Kimberly Prescott, Taitum O Cothren, John T Holsten, Christopher J Evonko, Elan C Doyle, Faith E Bullock, Paul T Marron, Julia G Staton, Laura S Hatvany, Justin W Flack, Stacie L Beuschel, David A MacQueen, Todd C Peterson
Stroke is a leading cause of death and disability in the United States. Most strokes are ischemic, resulting in both cognitive and motor impairments. Animal models of ischemic stroke such as the distal medial cerebral artery occlusion (dMCAO) and photothrombotic stroke (PTS) procedures have become invaluable tools, with their own advantages and disadvantages. The dMCAO model is clinically relevant as it occludes the artery most affected in humans, but yields variability in the infarct location as well as the behavioral and cognitive phenotypes disrupted...
April 11, 2024: Behavioural Brain Research