation of the brain. The NMRs manifest themselves after the disruption of a corticosubcortical network involved in motor control, referred to as the 'negative motor network'. At present, the spatial topography of the negative motor areas (NMAs) is poorly known. Hence, the objectives of the present study were to establish the first probabilistic map of the NMAs of the upper limbs and face, identify potential subareas, and investigate the NMAs' relationships with the primary motor cortex...
February 7, 2019: Brain: a Journal of Neurology
Zhe Wang, Shu-Geng Gao, Qi Xue, Xiao-Tong Guo, Li-Xu Wang, Xin Yu, Yi-Kun Yang, Ju-Wei Mu
Background: Previous studies have demonstrated that survival of patients with non-small cell lung cancer (NSCLC) with oligometastasis may benefit from local treatment. The purpose of this study was to compare the efficacy of local surgical treatment with systematic chemoradiotherapy in NSCLC with oligometastasis. Methods: Data from a total of 172 patients with NSCLC with oligometastasis were collected at our Cancer Hospital from January 2006 to December 2016. The patients were divided into two groups: group A (82 cases) underwent primary surgical treatment and adjuvant chemotherapy was performed after operation, while group B (90 cases) received systematic chemotherapy and local radiotherapy...
December 2018: Journal of Thoracic Disease
Srinivas Balachander, Shyam Sundar Arumugham, Dwarakanath Srinivas
Despite advancements in pharmacotherapeutic and behavioral interventions, a substantial proportion of patients with obsessive-compulsive disorder (OCD) continue to have disabling and treatment-refractory illness. Neurosurgical interventions, including ablative procedures and deep brain stimulation (DBS), have emerged as potential treatment options in this population. We review the recent literature on contemporary surgical options for OCD, focusing on clinical aspects such as patient selection, presurgical assessment, and safety and effectiveness of these procedures...
January 2019: Indian Journal of Psychiatry
Paresh K Doshi, Shyam S Arumugham, Ajit Bhide, Sandeep Vaishya, Amit Desai, Om Prakash Singh, Suresh B Math, Shiv Gautam, T S Satyanarayana Rao, E Mohandas, Dwarkanath Srinivas, Ajit Avasthi, Sandeep Grover, Y C Janardhan Reddy
Neurosurgery for psychiatric disorders (NPD) has been practiced for >80 years. However, the interests have waxed and waned, from 1000s of surgeries in 1940-1950s to handful of surgery in 60-80s. This changed with the application of deep brain stimulation surgery, a surgery, considered to be "reversible" there has been a resurgence in interest. The Indian society for stereotactic and functional neurosurgery (ISSFN) and the world society for stereotactic and functional neurosurgery took the note of the past experiences and decided to form the guidelines for NPD...
January 2019: Indian Journal of Psychiatry
Joanna Sierpowska, Andreu Gabarrós, Alejandro Fernández-Coello, Àngels Camins, Sara Castañer, Montserrat Juncadella, Clément François, Antoni Rodríguez-Fornells
In the present study, we aimed to test the association between the correct function of the left ventral white matter pathways and semantic processing (dual stream models for language processing, Hickok & Poeppel, 2004), using a new set of language tasks during intraoperative electrical stimulation at white matter level. Additionally, we evaluated brain regions needed for correct performance on the different semantic tasks using lesion-symptom analyses (voxel lesion-symptom mapping and track-wise lesion analysis) in a sample of 62 candidates for the awake brain surgery...
January 31, 2019: NeuroImage: Clinical
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