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Systemic lupus erthymatosus

Momo Maruoka, Shinichiro Tsunoda, Tetsuya Furukawa, Okuto Honda, Takahiro Yoshikawa, Kazuyuki Fujita, Yuki Sekiguchi, Chieri Satou, Atsushi Saitou, Aki Nishioka, Masahiro Sekiguchi, Naoto Azuma, Masayasu Kitano, Kiyoshi Matsui, Hiroaki Shibahara, Hajime Sano
SUMMARY: A 39-year-old woman was diagnosed with Systemic lupus erthymatosus (SLE) in 1993, and initially received 30 mg of prednisolone (PSL) daily as treatment. In 2012, the patient was diagnosed with pregnancy-induced hypertension (PIH) complecated with proteinurea, hypertension and pretibial edema at 24 weeks of gestation. At onset, protein urea was 1.6 g/day and she was given bed rest in the hospital with a protein-restricted and low salt diet, which led to a decrease in protein urea to approximately 1 g/day...
2015: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
Patricia López, Dagmar Scheel-Toellner, Javier Rodríguez-Carrio, Luis Caminal-Montero, Caroline Gordon, Ana Suárez
OBJECTIVE: The aim of this study was to investigate the cellular populations and regulatory factors responsible for B-lymphocyte stimulator (BLyS) overexpression in SLE patients. METHODS: Surface and intracellular BLyS levels were quantified by flow cytometry in healthy and SLE monocytes cultured in the presence of TNF-α, IFN-α, IFN-γ, GM-CSF and SLE immune complexes (SLE-ICs), while soluble BLyS was measured by ELISA. Also, both surface and intracellular BLyS expression by different cell subsets was determined in 23 SLE patients and 16 healthy controls...
December 2014: Rheumatology
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