Sabrina Rossi, Sabina Barresi, Giovanna Stefania Colafati, Silvia Genovese, Chantal Tancredi, Valentino Costabile, Sara Patrizi, Isabella Giovannoni, Sofia Asioli, Pietro Luigi Poliani, Marina Paola Gardiman, Antonello Cardoni, Giada Del Baldo, Manila Antonelli, Francesca Gianno, Eleonora Piccirilli, Giorgia Catino, Licia Martucci, Denise Quacquarini, Francesco Toni, Fraia Melchionda, Elisabetta Viscardi, Mino Zucchelli, Sandro Dal Pos, Enza Gatti, Roberto Liserre, Elisabetta Schiavello, Francesca Diomedi-Camassei, Andrea Carai, Angela Mastronuzzi, Marco Gessi, Caterina Giannini, Antonio Novelli, Andrea Onetti Muda, Evelina Miele, Viola Alesi, Rita Alaggio
PATZ1-rearranged sarcomas are well-recognized tumors as part of the family of round cell sarcoma with EWSR1-non-ETS fusions. Whether PATZ1-rearranged central nervous system (CNS) tumors are a distinct tumor type is debatable. We thoroughly characterized a pediatric series of PATZ1-rearranged CNS tumors by chromosome microarray analysis (CMA), DNA methylation analysis, gene expression profiling and, when frozen tissue is available, optical genome mapping (OGM). The series consisted of 7 cases (M:F=1.3:1, 1-17 years, median 12)...
February 2024: Modern Pathology