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cognition stroke

Tanya N Turan, Sami Al Kasab, Alison Smock, George Cotsonis, David Bachman, Michael J Lynn, Azhar Nizam, Colin P Derdeyn, David Fiorella, Scott Janis, Bethany Lane, Jean Montgomery, Marc I Chimowitz
BACKGROUND: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial. METHODS: Subjects in the SAMMPRIS trial were included in this study. In order to have an assessment of cognitive function independent of stroke, patients with a stroke as a qualifying event whose deficits included aphasia or neglect were excluded from these analyses as were those with a cerebrovascular event during follow-up...
February 14, 2019: Cerebrovascular Diseases
Nancy P Duarte Delgado, Gloria Vásquez, Blanca L Ortiz-Reyes
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE...
February 11, 2019: Autoimmunity Reviews
Decai Zeng, ChunLan Jiang, Chunxiao Su, Ying Tan, Ji Wu
BACKGROUND: It is well known that atrial fibrillation (AF) carried a high risk of cognitive decline, which is independent of stroke or transient ischemic attack (TIA). Whether anticoagulation is associated with reduced risk of cognitive decline in participants with AF still remains controversial. We conducted a systematic review and meta-analysis to explore the effect of anticoagulation on the risk of cognitive decline in patients with AF. METHODS: We systematically searched the PubMed, Embase and the Cochrane Database for eligible studies published up to January 2018...
February 2019: Medicine (Baltimore)
Karen O B Appiah, Minal Patel, Ronney B Panerai, Thompson G Robinson, Victoria J Haunton
BACKGROUND: Blood pressure variability (BPV) in acute ischemic stroke (AIS) may be of prognostic significance. However, methodological heterogeneity of studies may contribute to inconsistent findings, and study findings are therefore not readily comparable. We investigated study methodologies which have assessed the long-term outcomes (≥7 days) of BPV post-AIS. MATERIALS AND METHODS: The literature search was conducted in OVID Medline, Embase, The Cochrane Library, and Web of Science following a predefined search strategy...
February 11, 2019: Blood Pressure Monitoring
Farah Francis, Lucia Ballerini, Joanna M Wardlaw
BACKGROUND: Perivascular spaces, visible on brain magnetic resonance imaging, are thought to be associated with small vessel disease, neuroinflammation, and to be important for cerebral hemodynamics and interstitial fluid drainage. AIMS: To benchmark current knowledge on perivascular spaces associations with risk factors, neurological disorders, and neuroimaging lesions, using systematic review and meta-analysis. SUMMARY OF REVIEW: We searched three databases for perivascular spaces publications, calculated odds ratios with 95% confidence interval and performed meta-analyses to assess adjusted associations with perivascular spaces...
February 14, 2019: International Journal of Stroke: Official Journal of the International Stroke Society
James E Orfila, Robert M Dietz, Krista M Rodgers, Andra Dingman, Olivia P Patsos, Ivelisse Cruz-Torres, Himmat Grewal, Frank Strnad, Christian Schroeder, Paco S Herson
Ischemic stroke is a leading cause of death worldwide and clinical data suggest that children may recover from stroke better than adults; however, supporting experimental data are lacking. We used our novel mouse model of experimental juvenile ischemic stroke (MCAO) to characterize age-specific cognitive dysfunction following ischemia. Juvenile and adult mice subjected to 45-min MCAO, and extracellular field recordings of CA1 neurons were performed to assess hippocampal synaptic plasticity changes after MCAO, and contextual fear conditioning was performed to evaluate memory and biochemistry used to analyze Nogo-A expression...
February 14, 2019: Journal of Cerebral Blood Flow and Metabolism
Nicolas Christ, Viola Mocke, Felix Fluri
BACKGROUND AND PURPOSE: The present study aimed to investigate whether cerebral microbleeds (CMB) are associated with vascular cognitive decline (VCD) already in the early course after ischemic stroke, and-if so-whether distinct cognitive domains are affected more preferentially by CMB. METHODS: In a prospective cohort study, cognitive performance was examined in 33 stroke patients showing ≥ 1 CMB on MRI. Matched for age, gender, clinical and radiological characteristics, 33 stroke survivors without CMB served as a control group...
February 14, 2019: Journal of Neurology
Melanie Dani, Sophie Bowen-Carpenter, Patrick J McGown
A 72-year-old woman presented with a complex partial seizure and right hemiparesis, after a four-week history of cognitive decline, apraxia and speech disturbance. She previously had chronic lymphocytic leukaemia (CLL) and had finished chemotherapy one year prior to presentation. She was receiving monthly intravenous immunoglobulins for bronchiectasis. Brain imaging showed hypodensity in the left temporo-parietal regions. Cerebrospinal fluid was positive for the JC virus, leading to a diagnosis of progressive multifocal leucoencephalopathy (PML)...
2019: European Journal of Case Reports in Internal Medicine
Hongyong Liu, Yuqiu Ye, Yanbing Chen, Yunqiang Zhang, Shaomin Li, Wentao Hu, Rongqian Yang, Zhesi Zhang, Hongquan Peng, Linsheng Lv, Xun Liu
Anemia is one of the major complications in predialysis patients with chronic kidney disease (CKD). A clearer cognition of the prognostic impact of hemoglobin (Hb) or hematocrit (Hct) target on the outcomes of predialysis patients with CKD is significant. This article aims to establish the suitable hemoglobin target to provide clinical guidance. MEDLINE, EmBase, the Cochrane Library and other databases were searched with both MeSH terms and keywords to gather researches that assessed all-cause mortality, stroke, treatment of renal replacement, and transfusion...
February 11, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Gulcihan Arkan, Ayse Beser, Meryem Ozturk Haney, Vesile Ozturk
BACKGROUND: When stroke survivors return to their lives in society, they often face issues such as physical or cognitive impairment, dependence on others, social isolation, and reduced self-esteem, which may lead to disastrous consequences in patients' self-perceived self-efficacy and self-confidence in everyday life. Self-efficacy plays an important role in the well-being of stroke patients. Accurate assessment of the stroke patients' self-efficacy by health professionals is critical to obtaining data regarding their functioning levels...
February 8, 2019: Journal of Nursing Research: JNR
Jaclyn K Schwartz, Carmen Enid Capo-Lugo, Abiodun Emmanuel Akinwuntan, Pamela Roberts, Shilpa Krishnan, Samir R Belagaje, Mark Kovic, Suzanne Perea Burns, Xiaolei Hu, Megan Danzl, Hannes Devos, Stephen J Page
Persons with mild stroke experience motor and cognitive impairments that negatively impact their health and quality of life. To address these deficits, it is essential for clinicians and researchers to precisely identify mild stroke survivors. Despite the fact that half of all strokes are categorized as mild, no standards exist on what constitutes a "mild" stroke. The purpose of this study is to summarize the current classification of mild stroke using a mapping review approach. Strategies to categorize "mild stroke" severity were explored in 188 papers indexed in the PubMed database...
February 11, 2019: PM & R: the Journal of Injury, Function, and Rehabilitation
César G Fraga, Kevin D Croft, David O Kennedy, Francisco A Tomás-Barberán
Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases. Tea, cocoa, fruits, and berries, as well as vegetables, are rich in polyphenols. Flavan-3-ols from cocoa have been found to be associated with a reduced risk of stroke, myocardial infarction, and diabetes, as well as improvements in lipids, endothelial-dependent blood flow and blood pressure, insulin resistance, and systemic inflammation...
February 12, 2019: Food & Function
Pasquale Caponnetto
The burden of mental illness is profound and growing. Each year, almost one in three adults in the non-institutionalized community has a diagnosable mental or addictive disorder, and this figure climbs to approximately 40% among emergency departments patients. We described the principal cardiovascular acute disease and their emotional and behavioral consequences where psychological intervention could improve the care pathway and clinical outcome. Peer-reviewed articles from Medline, Psycinfo, Web of Science, Scopus, and Cochrane library, about psychological and psychopathological sequelae in cardiovascular acute disease were searched...
November 6, 2018: Mental Illness
Yen-Ling Chiu, Hsiu-Hui Tsai, Yen-Jun Lai, Hsin-Yi Tseng, Yen-Wen Wu, Yu-Sen Peng, Cheng-Ming Chiu, Yi-Fang Chuang
BACKGROUND: Chronic kidney disease exhibits a prominent premature aging phenotype in many different organ systems, including the brain. Nevertheless, a comprehensive characterization of brain aging in non-demented patients with end-stage renal disease (ESRD) is lacking and it remains unclear if the collective changes of cognitive functions and brain structures in ESRD is compatible with aging. METHODS: We compared 56 non-demented, independently living dialysis patients (mean age 59...
February 7, 2019: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Ana Verdelho, Sofia Madureira, Manuel Correia, José Manuel Ferro, Mário Rodrigues, Manuel Gonçalves-Pereira, Mafalda Gonçalves, Ana Catarina Santos, Pedro Vilela, Helena Bárrios, Mariana Borges, Helena Santa-Clara
BACKGROUND: Cognitive impairment and cerebrovascular pathology are both frequent with ageing. Cognitive impairment due to vascular pathology of the brain, termed vascular cognitive impairment (VCI), is one of the most frequent causes of cognitive impairment in elderly subjects. Thus far, VCI has no specific pharmacological treatment. Recent observational studies have suggested a protective effect of physical activity in cognition, but adequate randomised controlled trials (RCT) are lacking...
February 11, 2019: Trials
Chiang-Soon Song, Oan-Na Lee, Hee-Soon Woo
BACKGROUND: Cognitive orientation to daily occupational performance (CO-OP) is a task-specific training applied using a cognitive behavioral approach to improve performance in daily activities and to enable the patient to overcome limitations related to them. OBJECTIVES: The purpose of this study was to investigate the effects of the CO-OP approach in comparison with task-specific upper extremity training (TUET) on performance related to daily and functional activities in individuals with chronic hemiparetic stroke...
February 5, 2019: Restorative Neurology and Neuroscience
Ro Julia Robotham, Jens Oestergaard Riis, Nele Demeyere
Cognitive deficits are common following stroke and have many negative consequences. They must be identified to provide appropriate interventions and care. In Denmark, the Montreal Cognitive Assessment (MoCA), a dementia screening tool, is commonly used to screen for cognitive deficits following stroke, despite its limitations in this context. This study aimed to make the Oxford Cognitive Screen (OCS), a stroke-specific cognitive screening tool, available in Danish and to provide population appropriate normative data...
February 11, 2019: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Amalie Saab, Shiona Glass-Kaastra, Gordon Bryan Young
BACKGROUND: We reviewed numerous variables for ischemic stroke patients admitted to a rehabilitation unit to determine those that were statistically associated with discharge destination. METHODS: A retrospective chart review of patients with ischemic stroke discharged from the rehabilitation unit between January 1, 2005 and December 31, 2015. Variables were examined for their association with discharge destination (home versus long-term care (LTC)). Univariable relationships with discharge destination were assessed, and a multivariable logistic regression model was built...
February 11, 2019: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Jan Willem van Dalen, Eric P Moll van Charante, William A van Gool, Edo Richard
OBJECTIVES: To evaluate whether discontinuation of antihypertensive medication in community-dwelling older people is associated with a reduction in memory complaints and/or incident dementia. DESIGN: Prospective observational cohort study within the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial. SETTING AND PARTICIPANTS: Community-dwelling participants (aged 70-78 years at baseline) who underwent 2-yearly assessments during 6-8 years of follow-up...
February 6, 2019: Journal of the American Medical Directors Association
J M Ramírez-Moreno, S Bartolomé Alberca, P Muñoz Vega, E J Guerrero Barona
OBJECTIVE: The symptoms of minor stroke and transient ischemic attack (TIA) are temporary and mild. Despite the transient nature of the focal symptoms and the absence of visible brain lesions in some patients, many experience persistent cognitive problems subsequently. We aimed to establish the discriminant capacity of the Montreal Cognitive Assessment (MoCA) in screening for cognitive impairment (CI) within 90 days of TIA. METHOD: A total of 50 patients with minor stroke or TIA were recruited...
February 5, 2019: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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