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Keywords (ICU OR intensive care* OR cri...

(ICU OR intensive care* OR critical*) AND (antibiotic OR antiinfective OR antimicrobial)

https://read.qxmd.com/read/38547383/update-and-approach-to-patients-with-brain-abscess
#1
JOURNAL ARTICLE
Lars Haukali Omland, Henrik Nielsen, Jacob Bodilsen
PURPOSE OF REVIEW: The epidemiology of brain abscess has changed in recent decades. Moreover, acute and long-term management remains challenging with high risks of mortality and neurological sequelae. This review describes recent advances in epidemiology, diagnosis, and treatment of brain abscess. RECENT FINDINGS: The incidence of brain abscess is increasing, especially among elderly individuals. Important predisposing conditions include dental and ear-nose-throat infections, immuno-compromise, and previous neurosurgery...
March 29, 2024: Current Opinion in Infectious Diseases
https://read.qxmd.com/read/38547361/rational-design-and-synthesis-of-fe-doped-co-based-coordination-polymer-composite-photocatalysts-for-the-degradation-of-norfloxacin-and-ciprofloxacin
#2
JOURNAL ARTICLE
Ye-Xia Li, Xin Chen, Zhi-Yang Jiang, Jian Luan, Fang Guo
The solar light-responsive Fe-doped Co-based coordination polymer (Fe@Co-CP) photocatalyst was synthesized under mild conditions. [Co(4-padpe)(1,3-BDC)] n (Co-CP) was first constructed using mixed ligands through the hydrothermal method. Then, Fe was introduced into the Co-CP framework to achieve the enhanced photocatalytic activity. The optimal Fe@Co-CP-2 exhibited excellent catalytic degradation performance for norfloxacin and ciprofloxacin under sunlight irradiation without auxiliary oxidants, and the degradation rates were 91...
March 28, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38546951/insights-on-the-genomic-diversity-virulence-and-resistance-profile-of-a-campylobacter-jejuni-strain-isolated-from-a-hospitalized-patient-in-brazil
#3
JOURNAL ARTICLE
Carolina Nogueira Gomes, Miliane Rodrigues Frazão, Amanda Aparecida Seribelli, Dillon Oliver Reese Barker, Emily Victoria Che, Mara Corrêa Lelles Nogueira, Eduardo Napoleon Taboada, Juliana Pfrimer Falcão
Campylobacteriosis is currently recognized as one of the major causes of foodborne bacterial diseases worldwide. In Brazil, there is insufficient data to estimate the impact of Campylobacter in public health. The aim of this present study was to characterize a C. jejuni CJ-HBSJRP strain isolated from a hospitalized patient in Brazil by its ability to invade human Caco-2 epithelial cells, to survive in U937 human macrophages, and to assess its phenotypic antimicrobial resistance profile. In addition, prophages, virulence and antimicrobial resistance genes were search using whole-genome sequencing data...
March 28, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38546721/comparison-of-daily-versus-admission-and-discharge-surveillance-cultures-for-multidrug-resistant-organism-detection-in-an-intensive-care-unit
#4
JOURNAL ARTICLE
Sarah E Sansom, Teppei Shimasaki, Thelma Dangana, Michael Y Lin, Michael E Schoeny, Christine Fukuda, Nicholas M Moore, Rachel D Yelin, Christine M Bassis, Yoona Rhee, Enrique Cornejo Cisneros, Pamela Bell, Karen Lolans, Khaled Aboushaala, Vincent B Young, Mary K Hayden
BACKGROUND: Admission and discharge screening of patients for asymptomatic gut colonization with multidrug-resistant organisms (MDROs) is a traditional approach to active surveillance, but its sensitivity for detecting colonization is uncertain. METHODS: Daily rectal or fecal swab samples and clinical data were collected over 12 months from patients in one 25-bed intensive care unit (ICU) in Chicago, IL USA and tested for the following multidrug-resistant organisms (MDROs): vancomycin-resistant enterococci (VRE); third-generation cephalosporin-resistant Enterobacterales, including extended-spectrum β-lactamase-producing Enterobacterales (ESBL); and carbapenem-resistant Enterobacterales (CRE)...
March 28, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38546675/gut-microbiome-alterations-at-acute-myeloid-leukemia-diagnosis-are-associated-with-muscle-weakness-and-anorexia
#5
JOURNAL ARTICLE
Sarah A Pötgens, Violaine Havelange, Sophie Lecop, Fuyong Li, Audrey M Neyrinck, Florence Bindels, Nathalie Neveux, Jean-Baptiste Demoulin, Ine Moors, Tessa Kerre, Johan Maertens, Jens Walter, Hélène Schoemans, Nathalie M Delzenne, Laure B Bindels
The gut microbiota makes critical contributions to host homeostasis, and its role in the treatment of acute myeloid leukaemia (AML) has attracted attention. We investigated whether the gut microbiome is affected by AML, and whether such changes are associated with cachectic hallmarks. Biological samples and clinical data were collected from 30 antibiotic-free AML patients at diagnosis and matched volunteers (1:1) in a multicenter cross-sectional prospective study. The composition and functional potential of the faecal microbiota were analyzed using shotgun metagenomics...
March 28, 2024: Haematologica
https://read.qxmd.com/read/38546432/antibiotic-prescription-sources-and-use-among-under-5-children-with-fever-cough-in-sub-saharan-africa
#6
JOURNAL ARTICLE
Getayeneh A Tesema, Godness K Biney, Vicky Q Wang, Edward K Ameyaw, Sanni Yaya
BACKGROUND: Childhood febrile illness is among the leading causes of hospital admission for children <5 y of age in sub-Saharan Africa (SSA). Antibiotics have played a pivotal role in enhancing health outcomes, especially for children <5 y of age. Antibiotics prescription pattern evidence exists for SSA, however, prescription sources (either from qualified or unqualified sources) and use among children with fever or cough have not been explored. Thus the present study assessed antibiotic prescription sources and use among children <5 y of age with fever and cough in SSA...
March 28, 2024: International Health
https://read.qxmd.com/read/38546392/complete-in-vitro-reconstitution-of-the-apramycin-biosynthetic-pathway-demonstrates-the-unusual-incorporation-of-a-%C3%AE-d-sugar-nucleotide-in-the-final-glycosylation-step
#7
JOURNAL ARTICLE
Shusuke Sato, Po-Hsun Fan, Yu-Cheng Yeh, Hung-Wen Liu
Apramycin is a widely used aminoglycoside antibiotic with applications in veterinary medicine. It is composed of a 4-amino-4-deoxy-d-glucose moiety and the pseudodisaccharide aprosamine, which is an adduct of 2-deoxystreptamine and an unusual eight-carbon bicyclic dialdose. Despite its extensive study and relevance to medical practice, the biosynthetic pathway of this complex aminoglycoside nevertheless remains incomplete. Herein, the remaining unknown steps of apramycin biosynthesis are reconstituted in vitro , thereby leading to a comprehensive picture of its biological assembly...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38546344/pillar-n-arenes-in-the-fight-against-biofilms-current-developments-and-future-perspectives
#8
REVIEW
Sekar Jothi Nayaki, Arivazhagan Roja, Ramya Ravindhiran, Karthiga Sivarajan, Murugan Arunachalam, Kavitha Dhandapani
The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among the challenges posed, biofilms stand out due to their formidable resistance to conventional antibiotics. This review delves into the burgeoning potential of pillar[ n ]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. The review is structured into two main sections, each dedicated to exploring distinct facets of pillar[ n ]arene applications...
March 28, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38546315/septic-arthritis-of-the-sternoclavicular-joint
#9
JOURNAL ARTICLE
George V Koshy, Richard Davis, Christopher Wilson
INTRODUCTION: Sternoclavicular joint (SCJ) septic arthritis is a rare but rapidly fatal joint infection. Without proper medical or surgical management, it can progress to osteomyelitis, chest wall abscess, mediastinitis, or myositis. CASE REPORT: A 57-year-old male with a past history of intravenous drug use presented to the emergency department (ED) with chest tenderness of one week duration. Vital signs were unremarkable, and exam was notable for tender, raised right SCJ without any fluctuance...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546272/botanicals-as-promising-antimicrobial-agents-for-enhancing-oral-health-a-comprehensive-review
#10
REVIEW
Ekta Narwal, Jairam Choudhary, Manoj Kumar, Ryszard Amarowicz, Sunil Kumar, Radha, Deepak Chandran, Sangram Dhumal, Surinder Singh, Marisennayya Senapathy, Sureshkumar Rajalingam, Muthamilselvan Muthukumar, Mohamed Mekhemar
The mouth houses the second largest diversity of microorganisms in the body, harboring more than 700 bacterial species colonizing the soft mucosa and hard tooth surfaces. Microbes are the cause of several health-related problems, such as dental carries, gingivitis, periodontitis, etc., in the mouth across different age groups and socioeconomic/demographic groups. Oral infections are major health problems that affect the standard of living. Compromised oral health is related to chronic conditions and systemic disorders...
March 28, 2024: Critical Reviews in Microbiology
https://read.qxmd.com/read/38546218/unveiling-the-genomic-landscape-of-salmonella-enterica-serotypes-typhimurium-newport-and-infantis-in-latin-american-surface-waters-a-comparative-analysis
#11
JOURNAL ARTICLE
Zhao Chen, Magaly Toro, Andrea I Moreno-Switt, Aiko D Adell, Enrique J Delgado-Suárez, Raquel R Bonelli, Celso J B Oliveira, Angélica Reyes-Jara, Xinyang Huang, Brett Albee, Christopher J Grim, Marc Allard, Sandra M Tallent, Eric W Brown, Rebecca L Bell, Jianghong Meng
Surface waters are considered ecological habitats where Salmonella enterica can persist and disseminate to fresh produce production systems. This study aimed to explore the genomic profiles of S. enterica serotypes Typhimurium, Newport, and Infantis from surface waters in Chile, Mexico, and Brazil collected between 2019 and 2022. We analyzed the whole genomes of 106 S . Typhimurium, 161 S . Newport, and 113 S . Infantis isolates. Our phylogenetic analysis exhibited distinct groupings of isolates by their respective countries except for a notable case involving a Chilean S ...
March 28, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38546011/cocaine-gut-a-rare-case-of-cocaine-induced-esophageal-gastric-and-small-bowel-necrosis
#12
JOURNAL ARTICLE
Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum
Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38545908/spread-and-persistence-of-antimicrobial-resistance-genes-in-wastewater-from-human-and-animal-sources-in-s%C3%A3-o-paulo-brazil
#13
JOURNAL ARTICLE
Milena Dropa, Jéssica Santiago Bispo da Silva, André Furugen César Andrade, Denis Hideki Nakasone, Marcos Paulo Vieira Cunha, Gesiane Ribeiro, Ronalda Silva de Araújo, Carlos Jesus Brandão, Barbara Ghiglione, Nilton Lincopan, Maria Inês Zanoli Sato, Terezinha Knöbl
The spread of antimicrobial resistance (AMR) through multiple reservoirs is a global concern. Wastewater is a critical AMR dissemination source, so this study aimed to assess the persistence of resistance genetic markers in wastewater using a culture-independent approach. Raw and treated wastewater samples (n = 121) from a wastewater treatment plant (WWTP), a human hospital, a veterinary hospital, and a pig farm were monthly collected and concentrated by filtration. DNA was extracted directly from filter membranes, and PCR was used in the qualitative search of 32 antimicrobial resistance genes (ARGs)...
March 28, 2024: Tropical Medicine & International Health
https://read.qxmd.com/read/38545709/-not-available
#14
JOURNAL ARTICLE
Nabila Kalla, Hamouda Ouanassa, Lina Noui, Amani Melizi, Souhila Aouidane, Zohra Merzougui
INTRODUCTION: In recent years, there has been a considerable increase in the prevalence of bacteria increasingly resistant to multiple families of antibiotics, which constitutes a major problem for public health. AIM: To determine the prevalence and different risk factors for the acquisition of multi-resistant bacteria. METHODS: This is an analytical and prospective study including patients hospitalized in the Batna University Hospital during the period from January 2023 to March 2023 presenting a documented infection with isolation of sensitive or multi-resistant strains...
March 5, 2024: La Tunisie Médicale
https://read.qxmd.com/read/38545587/a-review-of-core-biopsies-in-musculoskeletal-oncology
#15
REVIEW
Amar Kamat, Anto Anand Gopurathingal, Pramod Chinder, Suraj Hindiskere
Biopsy as a procedure is technically simple but conceptually a challenge. The principles of biopsy have remained more or less the same for 3 decades. With the advent of imaging, hospital facilities, and pathology modalities, we feel it is important that these principles are revisited. Uncertainties are spread across the literature regarding this very important first step in the care of an oncology patient. A surgeon planning the biopsy should be equipped with an MRI for planning. A biopsy has to be considered even for a benign-looking lesion...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38545494/severe-cutaneous-adverse-reactions-in-a-tertiary-care-center-in-jamaica
#16
JOURNAL ARTICLE
Alicia J S McNish, Jonathan D Ho, Althea D C East-Innis
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are associated with morbidity and mortality. OBJECTIVE: The aim was to determine the different types of SCARs, their morphology, common offending drugs, interventions, and outcomes. METHODS: A retrospective cohort study was conducted of all patients admitted to the dermatology service at the University Hospital of the West Indies with Stevens-Johnson syndrome (SJS), SJS/toxic epidermal necrolysis overlap (TEN), TEN, drug reaction with eosinophilia and systemic symptoms and acute generalized exanthematous pustulosis between January 1, 2012 to June 1, 2022...
June 2024: JAAD international
https://read.qxmd.com/read/38545465/biologically-active-secondary-metabolites-from-white-rot-fungi
#17
REVIEW
Orkun Pinar, Susana Rodríguez-Couto
In recent years, there has been a considerable rise in the production of novel metabolites derived from fungi compared to the ones originating from bacteria. These organic substances are utilized in various sectors such as farming, healthcare, and pharmaceutical. Since all dividing living cells contain primary metabolites, secondary metabolites are synthesized by utilizing intermediate compounds or by-products generated from the primary metabolic pathways. Secondary metabolites are not critical for the growth and development of an organism; however, they exhibit a variety of distinct biological characteristics...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38545458/antibacterial-activity-and-mechanism-of-x33-antimicrobial-oligopeptide-against-acinetobacter-baumannii
#18
JOURNAL ARTICLE
Qunlin Lu, Xiaoyu Wu, Yuan Fang, Yuanxiu Wang, Bin Zhang
Acinetobacter baumannii is a pathogenic bacterium widespread in human environments, especially in intensive care units, and is associated with high morbidity and infection rates. Multiple drug resistance in A. baumannii frequently leads to the death of patients, making the development of multi-effect antibacterial agents against this bacterium a research hotspot. We have previously found that the X33 antimicrobial oligopeptide can effectively inhibit the growth of Penicillium digitatum and Candida albicans ...
June 2024: Synthetic and Systems Biotechnology
https://read.qxmd.com/read/38545131/preliminary-investigation-on-the-occurrence-and-health-risk-assessment-of-antibiotics-in-cultured-tilapia-retailed-at-a-commercial-outlet-in-tema-ghana
#19
JOURNAL ARTICLE
Emmanuel Kaboja Magna, Francis Ofosu-Koranteng, Ruby Asmah, Emmanuel Tetteh-Doku Mensah, Ebenezer Koranteng Appiah, Patrick Senam Fatsi, Frank Adu-Nti, Zenobia Castel Kpodo, Ishmael Lente
In Ghana, Nile tilapia is one of the most commonly cultivated fish species. Bacterial infections, which mostly occur in intensive fish farming, are considered to be the most significant health issue facing these culture systems in Ghana's aquaculture industry. To prevent, and treat bacterial infections and promote fish growth, antimicrobials are often used, and in most cases at unregulated doses. However, this misuse and neglect of withdrawal durations for such antimicrobials may result in drug residues showing up in fish edible tissue, posing a risk to human consumers...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544661/oral-thrush-an-entity-with-a-diagnostic-dilemma
#20
Aakanksha V Tiwari, Suwarna Dangore-Khasbage
Candida albicans is a commensal found in the oral cavity. It is the most frequently encountered infection in the oral cavity which can be predisposed by a number of factors including most commonly compromised immunity, certain drugs, poor oral hygiene, and ill-fitting dentures. Clinical presentation involves whitish patches or erythema over the buccal mucosa, tongue, and palate depending on the type and occurrence of the condition. Oral physicians have a key role in the diagnosis of such lesions as they are well acquainted with their appearance and features...
February 2024: Curēus
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