Chris Amro, Ellen F Niu, Ellie Deianni, Laurie Smith, Maylene Qiu, Jared Torkington, Robyn B Broach, Lillias H Maguire, Scott M Damrauer, Kamal Itani, John P Fischer
BACKGROUND: This systematic review aims to identify genetic and biologic markers associated with abdominal hernia formation. METHODS: Following PRIMSA-guidelines, we searched PubMed, MEDLINE, Embase, Scopus, and COCHRANE databases. RESULTS: Of 5946 studies, 65 were selected, excluding parastomal hernias due to insufficient data. For inguinal hernias, five studies unveiled 92 susceptible loci across 66 genes, predominantly linked to immune responses...
February 27, 2024: American Journal of Surgery