Jodi L Nelson, Gregory M Blume, Saurabh K Bansal, Jacqueline R Kaufman, Florence R Woods, Xiaojun Zhang, Jorge C Kattah
BACKGROUND: The opsoclonus-myoclonus-ataxia syndrome (OMAS) represents a pathophysiology and diagnostic challenge. Although the diverse etiologies likely share a common mechanism to generate ocular, trunk, and limb movements, the underlying cause may be a paraneoplastic syndrome, as the first sign of cancer, or may be a postinfectious complication, and thus, the outcome depends on identifying the trigger mechanism. A recent hypothesis suggests increased GABAA receptor sensitivity in the olivary-oculomotor vermis-fastigial nucleus-premotor saccade burst neuron circuit in the brainstem...
June 1, 2022: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society