Bertrand Chauveau, Antoine Garric, Sylvaine Di Tommaso, Anne-Aurélie Raymond, Jonathan Visentin, Agathe Vermorel, Nathalie Dugot-Senant, Julie Déchanet-Merville, Jean-Paul Duong Van Huyen, Marion Rabant, Lionel Couzi, Frédéric Saltel, Pierre Merville
Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplantation. Defined by the Banff classification, its gold standard diagnosis remains a challenge, with limited inter-observer reproducibility of the histological scores and efficient immunomarker availability. We performed an immunohistochemical analysis of 3 interferon-related proteins, WARS1, TYMP and GBP1 in a cohort of kidney allograft biopsies including 17 ABMR cases and 37 other common graft injuries. Slides were interpreted, for an ABMR diagnosis, by four blinded nephropathologists and by a deep learning framework using convolutional neural networks...
November 9, 2022: Scientific Reports