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Haocheng Xu, Minghao Shao, Fan Zhang, Cong Nie, Hongli Wang, Wei Zhu, Xinlei Xia, Xiaosheng Ma, Feizhou Lu, Jianyuan Jiang
Purpose: Because Hirayama disease is stereotyped as a self-limited disease in the absence of a definite pathology, we investigated the potential relationship between snake-eyes appearance (SEA) and Hirayama disease to bring a new perspective in the pathological process of Hirayama disease based on relevant radiological and clinical evidence. Methods: A total of 30 cases observed SEA were selected from 293 patients with Hirayama disease to constitute the SEA group, and an equal number of cases were randomly selected from the remaining patients to form the non-SEA group...
2019: BioMed Research International
Dai Koguchi, Kazumasa Matsumoto, Masaomi Ikeda, Yoshinori Taoka, Takahiro Hirayama, Yasukiyo Murakami, Takuji Utsunomiya, Daisuke Matsuda, Norihiko Okuno, Akira Irie, Masatsugu Iwamura
Background: The prognostic value of histologic variants (HV) after radical cystectomy (RC) remains controversial. We evaluated the clinicopathological features and prognosis in patients with pure urothelial carcinoma (UC) and HV following RC. Methods: From 1990 to 2015, 286 patients with bladder cancer were treated with RC at six Kitasato University-affiliated hospitals. All patients were divided into two groups: pure UC and HV, which contained pure variants and mixed-type UC with variant pattern...
February 8, 2019: Japanese Journal of Clinical Oncology
K Kitagori, H Yoshifuji, T Oku, T Ayaki, A Kuzuya, T Nakajima, S Akizuki, R Nakashima, K Murakami, K Ohmura, Y Hirayama, R Takahashi, T Mimori
The whole protein of osteopontin (OPN full) and its cleaved form (OPN N-half) are involved in the immune response and the migration of immune cells to an inflammatory lesion. We have reported that serum OPN full and urine OPN N-half are elevated in lupus nephritis (LN). Neuropsychiatric systemic lupus erythematosus (NPSLE) is a refractory complication of SLE. To investigate whether OPN full and OPN N-half could serve as diagnostic markers for NPSLE, and to elucidate their role in NPSLE pathogenesis, the concentrations of OPN full and OPN N-half in cerebrospinal fluid (CSF) were measured in NPSLE and non-NPSLE patients...
February 11, 2019: Lupus
I Khan, G Rooh, R Rajaramakrishna, N Srisittipokakun, H J Kim, K Kirdsiri, J Kaewkhao
Traditional melt-quenching technique is adopted for synthesis of Sm2 O3 doped lithium barium gadolinium silicate (LBGS: Li2 O-BaO-Gd2 O3 -SiO2 ) glasses. These glass samples are characterized by different spectroscopic techniques under ambient conditions. Density and molar volume of the present LBGS glass samples increase with increasing Sm3+ ion-concentration. JO intensity parameters Ωλ (where λ = 2, 4 and 6) are evaluated by using Judd-Ofelt theory and Ω4  > Ω2  > Ω6 trend is observed...
January 29, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Hiroyuki Koga, Hiroki Nakamura, Hiroshi Murakami, Shunki Hirayama, Kota Imashimizu, Kinya Nishimura, Kazuhiro Suzuki, Ryohei Kuwatsuru, Eiichi Inada, Kenji Suzuki, Atsuyuki Yamataka
AIM: Thoracoscopic pulmonary lobectomy (TPL) is extremely challenging in cases where severe incomplete fissure causes densely fused pulmonary lobes (DFPL) since pulmonary arteries (PAs) are buried and completely concealed by DFPL. We describe TPL for DFPL including a technical tip to prevent pitfalls. MATERIALS AND METHODS: Four congenital pulmonary airway malformation (CPAM) and DFPL (left-upper: 2, left-lower: 1, right-middle: 1) were treated. During TPL, DFPL prevent interlobar PAs from being identified and searching for them only promotes bleeding and air leakage, serious pitfalls that affect the safety and success of TPL...
February 8, 2019: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Haruka Suzuki, Koji Yamanoi, Jumpei Ogura, Takahiro Hirayama, Koji Yasumoto, Shimpei Shitanaka, Yoshihide Inayama, Mie Sakai, Tsutomu Ohara, Koh Suginami
The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). A routine blood test at 28 weeks of gestation revealed moderate macrocytic anemia. Her haptoglobin level was markedly low, and a direct antiglobulin test (DAT) was positive. Based on these results, AIHA was considered...
2019: Case Reports in Obstetrics and Gynecology
Mie Sakai, Jumpei Ogura, Koji Yamanoi, Takahiro Hirayama, Tsutomu Ohara, Haruka Suzuki, Yoshihide Inayama, Koji Yasumoto, Koh Suginami
Congenital ATIII deficiency is one of the congenital thrombophilia diseases that can cause severe venous thromboembolism (VTE) in pregnant patients. A 30-year-old female, 4 gravida and 2 para, came to the emergency department with a complaint of oedema and pain in the left lower leg at 11 weeks of gestation. An inferior vena cava thrombus and pulmonary embolism were found. Because VTE was very severe, artificial abortion was performed, and VTE disappeared rapidly. She maintained oral administration of edoxaban (NOAC) and got pregnant naturally fifty-five weeks later after the abortion...
2019: Case Reports in Obstetrics and Gynecology
Toshihiko Okumura, Jun-Ichi Kawada, Masaharu Tanaka, Kotaro Narita, Tomonori Ishiguro, Yuji Hirayama, Sho Narahara, Genki Tsuji, Yuichiro Sugiyama, Michio Suzuki, Takeshi Tsuji, Shin Hoshino, Masahiro Nakatochi, Hideki Muramatsu, Hiroyuki Kidokoro, Yoshiyuki Takahashi, Yoshiaki Sato
BACKGROUND: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. In this study, we compared the effects of high- and low-dose corticosteroid therapy in a pediatric population with refractory MPP. METHODS: We retrospectively collected data from 91 pediatric MPP patients treated with adjunctive systemic corticosteroids between April 2014 and October 2016...
February 1, 2019: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Yohei Sotomi, Akio Hirata, Ryohei Amiya, Tomoaki Kobayashi, Atsushi Hirayama, Yasushi Sakata, Yoshiharu Higuchi
Clinical outcomes of the real-world Asian nonvalvular atrial fibrillation (NVAF) patients treated with DOAC and the incremental bleeding risk of add-on antiplatelet therapy to direct oral anticoagulants (DOACs) are still to be investigated. We conducted a single-center prospective observational registry of NVAF patients treated with DOACs: the DIRECT registry (UMIN000033283). All patients with NVAF (N = 2216) who were users of dabigatran (N = 648), rivaroxaban (N = 538), apixaban (N = 599), or edoxaban (N = 431) from June 2011 to November 2017 were enrolled (71...
January 25, 2019: American Journal of Cardiology
Ryoji Kinoshita, Susumu Manabe, Daiki Hirayama, Norihisa Yuge
In the surgical treatment of acute aortic dissection, the attachment of the dissected wall using surgical glue can be an effective procedure to stabilize the fragile dissected wall. A 42-year-old man underwent aortic root replacement for acute type A aortic dissection. However, after aortic declamping, he experienced severe myocardial impairment, which required an additional procedure of coronary artery bypass grafting. The unexpected myocardial ischaemia can be attributed to the inattentional use of surgical glue...
January 31, 2019: Interactive Cardiovascular and Thoracic Surgery
Masaaki Hirayama, Mikako Ito, Tomomi Minato, Asako Yoritaka, Tyler W LeBaron, Kinji Ohno
Hyposmia is one of the earliest and the most common symptoms in Parkinson's disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinary 8-hydroxy-2'-deoxyguanine (8-OHdG) levels by a randomized, double-blinded, placebo-controlled, crossover trial with an 8-week washout period in 20 patients with PD...
October 2018: Medical Gas Research
Kengo Horie, Kiyoshi Inoue, Shingo Suzuki, Saki Adachi, Saori Yada, Takashi Hirayama, Shizu Hidema, Larry J Young, Katsuhiko Nishimori
Behavioral neuroendocrinology has benefited tremendously from the use of a wide range of model organisms that are ideally suited for particular questions. However, in recent years the ability to manipulate the genomes of laboratory strains of mice has led to rapid advances in our understanding of the role of specific genes, circuits and neural populations in regulating behavior. While genome manipulation in mice has been a boon for behavioral neuroscience, the intensive focus on the mouse restricts the diversity in behavioral questions that can be investigated using state-of-the-art techniques...
November 8, 2018: Hormones and Behavior
Yoshito Kusuhara, Kei Daizumoto, Kaichi Kawai, Kento Hirayama, Minoru Kowada, Terumichi Shintani, Yayoi Fukuhara, Tsogt-Ochir Dondoo, Keisuke Ozaki, Megumi Tsuda, Tomoya Fukawa, Hiroyoshi Nakatsuji, Yoshimi Bando, Hisanori Uehara, Tomoharu Fukumori, Masayuki Takahashi, Hiro-Omi Kanayama
BACKGROUND/AIM: The aim of this study was to elucidate the relationship between the progression of bladder cancer (BCa) and TLR4 expression. MATERIALS AND METHODS: The relationship between TLR4 expression and prognosis of BCa patients was analyzed using a publicly available database and immunohistochemical staining of clinical samples. The effect of TLR4 knockdown was also examined on the invasive capabilities of BCa cells. Finally, to investigate the biological function of TLR4, the gene expression profile of TLR4-depleted BCa cells was analyzed by microarray analysis...
February 2019: Anticancer Research
Aoi Isono, Mieko Tsuji, Yu Sanada, Akari Matsushita, Shinichiro Masunaga, Tasuku Hirayama, Hideko Nagasawa
We developed new 10B carriers for boron neutron capture therapy (BNCT) that can effectively transport and accumulate boron clusters into cells. These carriers consist of lipopeptide, mercaptoundecahydrododecaborate (BSH) and a disulfide linker. The carriers were conceived according to the structure of pepducine, a membrane-penetrating lipopeptide targeting protease-activated receptor 1 (PAR1). To improve the membrane permeability of BSH, the structure was optimised using various lipopeptides possessing different peptides and lipid moieties...
February 1, 2019: ChemMedChem
Takashi Miida, Satoshi Hirayama
PURPOSE OF REVIEW: Lipoprotein-X (Lp-X) is an abnormal lipoprotein containing abundant free cholesterol and phospholipids, as well as some apolipoprotein E (apoE). Serum Lp-X increases in patients with cholestasis and lecithin-cholesterol acyltransferase deficiency, as well as in those receiving intravenous lipid emulsion. Lp-X is often associated with skin xanthomas in cholestatic patients. However, earlier studies showed that Lp-X is not taken up by murine macrophages, but exerts antiatherogenic actions...
January 28, 2019: Current Opinion in Endocrinology, Diabetes, and Obesity
Shintaro Yashima, Satoshi Hirayama, Takayuki Kurokawa, Thomas Salez, Haruna Takefuji, Wei Hong, Jian Ping Gong
The contact of a hydrogel during the rotational shearing on a glass surface in concentrated polymer solution was observed in situ. Dynamic contact patterns that rotate in-phase with the rotational shearing of the gel were observed for the first time. The contact patterns with a periodicity in the circumferential direction appeared and became fine with the shearing time. The patterns appeared more quickly at an elevated sliding velocity, polymer concentration, and normal pressure. Furthermore, the softness of the gel also substantially influenced the characteristics of the patterns...
January 29, 2019: Soft Matter
Hirotoshi Maruo, Hajime Tsuyuki, Yuji Shimizu, Yasushi Shibasaki, Koichi Nakamura, Yukihiro Higashi, Tsuyoshi Shoji, Kazuhisa Hirayama, Masanori Yamazaki
We report the cases we encountered in our department involving 4 patients with malignant ilial lymphoma that caused ileocolic intussusception. The patients were 2 male and 2 female, aged 65-76 years. All patients' chief complaint was abdominal pain. Computed tomography revealed target signs characteristic of intussusception. Colonoscopy showed a tumor that escaped into the colon, leading to the diagnosis of ileocolic intussusception due to an ileal tumor. However, definitive diagnosis could not be achieved from biopsy...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hajime Tsuyuki, Hirotoshi Maruo, Yuji Shimizu, Yasushi Shibasaki, Koichi Nakamura, Yukihiro Higashi, Tsuyoshi Shoji, Kazuhisa Hirayama, Masanori Yamazaki
The patient was a 76-year-old man who was admitted to our hospital with a diagnosis of ileus. A gallbladder tumor was found incidentally on CT, and it was diagnosed as gallbladder cancer. Enlargement of multiple lymph nodes, including the paraaortic lymph nodes, was observed, and PET-CT further showed FDG uptake in the lymph nodes. Based on these findings, the patient was diagnosed with Stage ⅣB gallbladder cancer with paraaortic lymph node metastases. Since surgical resection was not possible, chemotherapy with gemcitabine and cisplatin(GEM plus CDDP)was started...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Zhicheng Shao, Haneul Noh, Woong Bin Kim, Peiyan Ni, Christine Nguyen, Sarah E Cote, Elizabeth Noyes, Joyce Zhao, Teagan Parsons, James M Park, Kelvin Zheng, Joshua J Park, Joseph T Coyle, Daniel R Weinberger, Richard E Straub, Karen F Berman, Jose Apud, Dost Ongur, Bruce M Cohen, Donna L McPhie, Judith L Rapoport, Roy H Perlis, Thomas A Lanz, Hualin Simon Xi, Changhong Yin, Weihua Huang, Teruyoshi Hirayama, Emi Fukuda, Takeshi Yagi, Sulagna Ghosh, Kevin C Eggan, Hae-Young Kim, Leonard M Eisenberg, Alexander A Moghadam, Patric K Stanton, Jun-Hyeong Cho, Sangmi Chung
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional excitatory inputs from host neurons, and induced GABA-mediated inhibition in host neurons in vivo. However, schizophrenia cINs had dysregulated expression of protocadherin genes, which lie within documented schizophrenia loci. Mice lacking protocadherin-α showed defective arborization and synaptic density of prefrontal cortex cINs and behavioral abnormalities...
February 2019: Nature Neuroscience
J Fujioka, R Yamada, M Kawamura, S Sakai, M Hirayama, R Arita, T Okawa, D Hashizume, M Hoshino, Y Tokura
Electrons in conventional metals become less mobile under the influence of electron correlation. Contrary to this empirical knowledge, we report here that electrons with the highest mobility ever found in known bulk oxide semiconductors emerge in the strong-correlation regime of the Dirac semimetal of perovskite CaIrO3 . The transport measurements reveal that the high mobility exceeding 60,000 cm2 V-1 s-1 originates from the proximity of the Fermi energy to the Dirac node (ΔE < 10 meV). The calculation based on the density functional theory and the dynamical mean field theory reveals that the energy difference becomes smaller as the system approaches the Mott transition, highlighting a crucial role of correlation effects cooperating with the spin-orbit coupling...
January 21, 2019: Nature Communications
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