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https://read.qxmd.com/read/30879172/targeted-radioimmunotherapy-for-embryonal-tumor-with-multilayered-rosettes
#1
Kayleen Bailey, Neeta Pandit-Taskar, John L Humm, Pat Zanzonico, Stephen Gilheeney, Nai-Kong V Cheung, Kim Kramer
PURPOSE: We explored the use of intraventricular 131 I-Omburtamab targeting B7-H3 in patients with ETMR. METHODS: Patients were enrolled in an IRB approved, phase 1, 3 + 3 dose escalation trial. Patients with CNS disease expressing the antibody target antigen B7-H3 were eligible. We report on a cohort of three patients with ETMR who were enrolled on the study. Three symptomatic children (ages 14 months, 3 and 3.5 years) had large parietal masses confirmed to be B7-H3-reactive ETMR...
March 16, 2019: Journal of Neuro-oncology
https://read.qxmd.com/read/30865115/hydrocephalus-due-to-idiopathic-fourth-ventricle-outflow-obstruction
#2
Jianfeng Bai, Qingqing Yu, Xiaoyu Sun, Huaming Xiao, Kai Wang, Feng Sun, Qiangbo Sui
The fourth ventricle outlet obstruction (FVOO) is a rare but well-established cause of obstructive tetra-ventricular hydrocephalus, characterizing with dilatation or large cerebrospinal fluid collection of the foramina of Magendie and Luschka. In children, it is usually the consequence of posterior cerebral fossa malformations; while in adult, the occlusion is rather acquired than congenital, mostly linked to an inflammatory process, intraventricular hemorrhage, head trauma, brain tumors or Arnold-Chiari malformation...
March 6, 2019: Journal of Craniofacial Surgery
https://read.qxmd.com/read/30846234/prothrombotic-activity-of-cytokine-activated-endothelial-cells-and-shear-activated-platelets-in-the-setting-of-ventricular-assist-device-support
#3
Alice Apostoli, Valentina Bianchi, Nina Bono, Annalisa Dimasi, Kaitlyn R Ammann, Yana Roka Moiia, Andrea Montisci, Jawaad Sheriff, Danny Bluestein, Gianfranco B Fiore, Federico Pappalardo, Gabriele Candiani, Alberto Redaelli, Marvin J Slepian, Filippo Consolo
BACKGROUND: We systematically analyzed the synergistic effect of: (i) cytokine-mediated inflammatory activation of endothelial cells (ECs) with and (ii) shear-mediated platelet activation (SMPA) as a potential contributory mechanism to intraventricular thrombus formation in the setting of left ventricular assist device (LVAD) support. METHODS: Intact and shear-activated human platelets were exposed to non-activated and cytokine-activated ECs. To modulate the level of LVAD-related shear activation, platelets were exposed to shear stress patterns of varying magnitude (30, 50, and 70 dynes/cm2 , 10 minutes) via a hemodynamic shearing device...
February 18, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30838174/quantitative-evaluation-of-intraventricular-delivery-of-therapeutic-neural-stem-cells-to-orthotopic-glioma
#4
Margarita Gutova, Linda Flores, Vikram Adhikarla, Lusine Tsaturyan, Revathiswari Tirughana, Soraya Aramburo, Marianne Metz, Joanna Gonzaga, Alexander Annala, Timothy W Synold, Jana Portnow, Russell C Rockne, Karen S Aboody
Neural stem cells (NSCs) are inherently tumor-tropic, which allows them to migrate through normal tissue and selectively localize to invasive tumor sites in the brain. We have engineered a clonal, immortalized allogeneic NSC line (HB1.F3.CD21; CD-NSCs) that maintains its stem-like properties, a normal karyotype and is HLA Class II negative. It is genetically and functionally stable over time and multiple passages, and has demonstrated safety in phase I glioma trials. These properties enable the production of an "off-the-shelf" therapy that can be readily available for patient treatment...
2019: Frontiers in Oncology
https://read.qxmd.com/read/30814776/the-sovereignty-of-primary-cranial-tumors-meningiomas-vetting-the-cardinal-epidemiological-features
#5
Alqroom Rami, Eteiwi Suzan, Aldrous Rafeed, Al Manaseer Nooruddeen, Arabiyat Lamees, Alshurbaji Duaa, Abu Nowar Hussam, Al Shurbaji Amer
Introduction: Cranial meningiomas considered one of most frequently encountered primary intracranial tumors in our daily neurosurgical practice, represent about 36% of brain neoplasms. Aim: In this cohort analysis, we investigated epidemiological features of brain meningiomas diagnosed at a single institution. Special highlighting has been dedicated to demographic features, foretelling radiological signs, and concomitant factors predictive of tumor atypia. Material and Methods: This retrospective analysis was conducted by revising all medical registries of patients aged ≥18 years, with a diagnosis of brain meningioma treated at King Hussein Medical Center, patients were retrieved from the electronic hospital database during a 12-year period (2004 to 2015)...
December 2018: Medical Archives
https://read.qxmd.com/read/30797910/visual-controlled-endoscopic-biopsy-of-paraventricular-intraparenchymal-tumors
#6
Joachim Oertel, Doerthe Dörthe Keiner
OBJECT: Frame-based stereotaxy represents the gold standard for biopsy of deep-seated lesions. A visual control of possible bleeding in these lesions is not possible. Neuroendoscopic biopsy represents an alternative procedure for tissue-sampling in deep-seated intraventricular lesions. The authors present a technique for transventricular navigated endoscopic biopsy of lesions that are located in the paraventricular region. METHODS: Biopsy of paraventricular pathologies was performed in 6 male and 6 female patients between 03/2013 and 09/2018...
February 21, 2019: World Neurosurgery
https://read.qxmd.com/read/30797210/rapidly-growing-multifocal-benign-choroid-plexus-tumor-in-an-infant-case-report
#7
Kalina A Misiolek, Zachary G Osborn, Natalie Hauser, Diana Thomas, Jessica F Goodman, Daniel H Fulkerson
Choroid plexus papillomas (CPPs) are rare, benign tumors that can arise in young children. Most pediatric patients present with signs of hydrocephalus and require immediate treatment. The natural history of choroid plexus tumors in children without hydrocephalus is poorly defined. In this report, the authors present the very rare case of a child without hydrocephalus but with two intraventricular choroid plexus tumors discovered shortly after birth. Initial imaging had been performed for seizures and showed agenesis of the corpus callosum and enhancing tumors in the third and left lateral ventricles...
February 22, 2019: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/30792643/intracardiac-extension-of-wilms-tumor-a-case-of-a-2-5-year-old-girl-presenting-with-upper-venous-congestion-caused-by-tumor-growth-into-the-right-cardiac-ventricle
#8
Roland Imle, Georgi Tosev, Wolfgang Behnisch, Jens-Peter Schenk, Helmut Rauch, Andreas Mueller, Matthias Gorenflo, Tsvetomir Loukanov, Andreas Kulozik, Joanne Nyarangi-Dix
While Wilms tumors (WT) typically present solely with an abdominally palpable mass, rare cases exhibiting vascular tumor growth can also present with circulatory problems. Here, we report the case of a 2.5-year-old girl presenting with upper venous congestion and arterial hypertension as the primary symptoms of intraventricular tumor growth exhibiting remarkable tubular and perfused morphology. Clinical situation stabilized after initiation of neoadjuvant chemotherapy (NAC) with actinomycin D and vincristine, followed by surgical resection via laparotomy and sternotomy supported by cardiopulmonary bypass and deep hypothermia...
January 2019: Case Reports in Oncology
https://read.qxmd.com/read/30775062/neurocytoma-mimicking-macroadenoma
#9
Breno Nery, Fred Bernardes Filho, Rodrigo Antônio Fernandes Costa, Leandro César Tângari Pereira, Eduardo Quaggio, Rodolfo Mendes Queiroz, Lucas Giansante Abud, Daniela Pretti da Cunha Tirapelli
Background: Intraventricular and extraventricular central neurocytomas (CN) are equally frequent among 20-40-year-old men and women. However, sellar and suprasellar extraventricular CN are extremely rare, with only 12 reported cases. Case Description: The authors report the case of a Brazilian 27-year-old man who presented with progressive vision loss during the last 4 years and serious bilateral keratoconus. We also review the epidemiological, clinical, radiological, pathological, and treatment features of the 12 reported cases...
2019: Surgical Neurology International
https://read.qxmd.com/read/30766637/endoscopic-biopsy-of-intra-and-paraventricular-brain-tumors
#10
Krzysztof Stachura, Ewelina Grzywna, Roger M Krzyżewski, Borys M Kwinta, Dariusz Adamek, Marek M Moskała
Introduction: Selection of the optimal treatment method of intra- and paraventricular tumors often requires histopathological verification that can be obtained by endoscopic biopsy. Aim: To discuss the usefulness of the method in their own experience. Material and methods: The results of 32 biopsies carried out during a 15-year period were reviewed retrospectively. All tumors were located supratentorially, 25 of them were intraventricular and 7 paraventricular...
January 2019: Videosurgery and Other Miniinvasive Techniques
https://read.qxmd.com/read/30738944/stereotactic-guided-dilatable-endoscopic-port-surgery-for-deep-seated-brain-tumors-technical-report-with-comparative-case-series-analysis
#11
William C Newman, Johnathan A Engh
OBJECTIVE: Deep-seated brain tumors are often best treated with primary surgical excision. Traditional microsurgical techniques may cause retraction injury and extensive brain dissection. To mitigate this risk, stereotactic-guided tubular retractors were developed, but the risk of shear injury remains. We created a stereotactic-guided dilatable port system to create a corridor for deep brain tumor surgery along the trajectory of a brain needle in order to minimize iatrogenic brain injury...
February 7, 2019: World Neurosurgery
https://read.qxmd.com/read/30678836/hyperosmotic-intraventricular-drug-delivery-of-dv1-in-the-management-of-intracranial-metastatic-breast-cancer-in-a-mouse-model
#12
Satish Krishnamurthy, Jie Li, Alexa Bodman, Chaozai Zhang, Yilei Yang, Jing An
Advances in therapies for breast cancer with cerebral metastases has been slow, despite this being a common diagnosis, due to limited drug delivery by the blood brain barrier. Improvements in drug delivery for brain metastasis to target the metastases and bypass the blood brain barrier are necessary. In our study, we delivered an inhibitor of chemokine receptor 4 by convection enhanced delivery in a hyperosmotic solution to prevent brain metastasis in a mouse model of metastatic breast cancer. We found the inhibitor limited metastatic disease and more interestingly, the hyperosmotic solution targeted tumor tissue allowing for a higher accumulation of the therapy into tumor tissue...
January 21, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/30620941/ganglioglioma-arising-from-the-septum-pellucidum-case-report-and-review-of-the-literature
#13
Ajay Chatrath, Panagiotis Mastorakos, Gautam U Mehta, Miriam Wildeman, Shayan Moosa, John A Jane
BACKGROUND: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. CASE REPORT: The patient initially presented at 9 months of age with a pilocytic astrocytoma centered on the optic chiasm, treated with chemotherapy and radiation at 3 years of age...
January 8, 2019: Pediatric Neurosurgery
https://read.qxmd.com/read/30608927/continuous-and-bolus-intraventricular-topotecan-prolong-survival-in-a-mouse-model-of-leptomeningeal-medulloblastoma
#14
Gregory M Shackleford, Min Y Mahdi, Rex A Moats, Debra Hawes, Hung C Tran, Jonathan L Finlay, Tuan Q Hoang, Ellis F Meng, Anat Erdreich-Epstein
Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection of therapy into the CSF in a preclinical model of human Group 3 medulloblastoma, the molecular subgroup with the highest incidence of leptomeningeal disease. Initial tests of selected Group 3 human medulloblastoma cell lines in culture showed that D283 Med and D425 Med were resistant to cytosine arabinoside and methotrexate...
2019: PloS One
https://read.qxmd.com/read/30564912/surgical-treatment-of-post-inflammatory-hydrocephalus-analysis-of-101-cases
#15
Bartosz Polis, Lech Polis, Emilia Nowosławska
OBJECTIVE: The aim of this paper was to evaluate the outcomes of surgical treatment for post-inflammatory hydrocephalus in pediatric patients. The patient's age, surgical technique and type of implants, revision rate (depending on the cause for revision and shunt type), and final outcome measured with Neurologic Outcome Scale for Infants and Children (NOSIC) scale were evaluated. METHODS: We performed a retrospective analysis of 101 patients with post-inflammatory hydrocephalus, treated in Polish Mother's Memorial Hospital Research Institute since 2005...
December 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30561708/intraventricular-pilocytic-astrocytoma-with-kiaa1549-braf-fusion-arising-in-a-44-year-old
#16
Janice S Ahn, William Harrison, Elin Hughes, Roger E McLendon
Rare pilocytic astrocytomas (PA) have been described to arise in the ventricles of children. They are even less common in this location for the adult population. We present the case of a 44-year old man presenting with vision and mental status changes. Brain imaging revealed an intraventricular mass within the right ventricular atrium, most consistent with a meningioma. Microscopic examination revealed a neoplasm composed of elongated to plump bipolar astrocytes arranged in a fascicular architecture, accompanied by foci containing numerous Rosenthal fibers...
December 17, 2018: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/30503293/factors-predicting-ventriculostomy-revision-at-a-large-academic-medical-center
#17
Ashwin G Ramayya, Gregory Glauser, Brendan Mcshane, Marc Branche, Saurabh Sinha, Svetlana Kvint, Vivek Buch, Kalil G Abdullah, David Kung, H Isaac Chen, Neil R Malhotra, Ali Ozturk
BACKGROUND: Freehand bedside ventriculostomy placement can result in catheter malfunction requiring a revision procedure and cause significant patient morbidity. We performed a single-center retrospective review to assess factors related to this complication. METHODS: Using an administrative database and chart review, we identified 101 first-time EVD placements performed at the bedside. We collected data regarding demographics, medical co-morbidities, complications and catheter tip location...
November 29, 2018: World Neurosurgery
https://read.qxmd.com/read/30500581/lateral-intraventricular-anaplastic-meningioma-a-series-of-5-patients-at-a-single-institution-and-literature-review
#18
Hongxu Chen, Rui Lai, Xinpu Tang, Zhiyong Liu, Jianguo Xu
OBJECTIVE: Lateral intraventricular anaplastic meningiomas (LIAMs) are rare lesions. The aim of this study is to clarify clinical and radiological characteristics, the optimal treatment strategies of LIAMs with long-term follow-up. PATIENTS AND METHODS: From September 2008 to September 2017, 5 LIAM patients were enrolled in our study. The clinical profiles, radiological features, treatment strategies, and outcomes were retrospectively analyzed. RESULTS: Five patients (all females, mean age 48...
November 27, 2018: World Neurosurgery
https://read.qxmd.com/read/30497142/chordoma-of-the-corpus-callosum-case-report
#19
Lorenzo Rinaldo, David S Priemer, Alexander O Vortmeyer, Aaron A Cohen-Gadol, Daniel J Brat, Anita Mahajan, Caterina Giannini, Terry C Burns
Chordomas are neoplasms that typically arise from midline skeletal structures and rarely originate within the intradural compartment of the CNS. A chordoma arising from the corpus callosum has not been previously described. The authors report the surgical management of a chordoma originating within the splenium of the corpus callosum. To determine the incidence and distribution of intracranial intradural chordoma, a literature search for additional cases was performed. MEDLINE was searched using the MeSH keyword "chordoma," yielding 2010 articles...
November 1, 2018: Journal of Neurosurgery
https://read.qxmd.com/read/30460634/infusion-of-5-azacytidine-5-aza-into-the-fourth-ventricle-or-resection-cavity-in-children-with-recurrent-posterior-fossa-ependymoma-a-pilot-clinical-trial
#20
David I Sandberg, Bangning Yu, Rajan Patel, John Hagan, Emilie Miesner, Jennifer Sabin, Sarah Smith, Stephen Fletcher, Manish N Shah, Rachael W Sirianni, Michael D Taylor
BACKGROUND: DNA methylation inhibitors are logical therapeutic candidates for ependymomas originating in the posterior fossa of the brain. Our objective was to test the safety of infusing 5-Azacytidine (5-AZA), a DNA methylation inhibitor, directly into cerebrospinal fluid (CSF) spaces of the fourth ventricle or tumor resection cavity in children with recurrent ependymoma originating in the posterior fossa. MATERIALS AND METHODS: In patients with recurrent ependymoma whose disease originated in the posterior fossa, a maximal safe subtotal tumor resection was performed...
November 20, 2018: Journal of Neuro-oncology
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