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JOURNAL ARTICLE
Najiba Abdulrazzaq, Ayman Chkhis
OBJECTIVES: The WHO's Global Antimicrobial Resistance Surveillance System (GLASS) 2017-2018 reported a significant increase in antimicrobial resistance among nosocomial pathogens. This was the first national point of prevalence survey in United Arab Emirates. METHODS: A one-day multicenter cross-sectional survey using a unified web-based platform was conducted in forty-four hospitals across the country from 3 to 23 November 2019 to estimate the prevalence of antimicrobial use and healthcare-associated infections among both governmental and private sectors...
March 25, 2024: Infectious diseases now
#2
JOURNAL ARTICLE
Marco Ferraresi, Maria Katsarou, Alessandro Carlo Luigi Molinari, Sara Segreti, Giovanni Rossi
The number of vascular centers performing endovascular repair of ascending aortic disease is constantly increasing. Accordingly to the guidelines, open surgical repair remains the gold standard for these pathologies. However, approximately one quarter of patients are deemed unfit for open surgery. In this study, we describe three cases of ascending thoracic endovascular aortic repair (TEVAR) performed at our center. All the patients were deemed unfit for open surgery by the aortic team. Two patients had an ascending aortic pseudoaneurysm, and the third had a focal type A aortic dissection...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
#3
Lihua Jiang, Sen Chen
OBJECTIVE: The study aims to report a rare case of a novel homozygous variant in the LRBA gene, originating from uniparental disomy of paternal origin. This case contributes new clinical data to the LRBA gene variant database. METHODS: The study details the case of a 2-year-old child diagnosed in May 2023 at our center with a homozygous LRBA gene variant. Detailed clinical data of the patient were collected, including whole-exome sequencing of peripheral blood mononuclear cells, with parental genetic verification...
2024: Frontiers in Immunology
#4
JOURNAL ARTICLE
Anne-Valérie Burgener-Gasser, Jeanne Fasel, Delia Halbeisen, Karin Hartmann, Maja Weisser-Rohacek, Carole Kaufmann, Sarah Tschudin-Sutter
BACKGROUND: A reported history of penicillin allergy frequently leads to the prescription of carbapenems as a substitute for penicillin to avoid allergic reactions. Such self-reported allergies need to be accurately characterized to identify targeted antibiotic stewardship interventions that potentially minimize unnecessary carbapenem use. DESIGN: Retrospective cohort study. METHOD: The proportion of hospitalized patients with penicillin allergy history receiving carbapenem prescriptions was evaluated between January 1st, 2017 and December 31st, 2018 at the University Hospital Basel, Switzerland...
2024: Antimicrob Steward Healthc Epidemiol
#5
JOURNAL ARTICLE
Rachel L Randell, Stephen J Balevic, Rachel G Greenberg, Michael Cohen-Wolkowiez, Elizabeth J Thompson, Saranya Venkatachalam, Michael J Smith, Catherine Bendel, Joseph M Bliss, Hala Chaaban, Rakesh Chhabra, Christiane E L Dammann, L Corbin Downey, Chi Hornik, Naveed Hussain, Matthew M Laughon, Adrian Lavery, Fernando Moya, Matthew Saxonhouse, Gregory M Sokol, Andrea Trembath, Joern-Hendrik Weitkamp, Christoph P Hornik
Pharmacokinetic models rarely undergo external validation in vulnerable populations such as critically ill infants, thereby limiting the accuracy, efficacy, and safety of model-informed dosing in real-world settings. Here, we describe an opportunistic approach using dried blood spots (DBS) to evaluate a population pharmacokinetic model of metronidazole in critically ill preterm infants of gestational age (GA) ≤31 weeks from the Metronidazole Pharmacokinetics in Premature Infants (PTN_METRO, NCT01222585) study...
March 13, 2024: Antimicrobial Agents and Chemotherapy
#6
JOURNAL ARTICLE
Savannah Racketa, Kelvin Gandhi, Matthew Lambie
PURPOSE: To date, there are three published guidelines discussing management of infected pancreatic necrosis (IPN) with conflicting recommendations. Specifically, The World Society of Emergency Surgery lists piperacillin-tazobactam as a treatment option in addition to meropenem and ciprofloxacin plus metronidazole. Piperacillin-tazobactam may serve as an effective carbapenem-sparing alternative. Although previous studies shed light on antimicrobial penetration data, there is a lack of clinical data comparing piperacillin-tazobactam to meropenem...
February 10, 2024: Diagnostic Microbiology and Infectious Disease
#7
JOURNAL ARTICLE
Rajalakshmi Arjun, Vettakkara Kandy Muhammed Niyas, Febeena Hussain, Sandeep Surendran, Viji Mohan
BACKGROUND: Viridans Group Streptococci (VGS) are a group of distinct species that can cause bacteraemia and other invasive infections. They are also among the common organisms causing infective endocarditis. Data on the epidemiology and clinical profile of VGS is limited, especially from India. METHODS: We conducted an electronic medical record-based retrospective analysis of patients with VGS bacteraemia admitted to our hospital between January 2012 to December 2021...
2024: Le Infezioni in Medicina
#8
JOURNAL ARTICLE
Hussein Almehdar, Nagwan Yousef, Wilma van den Boogaard, Amna Haider, Rupa Kanapathipillai, Emad Al-Hodiani, Evgenia Zelikova, Waddah G Moh'd, Justine Michel, Rami Malaeb
BACKGROUND: Antimicrobial resistance (AMR) is an urgent global health concern, especially in countries facing instability or conflicts, with compromised healthcare systems. Médecins Sans Frontières (MSF) established an acute trauma hospital in Aden, Yemen, treating mainly war-wounded civilians, and implemented an antimicrobial stewardship (AMS) programme. This study aimed to describe clinical characteristics and identify antibiotic susceptibility patterns representative of patients treated with antibiotics...
April 2024: JAC-antimicrobial resistance
#9
JOURNAL ARTICLE
Huy Duc Tran, Sang Thanh Tran, Triet Minh Le, Vinh Ngoc Truong Pham, Kien Trung Le, An Trinh Ngoc Le, Viet Van Ung, Tan Danh Hoang, Thinh Huu Nguyen
BACKGROUND Pneumatosis intestinalis (PI) is an uncommon condition that is not specific to any particular disease. Currently, there is no specific clinical guideline for treating and diagnosing PI. Furthermore, there are numerous causes of PI, which makes it difficult for clinicians - internal medicine physicians as well as surgeons - to take a clinical approach to diagnosis and treatment. CASE REPORT We present 3 clinical scenarios with PI. In the first patient there was a solitary image of PI, which was treated successfully with parenteral nutrition and intravenous antibiotics, and he was discharged after 5 days...
March 1, 2024: American Journal of Case Reports
#10
JOURNAL ARTICLE
Takahiro Inoue, Manabu Kato, Takeshi Sasaki, Yusuke Sugino, Shunsuke Owa, Taketomo Nishikawa, Momoko Kato, Shinichiro Higashi, Satoru Masui, Kouhei Nishikawa
BACKGROUND: Robot-assisted radical cystectomy (RARC) with urinary diversion has become a standard surgical procedure because of its three-dimensional high-definition surgical field of view, flexibility, and stability. However, because of the highly complex steps of surgery, postoperative complications cannot be ignored. METHODS: This retrospective, single-center, observational cohort study investigated the postoperative complications following RARC at a non-high-volume center in Japan...
January 31, 2024: Translational Cancer Research
#11
JOURNAL ARTICLE
Gregory Vurture, Jordan Mendelson, Bogdan Grigorescu, George Lazarou
BACKGROUND: Surgical site infections (SSI) are a common complication of hysterectomy. Surgical bundles have been shown to reduce SSIs. Here we describe a bundle that was used to combat an abnormal rise in SSI events that resulted in a greater than 75% reduction at our institution. METHODS: A hysterectomy-specific bundle was developed based on the prior success of SSI prevention bundles. Development involved longitudinal education and training to ensure accuracy and compliance...
February 22, 2024: American Journal of Infection Control
#12
JOURNAL ARTICLE
Karin Hedström, Alberto Falk-Delgado, Helena Sackey
BACKGROUND: Dermal fillers containing copolyamide are used for breast augmentation and are marketed under different labels, such as Aquafilling, Los Deline, Aqualift, and Activegel. In recent years, the number of publications reporting complications after use of these fillers has increased. METHODS: Through a computerized search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review of published studies on complications, treatment options, and radiological findings related to breast augmentation with dermal fillers containing copolyamide was performed...
June 2024: JPRAS Open
#13
REVIEW
Carmen Mesas Burgos, Willemijn Irvine, Alexandre Vivanti, Peter Conner, Egle Machtejeviene, Nina Peters, Joan Sabria, Ana Sanchez Torres, Costanza Tognon, Alberto Sgró, Antti Kouvisalo, Hester Langeveld-Benders, Rony Sfeir, Marc Miserez, Nils Qvist, Ausra Lokosiute-Urboniene, Katrin Zahn, Julia Brendel, Jordi Prat, Simon Eaton, Alexandra Benachi
BACKGROUND: The European Reference Network for rare Inherited Congenital Anomalies, ERNICA, guidelines for gastroschisis cover perinatal period to help teams to improve care. METHOD: A systematic literature search including 136 publications was conducted. Research findings were assessed following the GRADE methodology. The evidence to decision framework was used to determine the strength and direction of recommendations. RESULTS: The mode or timing of delivery do not impact neonatal mortality, risk of NEC or time on parenteral nutrition (PN)...
February 12, 2024: Orphanet Journal of Rare Diseases
#14
REVIEW
Ethan Slouha, Stefan J Biput, Brandon Krumbach, Lucy A Clunes, Theofanis F Kollias
Appendectomy remains the gold standard for treating appendicitis, but advancements in laparoscopic techniques have shifted the paradigm. Natural orifice transluminal endoscopic surgery (NOTES) and transvaginal appendectomy (TVA) offer a potentially less invasive alternative to traditional laparoscopic appendectomy (LA). This article systematically reviews the procedures, perceptions, and complications of TVA to assess its viability as a surgical option. Between January 1, 2003, and November 1, 2023, 4832 case reports, case series, and experimental and observational peer-reviewed publications were examined and filtered using the keyword "Transvaginal Laparoscopic Appendectomy...
January 2024: Curēus
#15
JOURNAL ARTICLE
Nana Akazawa, Naoya Itoh, Fumika Mano-Usui, Hisato Tatsuoka, Norihiko Terada, Hanako Kurai
The clinical significance of enterococci in intra-abdominal infections, particularly those caused by multiple organisms, remains unclear. There are no definitive guidelines regarding the use of empiric therapy with antimicrobial agents targeting enterococci. In this study, we evaluated the impact of the initial antimicrobial therapy administration of anti-enterococcal agents on the treatment of intra-abdominal infections in patients with cancer in whom enterococci were isolated from ascitic fluid cultures. This retrospective study was conducted at Shizuoka Cancer Center between January 1, 2014, and December 31, 2020, on all adult patients with cancer with enterococci in their ascitic fluid cultures...
2024: PloS One
#16
JOURNAL ARTICLE
Bryan R Campbell, Alexandra S Rooney, Andrea Krzyzaniak, Joseph J Lee, Alyssa N Carroll, Richard Y Calvo, Kimberly A Peck, Matthew J Martin, Vishal Bansal, Michael J Sise, Michael J Krzyzaniak
BACKGROUND: Algorithms for managing penetrating abdominal trauma are conflicting or vague regarding the role of laparoscopy. We hypothesized that laparoscopy is underutilized among hemodynamically stable patients with abdominal stab wounds. METHODS: Trauma Quality Improvement Program data (2016-2019) were used to identify stable (SBP ≥110 and GCS ≥13) patients ≥16yrs with stab wounds and an abdominal procedure within 24hr of admission. Patients with a non-abdominal AIS ≥3 or missing outcome information were excluded...
February 1, 2024: American Journal of Surgery
#17
JOURNAL ARTICLE
Anders Wanhainen, Isabelle Van Herzeele, Frederico Bastos Goncalves, Sergi Bellmunt Montoya, Xavier Berard, Jonathan R Boyle, Mario D'Oria, Carlota F Prendes, Christos D Karkos, Arkadiusz Kazimierczak, Mark J W Koelemay, Tilo Kölbel, Kevin Mani, Germano Melissano, Janet T Powell, Santi Trimarchi, Nikolaos Tsilimparis, George A Antoniou, Martin Björck, Raphael Coscas, Nuno V Dias, Philippe Kolh, Sandro Lepidi, Barend M E Mees, Timothy A Resch, Jean Baptiste Ricco, Riikka Tulamo, Christopher P Twine, Daniela Branzan, Stephen W K Cheng, Ronald L Dalman, Florian Dick, Jonathan Golledge, Stephan Haulon, Joost A van Herwaarden, Nikola S Ilic, Arkadiusz Jawien, Tara M Mastracci, Gustavo S Oderich, Fabio Verzini, Kak Khee Yeung
OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta and iliac arteries in succession to the 2011 and 2019 versions, with the aim of assisting physicians and patients in selecting the best management strategy. METHODS: The guideline is based on scientific evidence completed with expert opinion on the matter. By summarising and evaluating the best available evidence, recommendations for the evaluation and treatment of patients have been formulated...
February 2024: European Journal of Vascular and Endovascular Surgery
#18
REVIEW
Samuel Grills, Nadia El-Diaz, Abigail Walker-Jacobs, Joseph Borucki, Philip Stather
OBJECTIVE: Infected aortic grafts and mycotic aneurysms represent one of the most complex challenges faced by vascular surgeons. Treatment has progressed from extra-anatomical bypass to in-situ reconstruction. Additionally, Bovine pericardium reconstruction (BPR) has increased, due to accessibility and reduced lower limb morbidity. There remains, however, limited evidence for its use. The aim is to pool all known data to understand outcomes following BPR of mycotic aneurysms or infected vascular grafts...
January 31, 2024: Annals of Vascular Surgery
#19
REVIEW
Xavier Deffieux, Marie-Aimée Perrouin-Verbe, Sandrine Campagne-Loiseau, Laurence Donon, Amélie Levesque, Jérome Rigaud, Nadja Stivalet, Aurélien Venara, Thibault Thubert, Adrien Vidart, Pierre-Olivier Bosset, Christine Revel-Delhom, Jean-Philippe Lucot, Jean François Hermieu
UNLABELLED: Complications associated with pelvic organ prolapse (POP) surgery using a synthetic non-absorbable mesh are uncommon (<5%) but may be severe and may hugely diminish the quality of life of some women. In drawing up these multidisciplinary clinical practice recommendations, the French National Authority for Health (Haute Autorité de santé, HAS) conducted an exhaustive review of the literature concerning the diagnosis, prevention, and management of complications associated with POP surgery using a synthetic mesh...
March 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#20
Kengo Yoshitomi, Yudai Koya, Koichiro Miyagawa, Yuki Maruno, Koki Yamaguchi, Ryuta Taniguchi, Koji Onitsuka, Yoshitaka Sakamoto, Shinji Oe, Masaru Harada
A liver cyst is hepatic fluid-filled cavities often detected in clinical surveillances such as a health examination. Although the liver cyst is usually asymptomatic and observed without any therapeutic intervention, it can be symptomatic and needs treatment due to its enlargement, hemorrhage, and infection. A 74-year-old woman presented with upper abdominal pain and a huge liver cyst in the left lobe. Several examinations including image findings revealed that the symptom could be derived from the liver cyst...
2024: Case Reports in Gastrointestinal Medicine
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