Lorenzo Tucci, Flaminia Fanelli, Ilaria Improta, Valentina Bissi, Claudia Lena, Greta Galante, Marco Mezzullo, Matteo Magagnoli, Anna Bianca Lalumera, Giacomo Colombin, Kimberly Coscia, Laura Rotolo, Valentina Vicennati, Uberto Pagotto, Guido Di Dalmazi
BACKGROUND: Various glucocorticoid replacement treatments (GRT) are available for adrenal insufficiency (AI). However, their effectiveness in restoring glucocorticoid rhythm and exposure lacks adequate biochemical markers. We described the diurnal salivary cortisol (SalF) and cortisone (SalE) rhythm among different GRTs and analysed the associations between saliva-derived parameters and life quality questionnaires. METHODS: Control subjects (CS, n=28) and AI patients receiving hydrocortisone (HC, n=9), cortisone acetate (CA, n=23), dual-release hydrocortisone once (DRHC-od, n=10) and twice a day (DRHC-td, n=6) collected 9 saliva samples from 07:00 to 23:00...
April 4, 2024: European Journal of Endocrinology