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https://read.qxmd.com/read/30761838/s1pr2-deficiency-enhances-neuropathic-pain-induced-by-partial-sciatic-nerve-ligation
#1
Qiang Gu, Jin-Chao Hou, Xiang-Ming Fang
Background/aim: Sphingosine 1-phosphate receptor 2 (S1PR2), a member of the seven-transmembrane receptor family, can be activated by its natural ligand sphingosine 1-phosphate (S1P) to initiate signal transduction and is involved in a wide range of biological effects such as immune cell migration and vascular permeability. Its relationship with neuropathic pain (NP) has not been reported. In this study, the effects of S1PR2 on the development of NP were studied. Materials and methods: We generated a model of NP by partial sciatic nerve ligation (pSNL)...
February 11, 2019: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/30753909/effects-of-microencapsulated-olfactory-ensheathing-cell-transplantation-on-neuropathic-pain-and-p2x7-receptor-expression-in-the-l4-5-spinal-cord-segment
#2
Wenjun Zhang, Yuguo Liu, Yi Sun, Zengxu Liu
OBJECTIVES: The aim of this study was to determine the role of microencapsulated olfactory ensheathing cell (MC-OEC) transplantation in rats with sciatic nerve injury-induced pain, and its relationship with P2 × 7 receptor expression in the L4-5 spinal cord segment. METHODS: Olfactory bulb tissues of healthy Sprague Dawley (SD) rats were collected to culture olfactory ensheathing cells using differential attachment methods. Forty-eight healthy SD rats were randomly assigned to four groups: the sham, chronic constriction injury (CCI), olfactory ensheathing cell (OEC), and MC-OEC groups...
February 9, 2019: Neuroscience Letters
https://read.qxmd.com/read/30740801/ginsenoside-rf-relieves-mechanical-hypersensitivity-depression-like-behavior-and-inflammatory-reactions-in-chronic-constriction-injury-rats
#3
Yangyi Li, Chengbo Chen, Shunyuan Li, Changcheng Jiang
The aim of this study was to investigate whether ginsenoside Rf can effectively relieve pain hypersensitivity in a neuropathic pain rat model. Neuropathic pain was induced in rats by chronic constriction injury (CCI) to the right sciatic nerve. Ginsenoside Rf was administered intraperitoneally after CCI surgery. The von Frey filament test and forced swimming test were performed to examine pain hypersensitivity and depression-like behavior in rats. Western blot was used to measure the levels of inflammatory cytokines in the dorsal root ganglion (DRG) and the spinal cord...
February 11, 2019: Phytotherapy Research: PTR
https://read.qxmd.com/read/30639439/biomarkers-mapping-of-neuropathic-pain-in-a-nerve-chronic-constriction-injury-mice-model
#4
S Vincenzetti, S Pucciarelli, Y Huang, M Ricciutelli, C Lambertucci, R Volpini, G Scuppa, L Soverchia, M Ubaldi, V Polzonetti
Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system and has a considerable impact on the quality of life. Neuropathic pain has a dynamic and complex aetiology and gives heterogeneous symptoms across patients; therefore, it represents an important clinical challenge. Current pharmacological treatment includes tricyclic antidepressant serotonin-noradrenaline uptake inhibitors such as duloxetine, pregabalin, and gabapentin. However, these drugs do not show efficacy in all patients suffering from neuropathic pain...
January 11, 2019: Biochimie
https://read.qxmd.com/read/30621742/sciatic-nerve-block-or-not-for-outpatient-total-knee-arthroplasty-study-protocol-for-a-randomized-controlled-trial
#5
Laurie Tran, Melissa Barthelemy, Pascal Boileau, Marc Raucoules-Aime, Michel Carles, Christophe Trojani
BACKGROUND: The number of patients operated on for total knee arthroplasty (TKA) is growing worldwide. Outpatient surgery is defined by a length of stay (LOS) in the hospital of less than 12 h. This can be limited for TKA, with the efficient management of pain and perioperative complications, such as blood loss, affecting a safe hospital discharge. Outpatient TKA with a suitable protocol, including multimodal measures, could improve the success rate of this procedure. Among the main measures, single-shot sciatic nerve block in association with continuous femoral nerve block for pain control needs to be evaluated in outpatient TKA...
January 8, 2019: Trials
https://read.qxmd.com/read/30585457/-effect-of-electroacupuncture-of-weizhong-bl-40-and-huantiao-gb-30-on-camp-pka-creb-signaling-of-spinal-cord-in-rats-with-neuropathic-pain
#6
Li-Ping Yan, Chang-Xin Qian, Cheng Ma, Ling-Ling Wang
OBJECTIVE: We have demonstrated that electroacupuncture (EA) of "Weizhong" (BL 40) and "Huantiao" (GB 30) could evidently relieve mechanical hyperalgesia in spared nerve injury (SNI) rats. The present study was designed to observe the effect of EA on levels of cAMP, and protein kinase A (PKA) and cAMP response element binding protein (CREB) in the lumbar spinal cord of the same pain model rats, so as to explore its mechanisms underlying improvement of neuropathic pain...
December 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/30567487/ultrasound-guided-continuous-femoral-nerve-block-a-randomized-trial-on-the-influence-of-femoral-nerve-catheter-orifice-configuration-six-hole-versus-end-hole-on-post-operative-analgesia-after-total-knee-arthroplasty
#7
Alessandra Novello-Siegenthaler, Mehdi Hamdani, Irène Iselin-Chaves, Roxane Fournier
BACKGROUND: Multiorifice catheters have been shown to provide superior analgesia and significantly reduce local anesthetic consumption compared with end-hole catheters in epidural studies. This prospective, blinded, randomized study tested the hypothesis that, in continuous femoral nerve block (CFNB) under ultrasound guidance, multiorifice catheter would reduce local anesthetic consumption at 24 h compared with end-hole catheter. METHODS: Eighty adult patients (aged ≥18 years) scheduled to undergo primary total knee arthroplasty under a combination of CFNB, sciatic nerve block and general anesthesia were randomized to CFNB using either a 3-pair micro-hole (Contiplex, BRAUN®, 20G - 400 mm) or an end-hole (Silverstim VYGON®, 20G - 500 mm) catheter...
December 19, 2018: BMC Anesthesiology
https://read.qxmd.com/read/30562225/local-infiltration-anaesthesia-versus-sciatic-nerve-and-adductor-canal-block-for-fast-track-knee-arthroplasty-a-randomised-controlled-clinical-trial
#8
Joanna Kastelik, Michael Fuchs, Michael Krämer, Ralf F Trauzeddel, Martin Ertmer, Philipp von Roth, Carsten Perka, Stephanie M Kirschbaum, Sascha Tafelski, Sascha Treskatsch
BACKGROUND: Local infiltration anaesthesia (LIA) was introduced as an innovative analgesic procedure for enhanced recovery after primary total knee arthroplasty (TKA). However, LIA has never been compared with analgesia based on an adductor canal catheter and a single-shot sciatic nerve block. OBJECTIVE: To evaluate two analgesic regimens for TKA comparing mobility, postoperative pain and patient satisfaction. DESIGN: Two-group randomised, controlled clinical trial...
December 17, 2018: European Journal of Anaesthesiology
https://read.qxmd.com/read/30507759/microencapsulated-olfactory-ensheathing-cell-transplantation-reduces-pain-in-rats-by-inhibiting-p2x4-receptor-overexpression-in-the-dorsal-root-ganglion
#9
Wenjun Zhang, Yuguo Liu, Baolin Yang, Zengxu Liu, Qing Yu
The aim of this study was to determine the role of microencapsulated olfactory ensheathing-cell transplantation (MC-OEC) in rats in which pain was induced by sciatic nerve injury, and its relationship with the expression level of the P2X4 receptor in the dorsal root ganglion. Olfactory bulb tissues of healthy Sprague-Dawley rats were collected to culture olfactory ensheathing cells using differential attachment methods. Ninety-six healthy Sprague-Dawley rats were randomly assigned to the sham, chronic constriction injury (CCI), olfactory ensheathing cell (OEC), and MC-OEC groups...
January 16, 2019: Neuroreport
https://read.qxmd.com/read/30411313/rebound-pain-following-peripheral-nerve-block-anaesthesia-in-acute-ankle-fracture-surgery-an-exploratory-pilot-study
#10
Rune Sort, Stig Brorson, Ismail Gögenur, Jesper K Nielsen, Ann M Møller
BACKGROUND: Peripheral nerve blocks (PNB) are increasingly used for anaesthesia and postoperative pain control in acute orthopaedic limb surgery but rebound pain upon cessation of PNBs may challenge the benefits on the pain profile. We aimed to explore the pain profile following acute ankle fracture surgery under PNB anaesthesia and investigate if rebound pain could pose a clinical problem. METHODS: Exploratory, observational study of adults scheduled for acute primary internal fixation of an ankle fracture under ultrasound-guided popliteal sciatic and saphenous ropivacaine block anaesthesia...
November 8, 2018: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/30405207/valproate-reduces-neuroinflammation-and-neuronal-death-in-a-rat-chronic-constriction-injury-model
#11
Jun-Yih Chen, Li-Wen Chu, Kuang-I Cheng, Su-Ling Hsieh, Yung-Shun Juan, Bin-Nan Wu
Valproate (VPA) is a well-known drug for treating epilepsy and mania, but its action in neuropathic pain is unclear. We used a chronic constriction injury (CCI) model to explore whether VPA prevents neuropathic pain-mediated inflammation and neuronal death. Rats were treated with or without VPA. CCI + VPA rats were intraperitoneally injected with VPA (300 mg/kg/day) from postoperative day (POD) 1 to 14. We measured paw withdrawal latency (PWL) and paw withdrawal threshold (PWT) 1 day before surgery and 1, 3, 7, 14 days after CCI and harvested the sciatic nerves (SN), spinal cord (SC) and dorsal root ganglia (DRG) on POD 3, 7, and 14...
November 7, 2018: Scientific Reports
https://read.qxmd.com/read/30369602/quercetin-attenuates-neuropathic-pain-in-rats-with-spared-nerve-injury
#12
Noriko Muto, Yoshikazu Matsuoka, Kyosuke Arakawa, Masako Kurita, Hiroki Omiya, Arata Taniguchi, Ryuji Kaku, Hiroshi Morimatsu
Quercetin is a flavonoid widely found in plants and marketed to the public as a supplement. Several studies have reported its effect on glial cells. This study aimed to examine the effect of quercetin on the development of neuropathic pain and the underlying mechanism in a spared nerve injury (SNI) rat model. Male Sprague-Dawley rats randomly assigned to the control or the quercetin group were subjected to SNI of the sciatic nerve. We measured pain behaviors on the hind paw and glial fibrillary acidic protein (GFAP) in the dorsal root ganglion (DRG) and spinal cord...
October 2018: Acta Medica Okayama
https://read.qxmd.com/read/30367337/neuroprotective-effect-of-anethole-against-neuropathic-pain-induced-by-chronic-constriction-injury-of-the-sciatic-nerve-in-mice
#13
Bing Wang, Guoxin Zhang, Mei Yang, Ning Liu, Yu-Xiang Li, Hanxiang Ma, Lin Ma, Tao Sun, Huanran Tan, Jianqiang Yu
Neuropathic pain is an intractable disease with few definitive therapeutic options. Anethole (AN) has been confirmed to possess potent anti-inflammatory and neuroprotective properties, but its effect on neuropathic pain has not been reported. The present study was designed to investigate the antinociceptive effect of AN on chronic constriction injury (CCI)-induced neuropathic pain in mice. AN (125, 250, and 500 mg/kg) and pregabalin (40 mg/kg) were intragastric administered for 8 consecutive days from the 7th day post-surgery...
December 2018: Neurochemical Research
https://read.qxmd.com/read/30349809/environmental-enrichment-alleviates-chronic-pain-in-rats-following-a-spared-nerve-injury-to-induce-neuropathic-pain-a-preliminary-study
#14
Madeleine Parent-Vachon, Pascal Vachon
Background: In mice, chronic pain can be alleviated with enriched environments (EEs). The purpose of this preliminary study is to investigate whether pain behaviors in rats with peripheral neuropathy would be altered when keeping these animals in either 1) standard laboratory cages or in 2) a significantly EE. Methods: Two groups of rats (n=8/group) underwent a spare nerve injury surgery of the right hind leg; one group (n=8) was returned to standard ventilated cages (2 rats/cage), the other (n=8) placed in an EE (8 rats/ferret cage with toys)...
2018: Veterinary medicine
https://read.qxmd.com/read/30342951/midterm-results-of-total-hip-arthroplasty-in-patients-with-high-hip-dislocation-after-suppurative-hip-arthritis
#15
Wei-Nan Zeng, Jun-Li Liu, Xiao-Lin Jia, Qiang Zhou, Liu Yang, Yun Zhang
BACKGROUND: Total hip arthroplasty (THA) is technically challenging in patients with high dislocation of the hip secondary to suppurative arthritis. The technical difficulty is attributable to the complex hip anatomy and the potential risk of recurrent infection in these patients. This study investigated the midterm results of THA in patients with Crowe type III and IV high dislocation of the hip secondary to suppurative arthritis. METHODS: This study retrospectively reviewed 45 patients (45 hips) who underwent cementless THA with a mean quiescent infection period of 34...
September 27, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30333433/analgesic-effects-of-minodronate-in-a-rat-chronic-pain-model
#16
Yuji Kasukawa, Naohisa Miyakoshi, Masazumi Suzuki, Hiroyuki Tsuchie, Chie Sato, Tetsuya Kawano, Manabu Akagawa, Yuichi Ono, Yoichi Shimada
We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0...
2018: Biomedical Research
https://read.qxmd.com/read/30276467/treatment-results-for-lumbar-epidural-lipomatosis-does-fat-matter
#17
Simon Heinrich Bayerl, Malte Dinkelbach, Petra Heiden, Vincent Prinz, Tobias Finger, Peter Vajkoczy
PURPOSE: The lumbar epidural lipomatosis (LEL) is a rare disease that can cause sciatic pain syndrome or neurological deficits comparable to symptoms caused by a classical spinal canal stenosis. In severe cases surgical decompression was conducted. However, the outcome after decompressive surgery has only been investigated in small case series. In this study we compared the outcome of LEL patients after microsurgery with the outcome of patients with classical spinal stenosis (CSS). METHODS: Patients with LEL (n = 38) and patients with CSS (n = 51), who received microsurgical decompression, were followed in a prospective observational study for 3 years...
October 1, 2018: European Spine Journal
https://read.qxmd.com/read/30276175/diosgenin-improves-functional-recovery-from-sciatic-crushed-nerve-injury-in-rats
#18
Byung-Ki Lee, Chang-Ju Kim, Mal-Soon Shin, Young Sam Cho
Peripheral nerve injuries are commonly encountered clinical problem and often result in chronic pain and severe functional deficit. Diosgenin is a plant steroidal saponin and has anti-inflammatory and anticancer effects. In the present study, we investigated the effect of diosgenin on functional recovery following sciatic crushed nerve injury in rats. Walking track analysis for the functional recovery which can be quantified with the sciatic function index (SFI) was conducted. Immunohistochemistry for c-Fos in the ventrolateral periaqueductal gray (vlPAG) and paraventricular nucleus (PVN) and western blot for brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthesis (iNOS) in the sciatic nerve were performed...
August 2018: Journal of Exercise Rehabilitation
https://read.qxmd.com/read/30254944/endometriosis-involving-the-sciatic-nerve-a-case-report-of-isolated-endometriosis-of-the-sciatic-nerve-and-review-of-the-literature
#19
Tal D Saar, Stefaan Pacquée, Dean Helmar Conrad, Mikhail Sarofim, Philippe De Rosnay, David Rosen, Greg Cario, Danny Chou
Endometriosis is a common gynecological condition which affects 5-10% of women of reproductive age and up to 50% of women with pelvic pain and infertility. The most commonly affected areas are the pelvic peritoneum, ovaries and rectovaginal septum. Isolated endometriosis of the sciatic nerve is very rare. Our patient suffered from worsening right hip and buttock pain with severe exacerbation during menstruation. Several different imaging modalities (ultrasound of her pelvis and right hip, as well as X-rays and computed tomography scans of her right hip and lumbosacral spine) failed to identify any pathology...
April 2018: Gynecology and minimally invasive therapy
https://read.qxmd.com/read/30236251/ultrasound-guided-adductor-canal-block-a-cadaver-study-investigating-the-effect-of-a-thigh-tourniquet
#20
A Nair, J Dolan, K E Tanner, C M Kerr, B Jones, P J Pollock, C F Kellett
BACKGROUND: Placement of local anaesthetic within the adductor canal using ultrasonography is an alternative to femoral nerve blocks for postoperative pain relief after knee joint replacement surgery. However, the effect of an inflated thigh tourniquet on the distribution of local anaesthetic within the adductor canal is unknown. The aim of this cadaveric study was to compare the distribution of radio-opaque dye within the adductor canal in the presence or absence of an inflated thigh tourniquet...
October 2018: British Journal of Anaesthesia
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