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JOURNAL ARTICLE
Miao Zhang, Yajuan Xu, Zongzong Sun, Yanjie Ban, Shanshan Zhai, Wentao Wang, Mengqi Wang, Jie You, Dongsun Chen, Shuanghui Zhu, Hui Guo
The aim of this study was to investigate the association between hypothyroidism in early pregnancy and small intestinal bacterial overgrowth (SIBO) and the effect of probiotics. Patients with hypothyroidism in early pregnancy and normal pregnant women during the same period were included in the methane-hydrogen breath test to compare the incidence of SIBO, smoothed curve fit, and differences in clinical symptoms. For those who combined with SIBO, the rate of clinical symptom conversion, thyroid hormones, and changes in associated inflammatory indexes were compared after 21 days of treatment with probiotics on top of conventional levothyroxine sodium tablets...
April 2024: Food Science & Nutrition
#2
JOURNAL ARTICLE
Remy W F Geenen, Aart J van der Molen, Ilona A Dekkers, Marie-France Bellin, Michele Bertolotto, Jean-Michel Correas, Gertraud Heinz-Peer, Andreas H Mahnken, Carlo C Quattrocchi, Alexander Radbruch, Peter Reimer, Giles Roditi, Carmen Sebastià, Fulvio Stacul, Laura Romanini, Olivier Clément, Torkel B Brismar
OBJECTIVES: Hysterosalpingography (HSG) is widely used for evaluating the fallopian tubes; however, controversies regarding the use of water- or oil-based iodine-based contrast media (CM) remain. The aim of this work was (1) to discuss reported pregnancy rates related to the CM type used, (2) to validate the used CM in published literature, (3) to discuss possible complications and side effects of CM in HSG, and (4) to develop guidelines on the use of oil-based CM in HSG. METHODS: A systematic literature search was conducted for original RCT studies or review/meta-analyses on using water-based and oil-based CM in HSG with fertility outcomes and complications...
April 4, 2024: European Radiology
#3
JOURNAL ARTICLE
Joris A J Osinga, Yindi Liu, Tuija Männistö, Marina Vafeiadi, Fang-Biao Tao, Bijay Vaidya, Tanja G M Vrijkotte, Lorena Mosso, Judit Bassols, Abel López-Bermejo, Laura Boucai, Ashraf Aminorroaya, Ulla Feldt-Rasmussen, Aya Hisada, Jun Yoshinaga, Maarten A C Broeren, Sachiko Itoh, Reiko Kishi, Ghalia Ashoor, Liangmiao Chen, Flora Veltri, Xuemian Lu, Peter N Taylor, Suzanne J Brown, Leda Chatzi, Polina V Popova, Elena N Grineva, Farkhanda Ghafoor, Amna Pirzada, Maryam Kianpour, Emily Oken, Eila Suvanto, Andrew Hattersley, Marisa Rebagliato, Isolina Riaño-Galán, Amaia Irizar, Martine Vrijheid, Juana Maria Delgado-Saborit, Ana Fernández-Somoano, Loreto Santa-Marina, Kristien Boelaert, Gabriela Brenta, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L Eaton, Haixia Guan, Sun Y Lee, Spyridoula Maraka, Lilah F Morris-Wiseman, Caroline T Nguyen, Zhongyan Shan, Mònica Guxens, Victor J M Pop, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, W Edward Visser, David M Carty, Christian Delles, Scott M Nelson, Erik K Alexander, Layal Chaker, Glenn E Palomaki, Robin P Peeters, Sofie Bliddal, Kun Huang, Kris G Poppe, Elizabeth N Pearce, Arash Derakhshan, Tim I M Korevaar
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity)...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
#4
JOURNAL ARTICLE
Xuan Huang, Chen Zhang, Jialei Zhu, Yueyan Li, Jing Tang
OBJECTIVE: The study aimed to review the oncological characteristics and treatment of pregnancy-associated cancers and analyze the obstetric and neonatal outcomes to provide evidence-based recommendations for reproductive function preservation, oncological treatment, and obstetric management. METHODS: We conducted an observational retrospective cohort study among pregnant patients with cancer in 7 Chinese tertiary A hospitals from 2003 to 2021. We conducted multiple logistic regression to determine the influence of various factors on preterm birth and small-for-gestational-age infants, log-binomial regression to analyze temporal changes, and χ² tests to explore the effects of cancer type/treatment...
March 11, 2024: Journal of Gynecologic Oncology
#5
Neha Nawale, Akash More, Shilpa Dutta, Namrata Choudhary, Sanket Mahajan, Shivani Khemani
To address infertility in a 34-year-old woman with hypothyroidism, this case study investigated an integrated holistic therapy approach. The woman presented with primary infertility and sought treatment at an infertility centre in Maharashtra, India. She underwent thorough evaluations for infertility, revealing a history of hypothyroidism. The therapy strategy included a six-month course of 50 mg levothyroxine, along with yoga and yog nidra. The yoga interventions, incorporating techniques such as surya namaskar, kriyas, yoga asanas, and pranayama, proved beneficial for weight management, stress reduction, and overall well-being...
January 2024: Curēus
#6
JOURNAL ARTICLE
Ling-Jun Li, Ruijin Lu, Shristi Rawal, Anna Birukov, Natalie L Weir, Michael Y Tsai, Jing Wu, Zhen Chen, Cuilin Zhang
BACKGROUND: Evidence has indicated that polyunsaturated fatty acids (PUFAs)-enriched diet could reduce inflammation due to thyroid autoimmunity in vivo, and therefore, enhance thyroid function. OBJECTIVE: We investigated whether early pregnancy plasma phospholipid PUFAs could benefit maternal thyroid function across pregnancy, which is critical to fetal brain development and growth in pregnancy. METHODS: Within the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singleton Cohort, we collected plasma samples longitudinally from 214 subjects (107 with gestational diabetes mellitus [GDM] matched with 107 controls) with a singleton pregnancy...
February 24, 2024: American Journal of Clinical Nutrition
#7
JOURNAL ARTICLE
Boniface Ago, Enya Okpani, Sylvester Abeshi, Lawson Ekpe
Miscarriages constitute a significant aspect of failed pregnancies and a source of worry for the patient and caregiver. Some of the causes of miscarriages remain unknown. Immunological conditions such as thyroid autoimmunity could play significant roles. Our objective was to determine the relationship between raised thyroid peroxidase antibodies and first trimester miscarriages in a low resource setting. This was a case control study at the Gynaecological Clinic of the University of Calabar Teaching Hospital, Nigeria; from 14th February 2020 to 13th January 2021, involving 145 cases who had first trimester miscarriages, and their matched controls who had apparently normal pregnancies, at same gestational ages...
2024: Prague Medical Report
#8
JOURNAL ARTICLE
Zi-Hao Wang, Feng-Zhi Liang, Xue-Rong Chen, Ping Wu, Wei Wu
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been extensively used as synthetic fluorine-containing compounds in various consumer products, including surfactants, cookware, lubricants, clothing, and food packaging, since the 1950s. Evidence has shown that PFASs cross the placental barrier and interfere with fetal thyroid hormone homeostasis, which is crucial for fetal growth and neurobehavioral development in children aged 2-9 years. However, no epidemiological data on the association between prenatal PFAS exposure and neonatal neurobehavioral development are available...
February 2024: Se Pu, Chinese Journal of Chromatography
#9
JOURNAL ARTICLE
Smruti Vaishnav, Dharak Pandya, Rama Shrivastava, Nimeshkumar Patel, Ajay G Phatak, Alpaben Patel
CONTEXT: Associations between adverse maternal complications and fetal outcomes are known entity in thyroid disorders during pregnancy. Thus, prompt identification of thyroid disorders and timely initiation of treatment is essential. Universal screening and early treatment of pregnant women for thyroid disorder should be considered especially in a resource-limited country like India with a high prevalence of undiagnosed thyroid disorders and adverse feto-maternal outcomes. AIMS: Early treatment will prevent feto-maternal complications in thyroid disorders in pregnant females visiting outpatient department in tertiary care hospital in rural settings...
December 2023: Journal of Family Medicine and Primary Care
#10
JOURNAL ARTICLE
Diána Simon, Szabina Erdő-Bonyár, Katalin Böröcz, Noémi Balázs, Ahmed Badawy, Anna Bajnok, Jasper Nörenberg, Tímea Serény-Litvai, Ákos Várnagy, Kálmán Kovács, Eszter Hantosi, Emese Mezősi, Péter Németh, Tímea Berki
The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto's thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study's objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP)...
January 24, 2024: International Journal of Molecular Sciences
#11
JOURNAL ARTICLE
Haofeng Wang, Yuting Peng, Xinru Xia, Yangqian Jiang, Jiangbo Du, Hong Lv, Hongxia Ma, Xiang Ma, Yuan Lin
CONTEXT: Adequate maternal thyroid hormone is vital for fetal neurodevelopment. Abnormal thyroid function can cause developmental defects in offspring from spontaneous pregnancies; however, research in assisted reproduction is lacking. OBJECTIVES: To investigate the association between thyroid disorders and offspring neurodevelopment from assisted reproduction. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: In this prospective and longitudinal birth cohort study (Jiangsu, China), we included 729 women who had their thyroid function tested before ART cycle and delivered liveborn babies between November 2015 and June 2020...
January 24, 2024: Journal of Clinical Endocrinology and Metabolism
#12
REVIEW
Keiji Kuroda
BACKGROUND: Aside from embryonic factors, various factors can intricately interfere with embryo implantation and maintenance of pregnancy, causing recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL). This review focuses the optimization of thyroid function, thrombophilia, immunity, and uterine milieu (OPTIMUM) treatment strategy on RIF and RPL. METHODS: Three studies employing the OPTIMUM treatment strategy for patients with RIF and/or RPL were reviewed...
2024: Reproductive Medicine and Biology
#13
JOURNAL ARTICLE
S Burlina, M G Dalfrà, A Marchetto, A Lapolla
PURPOSE: With the rise of medically assisted reproductive techniques (ART) the number of pregnancies complicated by gestational diabetes mellitus (GDM) has increased. The aim of this study was to evaluate retrospectively the outcomes of pregnancies complicated by GDM who conceive trough ART (cases) compared to those who conceived spontaneously (controls). METHODS: In 670 women with GDM, 229 cases and 441 controls, followed by the Diabetology of Padua, between 2010-2022, clinical-metabolic maternal characteristics and maternal-foetal outcomes were evaluated...
January 16, 2024: Journal of Endocrinological Investigation
#14
JOURNAL ARTICLE
Ghulam Abbas, Samina Aliya Sabir, Siddiq Ur Rehman, Beenish Gohar
OBJECTIVE: To evaluate thyroid function tests (TFTs) during pregnancy in women with previous history of miscarriage or stillbirth. METHODS: A cross-sectional study was carried out at the department of Obstetrics & Gynaecology and Endocrinology, Lady Reading Hospital, Peshawar from February 2021 to March 2022. All multigravida women attending the antenatal clinics were included using consecutive sampling. These women were placed into two groups, Group-A comprised of women with no prior history of miscarriages or stillbirths, and those with a history of foetal death during previous pregnancies were assigned Group-B...
2024: Pakistan Journal of Medical Sciences Quarterly
#15
REVIEW
Expanding the role of chromosomal microarray analysis in the evaluation of recurrent pregnancy loss.
Jasmine Eliwa, Ralph S Papas, William H Kutteh
Multiple factors contribute to recurrent pregnancy loss (RPL). This review highlights the latest international guidelines for RPL workup, including immunological testing, by the American Society for Reproductive Medicine (ASRM), the European Society of Human Reproduction and Embryology (ESHRE), and the Royal College of Obstetricians and Gynaecologists (RCOG). These three societies recommend testing for antiphospholipid syndrome. ESHRE and RCOG also recommend thyroid peroxidase antibody testing, whereas ASRM does not...
February 2024: Journal of Reproductive Immunology
#16
JOURNAL ARTICLE
Keiji Kuroda, Takashi Horikawa, Azusa Moriyama, Yuko Ojiro, Satoru Takamizawa, Hideaki Watanabe, Tetsuo Maruyama, Shuko Nojiri, Koji Nakagawa, Rikikazu Sugiyama
PURPOSE: To clarify the efficacy of the OPtimization of Thyroid function, Thrombophilia, IMmunity and Uterine Milieu (OPTIMUM) treatment strategy on pregnancy outcomes after euploid blastocyst transfer in advanced age women with recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL). METHODS: Between January 2019 and May 2022, 193 consecutive women aged ≥40 years with RIF and/or RPL received single euploid blastocyst transfer. Before embryo transfer, 127 women underwent RIF/RPL testing...
2023: Reproductive Medicine and Biology
#17
JOURNAL ARTICLE
Kai Liang, Qincheng Qiao, Mengmeng Yang, Yan Liu, Peng Lin, Li Chen, Xinguo Hou
BACKGROUND: The effect of iodine deficiency, especially during the fetal period, on thyroid cancer risk remains unclear. The evidence from observational studies is controversial because of the inevitable confounding factors. We studied the causal effect of congenital iodine deficiency on differentiated thyroid cancer (DTC) based on Mendelian randomization (MR). METHODS: Two-Sample MR analysis was performed using data from published genome-wide association studies, including congenital iodine deficiency syndrome (CIDS) (353 cases, 187,684 controls) and DTC (649 cases, 431 controls) data...
December 21, 2023: Pediatric Research
#18
JOURNAL ARTICLE
Xing Li, Zhuyuan Zhang, Wen Cai, Xuexin Zhou, Yan Zhang, Cailiang Wu, Xianming Xu, Hao Wu
BACKGROUND: The relationship of iron deficiency and thyroid hormone has been researched a lot among pregnant or other healthy population. However, invisible iron deficiency, namely shortage of serum ferritin (sFer) level, has been barely investigated among Chinese pregnant women. This study aimed to explore the effects of sFer status on thyroid function and pregnancy outcomes in a population-based upper first-class hospital. METHODS: A total of 781 singleton pregnant women of gestation in Shanghai General Hospital took part in this retrospective cohort study...
2023: International Journal of Women's Health
#19
JOURNAL ARTICLE
Junqing Li, Jimei Yang, Min Lv, Xiang Wang, Zhijing Chen, Na Zhou, Xuetao Hou, Zhen Song
OBJECTIVE: This study aimed to develop and internally validate a prediction model for estimating the risk of spontaneous abortion in early pregnancy. METHODS: This prospective cohort study included 9,895 pregnant women who received prenatal care at a maternal health facility in China from January 2021 to December 2022. Data on demographics, medical history, lifestyle factors, and mental health were collected. A multivariable logistic regression analysis was performed to develop the prediction model with spontaneous abortion as the outcome...
December 15, 2023: Clinics
#20
Marah Mansour, Rania Almasri, Noura Amin, George Hamwi, Rawdah Attoum, Ilda Moafak Kanbour, Sara Mohammad Talal Jeniat, Samar AlKhrait
INTRODUCTION AND IMPORTANCE: Molar pregnancy is the most common type of gestational trophoblastic disease. It manifests as vaginal bleeding, accompanied by high levels of β-human chorionic gonadotropin (β-HCG). This case aims to highlight the importance of considering gestational trophoblastic disease as a potential diagnosis and its serious complications. CASE PRESENTATION: A 24-year-old female presented with vomiting, nausea, and no complaint of vaginal bleeding...
December 2023: Annals of Medicine and Surgery
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