Lu Qian, Yanli Zhu, Chao Deng, Zhenxing Liang, Junmin Chen, Ying Chen, Xue Wang, Yanqing Liu, Ye Tian, Yang Yang
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators of many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, and inflammation. Accumulating evidence has shown that PGC-1s are implicated in many diseases, such as cancers, cardiac diseases and cardiovascular diseases, neurological disorders, kidney diseases, motor system diseases, and metabolic disorders...
March 1, 2024: Signal Transduction and Targeted Therapy