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Q T Zhang, P Y Xie, L N Yang, J L Zhou
Objective: To get an orthokeratology lens fitting model according to the research of the optometry examination data, which can help to improve the work efficiency and increase the hitting rate of prescription. Methods: The relationship between the basic optometry examination data and the effective optometry prescription was evaluated. We got 1 467 sets of data, including 80%(1 173) for training and 20%(294) for testing. The trail results were used for the 20% testing sets, and 100% completed sets for verification...
February 11, 2019: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Rebecca K Poole, Thomas L Devine, Kyle J Mayberry, Joan H Eisemann, Matt H Poore, Nathan M Long, Daniel H Poole
Fescue toxicosis is a multifaceted syndrome common in cattle grazing endophyte-infected tall fescue. The objective of this study was to evaluate the impact of the slick hair trait on physiological and reproductive parameters in heifers experiencing fescue toxicosis. Angus × Senepol heifers (n = 31) were blocked by weight (393.5 ± 17.3 kg) and phenotype relative to hair coat at birth, and randomly fed novel endophyte fescue (EN) or endophyte-infected fescue (EI) haylage in a total mixed ration for 91 d. Weekly measurements were collected to monitor heifer growth and response during ergot alkaloids exposure...
February 17, 2019: Journal of Animal Science
Hong-Yan Chen, Mi-Xue Jin, Lu Zhang, Ai-Jun Wang, Junhua Yuan, Qian-Li Zhang, Jiu-Ju Feng
Recently, two-dimensional materials have gained increasing research attention due to their large surface area, high physical and chemical stability, and excellent electrocatalytic performances. Herein, we reported a simple and fast one-pot aqueous method for synthesis of two-dimensional porous bimetallic PtPd alloyed nanosheets (NSs) using benzyldimethylhexadecylammonium chloride (HDBAC) as the capping agent and stabilizer. The formation mechanism involved the oriented attachment and self-assembly. The PtPd NSs exhibited excellent oxygen reduction reaction (ORR) activity with the positive shift (c...
January 29, 2019: Journal of Colloid and Interface Science
Simon Heeke, Hervé Delingette, Youta Fanjat, Elodie Long-Mira, Sandra Lassalle, Véronique Hofman, Jonathan Benzaquen, Charles-Hugo Marquette, Paul Hofman, Marius Ilié
Histopathology is the fundamental tool of pathology used for more than a century to establish the final diagnosis of lung cancer. In addition, the phenotypic data contained in the histological images reflects the overall effect of molecular alterations on the behavior of cancer cells and provides a practical visual reading of the aggressiveness of the disease. However, the human evaluation of the histological images is sometimes subjective and may lack reproducibility. Therefore, computational analysis of histological imaging using so-called "artificial intelligence" (AI) approaches has recently received considerable attention to improve this diagnostic accuracy...
February 13, 2019: Annales de Pathologie
Guan-Yi Xu, Ai-Mei Liao, Ji-Hong Huang, Jian-Guo Zhang, Kiran Thakur, Zhao-Jun Wei
Potato peel was used for the extraction of three types of polysaccharides (PW, PAL, and PAC) using water, alkaline, and acid treatments, respectively. The structure of the PP polysaccharides was examined by means of Fourier transform infrared spectroscopy (FT-IR) analysis and Gas chromatography-mass spectrometry (GC-MS). The results suggest that the extracted polysaccharides constituted essentially three functional groups; CO, CH, and OH. The polysaccharides were comprised of low proportions of proteins, 17-23% uronic acids, and approximately 70% carbohydrates...
February 13, 2019: International Journal of Biological Macromolecules
Shinji Matsuda, Ai Okanobu, Saki Hatano, Mikihito Kajiya, Shinya Sasaki, Yuta Hamamoto, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara
OBJECTIVES: Periodontal inflammation is regarded as a risk factor for drug-induced gingival overgrowth (DIGO). In order to elucidate the involvement of periodontal inflammation in DIGO, the periodontal status of subjects who do not develop DIGO despite receiving causative drugs (non-responders) needs to be examined. Therefore, the aim of the present study which was a pilot study was to assess periodontal inflammatory variables in responders (calcium channel blocker induced-GO patients), non-responders, and patients who did not receive causative drugs (non-consumers)...
February 15, 2019: Clinical Oral Investigations
Hao Wang, Xiangfeng Meng, Shu Li, Haiping Ren
Artificial intelligence is a blooming branch of medical device. Its development and quality control all rely on high quality clinical data. Since there is no established standard or guidance yet, it is important to study how to build and utilize a dataset appropriately and scientifically, especially for the decrease of clinical trial expense. With reference to the current status of premarket review and related guidance in developed countries, this paper analyzes the role and requirement of datasets in the quality control of AI medical device, providing useful information for regulation agencies and the development of public datasets for AI...
January 30, 2019: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
James M Wilson, Troy D Anderson, Thomas P Kuhar
Pyrifluquinazon (PQZ) is an Insecticide Resistance Action Committee (IRAC) Group 9 insecticide that has recently been registered for use in the United States for control of soft-bodied sucking insect pests. Although it has been classified as practically nontoxic to honey bees, Apis mellifera L. (Hymenoptera: Apidae), based on acute contact bioassays, additional information on sublethal effects of this insecticide on honey bees is lacking. Using a combination of laboratory assays with video movement tracking software and near-field evaluations of colonies foraging in a high-tunnel experiment, we determined that, when fed PQZ at a concentration of 84 mg active ingredient (ai)/liter (= ppm) in sugar water, a reduction in overall movement by the foraging worker bees was observed...
February 16, 2019: Journal of Economic Entomology
Shintaro Sukegawa, Takahiro Kanno, Masanori Masui, Yuka Sukegawa-Takahashi, Tsukasa Kishimoto, Ai Sato, Yoshihiko Furuki
PURPOSE: To compare the clinical outcomes of a single three-dimensional (3-D) anatomical plate versus two conventional straight miniplates for the open treatment of mandibular subcondylar fractures. METHODS: This retrospective clinical study included patients with mandibular subcondylar fractures treated by the retromandibular transparotid approach using a 3-D plate or two straight miniplates. Outcome variables included preoperative conditions of patients and fractures, extent of postoperative bone healing, and incidence of complications...
February 1, 2019: Journal of Cranio-maxillo-facial Surgery
Ali Kaab, Mohammad Sharifi, Hossein Mobli, Ashkan Nabavi-Pelesaraei, Kwok-Wing Chau
This study aims to employ two artificial intelligence (AI) methods, namely, artificial neural networks (ANNs) and adaptive neuro fuzzy inference system (ANFIS) model, for predicting life cycle environmental impacts and output energy of sugarcane production in planted or ratoon farms. The study is performed in Imam Khomeini Sugarcane Agro-Industrial Company (IKSAIC) in Khuzestan province of Iran. Based on the cradle to grave approach, life cycle assessment (LCA) is employed to evaluate environmental impacts and study environmental impact categories of sugarcane production...
February 6, 2019: Science of the Total Environment
Simon G Royce, WeiYi Mao, Rebecca Lim, Kilian Kelly, Chrishan S Samuel
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid dexamethasone (Dex) in experimental chronic AAD/asthma. Female BALB/c mice subjected to 11 wk of ovalbumin (Ova)-induced chronic AAD were intranasally administered MCA-MSCs (1 × 106 cells/mouse; once weekly on wk 10 and 11), Dex (0...
February 15, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Xiaonan Gao, Ai-Yun Fu, Bo Liu, Jun-Cheng Jin, Long-Tao Dou, Li-Xia Chen
The reactions of 2-(4-pyridyl) thiazole-4-carboxylic acid (Hptca) and CuCl2 ·6H2 O have led to a novel 3D mixed-valence, four-copper-center, metal-organic framework (MOF) [Cu8 Cl2 (ptca)10 ·17H2 O] n (1). The topology analysis using ToposPro software package for 1 resulted in three chain-based topology types of sra (42 , 63 , 8), pcu (412 , 63 ), and dia (66 ) via choosing corresponding connection atoms as central atoms. The study indicates that connection atoms associated directly with multiple coordination centers are applicable to act as central atoms...
February 15, 2019: Inorganic Chemistry
Zhanyu Pang, Dongbo Tu, Yan Cai
Three widely-used self-report anxiety scales, including the Self-Rating Anxiety Scale (SAS), the Beck Anxiety Inventory (BAI), and the State Anxiety Inventory (S-AI), were used to simultaneously compare the psychometric properties via an item response theory (IRT) model with Chinese university students as the sample. Although these scales were probably to measure the same underlying construct, namely, anxiety, their psychometric properties were different. Results showed that the BAI's measurement error was fewer than that of the other scales, with their anxiety severity ranging approximately from the 0...
2019: Frontiers in Psychology
Marko Topalovic, Nilakash Das, Pierre-Régis Burgel, Marc Daenen, Eric Derom, Christel Haenebalcke, Rob Janssen, Huib A M Kerstjens, Giuseppe Liistro, Renaud Louis, Vincent Ninane, Christophe Pison, Marc Schlesser, Piet Vercauter, Claus F Vogelmeier, Emiel Wouters, Jokke Wynants, Wim Janssens
The interpretation of pulmonary function tests (PFTs) to diagnose respiratory diseases is built on expert opinion which relies on the recognition of patterns and clinical context for the detection of specific diseases. In the study, we aimed to explore the accuracy and inter-rater variability of pulmonologists when interpreting PFTs and compared it against that of artificial intelligence (AI)-based software which was developed and validated in more than 1500 historical patient cases.120 pulmonologists from 16 European hospitals evaluated 50 cases comprising with PFT and clinical information resulting in 6000 independent interpretations...
February 14, 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Ai Ohnishi, Kunio Hashimoto, Eriko Ozono, Michiyo Sasaki, Ayako Sakamoto, Kasumi Tashiro, Hiroyuki Moriuchi
A 14-year-old girl developed 4 episodes of anaphylaxis of unknown etiology, which required intramuscular adrenaline administration each time. She had eaten pizza and a cheeseburger immediately before the first 2 episodes, respectively, but had not eaten anything for several hours before the last 2 episodes. It turned out that she had eaten the same ice lolly 4 hours before the first 3 episodes and a Café au lait Swirkle (a half-frozen beverage) 4 hours before the last episode. We detected carboxymethylcellulose sodium as the only common ingredient in all anaphylactic episodes...
February 14, 2019: Pediatrics
J Leston, C Crisp, C Lee, E Rink
OBJECTIVES: The primary objective of this study was to work with tribal communities to define and develop their own healthcare services and strategies for positive change regarding injection drug use, human immunodeficiency virus (HIV), and hepatitis C virus (HCV) infection. The secondary objective of this study was to incorporate community capacity building strategies to develop and sustain programming and resources to optimize tribal communities' responsiveness to reduce health disparities...
February 11, 2019: Public Health
Xiao-Yuan Shi, Ai-Ping Huang, Duo-Wen Xie, Xiao-Long Yu
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women. Multiple susceptible gene as well as environmental factors and their interaction each other are contributed to the PCOS risk. Several case-control studies have researched the associations of the vitamin D receptor gene (VDR) polymorphisms with PCOS susceptibility, but the jury is still out. Here, we carried out a meta-analysis to clarify polymorphisms between ApaI (C/A) (rs7975232), BsmI (G/A) (rs1544410), FokI (C/T) (rs10735810), TaqI (T/C) (rs731236) and Tru9I (G/A) (rs757343) in the VDR gene and PCOS susceptibility based on relative lager sample size...
February 14, 2019: BMC Medical Genetics
Jan Olsson, Jörgen Johansson, Emma Honkala, Bert Blomqvist, Eloise Kok, Bodil Weidung, Hugo Lövheim, Fredrik Elgh
BACKGROUND: Herpes simplex virus type 1 (HSV1), establishes life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe a protocol to generate a reliable and discriminative avidity index (AI) for anti-HSV1 IgG content in human sera. METHODS: Human serum from two distinct cohorts; one a biobank collection (Betula) (n = 28), and one from a clinical diagnostics laboratory at Northern Sweden University Hospital (NUS) (n = 18), were assessed for presence of IgG antibodies against HSV1 by a commercially available ELISA-kit...
February 14, 2019: BMC Infectious Diseases
Tomoko Arakawa, Shinya Fukuda, Tetsuya Hirata, Kazuaki Neriishi, Yu Wang, Arisa Takeuchi, Ai Saeki, Miyuki Harada, Yasushi Hirota, Takashi Matsumoto, Kaori Koga, Osamu Wada-Hiraike, Masatoshi Kurihara, Tomoyuki Fujii, Yutaka Osuga
In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. For better accuracy of diagnosis, the development of a sensitive and specific epithelial marker is beneficial. Previous studies showed that PAX8 is a highly sensitive and specific marker for primary and metastatic Mullerian epithelial tumors. Therefore, we sought to examine whether PAX8 is a highly sensitive marker for glands in extragenital endometriosis...
February 14, 2019: Reproductive Sciences
Zimo Yin, Haixin Ai, Li Zhang, Guofei Ren, Yuming Wang, Qi Zhao, Hongsheng Liu
The prediction of compound cytotoxicity is an important part of the drug discovery process. However, it usually appears as poor predictive performance because the datasets are high-throughput and have a class-imbalance problem. In this study, several strategies of performing a structure-activity relationship study for a cytotoxic endpoint in the AID364 dataset were explored to solve the class-imbalance problem. Random forest adaboost was used as the base learners for 10 types of molecular fingerprints and an ensemble method and six data-balancing methods were applied to balance the classes...
February 14, 2019: Journal of Applied Toxicology: JAT
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