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Laura E Davis, Courtney Fulton, Lev D Bubis, Jonathan Sussman, Lesley Moody, Lisa Barbera, Qing Li, Alyson L Mahar, Natalie G Coburn, Claire M B Holloway
PURPOSE: Studies examining symptom differences between surgeries for breast cancer patients rarely incorporate the effects of adjuvant treatment choice. We sought to understand differences in patient-reported symptoms between lumpectomy plus radiation and mastectomy in the year following surgery. METHODS: This cohort study used linked administrative datasets. The exposure was defined as lumpectomy plus radiation or mastectomy. The outcomes of moderate-to-severe (score ≥ 4) patient-reported symptoms were obtained using the Edmonton symptom assessment system (ESAS)...
March 16, 2019: Breast Cancer Research and Treatment
Richard J Holleyman, David J Deehan, Lucy Walker, Andre Charlett, Julie Samuel, Mark D F Shirley, Paul N Baker
INTRODUCTION: This study aimed to (1) report the rates of resistance against a variety of antibiotics for pure Staphylococcal infections, and (2) examine the impact of ALBC use at primary surgery has on resistance patterns for patients undergoing first-time revision of primary hip and knee arthroplasty for indication of infection. MATERIALS AND METHODS: Data from the National Joint Registry database for England and Wales were linked to microbiology data held by Public Health England to identify a consecutive series of 258 primary hip and knee arthroplasties performed between April 2003 and January 2014 that went on to have a revision for Staphylococcal deep periprosthetic infection...
March 15, 2019: Archives of Orthopaedic and Trauma Surgery
Mert Doğan, Mertcan Koçak, Özge Onursal Kılınç, Fatma Ayvat, Gülşah Sütçü, Ender Ayvat, Muhammed Kılınç, Özgür Ünver, Sibel Aksu Yıldırım
BACKGROUND: Functional range of motion is defined as the required range of motions for individuals to maintain maximal independence, along with optimal conditions for activities of daily living. Intervention plans for rehabilitation are directed towards the acquisition of anatomical range of motion. However, this isn't always possible based on person's etiology, prognosis, or severity of disease. RESEARCH QUESTION: The aim of this study is to determine functional range of motion during different unilateral, bilateral symmetrical and bimanual asymmetrical tasks of activities of daily living...
February 25, 2019: Gait & Posture
Laura M Fernandez, Albert Parlade, Elliot Wasser, Giovanna Dasilva, Rafael U de Azevedo, Cinthia Ortega, Rodrigo O Perez, Angelita Habr-Gama, Mariana Berho, Steven D Wexner
BACKGROUND: The observation of inferior oncologic outcomes after surgery for proximal colon cancers has led to the investigation of alternative treatment strategies, including surgical procedures and neoadjuvant systemic chemotherapy in selective patients. OBJECTIVE: The purpose of this study was to determine the accuracy of CT staging in proximal colon cancer in detecting unfavorable pathologic features that may aid in the selection of ideal candidates with unfavorable pathologic features for alternative treatment strategies, including extended lymph node dissection and/or neoadjuvant chemotherapy...
March 8, 2019: Diseases of the Colon and Rectum
Steven J Skube, Elliot G Arsoniadis, Megan L Sulciner, Scott R Gilles, Wolfgang B Gaertner, Robert D Madoff, Genevieve B Melton, Bruce A Peterson, Mary R Kwaan
BACKGROUND: Colon and rectal lymphomas are rare and can occur in the context of posttransplant lymphoproliferative disorder. Evidence-based management guidelines are lacking. OBJECTIVE: The purpose of this study was to characterize the presentation, diagnosis, and management of colorectal lymphoma and to identify differences within the transplant population. DESIGN: This was a retrospective review of patients evaluated for colorectal lymphoma between 2000 and 2017...
March 8, 2019: Diseases of the Colon and Rectum
Marit S de Vos, Jaap F Hamming, Hileen Boosman, Perla J Marang-van de Mheen
OBJECTIVES: Linkage of safety data to patient experience data may provide information to improve surgical care. This retrospective observational study aimed to assess associations between complications, incidents, patient-reported problems, and overall patient experience. METHODS: Routinely collected data from safety reporting on complications and incidents, as well as patient-reported problems and experience on the Picker Patient Experience Questionnaire 15, covering seven experience dimensions, were linked for 4236 surgical inpatients from an academic center (April 2014-December 2015, 41% response)...
March 6, 2019: Journal of Patient Safety
Tobias Peters, Immanuel Philipp Seitz, Stylianos Michalakis, Martin Biel, Barbara Wilhelm, Felix Friedrich Reichel, Guy Alexander Ochakovski, Eberhart Zrenner, Marius Ueffing, Birgit Korbmacher, Sven Korte, Karl Ulrich Bartz-Schmidt, Manuel Dominik Fischer, Consortium Rd-Cure
The purpose of this study was to examine the toxicity and side effects of a recombinant AAV8 vector, aimed to treat CNGA3-linked achromatopsia, after a single subretinal administration in cynomolgus macaques. Animals were followed in two studies: a 13-week study with 22 animals and a 28-day study with 12 animals. Both groups were divided into subgroups receiving either vehicle only, a low (1x1011 vector genomes (vg)), or a high dose (1x1012 vg) of rAAV.hCNGA3. In the 13-week study, an extra group received single high dose intravitreal injections...
March 13, 2019: Human Gene Therapy. Clinical Development
Emma Cavalli, Clara Levinson, Matthias Hertl, Nicolas Broguiere, Oscar Brück, Satu Mustjoki, Anja Gerstenberg, Daniel Weber, Gian Salzmann, Matthias Steinwachs, Gonçalo Barreto, Marcy Zenobi-Wong
Treating cartilage injuries and degenerations represents an open surgical challenge. The recent advances in cell therapies have raised the need for a potent off-the-shelf cell source. Intra-articular injections of TGF-β transduced polydactyly chondrocytes have been proposed as a chronic osteoarthritis treatment but despite promising results, the use of gene therapy still raises safety concerns. In this study, we characterized infant, polydactyly chondrocytes during in vitro expansion and chondrogenic re-differentiation...
March 12, 2019: Scientific Reports
Xiang Li, Shaolei Li, Shi Yan, Yaqi Wang, Xing Wang, Alan D L Sihoe, Yue Yang, Nan Wu
Objectives: This meta-analysis aimed to demonstrate the impact of preoperative exercise therapy on surgical outcomes in patients with lung cancer and COPD. Pulmonary function and muscle capacity were investigated to explore their potential links with outcome improvements after exercise. Methods: Articles were searched from PubMed, Embase, and the Cochrane Library with criteria of lung cancer patients with or without COPD, undergoing resection, and receiving preoperative exercise training...
2019: Cancer Management and Research
Arwa S Almasaudi, Ross D Dolan, Stephen T McSorley, Paul G Horgan, Christine Edwards, Donald C McMillan
INTRODUCTION: In the UK, colorectal cancer is the fourth most common cancer and the second most common cause of cancer death. Surgery is the primary modality of treatment, but it is not without complications. Post-operative complications have been linked to preoperative of weight loss and loss of lean tissue, and also to obesity. Given sex differences in body composition, an examination of body composition and post-operative complications may provide valuable information. Therefore, the aim was to examine the relationship between male/female body composition and post-operative complications in patients with operable colorectal cancer...
March 11, 2019: European Journal of Clinical Nutrition
C Albou-Ganem
Presbyopia is the progressive loss of accommodation. Accommodation is a quick, precise and involuntary action which enables the eye to change the power of the young crystalline lens to see clearly at all distances. Presbyopia is and age-linked physiologic phenomenon: it results from aging of the lens, which loses its elasticity, gradually becomes rigid and loses the ability to accommodate. Presbyopia has attained a prevalence of 80% in Europe and is increasing regularly due to the aging of the population. Various surgical techniques can be proposed...
March 8, 2019: Journal Français D'ophtalmologie
Ajul Shah, Brandon J Sumpio, Cynthia Tsay, Matthew Swallow, Biraja Dash, Stephanie L Thorn, Albert J Sinusas, Andrew Koo, Henry C Hsia, Alexander Au
BACKGROUND: A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been used to optimize wound healing in the setting of surgically closed wounds; however, the specific mechanisms of action by which NPWT may benefit patients after surgery remain unknown. Using a swine wound healing model, the current study investigates angiogenesis as a candidate mechanism. METHODS: Multiple excisional wounds were created on the dorsa of 10 male Yorkshire pigs and closed by primary suture...
April 2019: Annals of Plastic Surgery
Kyle H Sheetz, Justin B Dimick, Scott E Regenbogen
BACKGROUND: Bundled payment programs broaden hospitals' responsibility for spending to entire episodes of care. After demonstration programs in cardiac surgery and joint replacement, these payment reforms could soon extend to major operations like colectomy under Medicare's Bundled Payments for Care Improvement - Advanced Model. OBJECTIVE: This study aims to evaluate how specific policies and surgical practice patterns would influence hospital reimbursement in a bundled payment program for colectomy...
March 5, 2019: Diseases of the Colon and Rectum
G Yonis, C S Cabalag, E Link, C P Duong
Oral contrast studies are used to detect anastomotic leak (AL) postesophagectomy. However, recent evidence suggests oral contrast studies have low sensitivity in detecting ALs, and their false positive results can lead to unnecessary prolonged hospital stay. The objective of this study was to determine if oral contrast studies should be used routinely post-esophagectomy for cancer. A systematic literature search was conducted for studies published between January 1990 and June 2018. Data extracted for analyses included type of esophagectomy, operative morbidity (such as AL and pneumonia), mortality rates, timing of contrast study, and type of oral contrast used...
March 11, 2019: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Jia-Wen Xiang, Yuan Xiao, Yuwen Gan, Huimin Chen, Yunfei Liu, Ling Wang, Qian Nie, Fangyuan Liu, Xiaodong Gong, Jia-Ling Fu, Wen-Jie Qing, Lan Yang, Jie Xie, Zhongwen Luo, Ruili Qi, Zhigang Chen, David Wan-Cheng Li
PURPOSE: It has been well established that sumoylation acts as an important regulatory mechanism that controls many different cellular processes. In the eye, we and others have shown that sumoylation plays an indispensable role during mouse eye development. Whether sumoylation is implicated in ocular pathogenesis remains to be further studied. In the present study, we have examined the expression patterns of the de-sumoylation enzymes (SENPs) in the in vitro cataract models induced by glucose oxidase and UVA irradiation...
March 10, 2019: Current Molecular Medicine
Shubing Cai, Sijiu Wang, Dana B Mukamel, Thomas Caprio, Helena Temkin-Greener
OBJECTIVES: To explore profiles of obese residents who receive post-acute care in nursing homes (NHs) and to assess the relationship between obesity and hospital readmissions and how it is modified by individual comorbidities, age, and type of index hospitalizations. DESIGN: Retrospective cohort study. SETTING AND PARTICIPANTS: Medicare fee-for-service beneficiaries who were newly admitted to free-standing US NHs after an acute inpatient episode between 2011 and 2014 (N = 2,323,019)...
March 7, 2019: Journal of the American Medical Directors Association
Vrunda B Desai, Jason D Wright, Cary P Gross, Haiqun Lin, Francis P Boscoe, Lindsey M Hutchison, Peter E Schwartz, Xiao Xu
BACKGROUND: Occult uterine cancer at the time of benign hysterectomy poses unique challenges in patient care. There is large variability and uncertainty in estimated risk of occult uterine cancer in the literature and prior research often did not differentiate/include all subtypes. OBJECTIVES: To thoroughly examine the prevalence of occult uterine cancer in a large population-based sample of women undergoing hysterectomy for presumed benign indications and to identify associated risk factors...
March 7, 2019: American Journal of Obstetrics and Gynecology
Zoltán Janka
Depending on the personal attitude toward a given style and performance, music can influence mental activities such as emotion, mood, motivation, psychomotor tempo and possibly cognition. Experimental data indicate that music can alter physiological parameters of somatic functions (blood pressure, heart rhythm, peripheral blood flow, respiration). However, efforts are taken in medicine and neuroscience to decipher brain physiological and morphological correlates in processing or performing music. Modern imaging techniques brought a significant advance in this respect...
March 2019: Orvosi Hetilap
Jae-Sik Nam, Sang-Beom Jeon, Jun-Young Jo, Kyoung-Woon Joung, Ji-Hyun Chin, Eun-Ho Lee, Cheol Hyun Chung, In-Cheol Choi
Although unruptured intracranial aneurysms are increasingly being diagnosed incidentally, perioperative rupture risk of unruptured intracranial aneurysm in patients undergoing cardiovascular surgery remains unclear. Therefore, we conducted an observational study to assess the prevalence and perioperative rupture risk of unruptured intracranial aneurysm in patients undergoing cardiovascular surgery. Adult patients (n = 4864) who underwent cardiovascular surgery between January 2010 and December 2016 were included...
March 8, 2019: Brain: a Journal of Neurology
Maria Peris-Celda, Avital Perry, Lucas P Carlstrom, Christopher S Graffeo, Michael J Link
The suprameatal tubercle is a variable prominence of the posterior aspect of the petrous part of the temporal bone located above the internal acoustic meatus. An enlarged suprameatal tubercle (EST) may present an obstacle during posterior fossa operations, including microvascular decompression (MVD).  In this video we present the case of a 55-yr-old woman with 2 yr of medically refractory left V2-3 typical trigeminal neuralgia. Magnetic resonance imaging (MRI) was suspicious for a compressive superior cerebellar artery (SCA) loop, and negative for any other pathological findings...
March 9, 2019: Operative Neurosurgery (Hagerstown, Md.)
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